AKATSU Chizuru 赤津ちづる

Researcher Number	60735984
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2021: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General medical chemistry Except Principal Investigator Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator CD72 / 免疫学 / 慢性感染症 / 樹状細胞 / 硫酸化糖鎖 / レクチン / 自己免疫 / B細胞 Except Principal Investigator CD22 / Siglec … More / シアル酸 / シスリガンド / レクチン / 細胞接着 / LFA-1 / B細胞 / CEACAM-1 / proximity labeling / CD72 / 分化過程での制御 / Proximity labeling / チロシンホスファターゼ / 糖鎖シスリガンド / BCR / シグナル伝達 / 免疫不全 / Bリンパ球 / Glycocalyx Less

Bリンパ球を用いたレクチンを起点とする細胞表面分子ネットワークの機能解明
- Principal Investigator
  
  鍔田武志
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Nihon University
抑制性分子CD72の樹状細胞疲弊における役割の解明Principal Investigator
- Principal Investigator
  
  赤津ちづる
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Regulation of B lymphocyte activation by molecular interactions in glycocalyx
- Principal Investigator
  
  Tsubata Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of heparin/heparan sulfate on regulation of B cell inhibitory receptor CD72Principal Investigator
- Principal Investigator
  
  AKATSU Chizuru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi2020
- Author(s)
  Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.
- Total Pages
  693
- Publisher
  Springer
- ISBN
  9781071604298
- Data Source
  KAKENHI-PROJECT-18H02610
[Book] Lectin Purification and Analysis: Methods and Protocols2020
- Author(s)
  Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.
- Total Pages
  699
- Publisher
  Springer
- ISBN
  9781071604304
- Data Source
  KAKENHI-PROJECT-20K07048
[Journal Article] The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating <i> Cd45 <sup>?/?</sup> </i> immunodeficient B cells2022
- Author(s)
  Akatsu Chizuru、Alborzian Deh Sheikh Amin、Matsubara Naoko、Takematsu Hiromu、Schweizer Astrid、Abdu-Allah Hajjaj H. M.、Tedder Thomas F.、Nitschke Lars、Ishida Hideharu、Tsubata Takeshi
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 723 Pages: 723-723
- DOI
  10.1126/scisignal.abf9570
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07048, KAKENHI-PROJECT-18H02610, KAKENHI-PUBLICLY-20H05349, KAKENHI-PROJECT-21K06074, KAKENHI-PROJECT-21H02679
[Journal Article] The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells2021
- Author(s)
  Alborzian Deh Sheikh Amin、Akatsu Chizuru、Abdu-Allah Hajjaj H. M.、Suganuma Yuki、Imamura Akihiro、Ando Hiromune、Takematsu Hiromu、Ishida Hideharu、Tsubata Takeshi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 11 Pages: 2544-2551
- DOI
  10.4049/jimmunol.2100109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07048, KAKENHI-PROJECT-18H02610, KAKENHI-PUBLICLY-20H05349, KAKENHI-PROJECT-21K06074, KAKENHI-PROJECT-21H02679
[Journal Article] Identification of Siglec Cis-Ligands by Proximity Labeling2020
- Author(s)
  Alborzian Deh Sheikh Amin、Akatsu Chizuru、Tsubata Takeshi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2132 Pages: 75-83
- DOI
  10.1007/978-1-0716-0430-4_8
- ISBN
  9781071604298, 9781071604304
- Data Source
  KAKENHI-PROJECT-18H02610
[Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhances antibody production in mice2018
- Author(s)
  2.Matsubara N, Imamura A, Yonemiz Tu, Akatsu C, Yang H, Ueki A, Watanabe N, Abdu-Allah H, Numoto N, Takematsu H, Kitazume S, Tedder FT, Marth JD, Ito N, Ando H, Ishida H, Kiso M, and Tsubata T
- Journal Title
  
  Frontiers in Immunology
  
  Volume: - Pages: 820-820
- DOI
  10.3389/fimmu.2018.00820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08601, KAKENHI-PROJECT-17K17695, KAKENHI-PROJECT-26293062, KAKENHI-PROJECT-18H03942
[Journal Article] Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors.2018
- Author(s)
  Hishinuma S, Tamura Y, Kobayashi C, Akatsu C, Shoji M
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 19 Issue: 12 Pages: 4067-75
- DOI
  10.3390/ijms19124067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17695
[Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhance antibody production in mice.2018
- Author(s)
  Matsubara, N., Imamura, A., Yonemizu, T., Akatsu, C., Yang, H., Ueki, A., Watanabe, N., Abdu-Allah, H., Numoto, N., Takematsu, H., Kitazume, S., Tedder, T. F., Marth, J. D., Ito, N., Ando, H., Ishida, H., Kiso, M. and Tsubata, T.
- Journal Title
  
  Front. Immunol.
  
