Kageyama Shun-ichiro 影山俊一郎

Researcher Number	60644979
Other IDs	https://orcid.org/0000-0002-1505-9887
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2025: 地方独立行政法人東京都立病院機構東京都立駒込病院(臨床研究室), 放射線診療科(治療部), 非常勤医師
Affiliation (based on the past Project Information) *help	2016 – 2024: 国立研究開発法人国立がん研究センター, 東病院, 医員 2013 – 2015: 東京都立駒込病院(臨床研究室), その他部局等, その他
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 放射線治療 / 食道癌 / 肺非小細胞癌 / cell free DNA / Viral Reaction / Non-coding RNA / Type I IFN / Radiotherpy / ISRE / RNA virus sensor … More / RIG-I / 1細胞解析 / RNA sensor pathway / がん免疫応答 / JAK-STAT / がん免役 / がん免疫療法 / RNA seq / 免疫 / 放射線 / Type I interferon / Esophageal Cancer / Radiation / 免疫チェックポイント / PD-L1 / STING / エクソームシークエンス / sequence / digital PCR / EGFR / radiation / 血中DNA / 次世代シークエンサー / 血漿DNA / 遺伝子診断 / cfDNA … More Except Principal Investigator 放射線治療 / ctDNA / リキッドバイオプシー / 非小細胞肺癌 / 食道癌 / 大腸癌 / 空間解析 / 早期肺癌 / cfDNA / cDNA / 腫瘍微小環境 / 免疫応答 / マクロファージ / PD-L1 / 1細胞解析 / 新規併用療法の開発戦略 / オミックス統合解析 / DNA損傷反応 / CDC7阻害剤TAK-931 / マルチオミックス解析 / 併用療法戦略 / がん治療薬 / 複製ストレス / TAK-931 / CDC7阻害剤 / 薬効・薬理研究 / バイオマーカー / トランスクリプトーム解析 / 橋渡し研究 / Drug Discovery / 低分子阻害剤 / CDC7キナーゼ / DNA複製ストレス Less

Interactomeと空間解析を用いた放射線治療による免疫微小環境変化の解析
- Principal Investigator
  
  北條秀博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
Evaluation of the usefulness of circulating tumor DNA in blood as a biomarker for predicting recurrence after radiotherapy for early stage lung cancer.
- Principal Investigator
  
  中村匡希
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
大規模臨床試験GALAXYのctDNAおよび画像統合解析による放射線治療の最適化
- Principal Investigator
  
  大吉秀和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
Impact of non-coding RNA pathways in radiation-induced immune responsePrincipal Investigator
- Principal Investigator
  
  Kageyama Shun-Ichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
1細胞解析を用いた放射線治療による腫瘍微小環境、免疫応答変化の解析
- Principal Investigator
  
  北條秀博
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
Research and developement of liquid biopsy to predict the recurrence of early-stage lung cancer after radiotherapy
- Principal Investigator
  
  中村匡希
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models
- Principal Investigator
  
  Akihiro Ohashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
analysis of cancer immune reaction by irradiationPrincipal Investigator
- Principal Investigator
  
  Shun-Ichiro Kageyama
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Cancer Center Japan
Establishment of a cancer diagnosis method using DNA increase derived from plasma tumor after the radiation therapyPrincipal Investigator
- Principal Investigator
  
  Kageyama Shun-ichiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Cancer Center Japan
Establishment of a cancer diagnosis method using DNA increase derived from plasma tumor after the radiation therapyPrincipal Investigator
- Principal Investigator
  
  Kageyama Shun-ichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Tokyo Metropolitan Komagome Hospital (Clinical research laboratory)

All 2024 2023 2022 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] Detection of Pretreatment Circulating Tumor DNA Predicts Recurrence after High-Dose Proton Beam Therapy for Early-Stage Non-Small Cell Lung Cancer2023
- Author(s)
  Nakamura Masaki、Kageyama Shun-Ichiro、Hirata Hidenari、Tochinai Taku、Hojo Hidehiro、Motegi Atsushi、Kanai Akinori、Suzuki Yutaka、Tsuchihara Katsuya、Akimoto Tetsuo
- Journal Title
  
