Sakashita Akihiko 坂下陽彦

Researcher Number	60893873
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, バイオリソース研究センター, チームディレクター 2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 慶應義塾大学, 医学部(信濃町), 助教
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Biological Sciences Except Principal Investigator Basic Section 44020:Developmental biology-related
Keywords	Principal Investigator 内在性レトロウイルス / レトロトランスポゾン / 種間トランスクリプトーム比較 / ハムスターモデル / 初期発生制御 / MERVL / クロマチン / 細胞分化 / クロマチンポテンシャル / エピゲノム制御 … More / トランスクリプトーム / クロマチン構造変化 / 初期発生 / 全能性制御 / 生殖細胞形成 / KRAB-ZFP / 生殖系列 / 転写制御 / エンハンサー / A-MYB / KRAB-Zincフィンガー / 精子形成 / エピゲノム … More Except Principal Investigator リピドーム / トランスクリプトーム / 子宮内膜 / 着床 / 胚発生 Less

個体発生において種間の多様性をもたらす内在性レトロウイルスの機能解析Principal Investigator
- Principal Investigator
  
  坂下陽彦
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Keio University
胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明
- Principal Investigator
  
  藍川志津
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo
内在性レトロウイルスによる宿主ゲノムのクロマチン再構築機構Principal Investigator
- Principal Investigator
  
  坂下陽彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Epigenetic regulation of ERV-driven enhancer in germline developmentPrincipal Investigator
- Principal Investigator
  
  Sakashita Akihiko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Keio University

All 2023 2022

All Journal Article Presentation Book

[Book] in vitroにおける個体発生の再構成をめざして2023
- Author(s)
  坂下陽彦
- Total Pages
  1
- Publisher
  ファルマシア 2023 年 59 巻 6 号
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Book] 実験医学2023年9月号2023
- Author(s)
  坂下陽彦、石津大嗣
- Total Pages
  6
- Publisher
  羊土社
- ISBN
  9784758125710
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023
- Author(s)
  Sakashita Akihiko、Ooga Masatoshi、Otsuka Kai、Maezawa So、Takeuchi Chikara、Wakayama Sayaka、Wakayama Teruhiko、Namekawa Satoshi?H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 13 Pages: 6668-6683
- DOI
  10.1093/nar/gkad479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution2023
- Author(s)
  Otsuka Kai、Sakashita Akihiko、Maezawa So、Schultz Richard M.、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.06.24.546405
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Mouse embryonic development requires transposable element expression2023
- Author(s)
  Akihiko Sakashita、Haruhiko Siomi
- Journal Title
  
  Nature Genetics
  
  Volume: 55 Issue: 3 Pages: 367-368
- DOI
  10.1038/s41588-023-01326-w
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Sakashita Akihiko、Shimizu-Hirota Ryoko、Takeda Norihiko、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Hiraoka Takehiro、Akaeda Shun、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 5 Pages: 320-320
- DOI
  10.1038/s41419-023-05832-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-23K15827, KAKENHI-PROJECT-22K19596, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-23K23803
[Journal Article] PRC1 suppresses a female gene regulatory network to ensure testicular differentiation2023
- Author(s)
  Maezawa So、Yukawa Masashi、Hasegawa Kazuteru、Sugiyama Ryo、Iizuka Mizuho、Hu Mengwen、Sakashita Akihiko、Vidal Miguel、Koseki Haruhiko、Barski Artem、DeFalco Tony、Namekawa Satoshi H.
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 8
- DOI
  10.1038/s41419-023-05996-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Transcription of MERVL retrotransposons is required for preimplantation embryo development2023
- Author(s)
  Sakashita Akihiko、Kitano Tomohiro、Ishizu Hirotsugu、Guo Youjia、Masuda Harumi、Ariura Masaru、Murano Kensaku、Siomi Haruhiko
- Journal Title
  
  Nature Genetics
  
  Volume: 55 Issue: 3 Pages: 484-495
- DOI
  10.1038/s41588-023-01324-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06091, KAKENHI-ORGANIZER-19H05749, KAKENHI-PUBLICLY-22H04700, KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-23K27370
[Journal Article] CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline2023
- Author(s)
  Kitamura Yuka、Takahashi Kazuki、Maezawa So、Munakata Yasuhisa、Sakashita Akihiko、Kaplan Noam、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.11.30.569508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Bioinformatics pipelines for identification of super-enhancers and 3D chromatin contacts2022
- Author(s)
  Akihiko Sakashita、Chikara Takeuchi、So Maezawa、Satoshi H. Namekawa
- Journal Title
  
