KAJITANI NAOTO 梶谷直人

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Kajitani Naoto 梶谷直人

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Researcher Number	60755742
Other IDs	https://orcid.org/0000-0001-7245-9206
Affiliation (Current)	2024: 熊本大学, 大学院生命科学研究部(医), 特任助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 熊本大学, 大学院生命科学研究部(医), 特任助教 2021: 熊本大学, 大学院生命科学研究部(医), 特別研究員 2019: 熊本大学, 大学院生命科学研究部(医), 特別研究員 2016 – 2018: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 研究員(移行)
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator アストロサイト / うつ病 / 抗うつ薬 / ドラッグ・リポジショニング / ドラッグリポジショニング / 反応性アストロサイト / LPA1受容体 / 精神神経薬理 / GDNF Except Principal Investigator うつ病 … More / 患者層別化 / 創薬 / 抗うつ薬 / リゾリン脂質 / 海馬 / アストロサイト / 電気けいれん療法 Less

Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
- Principal Investigator
  
  竹林実
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
海馬アストロサイトに着目した電気けいれん療法の作用機序解明
- Principal Investigator
  
  朴秀賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
ドラッグ・リポジショニングによるLPA1受容体を標的とした新規抗うつ薬の開発Principal Investigator
- Principal Investigator
  
  梶谷直人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
A study on pathogenesis of depression by focusing on pathogenesis-specific reactive astrocytesPrincipal Investigator
- Principal Investigator
  
  Kajitani Naoto
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Study focusing on astrocyte-derived GDNF as a molecular basis of treatment-resistant depression.Principal Investigator
- Principal Investigator
  
  Kajitani Naoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Tetraspanin heterogeneity of small extracellular vesicles in human biofluids and brain tissue2022
- Author(s)
  Okada-Tsuchioka Mami、Kajitani Naoto、Omori Wataru、Kurashige Takashi、Boku Shuken、Takebayashi Minoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 627 Pages: 146-151
- DOI
  10.1016/j.bbrc.2022.08.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-21K07536, KAKENHI-PROJECT-18H02756
[Journal Article] G protein-biased LPAR1 agonism promotes prototypic antidepressant effects2022
- Author(s)
  Kajitani Naoto、Okada-Tsuchioka Mami、Inoue Asuka、Miyano Kanako、Masuda Takeshi、Boku Shuken、Iwamoto Kazuya、Ohtsuki Sumio、Uezono Yasuhito、Aoki Junken、Takebayashi Minoru
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 514841-514841
- DOI
  10.1101/2022.11.02.514841
- Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-18H02756
[Journal Article] Reduced Cerebrospinal Fluid Levels of Lysophosphatidic Acid Docosahexaenoic Acid in Patients With Major Depressive Disorder and Schizophrenia2021
- Author(s)
  Omori Wataru、Kano Kuniyuki、Hattori Kotaro、Kajitani Naoto、Okada-Tsuchioka Mami、Boku Shuken、Kunugi Hiroshi、Aoki Junken、Takebayashi Minoru
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 24 Issue: 12 Pages: 948-955
- DOI
  10.1093/ijnp/pyab044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02756, KAKENHI-PROJECT-21K07501
[Journal Article] Differential anatomical and cellular expression of lysophosphatidic acid 1 receptor in adult mouse brain.2020
- Author(s)
  Kajitani Naoto, Okada-Tsuchioka Mami, Kano Kuniyuki, Omori Wataru, Boku Shuken, Aoki Junken, Takebayashi Minoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15534
[Journal Article] Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders.2019
- Author(s)
  Omori Wataru、Itagaki Kei、Kajitani Naoto、Abe Hiromi、Okada‐Tsuchioka Mami、Okamoto Yasumasa、Takebayashi Minoru
- Journal Title
  