  International Journal of Radiation Oncology*Biology*Physics
  
  Volume: - Issue: 5 Pages: 1085-1090
- DOI
  10.1016/j.ijrobp.2023.02.021
- Data Source
  KAKENHI-PROJECT-21K07689
[Journal Article] Transposable elements potentiate radiotherapy-induced cellular immune reactions via RIG-I-mediated virus-sensing pathways2023
- Author(s)
  Junyan Du, Shun-Ichiro Kageyama
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 818-818
- DOI
  10.1038/s42003-023-05080-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07582
[Journal Article] Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma2023
- Author(s)
  Oyoshi H, Du J, Sakai SA, Yamashita R, Okumura M, Motegi A, Hojo H, Nakamura M, Hirata H, Sunakawa H, Kotani D, Yano T, Kojima T, Nakamura Y, Kojima M, Suzuki A, Zenkoh J, Tsuchihara K, Akimoto T, Shibata A, Suzuki Y, Kageyama S. Shun-Ichiro
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 50 Pages: 9096-9096
- DOI
  10.1126/sciadv.adh9069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18232, KAKENHI-PROJECT-21K07661, KAKENHI-PROJECT-21K07582, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K21749
[Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation2022
- Author(s)
  Du Junyan、Kageyama Shun‐Ichiro、Yamashita Riu、Hirata Hidenari、Hakozaki Yumi、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Hirano Yasuhiro、Sunakawa Hironori、Minamide Tatsunori、Kotani Daisuke、Tanaka Kosuke、Yano Tomonori、Kojima Takashi、Ohashi Akihiro、Tsuchihara Katsuya、Akimoto Tetsuo
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1352-1361
- DOI
  10.1111/cas.15297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-21K07582, KAKENHI-PROJECT-20H03541
[Journal Article] Comprehensive screening for drugs that modify radiation-induced immune responses2022
- Author(s)
  M. Okumura, J. Du, S.I. Kageyama*, R. Yamashita, Y. Hakozaki, A. Motegi, H. Hojo, M. Nakamura, Y. Hirano, Y. Okuma, H. Okuma, K. Tsuchihara, and T. Akimoto
- Journal Title
  
  British journal of Cancer
  
  Volume: - Issue: 12 Pages: 1815-1823
- DOI
  10.1038/s41416-021-01688-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07582, KAKENHI-PROJECT-21K15804, KAKENHI-PROJECT-19K08190
[Journal Article] Comparative analysis of the immune responses in cancer cells irradiated with X-ray, proton and carbon-ion beams2021
- Author(s)
  Du Junyan、Kageyama Shun-Ichiro、Hirata Hidenari、Motegi Atsushi、Nakamura Masaki、Hirano Yasuhiro、Okumura Masayuki、Yamashita Riu、Tsuchihara Katsuya、Hojo Hidehiro、Hirayama Ryoichi、Akimoto Tetsuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 585 Pages: 55-60
- DOI
  10.1016/j.bbrc.2021.11.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08215, KAKENHI-PROJECT-18K15612, KAKENHI-PROJECT-20H03620, KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-21K07582
[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021
- Author(s)
  Iwai Kenichi、Nambu Tadahiro、Kashima Yukie、Yu Jie、Eng Kurt、Miyamoto Kazumasa、Kakoi Kazuyo、Gotou Masamitsu、Takeuchi Toshiyuki、Kogame Akifumi、Sappal Jessica、Murai Saomi、Haeno Hiroshi、Kageyama Shun-Ichiro、Kurasawa Osamu、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 21 Pages: 0-0
- DOI
  10.1126/sciadv.abf0197
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Journal Article] Identification of the mutation signature of the cancer genome caused by irradiation2021
- Author(s)
  Kageyama SI, Junyan D, Hojo H, Motegi A, Nakamura M, Tsuchihara K, Akimoto T.
- Journal Title
  
  Radiother Oncol.
  
  Volume: 155 Pages: 10-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07740
[Journal Article] Differences in failure patterns according to the EGFR mutation status after proton beam therapy for early stage non-small cell lung cancer.2020
- Author(s)
  Nakamura M, Kageyama SI, Udagawa H, Zenke Y, Yoh K, Niho S, Hojo H, Motegi A, Kirita K, Matsumoto S, Goto K, Akimoto T.
- Journal Title
  
  Radiother Oncol
  
  Volume: 149 Pages: 14-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07740
[Journal Article] Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer.2020
- Author(s)
  Sasaki A, Nakamura Y, Togashi Y, Kuno H, Hojo H, Kageyama SI, Nakamura N, Takashima K, Kadota T, Yoda Y, Mishima S, Sawada K, Kotani D, Kawazoe A, Kuboki Y, Taniguchi H, Kojima T, Doi T, Yoshino T, Yano T, Kobayashi T, Akimoto T, Nishikawa H, Shitara K.
- Journal Title
  
  Gastric Cancer.
  
  Volume: 23 Pages: 893-903
- NAID
  40022329655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07740
[Journal Article] TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma.2020
- Author(s)
  Bando H, Kotani D, Tsushima T, Hara H, Kadowaki S, Kato K, Chin K, Yamaguchi K, Kageyama SI, Hojo H, Nakamura M, Tachibana H, Wakabayashi M, Fukutani M, Togashi Y, Fuse N, Nishikawa H, Kojima T.
- Journal Title
  
  BMC Cancer.
  
