TAKUWA Noriko 多久和典子

… Alternative Names

多久和典子タクワノリコ

Less

Researcher Number	70150290
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2009 – 2019: 石川県立看護大学, 看護学部, 教授 2010: Ishikawa Prefectural Nursing University, 看護学部・健康科学講座, 教授 2008 – 2009: Ishikawa Prefectural Nursing University, 健康科学講座, 教授 2006 – 2007: Ishikawa Prefectural nursing University, Professor, 看護学部, 教授 2006 – 2007: 金沢大学, 医学系研究科, 協力研究員 … More 2001 – 2005: 金沢大学, 医学系研究科, 助手 2004: 金沢大学, 大学院・医学系研究科, 助手 1999 – 2000: 金沢大学, 医学部, 助手 1997 – 1998: 東京大学, 大学院・医学系研究科, 助手 1993 – 1996: 東京大学, 医学部(医), 助手 1988 – 1991: 東京大学, 医学部, 助手 1986: Faculty of Medicine, University of Tokyo (Instructor), 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General physiology / General medical chemistry / General medical chemistry / General physiology Except Principal Investigator General physiology / General physiology / Biological Sciences
Keywords	Principal Investigator スフィンゴシン-1-リン酸 / G蛋白共役型受容体 / がん血管新生 / ノックアウトマウス / スフィンゴシンキナーゼ / 脂質メディエーター / 遺伝子改変動物 / 低分子量G蛋白 / 心筋線維化 / トランスジェニックマウス … More / 細胞遊走 / 血管内皮 / Cキナーゼ / 血管平滑筋 / ATP / シグナル伝達 / JNK / 低分子量G蛋白質 / 細胞運動 / 転移 / 浸潤 / G protein-coupled receptor / 遺伝子改変マウス / 細胞内情報伝達 / 心筋リモデリング / S1P2受容体 / 骨髄移植実験 / マトリックスメタロプロテアーゼ / 酸化ストレス / TGFbeta-Smad system / 生理活性脂質 / 腫瘍血管新生 / 虚血後血管新生 / リゾリン脂質メディエーター / Gタンパク共役型受容体 / スフィンゴ脂質 / 末梢動脈疾患 / S1P2 / がん血行性転移 / 情報伝達 / 慢性炎症 / 臓器線維化 / 細胞老化 / 増殖因子 / カルシウム / 肺小細胞癌 / エンドセリン / タキキニン / ジアシルグリセロール / ボンベシン / 増殖制御 / サイクリン依存性キナーゼ / Cell cycle / Protein kinase C / Cyclin-dependent kinase / Endothelial cell / 機械力 / P_2 受容体 / 遺伝子発現 / P_2受容体 / P2受容体 / vascular / smooth muscle / mechanical stretch / P_0 purinoceptor / signal transduction / gene expression / ホスファチジルイノシトール3キナーゼ / 細胞周期 / サイクリン / ホスファチジルイノシトール3-キナーゼ / Rb蛋白 / 優性不活型変異体 / 構成活性型変異体 / NIH3T3細胞 / Phosphtidylinositol 3-kinase / cyclin D / cell cycle / p70^<s6k> / mTOR / NIH3T3 fibroblasts / 肺転移モデル / PDGF / Rac / Sphingosine-1-phosphate / cell movement / lung metastasis model / low molecular weight G protein / 活性酸素 / 血小板 / モデル動物 / 心筋障害 / 心筋 / sphingosine-1-phosphate / sphingosine kinase / cardiac fibrosis / oxidative stress / low molecular weightG proteins / 癌 / 脂質 / 生理活性 / スフィンゴシン / がん / 血管新生 / 血管内皮細胞 / Cancer / Signal transduction / Lipids / Bioactive molecules / マクロファージ / 細胞系譜特異的遺伝子改変マウス / 炎症 … More Except Principal Investigator Rac / Rho / スフィンゴシン-1-リン酸 / EDG / AGR-16 / Edg / 浸潤 / 転移 / 遊走 / sphingosine-1-phosphate / 細胞運動 / S1P / Edg受容体 / がん / 血管新生 / ノックアウトマウス / 脂質 / ATP / 受容体 / 情報伝達 / 細胞遊走 / Receptor / cell motility / 癌 / G蛋白共役型受容体 / フィンゴシン-1-リン酸 / S1P_2 / 血管成熟 / SIP_2 / SIP / PI3キナーゼ / 心血管 / ホメオスターシス / 病態生理 / 脂質メディエーター / スフィンゴシンー１－リン酸 / イノシトールリン脂質 / PI3-キナーゼ / シグナル伝達 / 血管障壁 / 血管医学 / 循環器・高血圧 / 生体分子 / 生理学 / 循環器疾患 / 血管 / 血管平滑筋 / 伸展 / 機械力 / 副甲状腺ホルモン関連ペプチド / 遺伝子発現 / P_2受容体 / Blood vessels / PTHrP / Mechanical force / Signalling / JNK / P_2 receptor / G protein / スフィゴシン-1-リン酸 / Signal transduction / cell migration / EDG受容体 / 器官形成 / 形態形成 / トランスジェニックマウス / Sphingosme-1-phosphate / Cell migration / gene targeting / ノックアウト / マウス / トランスジェニック / 【H^+】 / ペプチド共輸送 / 共輸送連結比 / ペプチド輸送電位 / 特異性 / 細胞内pH microclimate pH / 刷子縁膜 / 小腸 / 腎臓 / Proton-peptide cotransport / transport stoichiometry / specificity / peptide-transport potential / microclimate pH / intracellular pH / brush border membrane / intestine Less

