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Sekino Yuko  関野 祐子

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… Alternative Names

SEKINO Yuko  関野 祐子

関野 佑子  セキノ ユウコ

関野 祐子  セキノ ユウコ

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Researcher Number 70138866
Other IDs
External Links
Affiliation (Current) 2025: 東京大学, 大学院農学生命科学研究科(農学部), 特任教授
Affiliation (based on the past Project Information) *help 2022: 東京大学, 大学院農学生命科学研究科(農学部), 特任教授
2020 – 2021: 東京大学, 大学院薬学系研究科(薬学部), 特任教授
2015: 国立医薬品食品衛生研究所, 薬理部, 教授
2010: 国立医薬品食品衛生研究所, 薬理部, 研究員
2010: 群馬大学, 国立医薬品食品衛生研究所・薬理部, 研究員 … More
2009: National Institute of Health Sciences, 薬理部, 部長
2007 – 2009: 東京大学, 医科学研究所, 准教授
2005 – 2006: 東京大学, 医科学研究所, 助教授
2004: 群馬大学, 大学院・医学研究科, 助教授
2004: 群馬大学, 大学院・医学系研究科, 助教授
2002: 群馬大学, 医学部, 助教授
1999 – 2001: Gunma Univ. Shc. Med. Dept. of Neurobiology and Behavior, Assist. Professor, 医学部, 講師
1996 – 1998: 群馬大学, 医学部, 助手
1993: (財)東京都神経科学総合研究所, 神経生化学研究部門, 流動研究員
1993: 東京都神経科学総合研究所, 神経生化学研究部門, 流動研究員 Less
Review Section/Research Field
Principal Investigator
Neuroscience in general / Basic Section 90110:Biomedical engineering-related / Biological Sciences
Except Principal Investigator
Neuroscience in general / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences
Keywords
Principal Investigator
海馬 / 膜電位感受性色素 / アデノシン / LTP / 光学測定 / CA2 / 記憶 / 長期増強 / 光学的測定法 / マイクロ流路 … More / 膜電位イメージング / 多点電極神経活動記録 / 同期性神経活動イメージング / GABAb受容体 / マイクロ流体デバイス / カルシウムイメージング / ヒトiPS由来神経細胞 / ラット胎仔由来凍結神経細胞 / 細胞外電位記録 / 培養神経細胞 / CA3a / Adenosine / Optical Recording / Hippocampus / アデノシンA1受容体 / 海馬スライス / 光学的測定 / CA3-CA2-CA1 / 長期増強(LTP) / アデノシン受容体 / 光学測定法 / パッチクランプ / NMDA受容体 / GABA / シーター波 / 歯状回 / 上乳頭体核 / ゲート機構 / 情動 / 視床下部 / 海馬CA2 / シナプス可塑性 … More
Except Principal Investigator
ドレブリン / シナプス / アクチン / actin / 神経細胞 / drebrin / 神経培養 / アクチン結合蛋白 / 細胞骨格 / 樹状突起スパイン / dendritic spine / SH3P7 / aging / development / cytoskeleton / 樹状突起 / 老化 / グルタミン酸受容体 / 発達 / 神経発達 / シナプス可塑性 / ウイルスベクター / 脳分子プロファイル / モデル動物 / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / microtubule / axonal growth / actin-binding proteins / immunofluorescence staining / hippocampal neuronal culture / growthcone / 微小管 / 軸索成長 / 免疫蛍光染色 / 海馬初代培養神経細胞 / 成長円錐 / neuronal culture / signal transmission / synaptic plasticity / 培養 / シグナル伝達 / synapse / cyto keleton / neuron / spine / アルツハイマー / synaptic maturation / 遺伝子導入 / アクチンフィラメント / 海馬 / スパイン / シナプス成熟 / 樹状突起棘 / スパイカー / シナプス機能 / 行動分析 / シナプス形態形成 / 神経細胞培養 / ミオシンII / LTP / ノックアウト / 遺伝子発現 / 形態形成 / 学習 / 可塑性 / シナプス小胞 / 発生 / ノックアウトマウス / 統合失調症 / 神経発生 / シナプス形成 / フィロポデイア / PSD-95 / スパイン形成 / GFP / Alzheimer / 高頻度刺激 / 発火パターン / 大脳皮質 / Synchronous oscillation / 時空間パターン / 培養ニューロン / 記憶 / ニューロン回路 Less
  • Research Projects

