Oka Hiroko 岡広子

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OKA HIROKO 岡広子

OKA Hiroko 岡広子

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Researcher Number	60452588
Other IDs
Affiliation (Current)	2026: 広島大学, 医系科学研究科(歯), 主任特任学術研究員
Affiliation (based on the past Project Information) *help	2026: 広島大学, 医系科学研究科(歯), 主任特任学術研究員 2022 – 2024: 広島大学, 医系科学研究科(歯), 主任特任学術研究員 2019 – 2021: 広島大学, 医系科学研究科(歯), 特任講師 2018: 広島大学, 医歯薬保健学研究科(歯), 特任講師 2015: 広島大学, 医歯薬保健学研究院(歯), 特任講師 … More 2013: 広島大学, 医歯薬保健学研究院, 特任助教 2012 – 2013: 広島大学, 医歯薬保健学研究院(歯), 特任助教 2011: 広島大学, 医歯(薬)学総合研究科, 特任助教 2009: Hiroshima University, 大学院・医歯薬学総合研究科, 特任助教 2008: 広島大, 医歯(薬)学総合研究科, 助教 2008: Hiroshima University, 大学院・医歯薬学総合研究科, その他(特任助教) 2007: Hiroshima University, 大学院・医歯(薬)学総合研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 57080:Social dentistry-related / Functional basic dentistry / Morphological basic dentistry Except Principal Investigator Basic Section 57070:Developmental dentistry-related / Basic Section 49050:Bacteriology-related / Morphological basic dentistry
Keywords	Principal Investigator 歯科法医学 / メチル化 / 年齢推定 / 歯周組織 / 炎症 / エピジェネティクス / 石灰化 / 歯 / 硬組織 / 国際 … More / DNA / 口腔内試料からの年齢推定 / 口腔内試料 / 受容体 / LDL受容体ファミリー / F-spondin / 硬組織破壊 / 炎症性疼痛 / 組織破壊 / cyclic ADP-ribose / 疼痛 … More Except Principal Investigator 法医解剖 / メタゲノム解析 / 口腔検体 / 全身疾患 / 歯周病原性細菌 / マイクロバイオーム解析 / 次世代シークエンサー / 歯周病菌ピラミッド / Tannerella forsythia / Treponema denticola / Porphyromonas gingivalis / レッドコンプレックス / 歯周炎 / パーシスター形成 / TAシステム / トキシン・アンチトキシン　システム / 酸化ストレス / 生育阻害 / トキシン・アンチトキシン / ストレス応答 / 細胞死 / 膜タンパク質 / トキシン・アンチトキシンシステム / 黄色ブドウ球菌 / トランスジェニックマウス / 歯槽骨吸収 / 炎症性サイトカイン / 骨吸収 / ペプチド / 抗炎症作用 / IL-6 / 骨芽細胞 / F-spondin Less

全身における口腔細菌の存在・分布と全身病態との関連の解明Principal Investigator
- Principal Investigator
  
  岡広子
- Project Period (FY)
  2026 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Hiroshima University
歯周病原性細菌に着目した小児の免疫疾患・感染症の制御に向けた基盤構築
- Principal Investigator
  
  野村良太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Hiroshima University
Evaluation of epigenetic aging changes in hard tissues and its application on age estimationPrincipal Investigator
- Principal Investigator
  
  Oka Hiroko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Hiroshima University
Elucidation of Bacterial Cell Death Regulation and Persister Formation by a Novel TA System in Staphylococcus aureus
- Principal Investigator
  
  KATO FUMINORI
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Hiroshima University
Development of Asian age prediction method based on DNA methylationPrincipal Investigator
- Principal Investigator
  
  Oka Hiroko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Hiroshima University
Effect of F-spondin on the inhibition of alveolar bone resorption
- Principal Investigator
  
  Kitagawa Masae
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
Study on the mechanism of F-spondin/LDL receptor family for hard tissue destructionPrincipal Investigator
- Principal Investigator
  
  OKA HIROKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
Study for oral-facial pain control mechanism by periodontal specific cells.Principal Investigator
- Principal Investigator
  
