Kouzu Hidemichi 神津英至

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KOUZU Hidemichi 神津英至

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Researcher Number	60596609
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023: 札幌医科大学, 医学部, 講師 2020 – 2022: 札幌医科大学, 医学部, 助教 2013 – 2014: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine
Keywords	Principal Investigator AMP deaminase / 心不全 / 糖尿病 / 代謝 / BCKDH / 分岐鎖アミノ酸 / アミノ酸 / 心筋代謝 / 酢酸 / サルコペニア … More / 核酸 / エネルギー代謝 / 拡張機能障害 / 拡張機能 Less

心筋分岐鎖アミノ酸代謝を標的とした心不全治療の開発Principal Investigator
- Principal Investigator
  
  神津英至
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Development of novel therapy for heart failure targeting the crosstalk between amino acid and nucleotide metabolismPrincipal Investigator
- Principal Investigator
  
  Kouzu Hidemichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Molecular mechanisms of left ventricular diastolic dysfunction in the type 2 diabetic heartPrincipal Investigator
- Principal Investigator
  
  KOUZU Hidemichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020 2015 2013 Other

All Journal Article Presentation

[Journal Article] Role of AMP deaminase in diabetic cardiomyopathy2024
- Author(s)
  Miura T, Kouzu H, Tanno M, Tatekoshi Y, Kuno A
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: - Issue: 12 Pages: 3195-3211
- DOI
  10.1007/s11010-024-04951-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07481, KAKENHI-PROJECT-21K08035
[Journal Article] Downregulation of extramitochondrial <scp>BCKDH</scp> and its uncoupling from <scp>AMP</scp> deaminase in type 2 diabetic <scp>OLETF</scp> rat hearts2023
- Author(s)
  Ogawa Toshifumi、Kouzu Hidemichi、Osanami Arata、Tatekoshi Yuki、Sato Tatsuya、Kuno Atsushi、Fujita Yugo、Ino Shoya、Shimizu Masaki、Toda Yuki、Ohwada Wataru、Yano Toshiyuki、Tanno Masaya、Miki Takayuki、Miura Tetsuji
- Journal Title
  
  Physiological Reports
  
  Volume: 11 Issue: 4
- DOI
  10.14814/phy2.15608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-20K08452
[Journal Article] Adenosine monophosphate deaminase in the endoplasmic reticulummitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts.2023
- Author(s)
  Osanami A, Sato T, Toda Y, Shimizu M, Kuno A, Kouzu H, Yano T, Ohwada W, Ogawa T, Miura T, Tanno M.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 14 Issue: 4 Pages: 560-569
- DOI
  10.1111/jdi.13982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-21K08035, KAKENHI-PROJECT-21K08110
[Journal Article] Plasma amino acid profiling improves predictive accuracy of adverse events in patients with heart failure2021
- Author(s)
  Kouzu Hidemichi、Katano Satoshi、Yano Toshiyuki、Ohori Katsuhiko、Nagaoka Ryohei、Inoue Takuya、Takamura Yuhei、Ishigo Tomoyuki、Watanabe Ayako、Koyama Masayuki、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Miura Tetsuji
- Journal Title
  