    (17 results)
  • Research Products

    (82 results)
  • Co-Researchers

    (160 People)
  •  Imaging device development for hyperpolarization response analysis forming neural activity rhythmPrincipal Investigator

    • Principal Investigator
      Sekino Yuko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      The University of Tokyo
  •  Comprehensive Brain Science Network

    • Principal Investigator
      Kimura Minoru
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
  •  海馬シナプス伝達抑制機構の光学測定法を用いた解析Principal Investigator

    • Principal Investigator
      関野 祐子
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  Actin-dependent regulation of synapse function and its role in higher brain fuction

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gunma University
  •  Role of actin cytoskeleton in the axonal growthcone during brain development

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gunma University
  •  樹状突起スパイン内細胞骨格再編成の分子基盤とその制御機構

    • Principal Investigator
      白尾 智明
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Gunma University
  •  Regulation of synaptic actin reorganization by signal transmission with drebrin family

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      Gunma University
  •  視床下部神経活動による海馬内ニューロネットワークの制御機構Principal Investigator

    • Principal Investigator
      関野 祐子
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gunma University
  •  内因性アデノシンによる局所神経回路の機能制御Principal Investigator

    • Principal Investigator
      関野 佑子
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      Gunma University
  •  視床下部神経活動による海馬ニューロネットワークの制御機構Principal Investigator

    • Principal Investigator
      関野 祐子
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gunma University
  •  樹状突起スパインの再形成機構

    • Principal Investigator
      HAYASHI Kensuke
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gunma University
  •  Distribution of drebrin containing synapses in the brain

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Neuroscience in general
    • Research Institution
      Gunma University School of Medicine
  •  Development and Aging of Neuronal Synapse

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gunma University
  •  Analysis using optical recording for synaptic plasticity of non-LTP type in hippocampal slicesPrincipal Investigator

    • Principal Investigator
      SEKINO Yuko
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      Gunma University, School of Medidcine
  •  中枢シナプス細胞骨格異常が引き起こす記憶情報処理障害に関する研究

    • Principal Investigator
      SHIRAO Tomoaki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      Gunma University
  •  コバリアンス学習におけるシナプス結合可塑性の細胞・分子機構

    • Principal Investigator
      黒田 洋一郎
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  膜電位感受性色素を用いた海馬スライス内神経回路網の解析-長期増強と抑制の発現機構とその神経回路Principal Investigator

    • Principal Investigator
      関野 祐子
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

All 2023 2022 2021 2020 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] Lecture Notes in Artificial Intelligence2007

    • Author(s)
      Yuko Sekino
    • Publisher
      Role for signal propagation through the hippocampal CA2 field in memory formation
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Book] in Web Intelligence Meets Brain Informatics Ning Zhong, Jiming Liu, Yiyu Yao, Jinglong Wu, Shengfu Lu2007

    • Author(s)
      関野祐子, 白尾智明
    • Publisher
      Kuncheng Li (Eds) in Lecture Notes in Artificial Intelligence
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons2023

    • Author(s)
      Koganezawa Noriko、Roppongi Reiko T.、Sekino Yuko、Tsutsui Izuo、Higa Ayaka、Shirao Tomoaki
    • Journal Title

      Journal of Visualized Experiments

      Volume: 191 Issue: 191 Pages: 0-0

    • DOI

      10.3791/64872

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-19K08010
  • [Journal Article] Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons2023

