Kunisawa Kazuo 國澤和生

Researcher Number	60780773
Other IDs
Affiliation (Current)	2026: 藤田医科大学, 医療科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024 – 2026: 藤田医科大学, 医療科学研究科, 准教授 2021 – 2023: 藤田医科大学, 保健学研究科, 講師 2018 – 2022: 藤田医科大学, 保健学研究科, 助教 2017: 藤田保健衛生大学, 保健学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 49030:Experimental pathology-related / Psychiatric science
Keywords	Principal Investigator ストレス / ミクログリア / 髄鞘 / ユビキチン化酵素 / 前頭前皮質 / アデノ随伴ウイルス / ユビキチン修飾系 / GLT-1 / Nedd4L / うつ病 … More / ネットワーク / 軸索 / 神経活動 / 炎症性サイトカイン / パイロトーシス / 髄鞘-軸索相互作用 / オリゴデンドロサイト / 脱髄性疾患 / トリプトファン代謝 / 免疫異常 / 運動機能 / IDO / 脱髄 / PLP4e/- / 多発性硬化症 / IDO2 … More Except Principal Investigator トリプトファン代謝 / うつ病 / キヌレニナーゼ / 乾癬 / 末梢免疫細胞 / 炎症性サイトカイン / 免疫応答 / うつ病バイオマーカー / 骨髄由来免疫抑制細胞MDSC / 炎症系サイトカイン / モデル動物 / プレパルスインヒビション / フェンサイクリジン / 神経発達障害 / 酸化ストレス / キヌレニン-3-モノオキシゲナーゼ / PolyI:C / 3-ヒドロキシキヌレニン / キヌレン酸 / 統合失調症 / ポリイノシン-ポリシチジン（PolyI:C） / フェンサイクリジン（PCP） / キヌレニン-3-モノオキシゲナーゼ（KMO） / MAGE-D1 / 診断バイオマーカー / 精神薬理学 / うつ様症状 / 疼痛性障害 / ユビキチン化セロトニントランスポーター / ユビキチン化 / セロトニントランスポーター / 診断 / バイオマーカー / うつ Less

末梢免疫細胞死機構に着目したうつ病の創薬基盤および次世代診断法の確立Principal Investigator
- Principal Investigator
  
  國澤和生
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
乾癬におけるトリプトファン代謝に着目した病態解明と制御法の開発
- Principal Investigator
  
  齋藤邦明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fujita Health University
Mechanisms of peripheral-CNS immune responses in the development of major depressive disorder induced by stress
- Principal Investigator
  
  鍋島俊隆
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
The influence of disruption of myelin-neuron network on major depressive disorderPrincipal Investigator
- Principal Investigator
  
  Kunisawa Kazuo
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
Prevention and treatment strategies focusing on tryptophan metabolism, a common factor in the pathogenesis and pathophysiology hypothesis of schizophrenia.
- Principal Investigator
  
  Mouri Akihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
The role of ubiquitin-related enzyme Nedd4L in major depressive disorderPrincipal Investigator
- Principal Investigator
  
  Kunisawa Kazuo
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
The role of tryptophan-metabolizing enzymes in demyelination diseasesPrincipal Investigator
- Principal Investigator
  
  Kunisawa Kazuo
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Fujita Health University
Development of the next-generation diagnosis method for depression by using byomakers based on pathophysiological mechanism
- Principal Investigator
  
  Nabeshima Toshitaka
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Fujita Health University

All 2025 2024 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] High-Cellulose Diet Ameliorates Cognitive Impairment by Modulating Gut Microbiota and Metabolic Pathways in Mice2025
- Author(s)
  Tanabe Moeka、Kunisawa Kazuo、Saito Imari、Ojika Haruto、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  The Journal of Nutrition
  
  Volume: - Issue: 6 Pages: 1689-1699
- DOI
  10.1016/j.tjnut.2025.04.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27534
[Journal Article] Chronic social defeat stress induces the down‐regulation of the <scp>Nedd4L‐GLT</scp>‐1 ubiquitination pathway in the prefrontal cortex of mice2024
- Author(s)
  Kosuge Aika、Kunisawa Kazuo、Iida Tsubasa、Wulaer Bolati、Kawai Tomoki、Tanabe Moeka、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 168 Issue: 9 Pages: 2479-2494
- DOI
  10.1111/jnc.16100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27534
[Journal Article] Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid2024
- Author(s)
  Kurahashi Hitomi、Kunisawa Kazuo、Tanaka Kenji F.、Kubota Hisayoshi、Hasegawa Masaya、Miyachi Mai、Moriya Yuka、Hasegawa Yoichi、Nagai Taku、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 50 Issue: 5 Pages: 739-750
- DOI
  10.1038/s41386-024-02004-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27534, KAKENHI-PROJECT-24K02218, KAKENHI-PROJECT-24KJ2127
[Journal Article] Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline2024
- Author(s)
  Hasegawa Masaya、Kunisawa Kazuo、Wulaer Bolati、Kubota Hisayoshi、Kurahashi Hitomi、Sakata Takatoshi、Ando Honomi、Fujigaki Suwako、Fujigaki Hidetsugu、Yamamoto Yasuko、Nagai Taku、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 182 Issue: 7 Pages: 1466-1486
- DOI
  10.1111/bph.17407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11891, KAKENHI-PROJECT-23K27534, KAKENHI-PROJECT-24K02218, KAKENHI-PROJECT-24KJ2127
[Journal Article] Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta2024
- Author(s)
  Hasegawa Masaya、Niijima Moe、Kunisawa Kazuo、Teshigawara Tomoaki、Kubota Hisayoshi、Fujigaki Suwako、Fujigaki Hidetsugu、Yamamoto Yasuko、Kim Hyoung-Chun、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 737 Pages: 150922-150922
- DOI
  10.1016/j.bbrc.2024.150922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11891, KAKENHI-PROJECT-23K27534, KAKENHI-PROJECT-24KJ2127
[Journal Article] Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation2024
- Author(s)
  Kubota Hisayoshi、Kunisawa Kazuo、Hasegawa Masaya、Kurahashi Hitomi、Kagotani Kazuhiro、Fujimoto Yuki、Hayashi Akihito、Sono Ryoji、Tsuji Takehiko、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Neurochemistry International
  