  Volume: 20 Pages: 336-336
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07740
[Journal Article] Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients.2018
- Author(s)
  Kageyama S, Nihei K, Karasawa K,, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T.
- Journal Title
  
  Oncotarget
  
  Volume: 10;9(27) Issue: 27 Pages: 19368-19378
- DOI
  10.18632/oncotarget.25053
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10411, KAKENHI-PROJECT-16K19856, KAKENHI-PROJECT-16K10412, KAKENHI-PROJECT-18K08798, KAKENHI-PROJECT-16K11029
[Presentation] Prediction of postoperative recurrence by integrating preoperative ctDNA levels and tumor metastasis volume in patients (pts) with colorectal cancer (CRC) with resectable lung or liver metastasis.2024
- Author(s)
  H. Oyoshi, H. Bando, R. Yamashita, S. Kageyama, S. Horasawa, M. Nakamura, T. Fujisawa, K. Tomizawa, A. Motegi, S. Mishima, D. Kotani, H. Taniguchi, E. Oki, I. Takemasa, T. Kato, Y. Nakamura, M. Mori, A. A. Jurdi, M. C. Liu, and T. Yoshino
- Organizer
  2024 ASCO Gastrointestinal Cancers Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07172
[Presentation] 1 細胞解析を用いた放射線治療による食道癌患者組織での免疫学的変化の経時的解析.2024
- Author(s)
  大吉秀和, 杜君顔, 酒井俊輔, 山下理宇, 奥村真之, 中村匡希, 平田秀成, 砂川弘憲, 矢野友規, 小島隆嗣, 小嶋基寛, 土原一哉 , 秋元哲夫 , 柴田淳史, 鈴木穣, 影山俊一郎
- Organizer
  日本癌学会2024
- Data Source
  KAKENHI-PROJECT-21K07661
[Presentation] 時空間解析による放射線治療による食道がん患者組織での免疫環境変化の解析2023
- Author(s)
  大吉秀和, 山下理宇, 茂木厚, 北條秀博, 小谷大輔, 小島隆嗣 , 中村優香, 小嶋基寛 , 鈴木絢子, 善光純子, 土原一哉 , 秋元哲夫 , 柴田淳史, 鈴木穣 , 影山俊一郎
- Organizer
  日本癌治療学会2023
- Data Source
  KAKENHI-PROJECT-21K07661
[Presentation] 早期非小細胞肺癌における治療前循環腫瘍DNA検出による再発高リスク群の選別2022
- Author(s)
  中村匡希、影山俊一郎、平田秀成、大吉秀和、藤澤建志、北條秀博、茂木厚、秋元哲夫
- Organizer
  日本放射線腫瘍学会第35回学術大会
- Data Source
  KAKENHI-PROJECT-21K07689
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Morita T.Y., Yu J., Kashima Y., Tanaka K., Hakozaki Y., Kageyama S., Nakamura A., Lightcap E., Niu H., Kannan K., and Ohashi A.
- Organizer
  The 32nd EORTC-NCI-AACR symposium, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan., 2021
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] 放射線治療後の血漿中腫瘍由来ＤＮＡを利用したシークエンス解析法の確立2017
- Author(s)
  影山俊一郎
- Organizer
  第３０回日本放射線腫瘍学会
- Data Source
  KAKENHI-PROJECT-16K19856
[Presentation] 放射線治療によるcell free DNA増加を利用した診断法の確立2017
- Author(s)
  影山俊一郎
- Organizer
  第18回放射線増感研究会
- Place of Presentation
  奈良県文化会館（奈良県奈良市）
- Year and Date
  2017-02-05
- Invited
- Data Source
  KAKENHI-PROJECT-16K19856

1. 北條秀博 (60638774)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 中村匡希 (90804287)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Karasawa Katsuyuki (80177617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Nihei Keizi (30466205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Akihiro Ohashi (80835249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 小林進 (70792836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鹿島幸恵 (80831883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 大吉秀和 (70913515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 坂東英明 (00630948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. HIRAYAMA Ryoichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. HIRANO Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MOTEGI Atushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. Tsuchihara Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 秋元哲夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 柴田淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kageyama Shun-ichiro 影山 俊一郎

Research Projects

Research Products

Co-Researchers

Interactomeと空間解析を用いた放射線治療による免疫微小環境変化の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the usefulness of circulating tumor DNA in blood as a biomarker for predicting recurrence after radiotherapy for early stage lung cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大規模臨床試験GALAXYのctDNAおよび画像統合解析による放射線治療の最適化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of non-coding RNA pathways in radiation-induced immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

1細胞解析を用いた放射線治療による腫瘍微小環境、免疫応答変化の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research and developement of liquid biopsy to predict the recurrence of early-stage lung cancer after radiotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

analysis of cancer immune reaction by irradiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a cancer diagnosis method using DNA increase derived from plasma tumor after the radiation therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a cancer diagnosis method using DNA increase derived from plasma tumor after the radiation therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Detection of Pretreatment Circulating Tumor DNA Predicts Recurrence after High-Dose Proton Beam Therapy for Early-Stage Non-Small Cell Lung Cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transposable elements potentiate radiotherapy-induced cellular immune reactions via RIG-I-mediated virus-sensing pathways2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation2022

Kageyama Shun-ichiro 影山俊一郎

[Presentation] 時空間解析による放射線治療による食道がん患者組織での免疫環境変化の解析2023