    • Author(s)
      Lin Waka、Shiomoto Shusaku、Yamada Saki、Watanabe Hikaru、Kawashima Yudai、Eguchi Yuichi、Muramatsu Koichi、Sekino Yuko
    • Journal Title

      iScience

      Volume: 26 Issue: 4 Pages: 106285-106285

    • DOI

      10.1016/j.isci.2023.106285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Journal Article] Neurons Induce Tiled Astrocytes with Branches That Avoid Each Other2022

    • Author(s)
      Hayashi MK, Sato K, Sekino Y
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 8 Pages: 4161-4161

    • DOI

      10.3390/ijms23084161

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05963, KAKENHI-PROJECT-20H04511
  • [Journal Article] Adenosine A1 receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area2022

    • Author(s)
      Kawamura Masahito、Sekino Yuko
    • Journal Title

      Purinergic Signalling

      Volume: - Issue: 4 Pages: 623-632

    • DOI

      10.1007/s11302-022-09897-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07745, KAKENHI-PROJECT-20H04511
  • [Journal Article] Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease.2022

    • Author(s)
      Kobayashi Y, Kobuchi S, Koganezawa N, Sekino Y, Shirao T, Saito T, Saido TC, Saito Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 610 Pages: 85-91

    • DOI

      10.1016/j.bbrc.2022.04.050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-21K06249, KAKENHI-PROJECT-22K06297, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-19K08010
  • [Journal Article] NMDA receptor‐dependent and ‐independent effects of natural compounds and crude drugs on synaptic states as revealed by drebrin imaging analysis2021

    • Author(s)
      Koganezawa Noriko、Sekino Yuko、Kawakami Hitomi、Fuchino Hiroyuki、Kawahara Nobuo、Shirao Tomoaki
    • Journal Title

      European Journal of Neuroscience

      Volume: 00 Issue: 11 Pages: 1-13

    • DOI

      10.1111/ejn.15231

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08010, KAKENHI-PROJECT-20H04511
  • [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates2021

    • Author(s)
      Okada Masayasu、Kawagoe Yosuke、Sato Yuta、Nozumi Motohiro、Ishikawa Yuya、Tamada Atsushi、Yamazaki Hiroyuki、Sekino Yuko、Kanemura Yonehiro、Shinmyo Yohei、Kawasaki Hiroshi、Kaneko Naoko、Sawamoto Kazunobu、Fujii Yukihiko、Igarashi Michihiro
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s13041-021-00755-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17955, KAKENHI-PROJECT-17KK0144, KAKENHI-PUBLICLY-18H05119, KAKENHI-PROJECT-17H03541, KAKENHI-PROJECT-18K06459, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17K10888, KAKENHI-PUBLICLY-20H05056, KAKENHI-PROJECT-18H04013, KAKENHI-PROJECT-20H03338, KAKENHI-PLANNED-21H05106, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-20H03565, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-21K19306
  • [Journal Article] Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro.2021

    • Author(s)
      Kobayashi Y, Okada T, Miki D, Koganezawa N, Sekino Y, Shirao T, Dinitz GB, Saito Y.
    • Journal Title

      Neurochem International

      Volume: 142 Pages: 104902-104902

    • DOI

      10.1016/j.neuint.2020.104902

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-19K08010, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-21K06249
  • [Journal Article] Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro.2021

    • Author(s)
      Togo K, , Fukusumi H, Shofuda T, Ohnishi H, Yamazaki H, Hayashi M, Kawasaki N, Takei N, Nakazawa T, Saito Y, Baba K, Hashimoto H, Sekino Y, Shirao T, Mochizuki H, Yanemura H
    • Journal Title

      Mol Brain

      Volume: 14 Issue: 1 Pages: 149-149

    • DOI

      10.1186/s13041-021-00851-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-21H02617, KAKENHI-PROJECT-20K05963
  • [Journal Article] Ciliary GPCR-associated transcriptome reveals key regulators as cilia length control.2021