  Volume: 180 Pages: 105858-105858
- DOI
  10.1016/j.neuint.2024.105858
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27534, KAKENHI-PROJECT-24KJ2127
[Journal Article] Ido2 Deficiency Exacerbates Motor Impairment and Reduces Aryl Hydrocarbon Receptor Activity through Decreased Kynurenine in a Chronic Demyelinating Mouse Model2024
- Author(s)
  Kunisawa Kazuo、Hara Mitsuki、Yoshidomi Koyo、Kon Yuki、Yamamoto Yasuko、Fujigaki Suwako、Wulaer Bolati、Kosuge Aika、Tanabe Moeka、Saitoh Sei、Takahashi Kazuo、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 62 Issue: 1 Pages: 109-122
- DOI
  10.1007/s12035-024-04263-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11891, KAKENHI-PROJECT-23K27534
[Journal Article] Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine2024
- Author(s)
  Tanabe Moeka、Kunisawa Kazuo、Saito Imari、Kosuge Aika、Tezuka Hiroyuki、Kawai Tomoki、Kon Yuki、Yoshidomi Koyo、Kagami Akari、Hasegawa Masaya、Kubota Hisayoshi、Ojika Haruto、Fujii Tadashi、Tochio Takumi、Hirooka Yoshiki、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 30 Issue: 5 Pages: 2137-2151
- DOI
  10.1038/s41380-024-02826-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27534, KAKENHI-PROJECT-24KJ2127
[Journal Article] Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine2022
- Author(s)
  Kubota Hisayoshi、Kunisawa Kazuo、Niijima Moe、Hirakawa Mami、Mori Yuko、Hasegawa Masaya、Fujigaki Suwako、Fujigaki Hidetsugu、Yamamoto Yasuko、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 629 Pages: 142-151
- DOI
  10.1016/j.bbrc.2022.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07931
[Journal Article] Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice2022
- Author(s)
  Kunisawa Kazuo、Shan Jiajing、Lu Qiaohui、Yang Yang、Kosuge Aika、Kurahashi Hitomi、Saito Kuniaki、Zou Libo、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Neurochemical Research
  
  Volume: 47 Issue: 9 Pages: 2880-2889
- DOI
  10.1007/s11064-022-03692-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Journal Article] Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice2022
- Author(s)
  Yang Yang、Mouri Akihiro、Lu Qiaohui、Kunisawa Kazuo、Kubota Hisayoshi、Hasegawa Masaya、Hirakawa Mami、Mori Yuko、Libo Zou、Saito Kuniaki、Nabeshima Toshitaka
- Journal Title
  
