HOSOMI SHUHEI 細見周平

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Hosomi Shuhei 細見周平

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Researcher Number	60554938
Other IDs	https://orcid.org/0000-0002-8808-5672
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 大阪公立大学, 大学院医学研究科, 准教授 2022 – 2023: 大阪公立大学, 大学院医学研究科, 講師 2016 – 2021: 大阪市立大学, 大学院医学研究科, 講師 2015: 大阪市立大学, 大学院医学研究科, 病院講師 2014: 大阪市立大学, 医学(系)研究科(研究院), 病院講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Immunology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 57:Oral science and related fields / Basic Section 57070:Developmental dentistry-related / Basic Section 55020:Digestive surgery-related / Basic Section 53010:Gastroenterology-related / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator 小胞体ストレス / クローン病 / 肥満細胞 / NKG2D / 炎症性腸疾患 / 便秘モデル / オプシン / 光受容 / 腸蠕動音 / 消化管蠕動 … More / interleukin-23 / interleukin-12 / Amphiregulin / 樹状細胞 / 腸管上皮細胞間リンパ球 / 自然免疫 / MULT1 / IgA / Xbp1 / 腸管免疫 … More Except Principal Investigator 味覚受容体 / 味覚障害 / Tas1r3 / 骨格筋 / TAS1R3受容体 / 5-FU系抗がん剤 / 小腸上皮特異的Tas1r3欠損マウス / ヘテロダイマー / Gタンパク質共益型受容体 / 骨粗しょう症 / サルコペニア / エネルギー代謝 / うま味受容体 / 間葉系幹細胞 / 脂肪細胞分化 / 小児肥満 / 脂肪 / 肥満症 / 肥満 / 肝再生 / 小腸上皮味覚受容体 / 小腸 / NAFLD / 炎症性腸疾患 / 炎症発癌 / 栄養吸収 / 腸炎モデル / 薬剤性腸炎モデル / 脂肪肝炎モデル / がん筋層浸潤 / 炎症 / 骨 / DKK-1 / 扁平上皮がん / シングルセルRNA-seq / 舌筋再生 / 筋再生 / リンパ節転移 / 口腔扁平上皮がん / 舌がん / 舌筋 Less

音と光による消化管蠕動制御デバイス開発に向けた基盤研究Principal Investigator
- Principal Investigator
  
  細見周平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
5-FU系抗がん剤による味覚障害に対する消化管味覚受容体を介した新たな治療戦略
- Principal Investigator
  
  平良高一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka Metropolitan University
うま味でサルコペニア克服に挑戦する
- Principal Investigator
  
  古株彰一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu Dental College
Understanding of the relationship between skeletal muscle and cancer for regulating muscle invasion of oral squamous cell carcinoma
- Principal Investigator
  
  Kokabu Shoichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu Dental College
Integrated understanding of taste receptor-mediated intestinal homeostasis mechanisms
- Principal Investigator
  
  Fujiwara Yasuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Elucidation of the mechanism of NAFLD and liver regeneration failure using mice deficient in small intestinal epithelial specific taste receptors.
- Principal Investigator
  
  Shinkawa Hiroji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
The molecular mechanism of umami receptor in energy metabolism for preventing pediatric obesity
- Principal Investigator
  
  Morikawa Kazumasa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Iwate Medical University
Analysis of the Mechanisms of Enterocolitis Development and Intestinal Fibrosis Mediated by Endoplasmic Reticulum Stress in Mast CellsPrincipal Investigator
- Principal Investigator
  
  Hosomi Shuhei
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Immune response for endoplasmic reticulum stress on intestinal inflammationPrincipal Investigator
- Principal Investigator
  
  HOSOMI Shuhei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka City University
Role of endoplasmic reticulum stress on induction of NKG2D-ligand, leading to enteritisPrincipal Investigator
- Principal Investigator
  
  Hosomi Shuhei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Osaka City University

All 2024 2023 2020 2019 2018 2017 2015

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科2020
- Author(s)
  細見周平
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-19K08450
[Journal Article] Epithelial endoplasmic reticulum stress orchestrates a protective IgA response2019
- Author(s)
  Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Targan SR, Macpherson AJ, Kaser A, Blumberg RS
- Journal Title
  