    • Author(s)
      Kobayashi Y, Tomoshige S, Imakado K, Sekino Y, Shirao T, Koganezawa N, Dinitz GB, Miyamoto T, Saito Y.
    • Journal Title

      FASEB BioAdvances

      Volume: 3 Issue: 9 Pages: 744-767

    • DOI

      10.1096/fba.2021-00029

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-21K06249
  • [Journal Article] Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.2020

    • Author(s)
      Fukushima H, Yoshioka M, Kawatou M, Lopez-Davila V, Takeda M, Kanda Y, Sekino Y, Yoshida Y,Yamashita JK
    • Journal Title

      PLoS One

      Volume: 15 Issue: 11 Pages: 0241287-0241287

    • DOI

      10.1371/journal.pone.0241287

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20471, KAKENHI-PROJECT-18H04048, KAKENHI-PROJECT-20H04511, KAKENHI-PROJECT-17H04176
  • [Journal Article] 気になる脳部位海馬のCA2領域2009

    • Author(s)
      関野祐子
    • Journal Title

      分子精神医学 9

      Pages: 164-169

    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin2009

    • Author(s)
      Takahashi, T, 山崎博幸, 花村健次, 関野祐子, 白尾智明
    • Journal Title

      J Cell Sci.

      Volume: 122 Pages: 1211-1229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin2009

    • Author(s)
      Takahashi, T, Yamazaki, H, Hanamura K, Sekino Y, Shirao T
    • Journal Title

      J Cell Sci. 122

      Pages: 1211-1229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin2009

    • Author(s)
      Takahashi, T., Yamazaki, H., Hanamura, K., Sekino, Y., Shirao, T.
    • Journal Title

      Journal of Cell Science 122

      Pages: 1211-1219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Journal Article] Three-dimensional distribution of Fos-positive neurons in the supramammillary nucleus of the rat exposed to novel environment2009

    • Author(s)
      Ito M, Shirao T, Doya K, Sekino Y.(C.A.)
    • Journal Title

      Neuroscience Research 64

      Pages: 397-402

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Journal Article] 樹状突起スパインの形成と機能制御に関わるアクチン細胞骨格蛋白質2008

    • Author(s)
      児島 伸彦, 関野 祐子, 白尾 智明
    • Journal Title

      蛋白質・核酸・酵素 53

      Pages: 472-473

    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Expression of drebrin E in migrating neuroblasts in adult ratbrain : coincidence between drebrin E disappearance from cell body and cessation of migration2008

    • Author(s)
      Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T
    • Journal Title

      Neuroscience 152

      Pages: 670-682

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Journal Article] Expression of drebrin E in migrating neuroblasts in adult rat brain : coincidence between drebrin E disappearance from cell body and cessation of migration2008

    • Author(s)
      Song M, 児島伸彦, 花村健次, 関野祐子, Inoue KH, Mikuni M, 白尾智明
    • Journal Title

      Neuroscience

      Volume: 152 Pages: 670-682

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Imaging activity of neuronal populations with new longwavelength voltage-sensitive dyes2008

    • Author(s)
      Kee MZ, Wuskell JP, Loew LM, Augustine GJ, Sekino Y
    • Journal Title

      Brain Cell Biol. 36

      Pages: 157-172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Journal Article] Expression of drebrin E in migrating neuroblasts in adult rat brain : coincidence between drebrin E disappearance from cell body and cessation of migration2008

    • Author(s)
      Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T.
    • Journal Title

      Neuroscience 152

      Pages: 670-682

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Role of actin cytoskeleton in dendritic spine morphogenesis2007

    • Author(s)
      Sekino Y
    • Journal Title

      Neurochem. Int. (印刷中)

    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Roie of actin cytoskeleton in dendritic spine morphogenesis2007

