shinohara mitsuru 篠原充

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Shinohara Mitsuru 篠原充

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Researcher Number	60800521
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 副部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 副部長 2021: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 副部長 2020: 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 室長 2020: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター分子基盤研究部, 室長 2018 – 2019: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2017: 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 室長
Review Section/Research Field	Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アルツハイマー病 / APOE2 / アミロイドβ / 認知症 / 肥満 / APOE２ / 長寿 / シナプス

肥満とAPOE2の認知症保護作用のクロストークの解明と治療法開発への応用Principal Investigator
- Principal Investigator
  
  篠原充
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
アルツハイマー病保護因子APOE２多型の作用機序の解明と治療薬開発への応用Principal Investigator
- Principal Investigator
  
  篠原充
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Study of two-step amyloid-beta accumulation in human brainsPrincipal Investigator
- Principal Investigator
  
  Shinohara Mitsuru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
アミロイドβの蓄積をもたらすシナプスの分子的実態の解明Principal Investigator
- Principal Investigator
  
  篠原充
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Center for Geriatrics and Gerontology

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] Diabetes Mellitus, A risk factor for Alzheimer's Disease2019
- Author(s)
  Mitsuru Shinohara, Naoyuki Sato
- Total Pages
  17
- Publisher
  Springer, Singapore
- ISBN
  9789811335396
- Data Source
  KAKENHI-PROJECT-18H02725
[Book] The Roles of Apolipoprotein E, Lipids, and Glucose in the Pathogenesis of Alzheimer's Disease2019
- Author(s)
  Mitsuru Shinohara, Naoyuki Sato
- Total Pages
  17
- Publisher
  Springer, Singapore
- ISBN
  9789811335396
- Data Source
  KAKENHI-PROJECT-18H02725
[Journal Article] APOE genotypes modify the obesity paradox in dementia2023
- Author(s)
  Shinohara Mitsuru、Gheni Ghupurjan、Hitomi Junichi、Bu Guojun、Sato Naoyuki
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 94 Issue: 9 Pages: 670-680
- DOI
  10.1136/jnnp-2022-331034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02844, KAKENHI-PROJECT-23K21640
[Journal Article] Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease2021
- Author(s)
  Shinohara Mitsuru、Kikuchi Masataka、Onishi‐Takeya Miyuki、Tashiro Yoshitaka、Suzuki Kaoru、Noda Yasuhiro、Takeda Shuko、Mukouzono Masahiro、Nagano Seiichi、Fukumori Akio、Morishita Ryuichi、Nakaya Akihiro、Sato Naoyuki
- Journal Title
  
  FASEB BioAdvances
  
  Volume: - Issue: 5 Pages: 323-333
- DOI
  10.1096/fba.2020-00151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06629, KAKENHI-PROJECT-18H02725, KAKENHI-PROJECT-20K15778
[Journal Article] Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes2020
- Author(s)
  Shinohara Mitsuru、Tashiro Yoshitaka、Shinohara Motoko、Hirokawa Junko、Suzuki Kaoru、Onishi‐Takeya Miyuki、Mukouzono Masahiro、Takeda Shuko、Saito Takashi、Fukumori Akio、Saido Takaomi C.、Morishita Ryuichi、Sato Naoyuki
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 2 Pages: 2425-2435
- DOI
  10.1096/fj.201901028rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04154, KAKENHI-PROJECT-18H02725, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H05080
[Journal Article] Interaction between APOE genotype and diabetes in cognitive decline2020
- Author(s)
  Shinohara Mitsuru、Tashiro Yoshitaka、Suzuki Kaoru、Fukumori Akio、Bu Guojun、Sato Naoyuki
- Journal Title
  
