Tanaka T 田中智和

… Alternative Names

Tanaka Tomokazu 田中智和

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Researcher Number	60781903
Other IDs
Affiliation (Current)	2025: 佐賀大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 佐賀大学, 医学部附属病院, 助教 2017 – 2022: 佐賀大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 49020:Human pathology-related / Digestive surgery
Keywords	Principal Investigator ファルネシル化 / ファルネシル転換酵素阻害薬 / HIF-1α / ファルネシル転換酵素 / 食道癌 / 活性酸素 / 上皮間葉転換 / 低酸素誘導因子 / 食道扁平上皮癌 / 肝癌 … More / NAFLD / NASH / NAFLD/NASH肝癌 / 抗炎症反応 / NAFLD/NASH関連肝癌 / 癌 / 胃癌 / 腹膜播種 … More Except Principal Investigator 胃癌 / 低酸素環境 / 活性酸素 / 硫黄呼吸 / HIF-1a / 食道扁平上皮癌 / ファルネシル転換酵素 / 悪液質 / 炎症性サイトカイン / ファルネシル転換酵素阻害薬 / ファルネシル化 / 癌悪液質 / 細胞傷害性T細胞 / マクロファージ / 腫瘍免疫 / 多核巨細胞 / CD1a / 単球 / 樹状細胞 / 胆嚢癌 / ミトコンドリア休眠 / Mieap / 低酸素 / 癌浸潤 / hypoxia / MMP-1 / MALM / mieap / ROS / HIF-1 / 脂肪酸代謝 / Warburg効果 / 癌 / カルニチン / パルミチン酸 / YC-1 / 脂肪酸合成 / HIF-1α Less

蛋白ファルネシル化に着目した免疫チェックポイント阻害剤の新規併用療法の開発Principal Investigator
- Principal Investigator
  
  田中智和
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
A novel therapeutic strategy for hypoxic esophageal squamous cell carcinoma targeting HIF-1a and sulfur respiration
- Principal Investigator
  
  能城浩和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
食道扁平上皮癌に対する蛋白ファルネシル化に着目した新規治療開発に向けた基礎的研究Principal Investigator
- Principal Investigator
  
  田中智和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
Immune response and direct interaction of CD1a-positive dendritic cells in gallbladder cancer
- Principal Investigator
  
  Kai Keita
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Saga University
Basic research for development of new treatment for cachexia by gastric cancer focusing on protein farnesylation
- Principal Investigator
  
  Noshiro Hirokazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
Novel therapeutic strategy for hepatocellular carcinoma by farnesyltransferase inhibitorPrincipal Investigator
- Principal Investigator
  
  Tanaka Tomokazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Saga University
Impaired hypoxia-induced mitochondrial sleep may increase malignant behavior of gastric cancer cells
- Principal Investigator
  
  Kitajima Yoshihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
Basic research of novel therapeutic strategy focusing on fatty acid metabolism alteration of gastric cancer cells under hypoxia
- Principal Investigator
  
  Noshiro Hirokazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Novel therapeutic strategy for scirrhous gastric cancer using farnesyltransferase inhibitorPrincipal Investigator
- Principal Investigator
  
  Tanaka Tomokazu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection2022
- Author(s)
  Kai Keita、Ide Takao、Tanaka Tomokazu、Yukimoto Kumpei、Irie Hiroyuki、Noshiro Hirokazu、Aishima Shinichi
- Journal Title
  
  Journal of Gastrointestinal Cancer
  
  Volume: - Issue: 3 Pages: 996-999
- DOI
  10.1007/s12029-022-00893-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07408
[Journal Article] Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases2021
- Author(s)
  Kai Keita、Hashiguchi Mariko、Kurihara Makiko、Tanaka Yuya、Kitamura Sho、Nakamura Mitsuo、Shichijo Chika、Yamamoto-Rikitake Mihoko、Okuma Ryoichi、Hikari Takako、Okuma Emi、Uchiyama Michiko、Aoki Shigehisa、Nakao Yoshifumi、Yokoyama Masatoshi、Aishima Shinichi
- Journal Title
  