  Neurochemical Research
  
  Volume: 47 Issue: 9 Pages: 2865-2879
- DOI
  10.1007/s11064-022-03694-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Journal Article] Exploring the factors underlying remyelination arrest by studying the post‐transcriptional regulatory mechanisms of cystatin F gene2021
- Author(s)
  Li Jiayi、Durose Wilaiwan Wisessmith、Ito Junko、Kakita Akiyoshi、Iguchi Yohei、Katsuno Masahisa、Kunisawa Kazuo、Shimizu Takeshi、Ikenaka Kazuhiro
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 157 Issue: 6 Pages: 2070-2090
- DOI
  10.1111/jnc.15190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K16679
[Journal Article] Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid2021
- Author(s)
  Mori Yuko、Mouri Akihiro、Kunisawa Kazuo、Hirakawa Mami、Kubota Hisayoshi、Kosuge Aika、Niijima Moe、Hasegawa Masaya、Kurahashi Hitomi、Murakami Reiko、Hoshi Masato、Nakano Takashi、Fujigaki Suwako、Fujigaki Hidetsugu、Yamamoto Yasuko、Nabeshima Toshitaka、Saito Kuniaki
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 405 Pages: 113191-113191
- DOI
  10.1016/j.bbr.2021.113191
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07490, KAKENHI-PROJECT-18K19761, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20K07432, KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K16679
[Journal Article] Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice2021
- Author(s)
  Wulaer Bolati、Kunisawa Kazuo、Tanabe Moeka、Yanagawa Aika、Saito Kuniaki、Mouri Akihiro、Nabeshima Toshitaka
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 43-43
- DOI
  10.1186/s13041-021-00760-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K16679
[Journal Article] Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress2021
- Author(s)
  Kosuge Aika、Kunisawa Kazuo、Arai Satoshi、Sugawara Yumika、Shinohara Katsuki、Iida Tsubasa、Wulaer Bolati、Kawai Tomoki、Fujigaki Hidetsugu、Yamamoto Yasuko、Saito Kuniaki、Nabeshima Toshitaka、Mouri Akihiro
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 96 Pages: 200-211
- DOI
  10.1016/j.bbi.2021.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K16679
[Journal Article] Prefrontal cortex miR‐874‐3p prevents lipopolysaccharide‐induced depression‐like behavior through inhibition of indoleamine 2,3‐dioxygenase 1 expression in mice2020
- Author(s)
  Suento Willy Jaya、Kunisawa Kazuo、Wulaer Bolati、Kosuge Aika、Iida Tsubasa、Fujigaki Suwako、Fujigaki Hidetsugu、Yamamoto Yasuko、Tanra Andi Jayalangkara、Saito Kuniaki、Mouri Akihiro、Nabeshima Toshitaka
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: - Issue: 6 Pages: 1963-1978
- DOI
  10.1111/jnc.15222
- NAID
  130008001606
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20K16679
[Journal Article] Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo2020
- Author(s)
  Kunisawa Kazuo、Hatanaka Nobuhiko、Shimizu Takeshi、Kobayashi Kenta、Osanai Yasuyuki、Mouri Akihiro、Shi Qian、Bhat Manzoor A.、Nambu Atsushi、Ikenaka Kazuhiro
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 159-159
- DOI
  10.1186/s13041-020-00698-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-20K16679
[Journal Article] Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus2020
- Author(s)
  Wulaer Bolati、Kunisawa Kazuo、Hada Kazuhiro、Jaya Suento Willy、Kubota Hisayoshi、Iida Tsubasa、Kosuge Aika、Nagai Taku、Yamada Kiyofumi、Nitta Atsumi、Yamamoto Yasuko、Saito Kuniaki、Mouri Akihiro、Nabeshima Toshitaka
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 157 Issue: 3 Pages: 642-655
- DOI
  10.1111/jnc.15022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20K16679
[Journal Article] Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in the object-based attention test in mice2020
- Author(s)
  Wulaer Bolati、Kunisawa Kazuo、Kubota Hisayoshi、Suento Willy Jaya、Saito Kuniaki、Mouri Akihiro、Nabeshima Toshitaka
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 391-391
- DOI
  10.1186/s13041-020-00711-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20K16679
[Journal Article] Indoleamine 2,3‐dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma2019
- Author(s)
  Yamasuge Wakana、Yamamoto Yasuko、Fujigaki Hidetsugu、Hoshi Masato、Nakamoto Kentaro、Kunisawa Kazuo、Mouri Akihiro、Nabeshima Toshitaka、Saito Kuniaki
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 10 Pages: 3061-3067
- DOI
  10.1111/cas.14179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07490, KAKENHI-PROJECT-18K19761, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-17K01969, KAKENHI-PROJECT-17K15785, KAKENHI-PROJECT-18K15377
[Journal Article] Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression2019
- Author(s)
  Lu Qiaohui、Mouri Akihiro、Yang Yang、Kunisawa Kazuo、Teshigawara Tomoaki、Hirakawa Mami、Mori Yuko、Yamamoto Yasuko、Libo Zou、Nabeshima Toshitaka、Saito Kuniaki
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 372 Pages: 112053-112053
- DOI
  10.1016/j.bbr.2019.112053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19761, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-18K15377
[Journal Article] Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues2019
- Author(s)
  Yoshida Yukihiro、Fujigaki Hidetsugu、Kato Koichi、Yamazaki Kyoka、Fujigaki Suwako、Kunisawa Kazuo、Yamamoto Yasuko、Mouri Akihiro、Oda Akifumi、Nabeshima Toshitaka、Saito Kuniaki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10243-10243
- DOI
  10.1038/s41598-019-46666-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07490, KAKENHI-PROJECT-18K19761, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-17K01969, KAKENHI-PROJECT-17K08257, KAKENHI-PROJECT-18K15377
[Journal Article] Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling2018
- Author(s)