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  
  Volume: 12 Issue: 1 Pages: 2425-2435
- DOI
  10.1002/dad2.12006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04154, KAKENHI-PROJECT-18H02725, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K10304
[Presentation] 危険因子や保護因子の作用から解き明かすアルツハイマー病の発症機序と治療戦略2023
- Author(s)
  篠原充
- Organizer
  第42回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21640
[Presentation] ApoEと受容体の結合を阻害する薬剤の検討2023
- Author(s)
  篠原充
- Organizer
  脳とこころの研究センター第8回東海地区拡大ワークショップ
- Data Source
  KAKENHI-PROJECT-23K21640
[Presentation] ApoEと受容体の結合を阻害する薬剤の検討2023
- Author(s)
  篠原充
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21640
[Presentation] アルツハイマー病の危険因子APOEに着目した病態解明、治療薬開発2022
- Author(s)
  篠原充
- Organizer
  第64回日本老年医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21640
[Presentation] 原因因子や危険因子に着目した病態解明,　治療薬開発2020
- Author(s)
  篠原充
- Organizer
  第39回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] 危険因子にも着目したアルツハイマー病の病態機構の解明、治療薬開発の研究2020
- Author(s)
  篠原充
- Organizer
  第62回日本老年医学会
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] タウELISA の剖検脳での検討2020
- Author(s)
  篠原充
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] Implications from Alzheimer's disease risk factors2019
- Author(s)
  Mitsuru Shinohara
- Organizer
  The 5th NCGG-ICAH Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] ob/obマウスにおけるAβ42の増加は寿命を短くさせる2019
- Author(s)
  篠原充
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] Increased Levels of Aβ42 Decrease the Lifespan of Ob/Ob Mice with Dysregulation of Microglia and Astrocytes2019
- Author(s)
  Mitsuru Shinohara
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] サンドイッチELISAを活用した剖検脳研究からの知見2019
- Author(s)
  篠原充
- Organizer
  第38回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] 危険因子にも着目したアルツハイマー病の治療標的の同定と治療薬の開発2019
- Author(s)
  篠原充
- Organizer
  第8回大阪大学神経難病フォーラム
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] Insights from biochemical analyses of regional distribution of Alzheimer's pathologies2018
- Author(s)
  篠原充
- Organizer
  ICN2018 TOKYO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02725
[Presentation] アミロイドβの脳領域分布に着目した研究2018
- Author(s)
  篠原充
- Organizer
  第18回関西・中部認知症研究会
- Data Source
  KAKENHI-PROJECT-17H07419
[Presentation] 脳領域間の違いに着目したアルツハイマー病研究2018
- Author(s)
  篠原充
- Organizer
  第25回メイヨーニューロサイエンスフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17H07419

1. 菊地正隆 (90722538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 齊藤祐子 (60344066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 赤津裕康 (00399734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 村山繁雄 (50183653)

# of Collaborated Projects: 1 results

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5. 大塚礼 (00532243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 笹栗弘貴 (10783053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 西田裕紀子 (60393170)

# of Collaborated Projects: 1 results

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8. 佐藤亜希子 (80800979)

# of Collaborated Projects: 1 results

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9. 小木曽昇 (40638350)

# of Collaborated Projects: 1 results

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10. 里直行

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# of Collaborated Products: 3 results
11. 中谷明弘

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shinohara mitsuru 篠原 充

Shinohara Mitsuru 篠原 充

Research Projects

Research Products

Co-Researchers

肥満とAPOE2の認知症保護作用のクロストークの解明と治療法開発への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病保護因子APOE２多型の作用機序の解明と治療薬開発への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of two-step amyloid-beta accumulation in human brainsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミロイドβの蓄積をもたらすシナプスの分子的実態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Diabetes Mellitus, A risk factor for Alzheimer's Disease2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] The Roles of Apolipoprotein E, Lipids, and Glucose in the Pathogenesis of Alzheimer's Disease2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] APOE genotypes modify the obesity paradox in dementia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction between APOE genotype and diabetes in cognitive decline2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 危険因子や保護因子の作用から解き明かすアルツハイマー病の発症機序と治療戦略2023

Author(s)

Organizer

Data Source

[Presentation] ApoEと受容体の結合を阻害する薬剤の検討2023

Author(s)

Organizer

Data Source

[Presentation] ApoEと受容体の結合を阻害する薬剤の検討2023

Author(s)

Organizer

Data Source

[Presentation] アルツハイマー病の危険因子APOEに着目した病態解明、治療薬開発2022

Author(s)

Organizer

Data Source

[Presentation] 原因因子や危険因子に着目した病態解明, 治療薬開発2020

Author(s)

Organizer

shinohara mitsuru 篠原充

Shinohara Mitsuru 篠原充

[Presentation] 原因因子や危険因子に着目した病態解明,　治療薬開発2020