Investigation on the roles for sphingolipid signaling in the regulation of macrophage functionsPrincipal Investigator
- Principal Investigator
  
  Takuwa Noriko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Ishikawa Prefectural Nursing University
A Novel Strategy for Controlling Chronic Inflammation and Fibrosis: Targeting Sphingolipid SignalingPrincipal Investigator
- Principal Investigator
  
  Takuwa Noriko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Ishikawa Prefectural Nursing University
Mechanisms for the regulation of vascular homeostasis by functional lipid molecules
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Regulation of tumor angiogenesis and metastasis, and postischemic angiogenesis by sphingosine-1-phosphate signaling systemPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Ishikawa Prefectural Nursing University
Role of functionallipids in cardiovascular homeostasis and diseases
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Pathophysiological roles of the sphingosine-1-phosphate signaling system in vivoPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Ishikawa Prefectural Nursing University
Molecular mechanisums for S1P_2 G protein coupled receptor-mediated inhibition of tumor progressionPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University
Signaling for regulating hematogenous metastasis of tumors
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Interrated research on the physiological role ofbioactive sphingosine-1-phosphate and Edg receptors by using genetically engineered maice.
- Principal Investigator
  
  TAKUWA Yho
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
G蛋白共役型受容体による癌の浸潤・転移の制御とその分子メカニズム
- Principal Investigator
  
  多久和陽
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Physiological and pathophysiological roles of the S1P signaling system : an in vivo studyPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University Graduate School of Medicine
G蛋白共役型受容体による癌の浸潤・転移の制御とその分子メカニズム
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Molecular dissection of the physiological role of bioactive sphingosine-1-phosphate and Edg receptors
- Principal Investigator
  
  TAKUWA Yho
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Investigation on physiological roles of sphingosine-1-phosphate signaling system using genetically engineered mice.Principal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KANAZAWA UNIVERSITY
Molecular biological analysis of the lipid morphogen sphingosine-1-phosphate
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Molecular biological research of biological functions of the sphingoshine-1-phosphate receptors
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General physiology
- Research Institution
  kanazawa University
Investigation on Molecular Link Between the Phosphatidylinositol 3-Kinase Signaling Pathway and the Cell Cycle MachineryPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Molecular Mechanisms for Mechanotransduction in Vascular Smooth Muscle and Endothelial cellPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
Molecular mechanisms for local regulation of vascular tonics
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo
Protein kinase C-mediated bidirectional regulation of endothelial cell growthPrincipal Investigator
- Principal Investigator
  
  TAKUWA Noriko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo
細胞増殖のシグナル伝達機構:Cキナーゼ活性化によるコンピテンス効果発現の分子機構Principal Investigator
- Principal Investigator
  
  多久和典子
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
細胞増殖制御におよぼすカルシウム流入の役割とその作用機序Principal Investigator
- Principal Investigator
  
  多久和典子
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
新しい生理活性物質エンドセリンの細胞増殖促進作用とその作用機序の研究Principal Investigator
- Principal Investigator
  
  多久和典子
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
異なる細胞増殖因子間に生ずる協同相乗作用の分子機構の研究Principal Investigator
- Principal Investigator
  
  多久和典子
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
血管作働性生理活性物質及びANPの腎メサンギウム細胞に及ぼす作用の研究Principal Investigator
- Principal Investigator
  
  多久和典子
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
Characterization and energetic analysis of <H^+> -dependent active transport in cells of visceral organs
- Principal Investigator
  
  HOSHI Takeshi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo

[Book] Bioactive Lipid Mediators2017
- Author(s)
  Takuwa N, OkamotoY, Yoshioka K and Takuwa Y.
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26460374
[Book] Lysophospholipid Receptors : Signaling and Biochemistry(Role of sphingosine-1-phosphate signaling in atherosclerosis.)(Chun J., Hla T., Spiegel S., Moolenaar W. eds., John Wiley & Sons, Hoboken)2011
- Author(s)
  Takuwa Y., Wang F., Okamoto Y., Yoshioka K., Takuwa N.
- Publisher
  New Jersey, U.S.A(in press)
- Data Source
  KAKENHI-PROJECT-20590288
[Book] Vascular Biology Update2007
- Author(s)
  尾山治、多久和陽
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17014034
[Book] Sphingolipid Biology.2006
- Author(s)
  Yoh Takuwa et al.
- Total Pages
  531
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17014034
[Book] Sphingolipid Biology2006
- Author(s)
  Y. Takuwa
- Total Pages
  531
- Publisher
  Springer
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Book] Sphingolipid Biology2006
- Author(s)
  Yoh Takuwa
- Total Pages
  531
- Publisher
  Springer
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Book] Sphingolipid Biology.2006
- Author(s)
  Yoh Takuwa
- Total Pages
  531
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17390054
[Book] Signaling mechanisms for positive and negative regulation of cell motility by sphingosine-1-phosphate receptors. (Y. Hirabayashi, Y. Igarashi, A.H.Merrill(Eds.), Sphingolipid Biology)2006
- Author(s)
  Y. Takuwa, N. Sugimoto, N. Takuwa, Y. Igarasi, Y. Hirabayashi
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17014034
[Book] Sphingolipid Biology.2006
- Author(s)
  Y. Takuwa
- Total Pages
  531
- Publisher
  Springer
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Book] Sphingolipid Biology.2006
- Author(s)
  Yoh Takuwa
- Total Pages
  531
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.2020
- Author(s)
  Islam Shahidul、Yoshioka Kazuaki、Aki Sho、Ishimaru Kazuhiro、Yamada Hiroki、Takuwa Noriko、Takuwa Yoh
- Journal Title
  