  Yamamoto Yasuko、Yamasuge Wakana、Imai Shinjiro、Kunisawa Kazuo、Hoshi Masato、Fujigaki Hidetsugu、Mouri Akihiro、Nabeshima Toshitaka、Saito Kuniaki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15917-15917
- DOI
  10.1038/s41598-018-34166-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01969, KAKENHI-PROJECT-18K19761, KAKENHI-PROJECT-17K15785, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-17H07222, KAKENHI-PROJECT-16K10195, KAKENHI-PROJECT-18K15377
[Journal Article] Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability2018
- Author(s)
  Kunisawa Kazuo、Shimizu Takeshi、Kushima Itaru、Aleksic Branko、Mori Daisuke、Osanai Yasuyuki、Kobayashi Kenta、Taylor Anna M.、Bhat Manzoor A.、Hayashi Akiko、Baba Hiroko、Ozaki Norio、Ikenaka Kazuhiro
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 147 Issue: 3 Pages: 395-408
- DOI
  10.1111/jnc.14553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-18H04040, KAKENHI-PROJECT-17H05090, KAKENHI-PROJECT-18K15377
[Patent] SCREENING METHOD AND THERAPEUTIC AGENT FOR MENTAL DISORDER2024
- Inventor(s)
  國澤和生, 毛利彰宏, 鍋島俊隆:
- Industrial Property Rights Holder
  國澤和生, 毛利彰宏, 鍋島俊隆:
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27534
[Patent] 細胞表面マーカーを用いた精神疾患診断方法2024
- Inventor(s)
  國澤和生, 齋藤邦明、毛利彰宏, 鍋島俊隆,他4名
- Industrial Property Rights Holder
  國澤和生, 齋藤邦明、毛利彰宏, 鍋島俊隆,他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-123017
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K27534
[Patent] 精神障害に対する治療薬及びスクリーニング方法2024
- Inventor(s)
  國澤和生, 毛利彰宏, 鍋島俊隆
- Industrial Property Rights Holder
  國澤和生, 毛利彰宏, 鍋島俊隆
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-23K27534
[Patent] SCREENING METHOD AND THERAPEUTIC AGENT FOR MENTAL DISORDER2024
- Inventor(s)
  國澤和生, 毛利彰宏, 鍋島俊隆:
- Industrial Property Rights Holder
  國澤和生, 毛利彰宏, 鍋島俊隆:
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] トリプトファン代謝はキノリン酸/キヌレン酸バランスを介し、ペンチレンテトラゾール誘発てんかん発作に寄与する.2024
- Author(s)
  毛利彰宏, 西川貴也, 國澤和生, 長谷川眞也, 山岸修平, 坂田昂駿, 須貝智也, 沓村憲樹, 齋藤邦明, 鍋島俊隆.
- Organizer
  NEURO2024.
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 膜貫通型糖蛋白質Gpnmbは多発性硬化症の炎症反応に関与する.2024
- Author(s)
  國澤和生、今勇貴、吉富航洋、小菅愛加、鍋島俊隆、毛利彰宏.
- Organizer
  第36回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 多発性硬化症モデルにおけるインターフェロン調節因子の発現と局在.2024
- Author(s)
  小鹿晴登, 國澤和生, 田辺萌夏, 鍋島俊隆, 毛利彰宏.
- Organizer
  第34回神経行動薬理若手研究者の集い
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] Involvement of PGE2-EP1 signaling in the PTZ-induced epileptic seizure and its neuroinflamation-associated exacerbation.2024
- Author(s)
  Yukino Ishizaka, Akihiro Mouri, Kazuo Kunisawa, Takaya Nishikawa, Tomoyuki Furuyashiki, Shuh Narumiya, Toshitaka Nabeshima.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] The sucrose intake changes stress-induced behavior via glucose metabolism and noradrenergic neuronal system.2024
- Author(s)
  Takatoshi Sakata, Akihiro Mouri, Kunisawa Kazuo, Masaya Hasegawa, Masao Takemura, HIdetoshi Matunami, Kuniaki Saito, Toshitaka Nabeshima.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] The neuronal circuits implicated in the phencyclidine-induced behavioral impairments and therapeutic and side effects of aripiprazole.2024
- Author(s)
  Fumika Ando, Akihiro Mouri, Kazuo Kunisawa, Shuhei Yamagishi, Yuji Komaki, Kazuki Takano, Toshitaka Nabeshima.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 乳幼仔期の熱性けいれん発作は成体期においてモノアミン変化を伴う注意欠如・多動性障害様の行動を惹起する.2024
- Author(s)
  石坂友紀乃, 毛利彰宏, 國澤和生, 鍋島俊隆.
- Organizer
  第26回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] Enriched environment attenuates chronic unpredictable mild stress-induced depression-like behaviors and suppression of synaptic formation of newborn neurons by changing microglial phenotypes.2024
- Author(s)
  Masaya Hasegawa, Akihiro Mouri, Kazuo Kunisawa, Hitomi Kurahashi, Takatoshi Sakata, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima.
- Organizer
  APPW2025(第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会)
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] ストレス下でのスクロース摂取は糖代謝とノルアドレナリン神経機能障害を介してストレス誘発性行動を変化させる.2024
- Author(s)
  坂田昂駿, 毛利彰宏, 國澤和生, 長谷川眞也, 竹村正男, 松波英寿, 齋藤邦明, 鍋島俊隆.
- Organizer
  第26回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] Adolescent binge drinking induces behavioral abnormalities in adulthood caused by myelin abnormalities.2024
- Author(s)
  Kazuo Kunisawa, Yumika Sugawara, Kohei Yoshidomi, Yuki Kon, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] ストレスにより惹起されるうつ病発症における末梢-中枢連関の関与.2024
- Author(s)
  國澤和生、小菅愛加、鍋島俊隆、毛利彰宏.
- Organizer
  第 74 回脳の医学・生物学研究会第 3 回日本神経化学会若手 KYOUEN 合同大会
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] ニコチン受容体を標的とした自閉スペクトラム症の治療戦略2024
- Author(s)
  毛利彰宏, 倉橋仁美, 長谷川眞也, 國澤和生, 鍋島俊隆.
- Organizer
  APPW2025(第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会)
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 慢性ストレスによるNG2グリア細胞の発現変化とうつ様行動への関与.2024
- Author(s)
  成岡佑太, 國澤和生, 小川萌佳, 須貝智也, 沓村憲樹,鍋島俊隆, 毛利彰宏.
- Organizer
  第34回神経行動薬理若手研究者の集い
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] ストレス下でのスクロース摂取は糖代謝とノルアドレナリン神経機能障害を介してストレス誘発性行動を変化させる2024
- Author(s)
  坂田昂駿, 毛利彰宏, 國澤和生, 長谷川眞也, 竹村正男, 松波英寿, 齋藤邦明, 鍋島俊隆.
- Organizer
  2024年度生理研情動研究会
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] Pharmacological evaluation of anxiolytics and nicotine for anxiety-related behaviors and neuronal activities.2024
- Author(s)
  Karin Nakahara, Akihiro Mouri, Kazuo Kunisawa, Masaya Hasegawa, Toshitaka Nabeshima.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] The spatial cognitive dysfunction and microglial activation induced by adolescent social isolation through the hypoproduction of cystine by the damage of colonic goblet cells2024
- Author(s)
  Moeka Tanabe, Kazuo Kunisawa, Imari Saito, Aika Kosuge, Hiroyuki Tezuka, Tomoki Kawai, Masaya Hasegawa, Hisayoshi Kubota, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri..