    • Author(s)
      Sekino.Y, Kojima N, Shirao T.
    • Journal Title

      Neurochem.Int. 51

      Pages: 92-104

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Increase of AMPA receptors-mediated miniature EPSC amplitude after chronic NMDA receptor blockade in cultured hippocampal neurons2007

    • Author(s)
      Kato, K., Sekino, Y., Takahashi, H., Yasuda, H., Shirao, T.
    • Journal Title

      Neurosci. Lett 418

      Pages: 4-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Role of actin cytoskeleton in dendritic spine morphogenesis2007

    • Author(s)
      Sekino Y, Kojima N, Shirao T.
    • Journal Title

      Neurochem. Int. 51

      Pages: 92-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Many faces of Drebrin : from building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes2007

    • Author(s)
      Majoul, I., Shirao, T., Sekino, Y., Duden, R.
    • Journal Title

      Histochem. Cell Biol. 127

      Pages: 355-361

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Lecture Notes2007

    • Author(s)
      Yuko Sekino
    • Journal Title

      Artificial Intelligence, Role for signal propagation through the hippocampa

      Pages: 254-266

    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Role of actin cytoskeleton in dendritic spine morphogenesis2007

    • Author(s)
      Yuko Sekino
    • Journal Title

      Neurochem.Int 51

      Pages: 92-104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Role for signal propagation through the hippocampal CA2 field in memory formation2007

    • Author(s)
      Sekino Y
    • Journal Title

      Lecture Notes in Artificial Intelligence (印刷中)

    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Many faces of Drebrin:from building deneritic spines and stabilizinggap junctions to shaping neurite-like cell processes2007

    • Author(s)
      Majoul, I., Shirao, T., Sekino, Y., Duden, R.
    • Journal Title

      Histochem.Cell Biol 127

      Pages: 355-361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Role of actin cytoskeleton in dendritic spine morphogenesis2007

    • Author(s)
      関野祐子, 児島伸彦, 白尾智明
    • Journal Title

      Neurochem. Int.

      Volume: 51 Pages: 92-104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Journal Article] Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution : disappearance from dendritic spines and appearance in dendritic shafts2006

    • Author(s)
      Sekino, Y., Tanaka, S., Hanamura, K., Yamazaki, H., Sasagawa, Y., Xue Y., Hayashi, K., Shirao, T.
    • Journal Title

      MoL Cell. Neurosci 31

      Pages: 493-504

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution:disappearance from dendritic spines and appearance in dendritic shafts2006

    • Author(s)
      Sekino Y., Shirao T., et. al.
    • Journal Title

      Mol.cell.Neurosci. 31

      Pages: 493-504

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] 興奮性シナプスのアクチン結合タンパク-その動態と機能-2006

    • Author(s)
      関野 祐子
    • Journal Title

      蛋白質・核酸・酵素 51

      Pages: 350-356

    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Activation of N-methy1-D-aspartate receptor induces a shift of drebrin distribution:disappearance from dendritic spines and appearance in dendritic shafts2006

    • Author(s)
      Sekino, Y.
    • Journal Title

      Mol. Cell. Neurosci. 31

      Pages: 493-504

    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] 興奮性シナプスのアクチン結合タンパク-その動態と機能-2006

    • Author(s)
      関野 祐子,
    • Journal Title

      蛋白質・核酸・酵素 51

      Pages: 353-356

    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses2005

    • Author(s)
      Aoki, C., Sekino, Y., Hanamura, K., Fujisawa, S., Mahadomrongkul, V., Ren, Y., Shirao, T.
    • Journal Title

      J. Comp. Neurol. 483

      Pages: 383-402

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions.2005

    • Author(s)
      Mizui, T., Takahashi, H., Sekino, Y., Shirao. T.
    • Journal Title