  J Physiol Sci.
  
  Volume: 70 Pages: 18-18
- DOI
  10.1186/s12576-020-00745-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07864, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-20K07260, KAKENHI-PROJECT-20K07273
[Journal Article] TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions.2020
- Author(s)
  Aki Sho、Yoshioka Kazuaki、Takuwa Noriko、Takuwa Yoh
- Journal Title
  
  Mol Biol Cell.
  
  Volume: 31(5) Pages: 360-372
- DOI
  10.1091/mbc.e19-11-0662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-20K07260, KAKENHI-PROJECT-20K07273
[Journal Article] Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.2019
- Author(s)
  Ishimaru Kazuhiro、Yoshioka Kazuaki、Kano Kuniyuki、Kurano Makoto、Saigusa Daisuke、Aoki Junken、Yatomi Yutaka、Takuwa Noriko、Okamoto Yasuo、Proia Richard L.、Takuwa Yoh
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Pages: 18329-18329
- DOI
  10.1038/s41598-019-54877-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07864, KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542
[Journal Article] The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells2019
- Author(s)
  Aung KT, Yoshioka K, Ishimaru K, Aki S, Takuwa N, and Takuwa Y.
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Pages: 263-280
- DOI
  10.1007/s12576-018-0644-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409, KAKENHI-PROJECT-17K08542
[Journal Article] Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.2019
- Author(s)
  Sarker AK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, and Takuwa Y.
- Journal Title
  
  Endocrinology.
  
  Volume: 160 Pages: 235-248
- DOI
  10.1210/en.2018-00756
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409
[Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages2018
- Author(s)
  Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y.
- Journal Title
  
  PLOS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0197604
- NAID
  120006605152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PLANNED-17H06394, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-16K15409
[Journal Article] MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.2018
- Author(s)
  Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, and Takuwa Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 23 Pages: 670-687
- DOI
  10.1111/gtc.12609
- NAID
  120006621947
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409
[Journal Article] Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.2017
- Author(s)
  Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 12
- DOI
  10.1371/journal.pone.0182329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15K09135, KAKENHI-PROJECT-15K10970, KAKENHI-PROJECT-17H04166
[Journal Article] Phosphatidylinositol 3-kinase class II α-Isoform PI3K-C2α Is required for transforming growth factor β-induced smad signaling in endothelial cells.2015
- Author(s)
  Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Pages: 6086-105
- DOI
  10.1074/jbc.m114.601484
- NAID
  120005593954
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26460292, KAKENHI-PROJECT-26460374, KAKENHI-PROJECT-15K10970, KAKENHI-PROJECT-15H04673
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis byinducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia.
  
  Volume: 57 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells.2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perstective
  
  Volume: 2 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] スフィンゴシン-1-リン酸の炎症における多彩な役割2014
- Author(s)
  多久和　陽
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 138-146
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Receptor for advanced glycation end products - membrane type1 matrix metalloproteinase axis regulates tissue factor expression via RhoA and Rac1 activation in high-mobility group box-1 stimulated endothelial cells2014
- Author(s)
  Sugimoto K, Ohkawara H, Takuwa Y, Ishibashi T and Takeishi Y .
- Journal Title
  
  PLoS One
  
  Volume: 9 Pages: 1-13
- DOI
  10.1371/journal.pone.0114429
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591100, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162
[Journal Article] PI3キナーゼ・ファミリーの血管における生理機能：クラスIIα型PI３キナーゼC2αによる新たな血管恒常性維持機構2013
- Author(s)
  吉岡　和晃，　吉田　耕太郎，　多久和　典子，岡本　安雄，　多久和　陽
- Journal Title
  
  血管
  
  Volume: 36 Pages: 53-61
- NAID
  10031177130
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases2013
- Author(s)
  Takuwa Y, Ikeda H, Okamoto Y, Takuwa N, Yoshioka K
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1831 (1) Pages: 185-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine 1-phosphate as a mediator involved in development offibrotic diseases2013
- Author(s)
  Takuwa Y
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 183 Pages: 1427-1438
- DOI
  10.1016/j.bbalip.2012.06.008
- NAID
  120004966619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-22590716, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-23116509
[Journal Article] PI3キナーゼ・ファミリーの血管における生理機能:クラスIIα型PI3キナーゼC2αによる新たな血管恒常性維持機構2013
- Author(s)
  吉岡和晃, 吉田耕太郎, 多久和典子, 岡本安雄, 多久和陽
- Journal Title
  