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 社会的隔離ストレスによる大腸杯細胞の減少は腸内細菌叢を変容させ、空間認知機能障害を誘発する.2024
- Author(s)
  國澤和生、田辺萌夏、齋藤いまり、小菅愛加、河合智貴、窪田悠力、齋藤邦明、鍋島俊隆、毛利彰宏.
- Organizer
  第28回腸内細菌学会学術集会.
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] マウスモデル及び老齢マウスの病態における神経炎症仮説を基にしたトリプトファン代謝. .2024
- Author(s)
  毛利彰宏、國澤和生、鍋島俊隆.
- Organizer
  第 54回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 末梢炎症性疾患に惹起される情動機能異常の分子基盤.2024
- Author(s)
  國澤和生、鍋島俊隆、毛利彰宏.
- Organizer
  第54回日本神経精神薬理学会.
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] The involvement of splenic immune cells in the depression-like behaviors induced by chronic social defeat stress.2024
- Author(s)
  Moeka Ogawa, Kazuo Kunisawa, Aika Kosuge, Hiroyuki Tezuka, Toshitaka Nabeshima, Akihiro Mouri.
- Organizer
  World Congress Collegium Internationale Neuro-Psychopharmacologicum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27534
[Presentation] 胎生期バルプロ酸曝露は5-HT1A受容体シグナルの低下を介して前頭前皮質でのNMDA受容体シグナルの亢進とASD様行動を惹起する2022
- Author(s)
  倉橋仁美、毛利彰宏、國澤和生、田中謙二、窪田悠力、長谷川眞也、小菅愛加、齋藤邦明鍋島俊隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Shati/Nat8l deficiency impairs attention by disrupting dopaminergic projections of the ventral tegmental area-prefrontal cortex in mice.2022
- Author(s)
  Kazuo Kunisawa, Bolati Wulaer, Aika Kosuge, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16679
[Presentation] 高食塩負荷による高血圧および情動・認知機能障害はPGE2/EP1-タウリン酸化シグナルが関与している2022
- Author(s)
  窪田悠力、毛利彰宏、國澤和生、長谷川眞也、倉橋仁美、小菅愛加、山本康子、手塚裕之、釘田雅則、長尾静子、齊藤邦明、鍋島俊隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus.2022
- Author(s)
  Kazuo Kunisawa, Bolati Wulaer, Kazuhiro Hada, Hisayoshi Kubota, Aika Kosuge, Tubasa Iida, Taku Nagai, Kiyofumi Yamada, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
- Organizer
  Asian Conference on Clinical Pharmacy 2022 (ACCP2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16679
[Presentation] 思春期でのアルコール暴飲は灰白質の髄鞘異常を介して成人期における行動異常を誘発する2022
- Author(s)
  菅原侑実香、國澤和生、吉富航平、今勇貴、齋藤邦明、毛利彰宏、鍋島俊隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] グリア細胞におけるトリプトファン代謝変容によるうつ病の病態形成2022
- Author(s)
  毛利彰宏、國澤和生、齋藤邦明、鍋島俊隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Shati/Nat8l欠損は腹側被蓋野-前頭前皮質間におけるドパミン作動性神経系の投射を障害することで注意機能障害を誘発する2022
- Author(s)
  國澤和生、Wulaer Bolati、小菅愛加、田辺萌夏、齋藤邦明、鍋島俊隆、毛利彰宏
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 慢性予測不能軽度ストレスによるうつ様行動および視床下部-下垂体-副腎系の調節不全はキヌレニン-3-モノオキシゲナーゼ発現低下によるキヌレン酸の増加が関与している2022
- Author(s)
  長谷川眞也、毛利彰宏、國澤和生、窪田悠力、倉橋仁美、小菅愛加、山本康子、齋藤邦明、鍋島俊隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] QPRT deficit leads motor and cognitive dysfunction through tau phosphorylation and oxidative stress in the dopaminergic neuronal system by quinolinic acid2021
- Author(s)
  Akihiro Mouri, Moe Niijima, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  The International College of Neuropsychopharmacology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] ミロイド β注入による認知機能低下におけるトリプトファン代謝を介した興奮－抑制バランスの関与（優秀賞受賞）2021
- Author(s)
  倉橋仁美、毛利彰宏、國澤和生、窪田悠力、長谷川眞也、山本康子、齋藤邦明、鍋島俊隆ア
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Deficiency of kynurenine 3-monooxygenase increases vulnerability to the PCP-induced behavioral abnormalities.2021
- Author(s)
  Hisayoshi Kubota, Akihiro Mouri, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima.
- Organizer
  The International College of Neuropsychopharmacology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] 慢性社会的敗北ストレスにより誘発されるうつ様行動において小脳血液‐脳関門の破綻が関与する2021
- Author(s)
  小菅愛加、國澤和生、手塚裕之、星　雅人、森田那奈架、河合智貴、山本康子、齋藤邦明、鍋島俊隆、毛利彰宏
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] MAGE-D1遺伝子欠損マウスに認められるうつ様行動におけるノルアドレナリン神経系の関与2021
- Author(s)
  毛利彰宏, 平川茉実, 横山美里, 渡辺研, 木村真理, 磯部凌輔, 國澤和生, 森優子, 山本康子, 野田幸裕, 齋藤邦明, 鍋島俊隆
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 前頭前皮質のmiR-874-3pはIDO1抑制を介してLPS誘発性のうつ様行動を緩解する2021
- Author(s)
  國澤和生, Suento Willy Jaya, Wulaer Bolati, 小菅愛加, 飯田翼, 藤垣英嗣, 山本康子, Tanra Andi Jayalangkara, 齋藤邦明, 鍋島俊隆, 毛利彰宏
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] シンポジウム1精神疾患の発症・病態における免疫・炎症・酸化ストレスの関与：母体免疫活性化による胎児脳形成異常・行動変化におけるトリプトファン代謝の関与.2021
- Author(s)
  毛利彰宏, 國澤和生, 齋藤邦明, 鍋島俊隆.
- Organizer
  第43回生物学的精神医学会・第51回日本神経精神薬理学会合同年会.
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] 慢性的な社会的敗北ストレスによるうつ様行動は, ミクログリアの活性化を介した脳梁の髄鞘異常を伴う2021
- Author(s)
  菅原侑実香, 國澤和生, 飯田翼, 齋藤成, 小菅愛加, Bolati Wulaer, 山本康子, 齋藤邦明, 毛利彰宏, 鍋島俊隆
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Chronic social defeat stress induces depression-like behavior through the decrease of GLT-1 ubiquitination in the mouse prefrontal cortex.2021
- Author(s)
  Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Willy Jaya Suento, Yasuko Yamamoto, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima.
- Organizer
  The International College of Neuropsychopharmacology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] キノリン酸代謝の低下はタウのリン酸化を亢進し、脳室拡大とドパミン神経期の低下と共に運動・認知機能の障害を惹起する2021
- Author(s)
  毛利彰宏、新島萌、國澤和生、高野一輝、山田雅之、勅使河原知明、窪田悠力、平川茉実、森優子、星雅人、藤垣英嗣、山本康子、長谷川眞也、倉橋仁美、齋藤邦明、鍋島俊隆
- Organizer
  第43回生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] MAGE-D1遺伝子欠損マウスに認められるうつ様行動はノルアドレナリントランスポーターのリン酸化低下を伴う2021
- Author(s)
  毛利彰宏、平川茉実、國澤和生、渡辺研、窪田悠力、木村真理、森優子、野田幸裕、齋藤邦明、鍋島俊隆
- Organizer
  第15回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] Chronic social defeat stress induces depression-like behaviors caused by myelin abnormalities in the corpus callosum through microglial activation2021
- Author(s)
  Kazuo Kunisawa, Tsubasa Iida, Sugawara Yumika, Sei Saitoh, Aika Kosuge, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.
- Organizer
  The International College of Neuropsychopharmacology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] 社会的敗北ストレス負荷によるうつ様行動はユビキチン化酵素Nedd4L発現低下によるグルタミン酸神経機能低下を介している2021
