Maimaitijiang Guzailiayi ＭａｉｍａｉｔｉｊｉａｎｇＧｕｚａｉｌｉａｙｉ

Researcher Number	60887107
Affiliation (Current)	2025: 国際医療福祉大学, トランスレーショナルニューロサイエンスリサーチセンター, 特任助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 国際医療福祉大学, トランスレーショナルニューロサイエンスリサーチセンター, 特任助教 2021 – 2022: 国際医療福祉大学, トランスレーショナルニューロサイエンスセンター, 特任助教 2020: 国際医療福祉大学, その他部局等, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / 0902:General internal medicine and related fields Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator エクソソーム / コネキシン / 急性炎症 / 脱髄 / 視神経脊髄炎 / バイオマーカー / 神経免疫疾患 / マイクロRNA / アストログリア / イソフォーム … More / グリア線維性蛋白 / エキソソーム / 脱髄疾患 / グリア炎症 / 実験的自己免疫性脳脊髄炎 / ギャップ結合 / 重症化 / 神経炎症 / 脱髄炎 / グリアコネキシン / グリア / 多発性硬化症 … More Except Principal Investigator 多発性硬化症 / 脱髄 / コネキシン / 脱髄疾患 / 神経免疫疾患 / 重症化 / エクソソーム / バイオマーカー / 神経変性疾患 / 伝搬 / オリゴマー / ミクログリア / シヌクレイン / 多系統萎縮症 / 自己抗体 / 慢性炎症性脱髄性多発神経炎 / ノド抗体 / ランビエ絞輪 / 視神経脊髄炎 / peripheral nerve / node of Ranvier / autoantibody / demyelinaiton / multiple sclerosis / 治療選択 / 予後不良因子 / 免疫細胞 / 視神経脊髄炎スペクトラム障害 / 遺伝的要因 / 環境因子 / グリア由来エキソソーム / グリア / マイクロRNA / イソフォーム / グリア線維性蛋白 / 実験的自己免疫性脳脊髄炎 / ギャップ結合 / 二次進行型 / 神経炎症 / エキソソーム / アストログリア Less

コネキシン43結合性マイクロRNAを介する多発性硬化症重症化機構の解明と治療開発
- Principal Investigator
  
  中村優理
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
視神経脊髄炎特異的なエキソソーム含有sno/lincRNAによる急性炎症拡大機序Principal Investigator
- Principal Investigator
  
  Maimaitijiang Guzailiayi
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立
- Principal Investigator
  
  渡邉充
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyushu University
elucidation of mechanism of exacerbation in neuromyelitis optica and development of biomarkers that predict relapse severityPrincipal Investigator
- Principal Investigator
  
  Maimaitijiang Guzailiayi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Elucidation of mechanisms of central and peripheral nervous system demyelination caused by newly discovered anti-nodal antibodies in autoimmune nodopathy
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Exacerbation of demyelination by glia connexin truncated isoform-expressing exosomes and its therapy development
- Principal Investigator
  
  Nakamura Yuri
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Development of blood novel biomarkers and therapy for multiple sclerosis by using glial connexin-expressing exosomePrincipal Investigator
- Principal Investigator
  
  Maimaitijiang Guzailiayi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Anti-LGI4 antibody is a novel juxtaparanodal autoantibody for chronic inflammatory demyelinating polyneuropathy2023
- Author(s)
  Zhang X, Kira J, Ogata H, Imamura T, Mitsuishi M, Fujii T, Kobayashi M, Kitagawa K, Namihira Y, Ohya Y, Maimaitijiang G, Yamasaki R, Fukata Y, Fukata M, Isobe N, Nakamura Y.
- Journal Title
  
  Neurology Neuroimmunology and Neuroinflammation
  
  Volume: 10(2) Issue: 2 Pages: 1-13
- DOI
  10.1212/nxi.0000000000200081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07467, KAKENHI-PROJECT-21K19390, KAKENHI-PROJECT-22K15717, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-20K16602, KAKENHI-PROJECT-21K15700, KAKENHI-PROJECT-21K15703, KAKENHI-PROJECT-20K22910, KAKENHI-PROJECT-23K23986, KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-22K07499
[Journal Article] A new clustering method identifies multiple sclerosis‐specific T‐cell receptors2021
- Author(s)
  Hayashi Fumie、Isobe Noriko、Glanville Jacob、Matsushita Takuya、Maimaitijiang Guzailiayi、Fukumoto Shoko、Watanabe Mitsuru、Masaki Katsuhisa、Kira Jun‐ichi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 8 Issue: 1 Pages: 163-176
- DOI
  10.1002/acn3.51264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K22910
[Journal Article] Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type2020
- Author(s)
  Matsuse D, Yamasaki R, Maimaitijiang G, Yamaguchi H, Masaki K, Isobe N, Matsushita T, Kira J.
- Journal Title
  