  血管
  
  Volume: 36(2) Pages: 53-61
- NAID
  10031177130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice2013
- Author(s)
  Cui H, Okamoto Y, Yoshioka K, et al.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 132 Pages: 1205-1214
- DOI
  10.1016/j.jaci.2013.07.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162
[Journal Article] クラスII α型PI-キナーゼの血管内皮細胞における新しい生理機能2013
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Journal Title
  
  生化学
  
  Volume: 85(9) Pages: 775-780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis.2013
- Author(s)
  Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 33 Pages: 96-108
- NAID
  130004943837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Sphingosine -1 -Phosphate Signaling and Cardiac Fibrosis.2013
- Author(s)
  Takuwa N
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 33 Pages: 96-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Essential role of class II PI3K-C2α in sphingosine-1-phosphate receptor-1 mediated signaling and migration in endothelial cells2013
- Author(s)
  Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa. Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288(4) Pages: 2325-2339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice2013
- Author(s)
  Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, et al
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 132(5) Pages: 1205-1214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis.2013
- Author(s)
  Takuwa N et al.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 33 Pages: 96-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] クラスII 型PI3 キナーゼC2αによる血管内皮シグナリング調節機能の蛍光ライブイメージング解析2013
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24(6) Pages: 560-568
- NAID
  130003393318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] クラスII 型PI3キナーゼC2αによる血管内皮シグナリング調節機能の蛍光ライブイメージング解析2013
- Author(s)
  吉岡　和晃，多久和　典子，岡本　安雄，　多久和　陽
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24 Pages: 560-568
- NAID
  130003393318
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] 血管新生の基礎と臨床2013
- Author(s)
  多久和陽
- Journal Title
  
  Bio Clinica
  
  Volume: 28 Pages: 16-17
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Essential role of class II PI3K-C2α in sphingosine-1-phosphate receptor-1 mediated signaling and migration in endothelial cells.2013
- Author(s)
  Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, TakuwaY
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 2325-2339
- DOI
  10.1074/jbc.m112.409656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-23116509
[Journal Article] クラスII α型PI-キナーゼの血管内皮細胞における新しい生理機能2013
- Author(s)
  吉岡　和晃，多久和　典子，岡本　安雄，　多久和　陽
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 775-780
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations.2013
- Author(s)
  Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 17 Pages: 793-804
- DOI
  10.1007/s10157-013-0796-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24406028, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-25670269
[Journal Article] 細胞内小胞輸送制御を介して血管新生を促進するクラスII型PI3キナーゼ2013
- Author(s)
  吉岡和晃, 吉田耕太郎, 多久和典子, 岡本安雄, 多久和陽
- Journal Title
  
  BIO Clinica
  
  Volume: 28(5) Pages: 22-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis2013
- Author(s)
  Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 33(2) Pages: 96-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-phosphate signaling in physiology and diseases2012
- Author(s)
  Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N
- Journal Title
  
  Biofactors
  
  Volume: 38(5) Pages: 329-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function2012
- Author(s)
  Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, et al
- Journal Title
  
  Nature Med
  
  Volume: 18(10) Pages: 1560-1569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Sphingosine-1-phosphate signialing in physiology and diseases.2012
- Author(s)
  Takuwa Y
- Journal Title
  
  Biofactors
  
  Volume: 38 Pages: 329-337
- DOI
  10.1002/biof.1030
- NAID
  120004966620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PUBLICLY-23116509
[Journal Article] Sphingosine-1 -phosphate signaling in physiology and diseases2012
- Author(s)
  Takuwa Y
- Journal Title
  
  BioFactors
  
  Volume: 38 Pages: 329-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis2011
- Author(s)
  Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y
- Journal Title
  
  Pharmaceuticals
  
  Volume: 4 Pages: 117-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Effects of gomisin A on vascular contraction in rat aortic rings Naunyn-Schmiedeberg Archives of Pharmacology2011
- Author(s)
  Seok YM, Choi YW, Kim GD, Kim HY, Takuwa Y, Kim IK.
- Journal Title
  
  Archives of Pharmacology
  
  Volume: 383(1) Pages: 45-56
- DOI
  10.1007/s00210-010-0571-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PUBLICLY-23116509, KAKENHI-PROJECT-23659170
[Journal Article] Sphingosine-1-phosphate-specific G protein-coupled receptorsas novel therapeutic targets for atherosclerosis.2011
- Author(s)
  Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y.
- Journal Title
  
  Pharmaceuticals.
  
