Kabata Hiroki 加畑宏樹

… Alternative Names

加畑宏樹カバタヒロキ

Less

Researcher Number	60528537
Other IDs	https://orcid.org/0000-0001-8853-6149
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 慶應義塾大学, 医学部(信濃町), 講師 2020 – 2021: 慶應義塾大学, 医学部(信濃町), 助教 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator ILC2 / IL-10 / 制御性自然リンパ球 / ILCreg / IL-4 / TSLP / IL-13 / IL-5 / シングルセル解析 / 亜鉛 … More / MT2A / ANXA1 / 活性化機構 / 新規物質 / 制御 / Drug repositioning / IL-33 / 治療 / 気管支喘息 / 新規治療薬 … More Except Principal Investigator 環境因子 / ソフトウェア医療機器 / 個別化治療 / ピークフロー / 気管支喘息 / 1細胞分泌時間イメージング法（LCI-S) / リンパ球 / 2型自然リンパ球 / 1細胞分泌時間イメージング法(LCI-S) / 免疫フェノタイプ / LCI-S / 難治性喘息 Less

呼吸器疾患における制御性自然リンパ球（ILCreg）の解析と新規治療戦略の確立Principal Investigator
- Principal Investigator
  
  加畑宏樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Optimizing personalized disease management by investigating the link between bronchial asthma, meteorological factors, and air pollution
- Principal Investigator
  
  正木克宜
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
気管支喘息及び慢性副鼻腔炎における高病原性ILC2を標的とした新規制御因子の探索Principal Investigator
- Principal Investigator
  
  加畑宏樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Novel therapeutic strategy for refractory asthma using immunophenotyping
- Principal Investigator
  
  福永興壱
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Identification of novel inhibitory compounds targeting ILC2Principal Investigator
- Principal Investigator
  
  Kabata Hiroki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
気管支喘息におけるナチュラルヘルパー細胞の関与Principal Investigator
- Principal Investigator
  
  加畑宏樹
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] THE INNATE IMMUNE NETWORK AND THERAPEUTIC APPROACHES IN ASTHMA2024
- Author(s)
  馬塲里英、加畑宏樹、福永興壱
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 73 Issue: 1 Pages: 14-20
- DOI
  10.15036/arerugi.73.14
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24342
[Journal Article] Protocol for lentiviral vector-based gene transfection in human ILC2s2024
- Author(s)
  Irie Misato、Kabata Hiroki、Fukunaga Koichi
- Journal Title
  
  STAR Protocols
  
  Volume: 5 Issue: 1 Pages: 102854-102854
- DOI
  10.1016/j.xpro.2024.102854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08240, KAKENHI-PROJECT-23K24342
[Journal Article] Current summary of clinical studies on anti-TSLP antibody, Tezepelumab, in asthma2023
- Author(s)
  Kurihara Momoko、Kabata Hiroki、Irie Misato、Fukunaga Koichi
- Journal Title
  
  Allergol. Int.
  
  Volume: 72 Issue: 1 Pages: 24-30
- DOI
  10.1016/j.alit.2022.11.006
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08240, KAKENHI-PROJECT-23K24342
[Journal Article] Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s2023
- Author(s)
  Irie Misato、Kabata Hiroki、Sasahara Kotaro、Kurihara Momoko、Shirasaki Yoshitaka、Kamatani Takashi、Baba Rie、Matsusaka Masako、Koga Satoshi、Masaki Katsunori、Miyata Jun、Araki Yasutomo、Kikawada Toru、Kabe Yasuaki、Suematsu Makoto、Yamagishi Mai、Uemura Sotaro、Moro Kazuyo、Fukunaga Koichi
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112610-112610
- DOI
  10.1016/j.celrep.2023.112610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08240, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-23K24342
[Journal Article] Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation2023
- Author(s)
  Tanaka Yumiko、Yamagishi Mai、Motomura Yasutaka、Kamatani Takashi、Oguchi Yusuke、Suzuki Nobutake、Kiniwa Tsuyoshi、Kabata Hiroki、Irie Misato、Tsunoda Tatsuhiko、Miya Fuyuki、Goda Keisuke、Ohara Osamu、Funatsu Takashi、Fukunaga Koichi、Moro Kazuyo、Uemura Sotaro、Shirasaki Yoshitaka
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 915-915
- DOI
  10.1038/s42003-023-05297-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18232, KAKENHI-PROJECT-21H02750, KAKENHI-PROJECT-23K24342
[Journal Article] Current overview of the role of neuropeptides in ILC2s and future directions2022
- Author(s)
  Irie Misato、Sasahara Kotaro、Artis David、Kabata Hiroki
- Journal Title
  
  Allergol. Int.
  