      Mol. Cell. Neurosci. 30

      Pages: 149-157

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Journal Article] Expression of drebrin E in migrating neuroblasts in adult rat brain : coincidence between drebrin E disappearance from cell body and cessation of migration

    • Author(s)
      Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T
    • Journal Title

      Neuroscience. (印刷中)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300117
  • [Patent] 樹状突起スパイン移行配列2011

    • Inventor(s)
      山崎博幸, 関野祐子, 白尾智明
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Acquisition Date
      2011-09-03
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Patent] ドレブリンA発現抑制動物神経細胞及び非ヒトモデル動物2010

    • Inventor(s)
      白尾智明, 佐治真理, 関野祐子, 小林利佳
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Acquisition Date
      2010-08-13
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Patent] シナプス成熟障害モデル動物2010

    • Inventor(s)
      白尾智明, 児島伸彦, 山崎博幸, 関野祐子, 花村健次
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Acquisition Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Patent] 領域分割画像生成方法、領域分割画像生成装置およびコンピュータープログラム2009

    • Inventor(s)
      関野祐子、馳澤盛一郎、朽名夏暦
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-09-14
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Patent] ドレブリンA発現抑制作用を有するアンチセンスオリゴヌクレオチド2009

    • Inventor(s)
      白尾智明, 関野祐子, 田中聡一
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Acquisition Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] High-throughput phenotypic assay using frozen neurons2023

    • Author(s)
      Higa A, Roppong RT, Koganezawa N, Sekino Y, Shirao T
    • Organizer
      The 12th International Society of Radiation Neurobiology Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Quantitative analysis for drebrin clusters along dendrites using immunocytochemical images of cultured rat hippocampal neurons2023

    • Author(s)
      Mase S, Mitsuoka T, Koganezawa N, Shirao T, Sekino Y,
    • Organizer
      The 12th International Society of Radiation Neurobiology Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] High-throughput screening using frozen neurons2023

    • Author(s)
      Roppongi RT, Koganezawa N, Sekino Y, Higa Y, Shirao T,
    • Organizer
      日本生理学会第100回記念大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] カンナビノイドの神経毒性と大麻の規制2023

    • Author(s)
      関野祐子
    • Organizer
      日本生理学会第100回記念大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] 薬物依存の神経化学と薬物乱用防止対策2022

    • Author(s)
      関野祐子
    • Organizer
      第69回北海道薬学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] ドレブリン阻害剤BTP2によるシナプスの形態変化2022

    • Author(s)
      藤瀬なぎさ、関野祐子、白尾智明、児島伸彦
    • Organizer
      第45回 日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Developmental neurotoxicity assessment of glutamate receptor binding agonists that cause learning and memory impairment:analysis of drebrin immunoreactivity in rat hippocampal cultured neuron.2021

    • Author(s)
      S Mase, I Tsutsui, T Mitsuoka, N Koganezawa, H Yamazaki, Y Kato, H Kawabe, T Shirao, Y Sekino
    • Organizer
      第48回 日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Effects of a synthetic cannabinoid,CP55940, on synaptogenesis of cultured hippocampal neurons: imaging analysis of drebrin immunocytochemistry2021

    • Author(s)
      S Mase, T Mitsuoka, N Koganezawa, H Yamazaki, Y Kato, I Tsutsui, T Shirao, H Kawabe, Y Sekino
    • Organizer
      第64回 日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] 認知症に効く漢方薬スクリーニング:オウバクとオンジの有効可能性2021

    • Author(s)
      小金澤紀子、関野祐子、白尾智明.
    • Organizer
      第28回HAB研究機構学術年会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Drebrin cluster analysis using cultured hippocampal neurons. 11 th International Society of Radiation Neurobiology2021

    • Author(s)
      S Mase, T Mitsuoka, N Koganezawa, T Shirao,Y Sekino.
    • Organizer
      11 th International Society of Radiation Neurobiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Assessment of CB agonist CP55940 in maturity for rat hippocampal neurons using a high-throughput immunocytochemical assay and image digital analysis2021

