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AKATSU Chizuru  赤津 ちづる

ORCIDConnect your ORCID iD *help
Researcher Number 60735984
Other IDs
Affiliation (based on the past Project Information) *help 2017 – 2021: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General medical chemistry
Except Principal Investigator
Basic Section 48040:Medical biochemistry-related
Keywords
Principal Investigator
CD72 / 免疫学 / 慢性感染症 / 樹状細胞 / 硫酸化糖鎖 / レクチン / 自己免疫 / B細胞
Except Principal Investigator
CD22 / Siglec … More / シアル酸 / シスリガンド / レクチン / Glycocalyx / 細胞接着 / LFA-1 / B細胞 / CEACAM-1 / proximity labeling / CD72 / 分化過程での制御 / Proximity labeling / チロシンホスファターゼ / 糖鎖シスリガンド / BCR / シグナル伝達 / 免疫不全 / Bリンパ球 Less
  • Research Projects

    (4 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (4 People)
  •  Bリンパ球を用いたレクチンを起点とする細胞表面分子ネットワークの機能解明

    • Principal Investigator
      鍔田 武志
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Nihon University
  •  抑制性分子CD72の樹状細胞疲弊における役割の解明Principal Investigator

    • Principal Investigator
      赤津 ちづる
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Regulation of B lymphocyte activation by molecular interactions in glycocalyx

    • Principal Investigator
      Tsubata Takeshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Functional analysis of heparin/heparan sulfate on regulation of B cell inhibitory receptor CD72Principal Investigator

    • Principal Investigator
      AKATSU Chizuru
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

  • [Book] Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi2020

    • Author(s)
      Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.
    • Total Pages
      693
    • Publisher
      Springer
    • ISBN
      9781071604298
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Book] Lectin Purification and Analysis: Methods and Protocols2020

    • Author(s)
      Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.
    • Total Pages
      699
    • Publisher
      Springer
    • ISBN
      9781071604304
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Journal Article] The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating <i> Cd45 <sup>?/?</sup> </i> immunodeficient B cells2022

    • Author(s)
      Akatsu Chizuru、Alborzian Deh Sheikh Amin、Matsubara Naoko、Takematsu Hiromu、Schweizer Astrid、Abdu-Allah Hajjaj H. M.、Tedder Thomas F.、Nitschke Lars、Ishida Hideharu、Tsubata Takeshi
    • Journal Title

      Science Signaling

      Volume: 15 Issue: 723 Pages: 723-723

    • DOI

      10.1126/scisignal.abf9570

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07048, KAKENHI-PROJECT-18H02610, KAKENHI-PUBLICLY-20H05349, KAKENHI-PROJECT-21K06074, KAKENHI-PROJECT-21H02679
  • [Journal Article] LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway2022

    • Author(s)
      Wang Ying、Liu Jun、Akatsu Chizuru、Zhang Runyun、Zhang Hai、Zhu Han、Liu Kangwei、Zhu Han-Ying、Min Qing、Meng Xin、Cui Chaoqun、Tang Yue、Yu Meiping、Li Yaxuan、Feng Xiaoqian、Wei Hao、Wen Zichao、Ji Sihan、Weigert Martin G.、Tsubata Takeshi、Wang Ji-Yang
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 36

    • DOI

      10.1073/pnas.2205629119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-21H02679
  • [Journal Article] The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells2021

    • Author(s)
      Alborzian Deh Sheikh Amin、Akatsu Chizuru、Abdu-Allah Hajjaj H. M.、Suganuma Yuki、Imamura Akihiro、Ando Hiromune、Takematsu Hiromu、Ishida Hideharu、Tsubata Takeshi
    • Journal Title

      The Journal of Immunology

      Volume: 206 Issue: 11 Pages: 2544-2551

    • DOI

      10.4049/jimmunol.2100109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07048, KAKENHI-PROJECT-18H02610, KAKENHI-PUBLICLY-20H05349, KAKENHI-PROJECT-21K06074, KAKENHI-PROJECT-21H02679
  • [Journal Article] Identification of Siglec Cis-Ligands by Proximity Labeling2020

    • Author(s)
      Alborzian Deh Sheikh Amin、Akatsu Chizuru、Tsubata Takeshi
    • Journal Title

      Methods in Molecular Biology

      Volume: 2132 Pages: 75-83

    • DOI

      10.1007/978-1-0716-0430-4_8

    • ISBN
      9781071604298, 9781071604304
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhances antibody production in mice2018