  ESC Heart Failure
  
  Volume: 8 Issue: 6 Pages: 5045-5056
- DOI
  10.1002/ehf2.13572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-20K19313
[Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload2021
- Author(s)
  Igaki Yusuke、Tanno Masaya、Sato Tatsuya、Kouzu Hidemichi、Ogawa Toshifumi、Osanami Arata、Yano Toshiyuki、Kuno Atsushi、Miki Takayuki、Nakamura Takashi、Miura Tetsuji
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 154 Pages: 21-31
- DOI
  10.1016/j.yjmcc.2021.01.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08522, KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-21K08110
[Journal Article] Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart2015
- Author(s)
  Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, Toshiyuki Tobisawa, Makoto Ogasawara, Satoko Ishikawa, Tetsuji Miura
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 80 Pages: 136-145
- DOI
  10.1016/j.yjmcc.2015.01.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860611, KAKENHI-PROJECT-26461132, KAKENHI-PROJECT-26461133
[Presentation] Distinct Contribution of Regional Body Compositions to Adverse Plasma Amino Acid Profile in Heart Failure Patients with and without Diabetes2024
- Author(s)
  Kawaharata W, Kouzu H, Yano T, Katano S, Numazawa R, Nagaoka R, Ohori K, Nishikawa R, Ohwada W, Fujito T, Nagano N, Koyama M, Furuhashi M
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07481
[Presentation] Downregulation of BCKDH activity and uncoupling from AMP deaminase underlie substrate inflexibility in type 2 diabetic hearts2023
- Author(s)
  Ogawa T, Kouzu H, Osanami A, Shimizu M, Toda Y, Ohwada W, Sato T, Yano T, Kuno A, Tanno M, Miura T, Furuhashi M
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Psoas muscle lipid infiltration assessed by CT imaging represents adverse plasma amino acid profile in patients with heart failure2023
- Author(s)
  Kawaharata W, Kouzu H, Ogura K, Yano T, Katano S, Numazawa R, Nagaoka R, Ohori K, Nishikawa R, Ohwada W, Fujito T, Nagano N, Koyama M, Furuhashi M
- Organizer
  第27回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07481
[Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes in Diabetic Hearts Lowers the Threshold for Mitochondrial Permeability Transition2022
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Toda Y, Miura T.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] 糖尿病合併心不全における血漿分枝鎖アミノ酸の規定因子と予後予測能の検討2022
- Author(s)
  神津英至, 片野唆敏, 大堀克彦, 長岡凌平, 沼澤瞭, 小山雅之, 永野伸卓, 藤戸健史, 大和田渉, 佐藤達也, 矢野俊之
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] SGLT2阻害薬による心保護効果における飢餓代謝の役割2022
- Author(s)
  神津英至, 小川俊史, 久野篤史, 丹野雅也, 矢野俊之, 三木隆幸, 三浦哲嗣
- Organizer
  第26回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Novel Role of Cardiac AMP Deaminase in Extramitochondrial BCAA Metabolism: A Potential Therapeutic Target for Lipotoxicity in Diabetic Hearts2022
- Author(s)
  Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Sato T, Yano T, Miura T, Tanno M.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Plasma 3-methylhistidine Predicts the Impact of Renin-angiotensin System Inhibition on Skeletal Muscle Preservation in Heart Failure Patients2022
- Author(s)
  Kouzu H, Katano S, Ohori K, Nagaoka R, Numazawa R, Koyama M, Nagano N, Fujito T, Ohwada W, Nishikawa R, Yano T
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T.
- Organizer
  CVMW2021 心血管代謝週間
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Intracellular Localization of AMP Deaminase and a Role of Cytosolic AMPD in XOR-mediated ROS Production2021
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T
- Organizer
  第85回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] The threshold for mitochondrial permeability transition is reduced by upregulated AMP deaminase in mitochondria-associated ER membranes in type 2 diabetic hearts.2021
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T.
- Organizer
  第5回日本循環器学会基礎研究フォーラム（BCVR）
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Role of AMPD3 in Mitochondria-associated ER Membranes in Regulation of Threshold for Mitochondrial Permeability Transition2021
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T
- Organizer
  第85回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Novel role of AMP deaminase in cardiac branched-chain amino acid metabolism: A potential therapeutic target for diabetic cardiomyopathy.2021
- Author(s)
  Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Mizuno M, Kuno A, Fujita Y, Ino S, Shimizu M, Ohwada W, Sato T, Yano T, Miura T, Tanno M.
- Organizer
  第25回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T and Miura T.
- Organizer
  AHA Scientific Sessions（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes and Cytosol Distinctively Contributes to Pressure Overload-induced Cardiac Dysfunction in Diabetic Hearts2021
- Author(s)
  Tanno M, Osanami A, Kouzu H, Ogawa T, Kuno A, Miura T
- Organizer
  第85回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Intracellular localization of AMP deaminase and its novel role in BCAA and lipid metabolism in diabetic cardiomyopathy.2021
- Author(s)
  Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Oshima H, Mizuno M, Kuno A, Fujita Y, Ino S, Shimizu M, Ohwada W, Sato T, Yano T, Tanno M, Miura T.
- Organizer
  ESC congress（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy2021
- Author(s)
  Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Mizuno M, Kuno A, Sugawara H, Fujita Y, Ino S, Ohwada W, Sato T, Yano T, Moniwa N, Tanno M, Miura T.
- Organizer
  第85回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Xanthine oxidoreductase-mediated metabolic and functional dysfunction is amplified by upregulated AMP deaminase in diabetic hearts.2020
- Author(s)
  Osanami A, Igaki Y, Tanno M, Sato T, Kouzu H, Kuno A, Miura T.
- Organizer
  第 24 回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Distinct intracellular localization and possible functional significance of AMP deaminase in diabetic cardiomyopathy.2020
- Author(s)
  Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Kuno A, Sato T, Miura T.
- Organizer
  第4回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Inhibition of xanthine oxidase ameliorates functional and metabolic impairment in type 2 diabetic hearts under pressure overload.2020
- Author(s)
  Igaki Y, Osanami A, Tanno M, Sato T, Ogawa T, Yano T, Kouzu H, Miura T.
- Organizer
  ESC congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Prognostic role of plasma amino acid profile in patients with chronic heart failure.2020
- Author(s)
  Kouzu H, Katano S, Yano T, Ohori K, Honma S, Shimomura K, Inoue T, Takamura Y, Takahashi R, Nishikawa R, Nagano N, Koyama M, Fujito T, Hashimoto A, Miura T.
- Organizer
  第 24 回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy.2020
- Author(s)
  Ogawa T, Kouzu H, Tatekoshi Y, Osanami A, Oshima H, Mizuno M, Kuno A, Igaki Y, Sugawara H, Fujita Y, Sato T, Yano T, Tanno M, Miki T, Miura T.
- Organizer
  ESC congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Plasma valine-to-glycine ratio is a novel prognostic maker for adverse events in patients with heart failure.2020
- Author(s)
  Kouzu H, Katano S, Yano T, Ohori K, Honma S, Shimomura K, Inoue T, Takamura Y, Takahashi R, Nishikawa R, Nagano N, Koyama M, Fujito T, Hashimoto A, Miura T.
- Organizer
  第84回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08452
[Presentation] Insufficient ATP supply due to excessive degradation of adenine nucleotides underlies after load-induced diastolic dysfunction in type 2 diabetic heart2013
- Author(s)
  Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Hiromichi Murase, Toshiyuki Tobisawa, Makoto Ogasawara, Tetsuji Miura
- Organizer
  The 17th Annual Scientific Meeting of the Japanese Heart Failure Society
- Place of Presentation
  さいたま市
- Data Source
  KAKENHI-PROJECT-25860611
[Presentation] Insufficient ATP supply due to excessive degradation of adenine nucleotides by AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart
- Author(s)
  Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Hiromichi Murase, Toshiyuki Tobisawa, Makoto Ogasawara, Shingo Muratsubaki, Tetsuji Miura
- Organizer
  The 36th Congress of the European Society of Cardiology
- Place of Presentation
  Barcelona
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25860611