  Volume: 1 Pages: 117-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] スフィンゴシン-1-リン酸と炎症2011
- Author(s)
  多久和陽
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 41 Pages: 14-25
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] スフィンゴシン-1-リン酸シグナル伝達系の新血管系における機能2011
- Author(s)
  岡本安雄, 吉岡和晃, 多久和典子, 多久和陽
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 536-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Protein-coupled sphingosine-1-phosphate receptors : potential molecular targets for angiogenic and anti-angiogenic therapies2011
- Author(s)
  Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y.
- Journal Title
  
  Biomed Rev
  
  Volume: 22 Pages: 15-29
- URL
  http://www.eurochicago.com/wp-content/uploads/2012/03/BMR-22-2011.pdf#page=22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis Pharmaceuticals2011
- Author(s)
  Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y.
- Journal Title
  
  Atherosclerosis Pharmaceuticals
  
  Volume: 4 Pages: 117-137
- DOI
  10.3390/ph4010117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Sphingosine-1-phosphate-specific G protein-coupled receptors as novel therapeutic targets for atherosclerosis.2011
- Author(s)
  Okamoto Y., Wang F., Yoshioka K., Takuwa N., Takuwa Y.
- Journal Title
  
  Pharmaceuticals 4
- URL
  http://www.mdpi.com/1424-8247/4/1/117/pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats2011
- Author(s)
  Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 128 Pages: 2215-2223
- DOI
  10.1002/ijc.25535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-21591964
[Journal Article] G Protein-coupled sphingosine-1-phosphate receptors: potential molecular targets for angiogenic and anti-angiogenic therapies.2011
- Author(s)
  Takuwa N, et al.
- Journal Title
  
  Biomed Rev
  
  Volume: 22 Pages: 15-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde2011
- Author(s)
  Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K Takuwa Y.
- Journal Title
  
  Am J Cancer Res
  
  Volume: 1(4) Pages: 460-481
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186046/?tool=pubmed
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde2011
- Author(s)
  Takuwa N, et al.
- Journal Title
  
  Am J Cancer Res
  
  Volume: 1 Pages: 460-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate spastic radial artery in coronary artery bypass grafting surgery2011
- Author(s)
  Takagi T, Okamoto Y, Tomita S, Sato A, Yamaguchi S, Takuwa Y, Watanabe G.
- Journal Title
  
  J Thorac Cardiovasc Surg
  
  Volume: 142(2) Pages: 59-65
- URL
  http://dx.doi.org/10.1016/j.jtcvs.2011.01.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1----Jekyll Hidden behind Hyde.2011
- Author(s)
  Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K, Takuwa Y.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 1 Pages: 460-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] G Protein-coupled sphingosine-1-phosphate receptors: potential molecular targets for angiogenic and anti-angiogenic therapies2011
- Author(s)
  Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y
- Journal Title
  
  Biomed Rev
  
  Volume: 22 Pages: 15-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde2011
- Author(s)
  Takuwa N
- Journal Title
  
  Am J Cancer Res
  
  Volume: 1 Pages: 460-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] G Protein-coupled sphingosine-1-phosphate receptors : potential molecular targets for angiogenic and anti-angiogenic therapies2011
- Author(s)
  Takuwa N
- Journal Title
  
  Biomed Rev
  
  Volume: 22 Pages: 15-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Crucial role of membrane type 1 matrix metalloproteinase(MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells2011
- Author(s)
  Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(9) Pages: 762-73
- URL
  http://www.jstage.jst.go.jp/article/jat/18/9/18_6783/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1-Jekyll Hidden behind Hyde.2011
- Author(s)
  Takuwa N., Du W., Kaneko E., Okamoto Y., Yoshioka K., Takuwa Y.
- Journal Title
  
  Am J Cancer Res 1
  
  Pages: 460-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Tumor-suppressive Sphingosine-1-phosphate Receptor-2 Counteracting Tumor-promoting Sphingosine-1-phosphate Receptor-1 and Sphingosine Kinase 1-Jekyll Hidden behind Hyde2011
- Author(s)
  Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K Takuwa Y
- Journal Title
  
  Am J Cancer Res
  
  Volume: 1(4) Pages: 460-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590344
[Journal Article] Involvement of membrane type1-matrix metalloproteinase (MT1-MMP) in rage activation signalingpathways2011
- Author(s)
  Kamioka M, Ishibashi T, Ohkawara H, Eguchi R, Sugimoto K, Uekita H, Matsui T, Yamagishi SI, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 226(6) Pages: 1554-1563
- DOI
  10.1002/jcp.22492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-21590340, KAKENHI-PROJECT-21590935, KAKENHI-PUBLICLY-23116509, KAKENHI-PROJECT-23659170
[Journal Article] Sustained delivery of sphingosine-1-phosphate usingpoly(lactic-co-glycolic acid)-based microparticles stimulatesAkt/ERK-eNOS mediated angiogenesis and vascular maturation restoringblood flow in ischemic limbs of mice2010
- Author(s)
  Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 634(1-3) Pages: 121-131
- DOI
  10.1016/j.ejphar.2010.02.038
- NAID
  120002086439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22590284
[Journal Article] S1P_2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis andtumor growth in vivo in mice.2010
- Author(s)
  Du, W, Takuwa.N., Yoshioka, K., Okamoto, Y., Gonda, K., Sugihara, K., Fukamizu, A., Asano, M., Takuwa, Y.
- Journal Title
  
  Cancer Research.
  
  Volume: 70 Pages: 772-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic miceinvolves reactive oxygen species.2010
- Author(s)
  N.Takuwa
- Journal Title
  
  Cardiovasc Res 85
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] the G protein-coupled receptor for sphingosine-1-phosphate, negativelyregulates tumor angiogenesis and tumor growth in vivo in mice2010
- Author(s)
  Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.
- Journal Title
  
  CancerRes.
  