  Methods Mol Biol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15108
[Journal Article] PRC1-mediated epigenetic programming is required to generate the ovarian reserve2022
- Author(s)
  Hu Mengwen、Yeh Yu-Han、Munakata Yasuhisa、Abe Hironori、Sakashita Akihiko、Maezawa So、Vidal Miguel、Koseki Haruhiko、Hunter Neil、Schultz Richard M.、Namekawa Satoshi H.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41467-022-31759-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PROJECT-21K15108, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-21H00233, KAKENHI-PUBLICLY-22H04700
[Journal Article] Suppression of endogenous retroviral enhancers in mouse embryos derived from somatic cell nuclear transfer2022
- Author(s)
  Shikata Daiki、Matoba Shogo、Hada Masashi、Sakashita Akihiko、Inoue Kimiko、Ogura Atsuo
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 13 Pages: 1032760-1032760
- DOI
  10.3389/fgene.2022.1032760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15705, KAKENHI-PROJECT-21K15108, KAKENHI-PLANNED-19H05758, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-23K20298
[Journal Article] Bioinformatics Pipelines for Identification of Super-Enhancers and 3D Chromatin Contacts2022
- Author(s)
  Sakashita Akihiko、Takeuchi Chikara、Maezawa So、Namekawa Satoshi H.
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2577 Pages: 123-146
- DOI
  10.1007/978-1-0716-2724-2_9
- ISBN
  9781071627235, 9781071627242
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PROJECT-22KJ2696, KAKENHI-PUBLICLY-21H00233, KAKENHI-PUBLICLY-22H04700
[Journal Article] Retrotransposons in the Mammalian Male Germline2022
- Author(s)
  Zhou Shumin、Sakashita Akihiko、Yuan Shuiqiao、Namekawa Satoshi H.
- Journal Title
  
  Sexual Development
  
  Volume: - Issue: 5-6 Pages: 1-19
- DOI
  10.1159/000520683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15108
[Journal Article] CRISPR-mediated activation of transposable elements in embryonic stem cells2022
- Author(s)
  Akihiko Sakashita、 Masaru Ariura、 Satoshi H. Namekawa
- Journal Title
  
  Methods Mol Biol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15108
[Journal Article] Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells2022
- Author(s)
  Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
- Journal Title
  
  Genes Dev
  
  Volume: 36 Issue: 1-2 Pages: 84-102
- DOI
  10.1101/gad.348782.121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21384, KAKENHI-PLANNED-18H05530, KAKENHI-PLANNED-19H05758, KAKENHI-PUBLICLY-20H04934, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-20K20582, KAKENHI-PROJECT-19K16017, KAKENHI-PROJECT-20K15705, KAKENHI-PROJECT-21K15108, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H04834, KAKENHI-PROJECT-21K19546, KAKENHI-PROJECT-23K20298
[Presentation] 転移因子が駆動する哺乳動物の個体発生2023
- Author(s)
  坂下陽彦
- Organizer
  東海医学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Presentation] 種固有の個体発生制御を担う内在性レトロウイルス機能の探索2023
- Author(s)
  坂下陽彦
- Organizer
  第46回分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Presentation] Regulation of host gene expression and cell fate by endogenous retrovirus during early stage of embryonic development2022
- Author(s)
  Akihiko Sakashita
- Organizer
  The 1st international symposium of Non-Genome Replication
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04700
[Presentation] マウス初期発生胚における内在性レトロウイルスを介した宿主ゲノム制御機構2022
- Author(s)
  坂下陽彦
- Organizer
  第94回日本遺伝学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04700

1. 藍川志津 (80884577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 可野邦行 (50636404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 前澤創

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. 羽田政司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 平岡毅大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 藤木克則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石津大嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakashita Akihiko 坂下 陽彦

Research Projects

Research Products

Co-Researchers

個体発生において種間の多様性をもたらす内在性レトロウイルスの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

内在性レトロウイルスによる宿主ゲノムのクロマチン再構築機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic regulation of ERV-driven enhancer in germline developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] in vitroにおける個体発生の再構成をめざして2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学2023年9月号2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mouse embryonic development requires transposable element expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PRC1 suppresses a female gene regulatory network to ensure testicular differentiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription of MERVL retrotransposons is required for preimplantation embryo development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bioinformatics pipelines for identification of super-enhancers and 3D chromatin contacts2022

Author(s)

Journal Title

Data Source

[Journal Article] PRC1-mediated epigenetic programming is required to generate the ovarian reserve2022

Author(s)

Sakashita Akihiko 坂下陽彦