  Journal of Neuroimmunology,
  
  Volume: 577395 Pages: 349-349
- Data Source
  KAKENHI-PROJECT-20K22910
[Presentation] Exosome GJA1-29k is a blood marker for progressive multiple sclerosis reflecting glial inflammation2023
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Ayako Sakoda, Katsuhisa Masaki, Mitsuru Watanabe, Satoshi Nagata, Ezgi Ozdemir, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura, Yuri Nakamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Serum glial fibrillary acidic protein is useful to predict multiple sclerosis disability progression2023
- Author(s)
  Jun-ichi Kira, Guzailiayi Maimaitijiang, Yuri Nakamura, Ayako Sakoda, Yoshie Yamato, Yuki Yanagihara, Yasutaka Iwanaga, Ken-ichiro Yamashita, Akira Yokote, Keiko Haro, Shozo Tobimatsu, Xu Zhang, Tomohiro Imamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Serum glial fibrillary acidic protein is useful to predict multiple sclerosis disability progression2023
- Author(s)
  un-ichi Kira, Guzailiayi Maimaitijiang, Yuri Nakamura, Ayako Sakoda, Yoshie Yamato, Yuki Yanagihara, Yasutaka Iwanaga, Ken-ichiro Yamashita, Akira Yokote, Keiko Haro, Shozo Tobimatsu, Xu Zhang, Tomohiro Imamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] IgG2 autoantibody relates to IVIg response and onion bulb formation in LGI4+ autoimmune nodopathy2023
- Author(s)
  Xu Zhang, Jun-ichi Kira, Akira Yokote, Ayako Sakoda, Takayasu Mishima, Yoshio Tsuboi, Ryota Sato, Takashi Kanda, Hidenori Ogata, Noriko Isobe, Masaki Kobayashi, Kazuo Kitagawa, Yukihiro Namihira, Yusuke Ohya, Yuko Fukata, Masaki Fukata, Tomohiro Imamura, Guzailiayi Maimaitijiang, Yuri Nakamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] IgG2 autoantibody relates to IVIg response and onion bulb formation in LGI4+ autoimmune nodopathy2023
- Author(s)
  Xu Zhang, Jun-ichi Kira, Akira Yokote, Ayako Sakoda, Takayasu Mishima, Yoshio Tsuboi, Ryota Sato, Takashi Kanda, Hidenori Ogata, Noriko Isobe, Masaki Kobayashi, Kazuo Kitagawa, Yukihiro Namihira, Yusuke Ohya, Yuko Fukata, Masaki Fukata, Tomohiro Imamura, Guzailiayi Maimaitijiang, Yuri Nakamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Plasma/urine exosomal microRNA-203 is a novel least-invasive biomarker for early Alzheimer’s disease2023
- Author(s)
  Tomohiro Imamura, Jun-ichi Kira, Motohiro Yukitake, Mikio Mitsuishi, Guzailiayi Maimaitijiang, Xu Zhang
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] Exosome GJA1-29k is a blood marker for progressive multiple sclerosis reflecting glial inflammation2023
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Ayako Sakoda, Katsuhisa Masaki, Mitsuru Watanabe, Satoshi Nagata, Ezgi Ozdemir, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura, Yuri Nakamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] Serum glial fibrillary acidic protein is useful to predict multiple sclerosis disability progression2023
- Author(s)
  Jun-ichi Kira, Guzailiayi Maimaitijiang, Yuri Nakamura, Ayako Sakoda, Yoshie Yamato, Yuki Yanagihara, Yasutaka Iwanaga, Ken-ichiro Yamashita, Akira Yokote, Keiko Haro, Shozo Tobimatsu, Xu Zhang, Tomohiro Imamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18266
[Presentation] エクソソーム中のコネキシン43(Cx43)低分子量イソフォームとグリア線維性酸性蛋白質(GFAP)は視神経脊髄炎(NMOSD)再発の血液バイオマーカーである2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 今村友裕, 渡邉充, 迫田礼子, 張旭, 磯部紀子, 吉良潤一
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-20K22910
[Presentation] グリアコネキシン低分子量イソフォーム発現エクソソームによる多発性硬化症の増悪機序2022
- Author(s)
  中村優理、グザリアイ・ママティジャン、今村友裕、柳原由記、岩永育貴、山下謙一郎、張旭、吉良潤一
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-20K22910
[Presentation] Exosomal GJA1-29k translational isoform is a novel blood biomarker for neuroinflammation in neuromyelitis optica2022
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Yuri Nakamura, Mitsuru Watanabe, Ayako Sakoda, Katsuhisa Masaki, Satoshi Nagata, Hiroo Yamaguchi, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] Foot-dorsiflexion power on the dominant hand side is useful to predict multiple sclerosis disability2022
- Author(s)
  Jun-ichi Kira, Ayako Sakoda, Yoshie Yamato, Yuki Yanagihara, Ban-yu Saitoh, Yasutaka Iwanaga, Kenichiro Yamashita, Guzailiayi Maimaitijiang, Tomohiro Imamura, Xu Zhang, Shozo Tobimatsu, Yuri Nakamura
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] 視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一.
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] グリアコネキシン低分子量イソフォーム発現エクソソームによる多発性硬化症の増悪機序2022
- Author(s)
  中村優理, グザリアイ・ママティジャン, 今村友裕, 柳原由記, 岩永育貴, 山下謙一郎, 張旭, 吉良潤一
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] エクソソーム中のコネキシン43(Cx43)低分子量イソフォームとグリア線維性酸性蛋白質(GFAP)は視神経脊髄炎(NMOSD)再発の血液バイオマーカーである2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 今村友裕, 渡邉充, 迫田礼子, 張旭, 磯部紀子, 吉良潤一
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15717
[Presentation] 視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー.2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K22910
[Presentation] Exosomal GJA1-29k translational isoform is a novel blood biomarker for neuroinflammation in neuromyelitis optica.2022
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Yuri Nakamura, Mitsuru Watanabe, Ayako Sakoda, Katsuhisa Masaki, Satoshi Nagata, Hiroo Yamaguchi, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] 視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Exosomal GJA1-29k translational isoform is a novel blood biomarker for neuroinflammation in neuromyelitis optica.2022
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Yuri Nakamura, Mitsuru Watanabe, Ayako Sakoda, Katsuhisa Masaki, Satoshi Nagata, Hiroo Yamaguchi, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K22910
[Presentation] T細胞受容体gamma鎖領域欠失型コピー数変異と多発性硬化症末梢血gamma delta T細胞分画の変化2021
- Author(s)
  グザリアイ・ママティジャン、迫田礼子、渡邉充、篠田紘司、中村優理、磯部紀子、松下拓也、吉良潤一
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K22910