  Volume: 71 Issue: 3 Pages: 294-300
- DOI
  10.1016/j.alit.2022.03.002
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17193
[Journal Article] Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients2022
- Author(s)
  Baba Rie、Kabata Hiroki、Shirasaki Yoshitaka、Kamatani Takashi、Yamagishi Mai、Irie Misato、Watanabe Risa、Matsusaka Masako、Masaki Katsunori、Miyata Jun、Moro Kazuyo、Uemura Sotaro、Fukunaga Koichi
- Journal Title
  
  Journal of Allergy and Clinical Immunology: Global
  
  Volume: 1 Issue: 4 Pages: 299-304
- DOI
  10.1016/j.jacig.2022.07.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08240, KAKENHI-PROJECT-21K18232, KAKENHI-PROJECT-23K24342
[Journal Article] TLR7 Agonist Suppresses Group 2 Innate Lymphoid Cell?mediated Inflammation via IL-27?Producing Interstitial Macrophages2021
- Author(s)
  Okuzumi Shinichi、Miyata Jun、Kabata Hiroki、Mochimaru Takao、Kagawa Shizuko、Masaki Katsunori、Irie Misato、Morita Hideaki、Fukunaga Koichi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 65 Issue: 3 Pages: 309-318
- DOI
  10.1165/rcmb.2021-0042oc
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17193, KAKENHI-PROJECT-20K17224
[Journal Article] The effect of statins for asthma. A systematic review and meta-analysis2021
- Author(s)
  Sunata Keeya、Kabata Hiroki、Kuno Toshiki、Takagi Hisato、So Matsuo、Masaki Katsunori、Fukunaga Koichi
- Journal Title
  