    • Author(s)
      光岡俊成, 間瀬省吾, 小金澤紀子, 加藤祐一, 白尾智明, 関野祐子
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Neuronal and synaptic maturation in long-term cultures of human iPSC-derived neurons generated by transcription factor-based rapid differentiation2021

    • Author(s)
      W Lin, S Yamada, H Watanabe, Y Kawashima, Y Sekino
    • Organizer
      Society for Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Upregulation of drebrin in dendritic spines and neuronal death induced by a synthetic cannabinoid,CP55940, in cultured rat hippocampal neurons.2021

    • Author(s)
      S Mase, T Mitsuoka, N Koganezawa, H Yamazaki, Y Kato, I Tsutsui, T Shirao, H Kawabe, Y Sekino.
    • Organizer
      第44回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] High-content imaging evaluation of crude drug effects on synaptic function2020

    • Author(s)
      Noriko Koganezawa, Hitomi Kawakami, Hiroyuki Fuchino, Yuko Sekino, Nobuo Kawahara, Tomoaki Shirao,
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] In Vitro Cardiac Safety Evaluation for Repurposed COVID-19 Drugs by Using Human iPS Cell-Derived-Cardiomyocyte with Gelatin Fiber Scaffold2020

    • Author(s)
      Saotome T, Baba A, Kato E, Joko S, Shimada N, Matsuzaki Y, Endo T, Ikegaya Y, Sekino Y, Sawada K
    • Organizer
      Safety Pharmacology Society Virtual Meeting
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Optimization of algorithms to quantify changes in drebrin distribution induced by glutamate stimulation of cultured neurons for a confocal quantitative image cytometer2020

    • Author(s)
      間瀬省吾、関野祐子、白尾智明、光岡俊成
    • Organizer
      第63回 日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] Introduction of the proposal from the addiction subcommittee, the science council of Japan, to promote understanding and overcoming addiction in Symposium “Academic trends towards understanding and overcoming addiction.2020

    • Author(s)
      Yuko Sekino
    • Organizer
      第43回日本神経科学大会,
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] 国際ルール組成におけるインサイドアウトin新規医療評価技術の普及に向けたルール・オブ・ルールの考え方2020

    • Author(s)
      関野祐子
    • Organizer
      第17回DIA日本年会2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H04511
  • [Presentation] ミオシンIIBを介する樹状突起スパイン内アクチン細胞骨格動態制御機構2010

    • Author(s)
      関野祐子
    • Organizer
      第83回薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] 扁桃体神経活動の膜電位イメージングとクラスタリング解析:機能解剖学的特徴抽出2010

    • Author(s)
      関野祐子
    • Organizer
      第115回日本解剖学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] Activity of Myosin IIB regulates dendritic-spine morphology of hippocampal neurons2010

    • Author(s)
      関野祐子、水井利幸、山崎博幸、白尾智明
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] 膜電位感受性色素による神経活動イメージングとその解析~神経活動のクラスタリングによる機能マッピング2010

    • Author(s)
      関野祐子
    • Organizer
      JST基礎研究シーズ報告会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-02
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] Maturation of AMPA receptors activity is regulated by expression of drebrin, an actin-binding protein, in cultured hippocampal neurons2009

    • Author(s)
      Kato, K., Yamazaki, H., Shirao, T., Sekino, Y.
    • Organizer
      The XXXV International Congress of Physiological Sciences (IUPS 2009)
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] Regulation of dendritic spine morphology by changing drebrin-A dynamics2009

    • Author(s)
      白尾智明, 花村健次, 高橋秀人, 水井利幸, 関野祐子
    • Organizer
      22nd The International Society of Nephrology Biennial Meeting, 2009
    • Place of Presentation
      BEXCO.(釜山、大韓民国)
    • Year and Date
      2009-08-23
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] 扁桃体外側核の興奮・抑制シナプス応答の可視化と時間空間パターン解析2009