- Author(s)
  小菅愛加、國澤和生、飯田　翼、齋藤邦明、鍋島俊隆、毛利彰宏
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] QPRT Deficit Leads Motor and Cognitive Dysfunction through Increase of Oxidative stress in the Dopaminergic Neurvous System by Quinolinic Acid.2021
- Author(s)
  Akihiro Mouri, Moe Niijima, Kazuo Kunisawa, Takano Kazuki, Masayuki Yamada, Romoaki Teshigawara, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Fujigaki Hidetsugu, Yasuko Yamamoto, Masaya Hasegawa, Hitomi Kurahashi, Kuniaki Saito, Toshitaka Nabeshimai
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] 前頭前皮質におけるIDO1は社会的敗北ストレスによるうつ様行動を制御する2021
- Author(s)
  國澤和生、小菅愛加、飯田翼、山本康子、齋藤邦明、鍋島俊隆、毛利彰宏.
- Organizer
  第43回生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-20K16679
[Presentation] Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress.2021
- Author(s)
  Kazuo Kunisawa, Aika Kosuge, Yumika Sugawara, Katsuki Shinohara, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K16679
[Presentation] キノリン酸代謝の低下はタウのリン酸化を亢進し、脳室拡大とドパミン神経期の低下と共に運動・認知機能の障害を惹起する2021
- Author(s)
  毛利　彰宏, 新島萌, 國澤和生, 齋藤邦明, 鍋島俊隆；
- Organizer
  第43回生物学的精神医学会（BP）、第51回日本神経精神薬理学会（NP）合同年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] ビフィズス菌の加熱殺菌体は慢性社会的敗北ストレスにより誘発されるうつ様行動及びインターロイキン１βの発現を抑制する2021
- Author(s)
  國澤和生、小菅愛加、菅原侑実香、篠原香月、飯田　翼、Bolati Wulaer、河合智貴、藤垣英嗣、山本康子、齋藤邦明、鍋島俊隆
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 高食塩負荷により惹起される高血圧および行動異常は末梢炎症反応を伴う2021
- Author(s)
  窪田悠力, 毛利彰宏, 國澤和生, 長谷川眞也, 倉橋仁美, 山本康子, 手塚裕之, 釘田雅則, 長尾静子, 齋藤邦明, 鍋島俊隆
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 社会的敗北ストレスは前頭前皮質でのGLT-1ユビキチン化低下を介して, うつ様行動を誘発する2021
- Author(s)
  小菅愛加, 國澤和生, 飯田翼, Wulaer Bolati, Suento Willy Jaya, 山本康子, 齋藤邦明, 毛利彰宏, 鍋島俊隆：
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] ニコチンは血清コルチコステロン量の増加を介した慢性予測不能軽度ストレスによるうつ様行動を緩解する2021
- Author(s)
  長谷川眞也, 毛利彰宏, 國澤和生, 窪田悠力, 倉橋仁美, 山本康子, 齋藤邦明, 鍋島俊隆
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] QPRTの欠損はキノリン酸によるドパミン作動性神経系における酸化ストレスを増強し、連動・認知機能障害を惹起する2021
- Author(s)
  毛利彰宏、新島　萌、國澤和生、髙野一輝、山田雅之、勅使河原知明、窪田悠力、平川茉実、森　優子、星　雅人、藤垣英嗣、山本康子、長谷川眞也、倉橋仁美、齋藤邦明、鍋島俊隆
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 慢性予測不能軽度ストレスによる行動変化におけるミクログリアに関連したキヌレニン代謝の関与2021
- Author(s)
  長谷川眞也、毛利彰宏、國澤和生、窪田悠力、倉橋仁美、山本康子、齋藤邦明、鍋島俊隆；
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] QPRTの欠損はキノリン酸によるドパミン作動性神経系における酸化ストレスを介した運動・認知機能障害を惹起する．2020
- Author(s)
  毛利彰宏、新島萌、勅使河原知明、國澤和生、窪田悠力、山本康子、齋藤邦明、鍋島俊隆
- Organizer
  第９３回日本薬理学会年会（2020.3.16-18横浜）
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] トリプトファン代謝酵素Indoleamine 2,3-dioxygenase 2欠損が脳内に及ぼす影響2020
- Author(s)
  石川雅樹、山本康子, 藤垣英嗣, 毛利彰宏, 國澤和生, 鍋島俊隆, 齋藤邦明
- Organizer
  第61回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] うつ病モデル動物における脳白質の異常2020
- Author(s)
  國澤和生, 飯田翼, 齊藤成, 小菅愛加, Bolati Wulaer, Willy Jaya Suento, 山本康子, 齋藤邦明, 毛利彰宏, 鍋島俊隆
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K16679
[Presentation] 胎生期PolyI:C曝露による統合失調症様モデルとキヌレニン代謝の関与2020
- Author(s)
  毛利彰宏、國澤和生、齋藤邦明、鍋島俊隆
- Organizer
  第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会（NPBPPP2020合同年会）
- Data Source
  KAKENHI-PROJECT-20K07931
[Presentation] Lipopolysaccharide injection triggers Indoleamine-2,3-dioxygenase1 and miR-874-3p interaction which leads to depression-like behavior in mouse．2019
- Author(s)
  Willy Jaya Suento, Kazuo Kunisawa, Bolati Wulaer, Tsubasa Iida, Aika Kosuge, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Impaired neurogenesis in the dentate gyrus of adult ShatiKO mice2019
- Author(s)
  Bolati Wulaer, Kazuo Kunisawa, Willy Jaya Suent, Tsubasa Iida, Aika Kosuge, Atsumi Nitta, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] IDO1は社会的敗北ストレス下におけるストレス脆弱性を制御する/ IDO1 regulates vulnerability to social defeat stress.2019
- Author(s)
  國澤和生、毛利彰宏、小菅愛加、飯田翼、Wulaer Bolati、山本康子、齋藤邦明、鍋島俊隆：
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28　新潟）
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Development of animal models and biomarker for depression focused on serotonergic systems2019
- Author(s)
  Akihiro Mouri, Kazuo Kunisawa, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Invited
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] The deficit of quinolinic acid phosphoribosyltransferase induces hypolocomotion and cognitive impairment through impairment of dopaminergic neuronal function2019
- Author(s)
  Moe Niijima, Akihiro Mouri, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Repeated social defeat stress induces depression-like behavior through the decrease of GLT-1 ubiquitination in the prefrontal cortex of mice．2019
- Author(s)
  Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Willy Jaya Suento, Yasuko Yamamoto, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Repeated social defeat stress induces microglial activation and myelin abnormality in the corpus callosum: a potential link to depression-like behavior.2019
- Author(s)
  Tsubasa Iida, Kazuo Kunisawa, Sei Saitoh, Aika Kosuge, Bolati Wulaer, Willy Jaya Suento, Yasuko Yamamoto, Akihiro Mouri, Kuniaki Saito and Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] 慢性予測不能軽度ストレス負荷は側坐核のドパミン機能亢進と前頭皮質・海馬のセロトニン機能低下を伴ううつ様行動を惹起する2019
- Author(s)
  毛利彰宏、キョヘイル、ヤンヤン、國澤和生、勅使河原知明、平川茉実、森優子、山本康子、シュウリボ、鍋島俊隆、齋藤邦明
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] IDO1 regulates vulnerability to social defeat stress2019
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  AsCNP-ASEAN 2019 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] 人工知能を用いたストレス負荷マウスの表情評価.2019
- Author(s)
  多田遼矢，毛利彰宏，寺本篤司，國澤和生，山田あゆみ，長谷川眞也，倉橋仁美，浅野僚子，窪田悠力，新島萌，山本康子，齋藤邦明，鍋島俊隆
- Organizer
  日本生体医工学会東海支部大会（2019.10.26名古屋）
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] The role of tryptophan metabolism in major depressive disorder2019