  Volume: 70(2) Pages: 772-781
- DOI
  10.1158/0008-5472.can-09-2722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22590284
[Journal Article] S1P_2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice2010
- Author(s)
  Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.
- Journal Title
  
  Cancer Res. 70(2)
  
  Pages: 772-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Y Takuwa S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.2010
- Author(s)
  W Du, N Takuwa, K Yoshioka, Y Okamoto, K Gonda, K Sugihara, A Fukamizu, M Asano
- Journal Title
  
  Cancer Res 70(2)
  
  Pages: 772-781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sphingosine-1-phosphate receptor type 1regulates glioma cell proliferation andcorrelates with patient survival2010
- Author(s)
  Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie A, Takuwa Y, Hamada JI.
- Journal Title
  
  Int JCancer
  
  Volume: 126(10) Pages: 2341-2352
- DOI
  10.1002/ijc.24933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22791337
[Journal Article] S1P_3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 85
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-coglycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice2010
- Author(s)
  Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y.
- Journal Title
  
  Eur J Pharmacol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Sustained delivery of sphingosine-1-phosphate using poly (lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.2010
- Author(s)
  Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y.
- Journal Title
  
  Eur J Pharmacol. 634
  
  Pages: 121-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.2010
- Author(s)
  X Qi, Y Okamoto, T Murakawa, F Wang, O Oyama, R Ohkawa, K Yoshioka, W Du, N Sugimoto, Y Yatomi, N Takuwa, Y Takuwa
- Journal Title
  
  Eur J Pharmacol 634
  
  Pages: 121-131
- NAID
  120002086439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] JI. Hamada Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma.2010
- Author(s)
  Y. Yoshida, M. Nakada, N. Sugimoto, T. Harada, Y. Hayashi, D. Kita, N. Uchiyama, Y. Hayashi, A. Yachie, Y. Takuwa
- Journal Title
  
  Int J Cancer 126(10)
  
  Pages: 2341-2352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice.2010
- Author(s)
  Wang F., Okamoto Y., Inoki I., Yoshioka K., Du W., Qi X., Takuwa N., Gonda K., Yamamoto Y., Ohkawa R., Nishiuchi T., Sugimoto N., Yatomi Y., Mitsumori K., Asano M., Kinoshita M., Takuwa Y.
- Journal Title
  
  J Clin Invest. 120
  
  Pages: 3979-3995
- NAID
  10029469757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis.2010
- Author(s)
  Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K.
- Journal Title
  
  World J Biol Chem.
  
  Volume: 1 Pages: 298-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Preventive effects of pravastatin on thrombintriggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo2010
- Author(s)
  Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 88(3) Pages: 492-501
- DOI
  10.1093/cvr/cvq221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species2010
- Author(s)
  多久和陽
- Journal Title
  
  Cardiovasc Res 85
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] S1P_2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.2010
- Author(s)
  Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 772-781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] S1P_3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  Takuwa.N., Ohkura, S., Takashima, S., Ohtani, K., Okamoto, Y., et al.
- Journal Title
  
  Cardiovascular Research.
  
  Volume: 85 Pages: 484-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] S1P_3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 85(3)
  
  Pages: 484-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y
- Journal Title
  
  Cardiovascular Research
  
  Volume: 85(3) Pages: 484-493
- DOI
  10.1093/cvr/cvp312
- NAID
  120001939472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-21591414, KAKENHI-PROJECT-22590284
[Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.2010
- Author(s)
  Qi, X., Okamoto, Y., Murakawa, T., Wang, F., Oyama, O., Ohkawa, R., Yoshioka, K., Du, W., Sugimoto, N., Yatomi, Y., Takuwa.N., Takuwa, Y
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 634 Pages: 121-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis2010
- Author(s)
  Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K.
- Journal Title
  
  World J Biol Chem
  
  Volume: 1(10) Pages: 298-306
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083935/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice.2010
- Author(s)
  Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, et al
- Journal Title
  
  J Clin Invest.
  
  Volume: 120 Pages: 3979-3995
- NAID
  10029469757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  N. Takuwa, S. Ohkura, S. Takashima, K. Ohtani, Y. Okamoto, T. Tanaka, K, Hirano, S. Usui, F. Wang, W. Du, K. Yoshioka, Y. Banno, M. Sasaki, I. Ichi, M. Okamura, N. Sugimoto, K. Mizugishi, Y. Nakanuma, I. Ishii, M. Takamura, S. Kaneko, S. Kojo, K. Satouchi, K. Mitumori, J. Chun, Y. Takuwa
- Journal Title
  
  Cardiovasc Res 85(3)
  
  Pages: 484-493
- NAID
  120001939472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis.2010
- Author(s)
  Takuwa Y., Du W., Qi X., Okamoto Y., Takuwa N., Yoshioka K.
- Journal Title
  
  World J Biol Chem 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Roles of sphingosine-1-phosphate signaling in angiogenesis.2010
- Author(s)
  Y Takuwa
- Journal Title
  
  World J Biol Chem.
  