  Journal of Asthma
  
  Volume: 59 Issue: 4 Pages: 801-810
- DOI
  10.1080/02770903.2021.1879850
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] ステロイド抵抗性喘息を考察する　喘息の重症化とステロイド抵抗性におけるILC22024
- Author(s)
  加畑宏樹, 中村玲奈, 馬塲里英, 福永興壱
- Organizer
  第72回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] ILC2の多様性(heterogeneity)と質的評価の重要性2024
- Author(s)
  加畑宏樹
- Organizer
  第64回日本呼吸器学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] 重症喘息患者に対するベンラリズマブ投与前後のリンパ球解析2024
- Author(s)
  入江美聡、加畑宏樹、正木克宜、山岸舞、鎌谷高志、鈴川真穂、原田紀宏、宮崎泰成、桂秀樹、放生雅章、杉本直也、河野雄太、權寧博、宮田純、上村想太郎、白崎善隆、福永興壱
- Organizer
  第64回日本呼吸器学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] 2型炎症における自然免疫ネットワーク2023
- Author(s)
  加畑宏樹
- Organizer
  日本職業・環境アレルギー学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] 重症喘息の新潮流 Treatable traitsとDupilumab2023
- Author(s)
  加畑宏樹
- Organizer
  日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] Annexin A1 Is A Cell-Intrinsic Regulator Of Human Group 2 Innate Lymphoid Cells Via Zinc2023
- Author(s)
  Hiroki Kabata, Misato Irie, Yoshitaka Shirasaki, Koichi Fukunaga
- Organizer
  33th Collegium Internationale Allergologicum biennial symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] 喘息の重症化とステロイド抵抗性におけるILC22023
- Author(s)
  加畑宏樹
- Organizer
  日本アレルギー学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] Zinc plays an essential role in type 2 cytokine production from ILC2s in asthma2023
- Author(s)
  Hiroki Kabata, Misato Irie, Rie Baba, Yoshitaka Shirasaki, Takashi Kamatani, Mai Yamagishi, Koichi Fukunaga
- Organizer
  European Respiratory Society International Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] ライブイメージング・シングルセル解析を用いたILC2の多様性と亜鉛を介した新規活性化制御機構の解明2023
- Author(s)
  加畑宏樹, 入江美聡, 馬塲里英, 福永興壱
- Organizer
  第63回日本呼吸器学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] ライブイメージング・シングルセル解析を用いたILC2の多様性と亜鉛を介した新規活性化制御機構の解明2023
- Author(s)
  加畑宏樹
- Organizer
  日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] ヒト2型自然リンパ球における内因性活性化制御機構の解明2022
- Author(s)
  入江美聡, 加畑宏樹, 松坂雅子, 馬塲里英, 鎌谷高志, 正木克宜, 白崎善隆, 福永興壱
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] 喘息患者の末梢血由来2型自然リンパ球のシングルセル解析2022
- Author(s)
  馬塲里英, 加畑宏樹, 桑江美聡, 渡辺理沙, 松坂雅子, 鎌谷高志, 白崎善隆, 山岸舞, 福永興壱
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] 喘息患者の末梢血由来2型自然リンパ球のシングルセル解析2022
- Author(s)
  馬塲里英, 加畑宏樹, 桑江美聡, 渡辺理沙, 松坂雅子, 鎌谷高志, 白崎善隆, 山岸舞, 福永興壱
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] 喘息病態におけるTSLPの役割と制御2022
- Author(s)
  加畑宏樹
- Organizer
  第71回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] スタチンによるILC2を介した2型気道炎症の抑制機序の解明2022
- Author(s)
  砂田啓英也、加畑宏樹、鎌谷高志、入江美聡、正木克宜、宮田純、福永興壱
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] LCI-Sを用いた喘息患者における末梢血由来2型自然リンパ球の解析2022
- Author(s)
  馬塲里英, 加畑宏樹, 桑江美聡, 渡辺理沙, 松坂雅子, 鎌谷高志, 白崎善隆, 山岸舞, 福永興壱
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] LCI-Sを用いた喘息患者における末梢血由来2型自然リンパ球の解析2022
- Author(s)
  馬塲里英, 加畑宏樹, 桑江美聡, 渡辺理沙, 松坂雅子, 鎌谷高志, 白崎善隆, 山岸舞, 福永興壱
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] LCI-Sを用いた2型自然リンパ球の新規制御機構の解明2022
- Author(s)
  入江美聡, 加畑宏樹, 松坂雅子, 馬塲里英, 鎌谷高志, 正木克宜, 白崎善隆, 福永興壱
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08240
[Presentation] LCI-Sを用いた2型自然リンパ球の新規制御機構の解明2022
- Author(s)
  入江美聡, 加畑宏樹, 松坂雅子, 馬塲里英, 鎌谷高志, 正木克宜, 白崎善隆, 福永興壱
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] ヒト2型自然リンパ球における内因性活性化制御機構の解明2022
- Author(s)
  入江美聡, 加畑宏樹, 松坂雅子, 馬塲里英, 鎌谷高志, 正木克宜, 白崎善隆, 福永興壱
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24342
[Presentation] 気管支喘息に対するスタチンの有効性の検証2021
- Author(s)
  奥隅真一, 宮田純, 加畑宏樹, 加川志津子, 田野崎貴絵, 桑江美聡, 秋山勇人, 西江美幸, 浅岡雅人, 砂田啓英也, 笹原広太郎, 冨保紗希, 福永興壱
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] 自然免疫ネットワークによるアレルギーの病態と制御2021
- Author(s)
  加畑宏樹, 奥隅真一, 宮田純, 福永興壱
- Organizer
  第70回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] 気管支喘息におけるIL-4とIL-13の役割を再考する2021
- Author(s)
  加畑宏樹
- Organizer
  第70回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] TLR7アゴニスト(R848)による好酸球性気道炎症抑制機序の解明2021
- Author(s)
  奥隅真一, 宮田純, 加畑宏樹, 加川志津子, 田野崎貴絵, 桑江美聡, 秋山勇人, 西江美幸, 浅岡雅人, 砂田啓英也, 笹原広太郎, 冨保紗希, 福永興壱
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K17193
[Presentation] TLR7を介したIL-33誘導性自然免疫型喘息の抑制効果における間質マクロファージの役割2021
- Author(s)
  奥隅真一, 宮田純, 加畑宏樹, 正木克宜, 加川志津子, 田野崎貴絵, 入江美聡, 秋山勇人, 西江美幸, 浅岡雅人, 砂田啓英也, 笹原広太郎, 冨保紗希, 福永興壱
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K17193

1. 鎌谷高志 (90645764)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 福永興壱 (60327517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. 白崎善隆 (70469948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 茂呂和世 (90468489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 正木克宜 (70570935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮田純 (80464866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上村想太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kabata Hiroki 加畑 宏樹

加畑 宏樹 カバタ ヒロキ

Research Projects

Research Products

Co-Researchers

呼吸器疾患における制御性自然リンパ球（ILCreg）の解析と新規治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimizing personalized disease management by investigating the link between bronchial asthma, meteorological factors, and air pollution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

気管支喘息及び慢性副鼻腔炎における高病原性ILC2を標的とした新規制御因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic strategy for refractory asthma using immunophenotyping

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel inhibitory compounds targeting ILC2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

気管支喘息におけるナチュラルヘルパー細胞の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] THE INNATE IMMUNE NETWORK AND THERAPEUTIC APPROACHES IN ASTHMA2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Protocol for lentiviral vector-based gene transfection in human ILC2s2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current summary of clinical studies on anti-TSLP antibody, Tezepelumab, in asthma2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current overview of the role of neuropeptides in ILC2s and future directions2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients2022

Author(s)

Journal Title

Kabata Hiroki 加畑宏樹

加畑宏樹カバタヒロキ

[Presentation] ステロイド抵抗性喘息を考察する　喘息の重症化とステロイド抵抗性におけるILC22024