  OKA Hiroko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
疼痛制御におけるcyclic ADP-riboseの役割と新規治療薬の開発Principal Investigator
- Principal Investigator
  
  岡広子
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University

All 2024 2023 2022 2020 2019 2018 2013 2012

All Journal Article Presentation

[Journal Article] Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.2024
- Author(s)
  Ito S, Misaki T, Nagasawa Y, Nomura R, Naka S, Fukunaga A, Matsuoka D, Matayoshi S, Matsumoto-Nakano M, Nakano K.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 28 Issue: 3 Pages: 192-200
- DOI
  10.1007/s10157-023-02411-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08242, KAKENHI-PROJECT-24K02655, KAKENHI-PROJECT-23K09146, KAKENHI-PROJECT-23K09435
[Journal Article] Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals2024
- Author(s)
  Kametani M、Nagasawa Y、Usuda M、Kaneki A、Ogawa M、Shojima K、Yamazaki H、Tokumoto K、Matsuoka Di、Suehara K、Suehiro Y、Akitomo T、Mitsuhata C、Misaki T、Ito S、Naka S、Matsumoto-Nakano Mi、Nakano K、Kishimoto H、Shinmura K、Nomura R
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 22 Pages: 12243-12243
- DOI
  10.3390/ijms252212243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27805, KAKENHI-PROJECT-24K02655, KAKENHI-PROJECT-23K09146, KAKENHI-PROJECT-24K10543, KAKENHI-PROJECT-23K19599
[Journal Article] Effects of mouthwash on periodontal pathogens and glycemic control in patients with type 2 diabetes mellitus.2024
- Author(s)
  Matayoshi S., Tojo F., Suehiro Y., Okuda M., Takagi M., Ochiai M., Kadono M., Mikasa Y., Okawa R., Nomura R., Itoh Y., Itoh N., Nakano K.
- Journal Title
  
  Scientific Reports
  
  Volume: 14(1) Issue: 1 Pages: 2777-2777
- DOI
  10.1038/s41598-024-53213-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02655
[Journal Article] Some tips on age estimation using DNA methylation in saliva samples as an index across the Japanese and Indonesian ethnicities2022
- Author(s)
  Hiroko Oka, Maretaningtias Dwi Ariani, Tomohiko Akazaki, Mutsumi Miyauchi, Masae Kitagawa
- Journal Title
  