    • Author(s)
      2.Matsubara N, Imamura A, Yonemiz Tu, Akatsu C, Yang H, Ueki A, Watanabe N, Abdu-Allah H, Numoto N, Takematsu H, Kitazume S, Tedder FT, Marth JD, Ito N, Ando H, Ishida H, Kiso M, and Tsubata T
    • Journal Title

      Frontiers in Immunology

      Volume: - Pages: 820-820

    • DOI

      10.3389/fimmu.2018.00820

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08601, KAKENHI-PROJECT-17K17695, KAKENHI-PROJECT-26293062, KAKENHI-PROJECT-18H03942
  • [Journal Article] Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors.2018

    • Author(s)
      Hishinuma S, Tamura Y, Kobayashi C, Akatsu C, Shoji M
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 19 Issue: 12 Pages: 4067-75

    • DOI

      10.3390/ijms19124067

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhance antibody production in mice.2018

    • Author(s)
      Matsubara, N., Imamura, A., Yonemizu, T., Akatsu, C., Yang, H., Ueki, A., Watanabe, N., Abdu-Allah, H., Numoto, N., Takematsu, H., Kitazume, S., Tedder, T. F., Marth, J. D., Ito, N., Ando, H., Ishida, H., Kiso, M. and Tsubata, T.
    • Journal Title

      Front. Immunol.

      Volume: 9 Pages: 820-820

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Journal Article] Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.2018

    • Author(s)
      Alborzian Deh Sheikh A, Akatsu C, Imamura A, Abdu-Allah HHM, Takematsu H, Ando H, Ishida H, Tsubata T
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495 Issue: 1 Pages: 854-859

    • DOI

      10.1016/j.bbrc.2017.11.086

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17695, KAKENHI-PROJECT-26293062, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-16K15235
  • [Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021

    • Author(s)
      赤津ちづる、遠藤萌恵、Quan-Zhen Li、沼本修孝、関根英治、藤田禎三、伊藤暢聡、鍔田武志
    • Organizer
      第29回日本Cell Death学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] CD72による死細胞へのB細胞自己免疫応答の抑制2021

    • Author(s)
      赤津ちづる
    • Organizer
      第2回細胞死コロキアム
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] CD72 inhibits lupus-specific B cell autoimmunity caused by response to apoptotic cells through recognition of lupus-specific self-antigens2021

    • Author(s)
      Akatsu C, Li QZ, Sekine H, Fujita T, and Tsubata T
    • Organizer
      The 50th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] 抑制性B細胞共受容体CD22(Siglec 2)による糖鎖依存的な免疫不全B細胞の機能回復2021

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志
    • Organizer
      第94回日本生化学大会
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依 存的な免疫不全B細胞の機能回復.2021

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志.
    • Organizer
      第 94 回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21H02679
  • [Presentation] 抑制性B細胞共受容体 CD22(Siglec-2) による糖鎖依 存的な免疫不全B細胞の機能回復2021

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志.
    • Organizer
      第 94 回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] The SHP-1-activating inhibitory co-receptor CD22 paradoxically augments BCR signaling in immunodeficient B cells.2020

    • Author(s)
      Chizuru Akatsu, Amin Alborzian Deh Sheikh and Takeshi Tsubata.
    • Organizer
      The 14th International Conference on Protein Phosphatase
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] 抑制性B細胞共受容体CD72の補体成分C1qを介する死細胞認識と自己免疫抑制2020

    • Author(s)
      赤津ちづる
    • Organizer
      第1回細胞死コロキアム
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] The SHP-1-activating inhibitory co-receptor CD22 paradoxically augments BCR signaling in immunodeficient B cells.2020

    • Author(s)
      Chizuru Akatsu, Amin Alborzian Deh Sheikh, and Takeshi Tsubata
    • Organizer
      The 14th International Conference on Protein Phosphatase
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07048
  • [Presentation] 内因性糖鎖リガンドによる CD22/Siglec-2 の機能制御.2019

    • Author(s)
      Amin Alborzian Deh Sheikh, 赤津ちづる、鍔田武志.
    • Organizer
      第 5 回糖鎖免疫研究会
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] 内因性糖鎖リガンドによるCD22/Siglec-2の機能制御2019

    • Author(s)
      Amin Alborzian Deh Sheikh, 赤津ちづる、鍔田武志
    • Organizer
      第5回糖鎖免疫研究会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] 抑制性 B 細胞共受容体 CD72 による SLE 関連自己抗原への自己免疫応答の抑制2019

    • Author(s)
      赤津ちづる、遠藤萌恵、沼本修孝、Quan-Zhen Li、関根英治、藤田禎三、伊藤暢聡、鍔田武志 .
    • Organizer
      第 34 回自己免疫研究会
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease.2018