  Acta Cytologica
  
  Volume: 65 Issue: 5 Pages: 440-447
- DOI
  10.1159/000517313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07408
[Journal Article] Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer2021
- Author(s)
  Kai Keita、Tanaka Tomokazu、Ide Takao、Kawaguchi Atsushi、Noshiro Hirokazu、Aishima Shinichi
- Journal Title
  
  Translational Oncology
  
  Volume: 14 Issue: 1 Pages: 100923-100923
- DOI
  10.1016/j.tranon.2020.100923
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07408
[Journal Article] Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation2019
- Author(s)
  Okuyama Keiichiro、Kitajima Yoshihiko、Egawa Noriyuki、Kitagawa Hiroshi、Ito Kotaro、Aishima Shinichi、Yanagihara Kazuyoshi、Tanaka Tomokazu、Noshiro Hirokazu
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-019-39563-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08650
[Presentation] Antitumor effects by suppression of HIF-1α and EMT of farnesyl transferase inhibitor in esophageal cancer cells2023
- Author(s)
  Kazuki Higure, Tomokazu Tanaka, Naoya Kimura, Shohei Matsufuji, Hirokazu Noshiro
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08778
[Presentation] Antitumor effects of Farnesyl transferase inhibitor in Esophageal cancer cells2022
- Author(s)
  Shohei Matsufuji, Tomokazu Tanaka, Naoya Kimura, Kazuki Higure, Hirokazu Noshiro
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08778
[Presentation] 蛋白ファルネシル化に着目した NASH 肝癌に対する新規薬物治療の可能性2022
- Author(s)
  山田浩平、田中智和、松藤祥平、伊藤孝太朗、北島吉彦、能城浩和
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K16776
[Presentation] NASH様状態における肝細胞癌細胞株に対するファルネシル転換酵素阻害薬の細胞増殖抑制作用の可能性2021
- Author(s)
  山田浩平、田中智和、松藤祥平、伊藤孝太朗、江川紀幸、北島吉彦、能城浩和
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19K16776
[Presentation] Farnesyltransferase inhibitor has anti-inflammatory and anti-tumor effects of HCC cell lines on NASH like condition2021
- Author(s)
  山田浩平、田中智和、松藤祥平、伊藤孝太朗、北島吉彦、能城浩和
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16776
[Presentation] Effectiveness of farnesyltransferase inhibitor on non-alcoholic steatohepatitis-related hepatocellular carcinoma2020
- Author(s)
  山田浩平、田中智和、松藤祥平、伊藤孝太朗、江川紀幸、能城浩和
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16776

1. Noshiro Hirokazu (90301340)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. Kitajima Yoshihiko (30234256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Kai Keita (60516540)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 菰原義弘 (40449921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 芥川剛至 (40839057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤孝太朗 (80920967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tanaka T 田中 智和

Tanaka Tomokazu 田中 智和

Research Projects

Research Products

Co-Researchers

蛋白ファルネシル化に着目した免疫チェックポイント阻害剤の新規併用療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel therapeutic strategy for hypoxic esophageal squamous cell carcinoma targeting HIF-1a and sulfur respiration

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

食道扁平上皮癌に対する蛋白ファルネシル化に着目した新規治療開発に向けた基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune response and direct interaction of CD1a-positive dendritic cells in gallbladder cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research for development of new treatment for cachexia by gastric cancer focusing on protein farnesylation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic strategy for hepatocellular carcinoma by farnesyltransferase inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impaired hypoxia-induced mitochondrial sleep may increase malignant behavior of gastric cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research of novel therapeutic strategy focusing on fatty acid metabolism alteration of gastric cancer cells under hypoxia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic strategy for scirrhous gastric cancer using farnesyltransferase inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Antitumor effects by suppression of HIF-1α and EMT of farnesyl transferase inhibitor in esophageal cancer cells2023

Tanaka T 田中智和

Tanaka Tomokazu 田中智和