  Science
  
  Volume: 363 Issue: 6430 Pages: 993-998
- DOI
  10.1126/science.aat7186
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19162
[Journal Article] New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 12018
- Author(s)
  Hosomi Shuhei、Grootjans Joep、Huang Yu-Hwa、Kaser Arthur、Blumberg Richard S.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1324-1324
- DOI
  10.3389/fimmu.2018.01324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19162
[Journal Article] Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation2017
- Author(s)
  Hosomi Shuhei、Grootjans Joep、Tschurtschenthaler Markus、Krupka Niklas、Matute Juan D.、Flak Magdalena B.、Martinez-Naves Eduardo、Gomez del Moral Manuel、Glickman Jonathan N.、Ohira Mizuki、Lanier Lewis L.、Kaser Arthur、Blumberg Richard
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Issue: 10 Pages: 2985-2997
- DOI
  10.1084/jem.20162041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19162
[Journal Article] 1.ER stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease2015
- Author(s)
  Hosomi S, Kaser A, Blumberg RS
- Journal Title
  
  Current Opinion in Gastroenterology
  
  Volume: 31(1) Issue: 1 Pages: 81-88
- DOI
  10.1097/mog.0000000000000144
- Open Access
- Data Source
  KAKENHI-PROJECT-26893231
[Presentation] 小腸上皮特異的味覚受容体の代謝異常関連脂肪性肝疾患における役割2024
- Author(s)
  中西紘一、新川寛二、河野沙紀、白井大介、細見周平、岩崎有作、南山幸子、竹村茂一、石沢武彰
- Organizer
  第77回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-21K08759
[Presentation] TNFα阻害剤投与中のクローン病手術症例の術後再発予防治療の検討2023
- Author(s)
  細見周平、藤本晃士、小林由美恵、中田理恵子、西田裕、鎌田紀子、藤原靖弘
- Organizer
  第78回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08450
[Presentation] 小胞体ストレス応答による2017
- Author(s)
  細見周平、杉田奈央子、大谷恒史、山上博一、谷川徹也、渡辺俊雄、藤原靖弘
- Organizer
  日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K19162
[Presentation] B Cells and Dendritic Cells React to Intestinal Epithelial Stress with a Coordinated and Protective IgA Response2015
- Author(s)
  Joep Grootjans, Shuhei Hosomi, Magdalena B. Flak, Kathy D. McCoy, Andrew J. Macpherson, Arthur Kaser and Richard S. Blumberg
- Organizer
  17th International Congress of Mucosal Immunology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2015-07-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893231

1. Kokabu Shoichiro (30448899)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. Fujiwara Yasuhiro (40285292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Shinkawa Hiroji (00554932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Morikawa Kazumasa (70514686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 土生学 (00360058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Addison William (40845046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤毅 (60406494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 矢田直美 (60468022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 永野健一 (60834348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中平光彦 (10253353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 竹村茂一 (00322363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 南山幸子 (00362989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 田中肖吾 (50382114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 久保正二 (80221224)

# of Collaborated Projects: 1 results

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15. 橋口大輔 (00625965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 齊藤桂子 (70788744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中道敦子 (20567341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉田竜介 (60380705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 寺北明久 (30212062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 小林由美恵 (90911610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 平良高一 (00783713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Sugita Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Blumberg Richard S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. Richard Blumberg S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

HOSOMI SHUHEI 細見 周平

Hosomi Shuhei 細見 周平

Research Projects

Research Products

Co-Researchers

音と光による消化管蠕動制御デバイス開発に向けた基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

5-FU系抗がん剤による味覚障害に対する消化管味覚受容体を介した新たな治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

うま味でサルコペニア克服に挑戦する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of the relationship between skeletal muscle and cancer for regulating muscle invasion of oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated understanding of taste receptor-mediated intestinal homeostasis mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of NAFLD and liver regeneration failure using mice deficient in small intestinal epithelial specific taste receptors.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular mechanism of umami receptor in energy metabolism for preventing pediatric obesity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the Mechanisms of Enterocolitis Development and Intestinal Fibrosis Mediated by Endoplasmic Reticulum Stress in Mast CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune response for endoplasmic reticulum stress on intestinal inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of endoplasmic reticulum stress on induction of NKG2D-ligand, leading to enteritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床免疫・アレルギー科2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Epithelial endoplasmic reticulum stress orchestrates a protective IgA response2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 12018

Author(s)

Journal Title

DOI

Data Source

HOSOMI SHUHEI 細見周平

Hosomi Shuhei 細見周平