  Volume: 1 Pages: 298-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  N.Takuwa
- Journal Title
  
  Cardiovasc Res
  
  Volume: 85 Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-d nsity lipoprotein in endothelial cells2009
- Author(s)
  Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 84(1) Pages: 127-136
- DOI
  10.1093/cvr/cvp177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] 生体におけるスフィンゴシン-1-リン酸シグナル系の機能2009
- Author(s)
  多久和陽
- Journal Title
  
  実験医学 27
  
  Pages: 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-d nsity lipoprotein in endothelial cells2009
- Author(s)
  K. Sugimoto, T. Ishibashi, T. Sawamura, N. Inoue, M. Kamioka, H. Uekita, H. Ohkawara, T. Sakamoto, N. Sakamoto, Y. Okamoto, Y. Takuwa, A. Kakino, Y. Fujita, T. Tanaka, T. Teramoto, Y. Maruyama, Y. Takeishi
- Journal Title
  
  Cardiovasc Res 84(1)
  
  Pages: 127-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] 生体におけるスフィンゴシン-1-リン酸シグナル系の機能2009
- Author(s)
  多久和陽
- Journal Title
  
  実験医学 27
  
  Pages: 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc422009
- Author(s)
  Shiratsuchi A, Ichiki M, Okamoto Y, Ueda N, Sugimoto N, Takuwa Y, Nakanishi Y.
- Journal Title
  
  J Biochem
  
  Volume: 145(1) Pages: 43-50
- DOI
  10.1093/jb/mvn139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis : Analyses using a new S1P(1) antagonist of non-sphingosine-1-phosphate analog2009
- Author(s)
  Yonesu K, Kawase Y, Inoue T, Takagi N, Tsuchida J, Takuwa Y, Kumakura S, Nara F.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 15 ; 77(6) Pages: 1011-1020
- URL
  http://dx.doi.org/10.1016/j.bcp.2008.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits2009
- Author(s)
  Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 16(6) Pages: 846-856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent-graft.2009
- Author(s)
  H. Zhong, O. Matsui, K. Xu, T. Ogi, J. Sanada, Y. Okamoto, Y. Tabata, Y. Takuwa
- Journal Title
  
  J Vasc Surg 50(6)
  
  Pages: 1433-1443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits.2009
- Author(s)
  H Ohkawara, T Ishibashi, M Shiomi, K Sugimoto, H Uekita, M Kamioka, Y Takuwa, T Teramoto, Y Maruyama, Y Takeishi
- Journal Title
  
  J Atheroscler Thromb 16(6)
  
  Pages: 846-856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] 生体におけるスフィンゴシン-1-リン酸シグナル系の機能2009
- Author(s)
  多久和陽、岡本安雄、杜娃、戚〓、吉岡和晃、多久和典子
- Journal Title
  
  実験医学 27(13)
  
  Pages: 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis: Analyses using a new S1P(1) antagonist of non-sphingosine-1-phosphate analog.2009
- Author(s)
  K. Yonesu, Y. Kawase, T. Inoue, N. Takagi, J. Tsuchida, Y. Takuwa, S. Kumakura, F. Nara
- Journal Title
  
  Biochem Pharmacol 15;77(6)
  
  Pages: 1011-1020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc422009
- Author(s)
  A. Shiratsuchi, M. Ichiki, Y. Okamoto, N. Ueda, N. Sugimoto, Y. Takuwa, Y. Nakanishi
- Journal Title
  
  J. Biochem. 145(1)
  
  Pages: 43-50
- NAID
  10024914309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] AThe role of class II PI 3-kinase signaling pathway in physiology and diseases, Curr Biodata Targeted Proteins Database2009
- Author(s)
  Y. Takuwa
- Journal Title
  
  Bloggs, J (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent-graft2009
- Author(s)
  Zhong H, Matsui O, Xu K, Ogi T, Sanada J, Okamoto Y, Tabata Y, Takuwa Y.
- Journal Title
  
  J Vasc Surg
  
  Volume: 50(6) Pages: 1433-1443
- URL
  http://www.jstage.jst.go.jp/article/jat/16/6/16_2394/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057
[Journal Article] A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P_2 receptor deficient mouse.2008
- Author(s)
  Takabatake M, Takuwa Y, Takuwa N, Yasuno H, Matsumoto S, Shibutani M, Mitsumori K.
- Journal Title
  
  J Vet Med Sci. 70
  
  Pages: 483-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependenton Rho but not Rho kinase.2008
- Author(s)
  S. Takashima, N. Sugimoto, N. Takuwa, Y. Okamoto, K. Yoshioka, M. Takamura, S. Takata, S. Kanekob, Y. Takuwa
- Journal Title
  
  Cardiovasc Res 79(4)
  
  Pages: 689-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse.2008
- Author(s)
  M. Takabatake, T. Takuwa, N. Takuw, H. Yasuno, S. Matsumoto, M. Shibutani, K. Mitsumori
- Journal Title
  
  J Vet Med Sci 70(5)
  
  Pages: 483-485
- NAID
  110006688954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sphingosine-1-phosphatesignaling and biological activitiesin the cardiovascular system2008
- Author(s)
  Y. Takuwa
- Journal Title
  
  Biochim. Biophys. Acta 1781
  
  Pages: 483-488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sphingosine-1-phosphatesignaling and biological activitiesin the cardiovascular system.2008
- Author(s)
  Y. Takuwa, Y. Okamoto, K. Yoshioka, N. Takuwa
- Journal Title
  