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] The role of tryptophan metabolism in major depressive disorder2019
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Invited
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] Deficiency of kynurenine 3-monooxygenase increases vulnerability to the PCP-induced behavioral abnormalities2019
- Author(s)
  Hisayoshi Kubota, Akihiro Mouri, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Impaired neurogenesis in the dentate gyrus of adult ShatiKO mice2019
- Author(s)
  Bolati Wulaer, Kazuo Kunisawa, Willy Jaya Suento, Tsubasa Iida, Aika Kosuge, Atsumi Nitta, Akihiro Mouri, Kuniaki Saito Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Antidepressant effects of XJ-Et-8 in mice chronically exposed to corticosterone2019
- Author(s)
  Jiajing Shan, Akihiro Mouri, Yang Yang, Qiaohui Lu, Kazuo Kunisawa , Tomoaki Teshigawara , Mami Hirakawa , Yuko Mori , Yasuko Yamamoto , Zou Libo , Toshitaka Nabeshima, Kuniaki Saito,
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Involvement of Noradrenergic Function in the Behavioral Changes in MAGE-D1 KO Mice.2019
- Author(s)
  毛利彰宏、平川茉実、渡辺研、國澤和生、森優子、窪田悠力、新島萌、山本康子、野田幸裕、鍋島俊隆、齋藤邦明
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28　新潟）
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] トリプトファン代謝経路が抑うつに与える影響-基礎研究と臨床研究のクロストーク-、2019
- Author(s)
  毛利彰宏、國澤和生、窪田悠力、新島萌、森優子、勅使河原知明、藤垣英嗣、山本康子、尾崎紀夫、齋藤邦明、鍋島俊隆
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2019（2019.8.31東京）
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Development of biomarker for depression focused on serotonergic systems from animal models.2019
- Author(s)
  Akihiro Mouri, Kazuo Kunisawa, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Lipopolysaccharide injection triggers Indoleamine-2,3-dioxygenase1 and miR-874-3p interaction which leads to depression-like behavior in mouse2019
- Author(s)
  Willy Jaya Suento, Kazuo Kunisawa, Bolati Wulaer, Tsubasa Iida, Aika Kosuge, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] IDO1 regulates vulnerability to social defeat stress2019
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  第42回日本神経科学大会第62回日本神経化学大会合同年会
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] The deficit of quinolinic acid phosphoribosyltransferase induces hypolocomotion and cognitive impairment through impairment of dopaminergic neuronal function2019
- Author(s)
  Moe Niijima, Akihiro Mouri, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] Deficiency of kynurenine 3-monooxygenase increases vulnerability to the PCP-induced behavioral abnormalities2019
- Author(s)
  Hisayoshi Kubota, Akihiro Mouri, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP)
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] Kynurenine 3-monooxygenase regulates expression of depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptor by kynurenic acid. AsCNP2019 (2019.10.11-13, 福岡)2019
- Author(s)
  Akihiro Mouri, Yuko Mori, Kazuo Kunisawa, Mami Hirakawa, Tomoaki Teshigawara, Hisayoshi Kubota, Moe Niijima, Hidetsugu Fujigaki, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  AsCNP2019 (2019.10.11-13, 福岡)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Prostaglandin E receptor subtype EP1 deficiency elicits AD/HD-like behavior correlated with a dysfunction of dopamine D1 receptor-ERK signaling in the prefrontal cortex2018
- Author(s)
  Akihiro Mouri,Tomoyuki Furuyashiki, Kazuo Kunisawa, Yasuko Yamamoto, Kiyofumi Yamada, Yukihiro Noda, Kuniaki Saito, Shu Narumiya, Toshitaka Nabeshima
- Organizer
  WCP2018 Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability2018
- Author(s)
  Kazuo Kunisawa, Takeshi Shimizu, Itaru Kushima, Yasuyuki Osanai, Kenta Kobayashi, Anna M. Taylor, Manzoor A. Bhat, Akiko Hayashi, Hiroko Baba, Norio Ozaki and Kazuhiro Ikenaka.
- Organizer
  第23回グリア研究会
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] DEVELOPMENT OF ANIMAL MODELS AND BIOMARKER FOR DEPRESSION FOCUSED ON SEROTONERGIC SYSTEMS2018
- Author(s)
  Akihiro Mouri1, Kazuo Kunisawa2, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  15th International Society for Tryptophan Research (ISTRY) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Repeated social defeat induces social interaction deficits associated with the alteration of kynurenine pathway activity in the prefrontal cortex2018
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] Repeated social defeat induces social interaction deficits associated with the alteration of kynurenine pathway activity in the prefrontal cortex2018
- Author(s)
  Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  WCP2018 Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] Involvement of kynurenine pathway in behavioral impairments in the offspring induced by the prenatal poly I: C injection2018
- Author(s)
  Moe Niijima, Akihiro Mouri, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Toshitaka Nabeshima, Kuniaki Saito
- Organizer
  WCP2018 Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] うつ病発症におけるトリプトファン代謝の関与2018
- Author(s)
  國澤和生、毛利彰宏、山本康子、齋藤邦明、鍋島俊隆
- Organizer
  第34回日本ストレス学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15377
[Presentation] MAGE-D1 REGULATES EXPRESSION OF DEPRESSION-LIKE BEHAVIOR THROUGH SEROTONIN TRANSPORTER UBIQUITYLATION2018
- Author(s)
  Akihiro Mouri, Kazuo Kunisawa, Mami Hirakawa, Yuko Mori, Ken Watanabe, Hidetsugu Fujigaki, Yasuko Yamamoto, Yukihiro Noda, Kuniaki Saito, Toshitaka Nabeshima
- Organizer
  15th International Society for Tryptophan Research (ISTRY) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04252
[Presentation] うつ病発症におけるトリプトファン代謝の関与2018
- Author(s)
  國澤和生、毛利彰宏、山本康子、齋藤邦明、鍋島俊隆
- Organizer
  第３４回日本ストレス学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04252