1. 久野篤史 (30468079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. 矢野俊之 (40444913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
3. 佐藤達也 (40592473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 丹野雅也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kouzu Hidemichi 神津 英至

KOUZU Hidemichi 神津 英至

Research Projects

Research Products

Co-Researchers

心筋分岐鎖アミノ酸代謝を標的とした心不全治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapy for heart failure targeting the crosstalk between amino acid and nucleotide metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of left ventricular diastolic dysfunction in the type 2 diabetic heartPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Role of AMP deaminase in diabetic cardiomyopathy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of extramitochondrial <scp>BCKDH</scp> and its uncoupling from <scp>AMP</scp> deaminase in type 2 diabetic <scp>OLETF</scp> rat hearts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenosine monophosphate deaminase in the endoplasmic reticulummitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma amino acid profiling improves predictive accuracy of adverse events in patients with heart failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Distinct Contribution of Regional Body Compositions to Adverse Plasma Amino Acid Profile in Heart Failure Patients with and without Diabetes2024

Author(s)

Organizer

Data Source

[Presentation] Downregulation of BCKDH activity and uncoupling from AMP deaminase underlie substrate inflexibility in type 2 diabetic hearts2023

Author(s)

Organizer

Data Source

[Presentation] Psoas muscle lipid infiltration assessed by CT imaging represents adverse plasma amino acid profile in patients with heart failure2023

Author(s)

Organizer

Data Source

[Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes in Diabetic Hearts Lowers the Threshold for Mitochondrial Permeability Transition2022

Author(s)

Organizer

Data Source

[Presentation] 糖尿病合併心不全における血漿分枝鎖アミノ酸の規定因子と予後予測能の検討2022

Author(s)

Organizer

Data Source

[Presentation] SGLT2阻害薬による心保護効果における飢餓代謝の役割2022

Author(s)

Organizer

Data Source

[Presentation] Novel Role of Cardiac AMP Deaminase in Extramitochondrial BCAA Metabolism: A Potential Therapeutic Target for Lipotoxicity in Diabetic Hearts2022

Author(s)

Organizer

Kouzu Hidemichi 神津英至

KOUZU Hidemichi 神津英至