    • Author(s)
      関野祐子
    • Organizer
      第52回日本神経化学学会大会
    • Place of Presentation
      伊香保
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] 扁桃体における抑制性局所回路のイメージング2009

    • Author(s)
      関野祐子
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] Postsynaptic modulation of glutamatergic responses by adenosine A1 receptors in the hippocampal CA1 region2009

    • Author(s)
      三輪秀樹、関野祐子、柳川右千夫
    • Organizer
      第32回神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20021010
  • [Presentation] ドレブリンの樹状突起スパインからシャフトへの移行における分子メカニズムの検討2009

    • Author(s)
      関野祐子
    • Organizer
      神経組織の成長・再生・移植研究会 第24回学術集会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-21
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Regulation of dendritic spine morphology by changing drebrin-A dynamics2009

    • Author(s)
      Shirao, T., Hanamura, K., Takahashi, H., Mizui, T., Sekino, Y.
    • Organizer
      21th ISN Biennial Meeting
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-23
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Spikar, a novel transcriptional-coactivator, regulates dendritic spine formation2008

    • Author(s)
      山崎 博幸, 加藤 健一, 関野 祐子, 白尾 智明
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] 成体脳の新生神経細胞の移動停止時にドレブリンEは細胞体から消失する。2007

    • Author(s)
      花村 健次, 宋 明橋, 児島 伸彦, 関野 祐子, 白尾 智明
    • Organizer
      第22回神経組織の成長・再生・移植研究会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2007-05-26
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Genetic and activity-dependent control of spinous actin cytoskele ton in spine formation2007

    • Author(s)
      Shirao, T., Takahashi, H., Mizui, T., Sekino, Y
    • Organizer
      21th ISN Biennial Meeting related Meeting
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2007-08-23
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Cessation of neuronal migration in adult rodent olfactory bulb is paralleled with the disappearance of drebrin E from the cell body2007

    • Author(s)
      花村 健次, 宋 明橋, 児島 伸彦、関野 祐子, 白尾 智明
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Chronic NMDA receptor blockade induces homeostatic synaptic scaling of AMPA receptors in cultured hippocampal neurons2007

    • Author(s)
      Kato K, Sekino Y, Takahashi H, Yasuda H, and Shirao T
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, CA
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Spikar-dependent spine formation does not necessary need the translocation of Spikar into nucleus2007

    • Author(s)
      山崎 博幸, 加藤 健一, 笹川 快夫, 関野 祐子, 白尾 智明
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19200029
  • [Presentation] Effects of chronic blockade of NMDA receptors during synapaptoge nesis on glutamate receptor-mediated currents in cultured hippocamal neurons2007

    • Author(s)
      加藤 健一, 白尾 智明, 高橋 秀人, 関野 祐子
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19200029
  • 1.  SHIRAO Tomoaki (20171043)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 26 results
  • 2.  HAYASHI Kensuke (50218567)
    # of Collaborated Projects: 3 results
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  • 3.  SAITOH Yoshiko (70241263)
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  • 6.  YAMAZAKI Hiroyuki (10334137)
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  • 7.  HANAMURA Kenji (40361365)
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  • 8.  KOJIMA Nobuhiko (80215251)
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  • 13.  Ohtsuka Toshihisa (40401806)
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  • 14.  Aoki Shigeki (80222470)
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  • 15.  Takao Hidemasa (10444093)
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  • 18.  Yoshiura Takashi (40322747)
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  • 19.  Nakata Yasuhiro (40362066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  Abe Osamu (50302716)
    # of Collaborated Projects: 1 results
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  • 21.  Masumoto Tomohiko (60302717)
    # of Collaborated Projects: 1 results
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  • 22.  Tokumaru Aya (60507391)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Matsumura Akira (90241819)
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  • 160.  川村 将仁
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