1. Mouri Akihiro (20597851)

# of Collaborated Projects: 4 results

# of Collaborated Products: 86 results
2. Nabeshima Toshitaka (70076751)

# of Collaborated Projects: 3 results

# of Collaborated Products: 84 results
3. 齋藤邦明 (80262765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 山本康子 (00331869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
5. 小菅愛加 (40973293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 清島眞理子 (00171314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤垣英嗣 (00612631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. KATSUNO Masahisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 斉藤邦明

# of Collaborated Projects: 0 results

# of Collaborated Products: 59 results
10. 井口洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 尾崎紀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 池中一裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kunisawa Kazuo 國澤 和生

Research Projects

Research Products

Co-Researchers

末梢免疫細胞死機構に着目したうつ病の創薬基盤および次世代診断法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乾癬におけるトリプトファン代謝に着目した病態解明と制御法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of peripheral-CNS immune responses in the development of major depressive disorder induced by stress

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The influence of disruption of myelin-neuron network on major depressive disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prevention and treatment strategies focusing on tryptophan metabolism, a common factor in the pathogenesis and pathophysiology hypothesis of schizophrenia.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of ubiquitin-related enzyme Nedd4L in major depressive disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of tryptophan-metabolizing enzymes in demyelination diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the next-generation diagnosis method for depression by using byomakers based on pathophysiological mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High-Cellulose Diet Ameliorates Cognitive Impairment by Modulating Gut Microbiota and Metabolic Pathways in Mice2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic social defeat stress induces the down‐regulation of the <scp>Nedd4L‐GLT</scp>‐1 ubiquitination pathway in the prefrontal cortex of mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation2024

Author(s)

Journal Title

Kunisawa Kazuo 國澤和生