  Psychiatry and Clinical Neurosciences
  
  Volume: 印刷中 Issue: 8 Pages: 494-500
- DOI
  10.1111/pcn.12859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07620, KAKENHI-PROJECT-18K15534
[Journal Article] Antidepressant amitriptyline‐induced matrix metalloproteinase‐9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line‐derived neurotrophic factor mRNA expression in rat astroglial cells.2019
- Author(s)
  Abe Hiromi、Kajitani Naoto、Okada‐Tsuchioka Mami、Omori Wataru、Yatsumoto Masahide、Takebayashi Minoru
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 印刷中 Issue: 3 Pages: 156-163
- DOI
  10.1002/npr2.12055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07620, KAKENHI-PROJECT-18K15534, KAKENHI-PROJECT-18H02756
[Journal Article] Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder.2019
- Author(s)
  Itagaki Kei、Takebayashi Minoru、Abe Hiromi、Shibasaki Chiyo、Kajitani Naoto、Okada-Tsuchioka Mami、Hattori Kotaro、Yoshida Sumiko、Kunugi Hiroshi、Yamawaki Shigeto
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 22 Issue: 4 Pages: 261-269
- DOI
  10.1093/ijnp/pyz005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07620, KAKENHI-PROJECT-18K15534, KAKENHI-PROJECT-18H02756
[Journal Article] Decreased serum levels of thrombospondin‐1 in female depressed patients2019
- Author(s)
  Okada‐Tsuchioka Mami、Omori Wataru、Kajitani Naoto、Shibasaki Chiyo、Itagaki Kei、Takebayashi Minoru
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 40 Issue: 1 Pages: 39-45
- DOI
  10.1002/npr2.12088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07620, KAKENHI-PROJECT-18K15534
[Journal Article] Possible Association between Serum Matrix Metalloproteinase-9 (MMP-9) Levels and Relapse in Depressed Patients following Electroconvulsive Therapy (ECT)2017
- Author(s)
  Shibasaki Chiyo、Itagaki Kei、Abe Hiromi、Kajitani Naoto、Okada-Tsuchioka Mami、Takebayashi Minoru
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 21 Issue: 3 Pages: 236-241
- DOI
  10.1093/ijnp/pyx086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Factors associated with relapse after a response to electroconvulsive therapy in unipolar versus bipolar depression.2017
- Author(s)
  Itagaki K, Takebayashi M, Shibasaki C, Kajitani N, Abe H, Okada-Tsuchioka M, Yamawaki S.
- Journal Title
  
  Journal of Affective Disorders.
  