  Volume: 9 Pages: 820-820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02610
[Journal Article] Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.2018
- Author(s)
  Alborzian Deh Sheikh A, Akatsu C, Imamura A, Abdu-Allah HHM, Takematsu H, Ando H, Ishida H, Tsubata T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 854-859
- DOI
  10.1016/j.bbrc.2017.11.086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17695, KAKENHI-PROJECT-26293062, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-16K15235
[Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021
- Author(s)
  赤津ちづる、遠藤萌恵、Quan-Zhen Li、沼本修孝、関根英治、藤田禎三、伊藤暢聡、鍔田武志
- Organizer
  第29回日本Cell Death学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021
- Author(s)
  赤津ちづる
- Organizer
  第2回細胞死コロキアム
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] CD72 inhibits lupus-specific B cell autoimmunity caused by response to apoptotic cells through recognition of lupus-specific self-antigens2021
- Author(s)
  Akatsu C, Li QZ, Sekine H, Fujita T, and Tsubata T
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] 抑制性B細胞共受容体CD22（Siglec 2）による糖鎖依存的な免疫不全B細胞の機能回復2021
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依存的な免疫不全B細胞の機能回復.2021
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志.
- Organizer
  第 94 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02679
[Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依存的な免疫不全B細胞の機能回復2021
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志.
- Organizer
  第 94 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] The SHP-1-activating inhibitory co-receptor CD22 paradoxically augments BCR signaling in immunodeficient B cells.2020
- Author(s)
  Chizuru Akatsu, Amin Alborzian Deh Sheikh and Takeshi Tsubata.
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] 抑制性B細胞共受容体CD72の補体成分C1qを介する死細胞認識と自己免疫抑制2020
- Author(s)
  赤津ちづる
- Organizer
  第1回細胞死コロキアム
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] The SHP-1-activating inhibitory co-receptor CD22 paradoxically augments BCR signaling in immunodeficient B cells.2020
- Author(s)
  Chizuru Akatsu, Amin Alborzian Deh Sheikh, and Takeshi Tsubata
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07048
[Presentation] 内因性糖鎖リガンドによる CD22/Siglec-2 の機能制御.2019
- Author(s)
  Amin Alborzian Deh Sheikh, 赤津ちづる、鍔田武志.
- Organizer
  第 5 回糖鎖免疫研究会
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] 内因性糖鎖リガンドによるCD22/Siglec-2の機能制御2019
- Author(s)
  Amin Alborzian Deh Sheikh, 赤津ちづる、鍔田武志
- Organizer
  第5回糖鎖免疫研究会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] 抑制性 B 細胞共受容体 CD72 による SLE 関連自己抗原への自己免疫応答の抑制2019
- Author(s)
  赤津ちづる、遠藤萌恵、沼本修孝、Quan-Zhen Li、関根英治、藤田禎三、伊藤暢聡、鍔田武志 .
- Organizer
  第 34 回自己免疫研究会
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease.2018
- Author(s)
  Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling.2018
- Author(s)
  Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] CD22の糖鎖リガンドはB細胞抗原受容体（BCR）の機能変化依存的にCD22のBCR抑制機能を制御する2018
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling.2018
- Author(s)
  Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata.
- Organizer
  Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling.2018
- Author(s)
  Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata
- Organizer
  Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] CD22 の糖鎖リガンドは B 細胞抗原受容体（BCR）の機能変化依存的に CD22 の BCR 抑制機能を制御する.2018
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
- Organizer
  第 91 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease2018
- Author(s)
  Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] B細胞抑制性因子CD72とSm/RNPの複合体形成様式の推測2018
- Author(s)
  沼本修孝, 赤津ちづる, 品川健朗, 鍔田武志, 伊藤暢聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] CD22糖鎖リガンドによるCD22の機能抑制2018
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志
- Organizer
  糖鎖免疫研究会2018
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] Ligand recognition of the SHP-1-activating inhibitory B cell co-receptor CD722018
- Author(s)
  Moe Endo, Chizuru Akatsu, Quan-Zhen Li, Chengsong Zhu, Teizo Fujita, Hideharu Sekine, Takeshi Tsubata
- Organizer
  Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] SHP-1-activating B lymphocyte co-receptors and autoimmune diseases2018
- Author(s)
  Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta
- Organizer
  Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
- Invited
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling.2018
- Author(s)
  Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata.
- Organizer
  The Regular Meeting of the Japanese Biochemical Society Kanto Branch
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] SHP-1-activating B lymphocyte co-receptors and autoimmune diseases2018
- Author(s)
  Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] SLE発症関連自己核酸抗原へのB細胞応答の新規抑制メカニズム2018
- Author(s)
  赤津ちづる、鍔田武志
- Organizer
  平成29年度新学術領域「ネオ・セルフ」若手の会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] CD45は糖鎖シスリガンドとしてCD22/Siglec-2を抑制することでBリンパ球分化を促進する2017
- Author(s)
  赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] 抑制性受容体CD72によるRNA関連自己抗原への自己免疫応答の制御2017
- Author(s)
  赤津ちづる、沼本修孝、伊藤暢聡、鍔田武志
- Organizer
  第32回自己免疫研究会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] CD72 recognizes RNA-related self-antigens and prevent autoimmunity2017
- Author(s)
  Takeshi Tsubata, Hongrui Yang, and Chizuru Akatsu
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] Cis-ligand dependent and independent interaction of receptor type protein tyrosine phosphatase CD45 with B cell inhibitory receptor CD222017
- Author(s)
  Amin Alborzian-Deh-Sheikh, Chizuru Akatsu, Hideharu Ishida, and Takeshi Tsubata
- Organizer
  平成29年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] Role of CD45 (PTPRC) in the regulation of SHP-1 (PTPN6)-activating receptor CD222017
- Author(s)
  Chizuru Akatsu, Amin Alborzian-Deh-Sheikh, and Takeshi Tsubata
- Organizer
  The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] The Inhibitory B Cell Co-Receptor CD72 Regulates B Cell Response to Self Nucleic Acids Crucial for Development of SLE2017
- Author(s)
  Chizuru Akatsu, Hongrui Yang, and Takeshi Tsubata
- Organizer
  Korean Association of Immunologists (KAI) International Meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD722017
- Author(s)
  Nobutaka Numoto, Chizuru Akatsu, Kenro Shinagawa, Takeshi Tsubata, and Nobutoshi Ito
- Organizer
  第55回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-17K17695
[Presentation] 結晶構造によるB細胞抑制性因子CD72のリガンド結合部位の推測2017
- Author(s)
  沼本修孝、赤津ちづる、品川健朗、劉志紅、Aslam Mohammad、鍔田武志、伊藤暢聡
- Organizer
  第17回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-17K17695

1. Tsubata Takeshi (80197756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 王継揚 (80231041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩井佳子 (90362467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 川口しのぶ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKATSU Chizuru 赤津 ちづる

Research Projects

Research Products

Co-Researchers

Bリンパ球を用いたレクチンを起点とする細胞表面分子ネットワークの機能解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抑制性分子CD72の樹状細胞疲弊における役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of B lymphocyte activation by molecular interactions in glycocalyx

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of heparin/heparan sulfate on regulation of B cell inhibitory receptor CD72Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Lectin Purification and Analysis: Methods and Protocols2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating <i> Cd45 <sup>?/?</sup> </i> immunodeficient B cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Siglec Cis-Ligands by Proximity Labeling2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhances antibody production in mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhance antibody production in mice.2018

Author(s)

Journal Title

Data Source

[Journal Article] Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021

Author(s)

Organizer

Data Source

[Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021

AKATSU Chizuru 赤津ちづる

[Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依存的な免疫不全B細胞の機能回復.2021

[Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依存的な免疫不全B細胞の機能回復2021

[Presentation] CD22 の糖鎖リガンドは B 細胞抗原受容体（BCR）の機能変化依存的に CD22 の BCR 抑制機能を制御する.2018