Ohashi Akihiro 大橋紹宏

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Akihiro Ohashi 大橋紹宏

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Researcher Number	80835249
Other IDs	https://orcid.org/0000-0002-4036-9385
Affiliation (Current)	2026: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Affiliation (based on the past Project Information) *help	2020 – 2026: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator ボトルネック効果 / 一細胞解析・空間解析 / fitness cost / CINパラドクス / 染色体不安定性（CIN） / 家族性乳がん・卵巣がん / 新規生殖細胞突然変異 / スプライシング異常 / 5’非翻訳領域に位置する新規BRCA2変異 / 家族性乳癌・卵巣癌症候群（HBOC） … More / 意義不明変異（VUS） / BRCA2 / 新規併用療法の開発戦略 / オミックス統合解析 / DNA損傷反応 / CDC7阻害剤TAK-931 / マルチオミックス解析 / 併用療法戦略 / がん治療薬 / 複製ストレス / TAK-931 / CDC7阻害剤 / 薬効・薬理研究 / バイオマーカー / トランスクリプトーム解析 / 橋渡し研究 / Drug Discovery / 低分子阻害剤 / CDC7キナーゼ / DNA複製ストレス … More Except Principal Investigator 腫瘍免疫 / 細胞周期 / 自然免疫応答 / 細胞老化 / 低分子化合物 / 創薬 / 炎症 / 老化 / T細胞 / double nicking / Cas9 / Cancer / Adenovirus vector / Human Papillomavirus Less

染色体不安定性を介した自然免疫応答惹起機構と腫瘍微小環境内での役割の解明
- Principal Investigator
  
  鎌田諒
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime University
Study on the Elucidation of the Cancer Chromosomal Instability (CIN) Paradox and the Development of Novel Therapeutic Strategies Targeting CIN VulnerabilitiesPrincipal Investigator
- Principal Investigator
  
  大橋紹宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of an Oncolytic Adenoviral Vector Targeting the Synergistic Effects of HPV Genome-Editing Disruption and Tumor Lysis for Cancer Therapy
- Principal Investigator
  
  清野透
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sasaki Foundation
Development of preventive and therapeutic strategies for age-related chronic inflammation by targeting senescence-associated T cells
- Principal Investigator
  
  錦見昭彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical modelsPrincipal Investigator
- Principal Investigator
  
  Akihiro Ohashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancerPrincipal Investigator
- Principal Investigator
  
  Ohashi Akihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation2022
- Author(s)
  Du Junyan、Kageyama Shun‐Ichiro、Yamashita Riu、Hirata Hidenari、Hakozaki Yumi、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Hirano Yasuhiro、Sunakawa Hironori、Minamide Tatsunori、Kotani Daisuke、Tanaka Kosuke、Yano Tomonori、Kojima Takashi、Ohashi Akihiro、Tsuchihara Katsuya、Akimoto Tetsuo
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1352-1361
- DOI
  10.1111/cas.15297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-21K07582, KAKENHI-PROJECT-20H03541
[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021
- Author(s)
  Iwai Kenichi、Nambu Tadahiro、Kashima Yukie、Yu Jie、Eng Kurt、Miyamoto Kazumasa、Kakoi Kazuyo、Gotou Masamitsu、Takeuchi Toshiyuki、Kogame Akifumi、Sappal Jessica、Murai Saomi、Haeno Hiroshi、Kageyama Shun-Ichiro、Kurasawa Osamu、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 21 Pages: 0-0
- DOI
  10.1126/sciadv.abf0197
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021
- Author(s)
  Kashima Yukie、Shibahara Daisuke、Suzuki Ayako、Muto Kyoko、Kobayashi Ikei S.、Plotnick David、Udagawa Hibiki、Izumi Hiroki、Shibata Yuji、Tanaka Kosuke、Fujii Masanori、Ohashi Akihiro、Seki Masahide、Goto Koichi、Tsuchihara Katsuya、Suzuki Yutaka、Kobayashi Susumu S.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 18 Pages: 4835-4848
- DOI
  10.1158/0008-5472.can-20-2811
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16879, KAKENHI-PROJECT-20H03541, KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-16K21746
[Presentation] CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage2023
- Author(s)
  大橋　紹宏
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] CENP-E inhibitor potently activates cGAS-STING pathway through misaligned chromosome-mediated micronucleation after mitotic slippage2022
- Author(s)
  大橋　紹宏
- Organizer
  The 34th EORTC-NCI-AACR Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] Property analysis of chromosomal instability adapted cells using multi omics approaches.2021
- Author(s)
  Morita T.M., Haeno H, Makinoshima H, Suzuki A, Kobayashi S.S. and Ohashi A.
- Organizer
  AACR Annual meeting, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] A CDC7-selective inhibitor, TAK-931, induces replication stress-mediated mitotic aberration and leads to antiproliferation in a broad range of cancer cells2021
- Author(s)
  Akihiro Ohashi
- Organizer
  The 94th Annual Meeting of the Japanese Biochemical Society 2021
- Invited
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Morita T.Y., Yu J., Kashima Y., Tanaka K., Hakozaki Y., Kageyama S., Nakamura A., Lightcap E., Niu H., Kannan K., and Ohashi A.
- Organizer
  The 32nd EORTC-NCI-AACR symposium, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021
- Author(s)
  Hakozaki Y., Kashima Y., Morita T.Y., Tanaka K, Kobayashi S.S. and Ohashi A.
- Organizer
  AACR Annual meeting, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan., 2021
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitors2021
- Author(s)
  Akihiro Ohashi
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association 2021
- Invited
- Data Source
  KAKENHI-PROJECT-20H03541

1. 鹿島幸恵 (80831883)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. 鎌田諒 (60801420)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 影山俊一郎 (60644979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 小林進 (70792836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 向原徹 (80435718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 桑田健 (00327321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 堀居拓郎 (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中井一貴 (21003063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山下大生 (40970835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 波江野洋 (70706754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 清野透 (10186356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中西友子 (10344863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 錦見昭彦 (70404019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 村井純子 (60532603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 北條秀博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 秋元哲夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Akihiro 大橋 紹宏

Akihiro Ohashi 大橋 紹宏

Research Projects

Research Products

Co-Researchers

染色体不安定性を介した自然免疫応答惹起機構と腫瘍微小環境内での役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the Elucidation of the Cancer Chromosomal Instability (CIN) Paradox and the Development of Novel Therapeutic Strategies Targeting CIN VulnerabilitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an Oncolytic Adenoviral Vector Targeting the Synergistic Effects of HPV Genome-Editing Disruption and Tumor Lysis for Cancer Therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of preventive and therapeutic strategies for age-related chronic inflammation by targeting senescence-associated T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage2023

Author(s)

Organizer

Data Source

[Presentation] CENP-E inhibitor potently activates cGAS-STING pathway through misaligned chromosome-mediated micronucleation after mitotic slippage2022

Author(s)

Organizer

Data Source

[Presentation] Property analysis of chromosomal instability adapted cells using multi omics approaches.2021

Author(s)

Organizer

Data Source

[Presentation] A CDC7-selective inhibitor, TAK-931, induces replication stress-mediated mitotic aberration and leads to antiproliferation in a broad range of cancer cells2021

Author(s)

Organizer

Data Source

[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021

Author(s)

Organizer

Data Source

Ohashi Akihiro 大橋紹宏

Akihiro Ohashi 大橋紹宏