1. 吉良潤一 (40183305)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. 今村友裕 (30725122)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. 真崎勝久 (90612903)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. Nakamura Yuri (40822375)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. 渡邉充 (30748009)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. 山崎亮 (10467946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 磯部紀子 (60452752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 松下拓也 (00533001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 迫田礼子 (70972230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 矢口貴博 (30434947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤井敬之 (30822481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 張旭 (60892669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 緒方英紀 (90778838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山口浩雄 (00701830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 竹内英之 (30362213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 松瀬大 (70596395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Maimaitijiang Guzailiayi Ｍａｉｍａｉｔｉｊｉａｎｇ Ｇｕｚａｉｌｉａｙｉ

Research Projects

Research Products

Co-Researchers

コネキシン43結合性マイクロRNAを介する多発性硬化症重症化機構の解明と治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

視神経脊髄炎特異的なエキソソーム含有sno/lincRNAによる急性炎症拡大機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

elucidation of mechanism of exacerbation in neuromyelitis optica and development of biomarkers that predict relapse severityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms of central and peripheral nervous system demyelination caused by newly discovered anti-nodal antibodies in autoimmune nodopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exacerbation of demyelination by glia connexin truncated isoform-expressing exosomes and its therapy development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of blood novel biomarkers and therapy for multiple sclerosis by using glial connexin-expressing exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anti-LGI4 antibody is a novel juxtaparanodal autoantibody for chronic inflammatory demyelinating polyneuropathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new clustering method identifies multiple sclerosis‐specific T‐cell receptors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type2020

Author(s)

Journal Title

Data Source

[Presentation] Exosome GJA1-29k is a blood marker for progressive multiple sclerosis reflecting glial inflammation2023

Author(s)

Organizer

Data Source

[Presentation] Serum glial fibrillary acidic protein is useful to predict multiple sclerosis disability progression2023

Author(s)

Organizer

Data Source

[Presentation] Serum glial fibrillary acidic protein is useful to predict multiple sclerosis disability progression2023

Author(s)

Organizer

Data Source

[Presentation] IgG2 autoantibody relates to IVIg response and onion bulb formation in LGI4+ autoimmune nodopathy2023

Author(s)

Maimaitijiang Guzailiayi ＭａｉｍａｉｔｉｊｉａｎｇＧｕｚａｉｌｉａｙｉ