  Legal Medicine (Tokyo) Online ahead of print
  
  Volume: - Pages: 102042-102042
- DOI
  10.1016/j.legalmed.2022.102042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10253
[Presentation] lgA腎症患者と習慣性扁桃炎患者の摘出扁桃における歯周病菌の検出率の比較2024
- Author(s)
  長澤康行，野村良太，三﨑太郎，伊藤誓悟，山崎博充，庄嶋健作，松岡大貴，仲周平，仲野道代，新村健，仲野和彦
- Organizer
  第67回日本腎臓学会学術大会
- Data Source
  KAKENHI-PROJECT-24K02655
[Presentation] Comprehensive analysis of oral bacteria related to red complex species.2024
- Author(s)
  Kametani M., Nagasawa Y., Usuda M., Kaneki A., Ogawa M., Shojima K., Yamazaki H., Tokumoto K., Matsuoka D., Suehara K., Suehiro Y., Akitomo T., Mitsuhata C., Misaki T., Ito S., Naka S., Matsumoto-Nakano M., Nakano K., Kishimoto H., Shinmura K., Nomura R.
- Organizer
  The 72nd Annual Meeting of Japanese Association for Dental Research
- Data Source
  KAKENHI-PROJECT-24K02655
[Presentation] 歯のDNAメチル化を指標とした年齢推定に向けた検討－歯根の石灰化に与えるメチル化の影響－2023
- Author(s)
  岡　広子
- Organizer
  第107次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-21K10253
[Presentation] 口腔から得られる検体のDNAメチル化を指標とした年齢推定にむけて2023
- Author(s)
  岡　広子
- Organizer
  第65回日本歯科基礎医学会アップデートシンポジウム
- Data Source
  KAKENHI-PROJECT-21K10253
[Presentation] DNAメチル化を指標としたアジア系の年齢推定に向けた検討－日本人とインドネシア人の唾液試料の比較－2020
- Author(s)
  岡　広子
- Organizer
  第104次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-18K09910
[Presentation] 歯のDNAメチル化を指標とした高解像度融解曲線分析による年齢推定に向けた検討－第2報2020
- Author(s)
  岡　広子
- Organizer
  日本法歯科医学会第14回学術大会
- Data Source
  KAKENHI-PROJECT-18K09910
[Presentation] 歯のDNAメチル化を指標とした高解像度融解曲線分析による年齢推定に向けた検討2019
- Author(s)
  岡　広子
- Organizer
  日本法歯科医学会第13回学術大会
- Data Source
  KAKENHI-PROJECT-18K09910
[Presentation] DNAメチル化を指標としたアジア系の年齢推定法開発に向けた検討2018
- Author(s)
  岡広子
- Organizer
  日本法歯科医学会第12回学術大会
- Data Source
  KAKENHI-PROJECT-18K09910
[Presentation] セメント芽細胞が発現するF-spondinの抗炎症作用に関する検討2013
- Author(s)
  北川雅恵,宮内睦美,岡広子,外丸祐介,高田隆
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-23792103
[Presentation] セメント芽細胞が発現するF-spondinの抗炎症作用に関する検討2013
- Author(s)
  北川　雅恵、宮内　睦美、岡　広子、外丸　祐介、高田　隆
- Organizer
  第55回歯科基礎医学会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Data Source
  KAKENHI-PROJECT-25462854
[Presentation] F-spondinは歯周組織の硬組織破壊を抑制する2013
- Author(s)
  岡広子，北川雅恵，高田隆
- Organizer
  第55回歯科基礎医学会学術大会．
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23792103
[Presentation] F-spondinは歯周組織の硬組織破壊を抑制する2013
- Author(s)
  岡広子,北川雅恵,高田隆
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2013-09-21
- Data Source
  KAKENHI-PROJECT-23792103
[Presentation] F-spondin Protects the Root Surface from Resorption2012
- Author(s)
  Hiroko Oka, Masae Kitagawa, Takashi Takata
- Organizer
  The 60th Annual Meeting of Japanese Association for Dental Research
- Place of Presentation
  新潟コンベンションセンター(新潟)
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23792103
[Presentation] F-spondin Protects the Root Surface from Resorption.2012
- Author(s)
  Hiroko Oka, Masae Kitagawa, Takashi Takata
- Organizer
  第60回国際歯科研究学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23792103

1. Kitagawa Masae (10403627)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. MIYAUCHI MUTSUMI (50169265)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. KATO FUMINORI (70452589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKATA TAKASHI (10154783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 野村良太 (90437385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 仲野和彦 (00379083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 光畑智恵子 (10335664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 松尾美樹 (20527048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 鋸屋侑布子 (40803078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 長尾正崇 (80227991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 秋友達哉 (90909681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. NAKA Shuhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 仲野道代

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 長澤康行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oka Hiroko 岡 広子

OKA HIROKO 岡 広子

OKA Hiroko 岡 広子

Research Projects

Research Products

Co-Researchers

全身における口腔細菌の存在・分布と全身病態との関連の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯周病原性細菌に着目した小児の免疫疾患・感染症の制御に向けた基盤構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of epigenetic aging changes in hard tissues and its application on age estimationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Bacterial Cell Death Regulation and Persister Formation by a Novel TA System in Staphylococcus aureus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Asian age prediction method based on DNA methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of F-spondin on the inhibition of alveolar bone resorption

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism of F-spondin/LDL receptor family for hard tissue destructionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for oral-facial pain control mechanism by periodontal specific cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

疼痛制御におけるcyclic ADP-riboseの役割と新規治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of mouthwash on periodontal pathogens and glycemic control in patients with type 2 diabetes mellitus.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Some tips on age estimation using DNA methylation in saliva samples as an index across the Japanese and Indonesian ethnicities2022

Author(s)

Journal Title

DOI

Data Source

Oka Hiroko 岡広子

OKA HIROKO 岡広子

OKA Hiroko 岡広子