    • Author(s)
      Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling.2018

    • Author(s)
      Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata
    • Organizer
      2018年度日本生化学会関東支部例会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] CD22の糖鎖リガンドはB細胞抗原受容体(BCR)の機能変化依存的にCD22のBCR抑制機能を制御する2018

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling.2018

    • Author(s)
      Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata.
    • Organizer
      Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling.2018

    • Author(s)
      Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata
    • Organizer
      Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] CD22 の糖鎖リガンドは B 細胞抗原受容体 (BCR)の機能変化依存的に CD22 の BCR 抑制機能を制御する.2018

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
    • Organizer
      第 91 回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease2018

    • Author(s)
      Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] B細胞抑制性因子CD72とSm/RNPの複合体形成様式の推測2018

    • Author(s)
      沼本修孝, 赤津ちづる, 品川健朗, 鍔田武志, 伊藤暢聡
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] CD22糖鎖リガンドによるCD22の機能抑制2018

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、鍔田武志
    • Organizer
      糖鎖免疫研究会2018
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] Ligand recognition of the SHP-1-activating inhibitory B cell co-receptor CD722018

    • Author(s)
      Moe Endo, Chizuru Akatsu, Quan-Zhen Li, Chengsong Zhu, Teizo Fujita, Hideharu Sekine, Takeshi Tsubata
    • Organizer
      Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] SHP-1-activating B lymphocyte co-receptors and autoimmune diseases2018

    • Author(s)
      Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta
    • Organizer
      Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling.2018

    • Author(s)
      Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata.
    • Organizer
      The Regular Meeting of the Japanese Biochemical Society Kanto Branch
    • Data Source
      KAKENHI-PROJECT-18H02610
  • [Presentation] SHP-1-activating B lymphocyte co-receptors and autoimmune diseases2018

    • Author(s)
      Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] SLE発症関連自己核酸抗原へのB細胞応答の新規抑制メカニズム2018

    • Author(s)
      赤津ちづる、鍔田武志
    • Organizer
      平成29年度新学術領域「ネオ・セルフ」若手の会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] CD45は糖鎖シスリガンドとしてCD22/Siglec-2を抑制することでBリンパ球分化を促進する2017

    • Author(s)
      赤津ちづる、Alborzian-Deh-Sheikh Amin、石田秀治、鍔田武志
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] 抑制性受容体CD72によるRNA関連自己抗原への自己免疫応答の制御2017

    • Author(s)
      赤津 ちづる、沼本修孝、伊藤暢聡、鍔田武志
    • Organizer
      第32回自己免疫研究会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] CD72 recognizes RNA-related self-antigens and prevent autoimmunity2017

    • Author(s)
      Takeshi Tsubata, Hongrui Yang, and Chizuru Akatsu
    • Organizer
      第46回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] Cis-ligand dependent and independent interaction of receptor type protein tyrosine phosphatase CD45 with B cell inhibitory receptor CD222017

    • Author(s)
      Amin Alborzian-Deh-Sheikh, Chizuru Akatsu, Hideharu Ishida, and Takeshi Tsubata
    • Organizer
      平成29年度日本生化学会関東支部例会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] Role of CD45 (PTPRC) in the regulation of SHP-1 (PTPN6)-activating receptor CD222017

    • Author(s)
      Chizuru Akatsu, Amin Alborzian-Deh-Sheikh, and Takeshi Tsubata
    • Organizer
      The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] The Inhibitory B Cell Co-Receptor CD72 Regulates B Cell Response to Self Nucleic Acids Crucial for Development of SLE2017

    • Author(s)
      Chizuru Akatsu, Hongrui Yang, and Takeshi Tsubata
    • Organizer
      Korean Association of Immunologists (KAI) International Meeting 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD722017

    • Author(s)
      Nobutaka Numoto, Chizuru Akatsu, Kenro Shinagawa, Takeshi Tsubata, and Nobutoshi Ito
    • Organizer
      第55回日本生物物理学会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • [Presentation] 結晶構造によるB細胞抑制性因子CD72のリガンド結合部位の推測2017

    • Author(s)
      沼本修孝、赤津ちづる、品川健朗、劉志紅、Aslam Mohammad、鍔田武志、伊藤暢聡
    • Organizer
      第17回日本蛋白質科学会
    • Data Source
      KAKENHI-PROJECT-17K17695
  • 1.  Tsubata Takeshi (80197756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  王 継揚 (80231041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  岩井 佳子 (90362467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  川口 しのぶ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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