  Volume: 208 Pages: 113-119
- DOI
  10.1016/j.jad.2016.08.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells2016
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka M, Yano R, Itagaki K, Shibasaki C, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 907-912
- DOI
  10.1016/j.bbrc.2016.09.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Identification of lysophosphatidic acid receptor 1 in astroglial cells as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants.2016
- Author(s)
  Kajitani, N., Miyano, K., Okada-Tsuchioka, M., Abe, H., Itagaki, K., Hisaoka-Nakashima, K., Morioka, N., Uezono, Y., Takebayashi, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 53 Pages: 27364-27370
- DOI
  10.1074/jbc.m116.753871
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Presentation] Comprehensive analysis of gene expression hippocampal astrocytes in a model of depression.2022
- Author(s)
  Koga Y, Miyako K, Kajitani N, Boku S, Takebayashi M.
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07501
[Presentation] Neonatal maternal separation-induced alternation of miRNAs andtheir possibility as biomarkers of major depressive disorder.2022
- Author(s)
  Boku S, Toda H, Koga M. Kajitani N, Takebayashi M.
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07501
[Presentation] うつ病の病態メカニズムにおけるリゾホスファチジン酸受容体の役割．2022
- Author(s)
  梶谷直人，岡田麻美，朴秀賢，竹林実．
- Organizer
  第44回日本生物学的精神医学会・第32回日本臨床精神神経薬理学会・第52回日本神経精神薬理学会年会・第6回日本精神薬学会総会・学術集会　4学会合同年会(BPCNPPPP4学会合同年会)
- Invited
- Data Source
  KAKENHI-PROJECT-21K07501
[Presentation] Establishment of a clinical setting-associated behavioral model of ECT and investigation of the mechanism of action of ECT with focus on astrocytes2022
- Author(s)
  Kotaro Miyako, Naoto Kajitani, Yusaku Koga, Shuken Boku, Minoru Takebayashi
- Organizer
  Society of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07599
[Presentation] Establishment of a clinical setting-associated behavioral model of ECT and investigation of the mechanism of action of ECT with focus on astrocytes.2022
- Author(s)
  Miyako K, Koga Y, Kajitani N, Boku S, Takebayashi M.
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07501
[Presentation] アストロサイトを介した三環系抗うつ薬の新たな作用機序2021
- Author(s)
  梶谷直人、岡田麻美、朴秀賢、竹林実
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07501
[Presentation] Distribution of multiple lysophosphatidic acid receptors in adult mouse brain2019
- Author(s)
  Kajitani N，Okada-Tsuchioka M，Abe H，Omori W，Itagaki K，Machino A，Takebayashi M．
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15534
[Presentation] Cellular localization of lysophosphatidic acid receptor 1 in the mouse brain.2018
- Author(s)
  Naoto Kajitani, Mami Okada-Tsuchioka, Hiromi Abe, Wataru Omori, Kei Itagaki, Minoru Takebayashi
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15534
[Presentation] 脳内における抗うつ薬受容体（LPA1）発現細胞の特定とその役割2018
- Author(s)
  梶谷直人、岡田麻美、安部裕美、大盛航、板垣圭、竹林実
- Organizer
  第５回サイコグリア研究会
- Data Source
  KAKENHI-PROJECT-18K15534
[Presentation] 抗うつ薬受容体（LPA1）の脳内発現とその役割2018
- Author(s)
  梶谷直人、岡田麻美、安部裕美、大盛航、板垣圭、竹林実
- Organizer
  第３７回躁うつ病の薬理・生化学的研究懇話会
- Data Source
  KAKENHI-PROJECT-18K15534
[Presentation] Identification of lysophosphatidic acid receptor 1 in astrocytes as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants2017
- Author(s)
  N Kajitani, K Miyano, M Okada-Tsuchioka, H Abe, W Omori, K Itagaki, Y Uezono, M Takebayashi
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19796
[Presentation] アストロサイトにおけるGDNF産生に関与する抗うつ薬受容体LPA1の同定2017
- Author(s)
  梶谷直人、宮野加奈子、岡田麻美、安部裕美、板垣圭、中島一恵、森岡徳光、上園保仁、竹林実
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2017
- Data Source
  KAKENHI-PROJECT-16K19796
[Presentation] アストロサイトを標的とした抗うつ薬の作用点としてのLPA1受容体の役割2017
- Author(s)
  梶谷直人
- Organizer
  第4回サイコグリア研究会
- Data Source
  KAKENHI-PROJECT-16K19796
[Presentation] アストロサイトにおいてGDNF産生作用を導く新たな「抗うつ薬受容体」の同定2016
- Author(s)
  梶谷直人、宮野加奈子、岡田麻美、安部裕美、板垣圭、上園保仁、竹林実
- Organizer
  題35回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  山口市
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16K19796

1. 可野邦行 (50636404)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 朴秀賢 (60455665)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 竹林実 (60304440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 青木淳賢 (20250219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岩本和也 (40342753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 服部功太郎 (50415569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKADA Mami

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
8. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. くぬ刀浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAJITANI NAOTO 梶谷 直人

Kajitani Naoto 梶谷 直人

Research Projects

Research Products

Co-Researchers

Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

海馬アストロサイトに着目した電気けいれん療法の作用機序解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ドラッグ・リポジショニングによるLPA1受容体を標的とした新規抗うつ薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on pathogenesis of depression by focusing on pathogenesis-specific reactive astrocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study focusing on astrocyte-derived GDNF as a molecular basis of treatment-resistant depression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tetraspanin heterogeneity of small extracellular vesicles in human biofluids and brain tissue2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G protein-biased LPAR1 agonism promotes prototypic antidepressant effects2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Cerebrospinal Fluid Levels of Lysophosphatidic Acid Docosahexaenoic Acid in Patients With Major Depressive Disorder and Schizophrenia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential anatomical and cellular expression of lysophosphatidic acid 1 receptor in adult mouse brain.2020

Author(s)

Journal Title

Data Source

[Journal Article] Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antidepressant amitriptyline‐induced matrix metalloproteinase‐9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line‐derived neurotrophic factor mRNA expression in rat astroglial cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased serum levels of thrombospondin‐1 in female depressed patients2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible Association between Serum Matrix Metalloproteinase-9 (MMP-9) Levels and Relapse in Depressed Patients following Electroconvulsive Therapy (ECT)2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Factors associated with relapse after a response to electroconvulsive therapy in unipolar versus bipolar depression.2017

KAJITANI NAOTO 梶谷直人

Kajitani Naoto 梶谷直人