  Biochim. Biophys. Acta 1781(9)
  
  Pages: 483-488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] The lysophospholipld mediator sphingoslne-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.2008
- Author(s)
  Oyama o. Sugimoto N, Qi x, Takuwa N. Mizugishi K, Koizumi J, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 78
  
  Pages: 301-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.2008
- Author(s)
  Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N.
- Journal Title
  
  Biochim Biophys Acta. 1781
  
  Pages: 483-488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Sphingosine-1-phosphatesignaling and biological activities in the cardiovascular system2008
- Author(s)
  Y. Takuwa
- Journal Title
  
  Biophys. Biochim. Acta-Mol Cell Biol Lipids (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] G_<(12)/(13)> and Gq mediate S1P_2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.2008
- Author(s)
  Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M, Takata S, Kaneko S, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 79
  
  Pages: 689-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.2008
- Author(s)
  Oyama O, Sugimoto N, Qi X, Takuwa N, Mizugishi K, Koizumi J, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 78
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in, a manner dependent on Rhobut not Rho kinase.2008
- Author(s)
  Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M. Takata S, Kaneko S, Takuwa Y.
- Journal Title
  
  Cardiovasc Res. 79
  
  Pages: 689-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse.2008
- Author(s)
  Takabatake M, Takuwa Y, Takuwa ti, Yasuno H. Matsumoto s. Shibutani M, Mitsumori K.
- Journal Title
  
  J Vet Med Sci. 70
  
  Pages: 483-5
- NAID
  110006688954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischemic hindlimbs of mice.2008
- Author(s)
  O. Oyama, N. Sugimoto, X. Qi, N. Takuwa, K. Mizugishi, J. Koizumi, Y. Takuwa
- Journal Title
  
  Cardiovasc Res 78
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sphingosine-1-phosphatesignaling and biological activities in the cardiovascular system.2008
- Author(s)
  Y. Takuwa
- Journal Title
  
  Biophys. Biochim. Acta-Mol Cell Biol Lipids. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.2008
- Author(s)
  Takuwa Y. Okamoto Y, Yoshioka K, Takuwa N
- Journal Title
  
  Biochim Biophys Acta. 781
  
  Pages: 483-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590288
[Journal Article] Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rhoand Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells.2007
- Author(s)
  K. Yoshioka, N. Sugimoto, N. Takuwa, Y. Takuwa
- Journal Title
  
  Mol Pharmacol 71(3)
  
  Pages: 912-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.2007
- Author(s)
  M. Yano, T. Matsumura, T. Senokuchi, N. Ishii, Y. Murata, K. Taketa, H. Motoshima, T. Taguchi, K. Sonoda, D. Kukidome, Y. Takuwa, T. Kawada, M. Brownlee, T. Nishikawa, E. Araki
- Journal Title
  
  Circ Res 100(10)
  
  Pages: 1442-1451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Satoh Synthesis and SAR studies of a novel class of S1P(1) receptor antaeonists.2007
- Author(s)
  T.Nakamura, K.Yonesu, Y.Mizuno, C.Suzuki, Y.Sakata, Y.Takuwa, F.Nara, S.
- Journal Title
  
  Bioorg Med Chem. 15
  
  Pages: 3548-3564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho-and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells.2007
- Author(s)
  K.Yoshioka, N.Sugimoto, N.Takuwa, Y.Takuwa
- Journal Title
  
  Mol Pharmacol. 71(3)
  
  Pages: 912-920
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] RhoA-dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling.2007
- Author(s)
  T. Sakamoto, T. Ishibashi, K. Sugimoto, N. Sakamoto, H. Ohkawara, M. Niinuma, K. Nagata, M. Kamioka, N. Sugimoto, A. Watanabe, M. Kurabayashi, Y. Takuwa, Y. Maruyama
- Journal Title
  
  Atherosclerosis 193(1)
  
  Pages: 44-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Ca2+-independent, inhibitory effects of cyclic AMP on Ca2+ regulation of phosphoinositide 3-kinase C2a, Rho and myosin phosphatase in vascular smooth muscle2007
- Author(s)
  MA. Azam, K. Yoshioka, S. Ohkura, N. Takuwa, N. Sugimoto, K. Sato, Y. Takuwa
- Journal Title
  
  J. Pharm. Exp. Ther 320(2)
  
  Pages: 907-916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Hypothalamic Neuropeptides and Appetite Response in Anorexia-Cachexia Animal.2007
- Author(s)
  Y. Ueta, H. Hashimoto, E. Onuma, Y. Takuwa, E. Ogata
- Journal Title
  
  Endocr J 54(6)
  
  Pages: 831-838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Ueta Parathyroid Hormone-Related Protein Induces Cachectic Syndromes without Directly Modulating the Expression of Hypothalamic Feeding-Regulating Peptides.2007
- Author(s)
  H.Hashimoto, Y.Azuma, M.Kawasaki, H.Fujihara, E.Onuma, H.Yamada-Okabe, Y.Takuwa, E.Ogata, Y.
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 292-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Parathyroid Hormone-Related Protein Induces Cachectic Syndromes without Directly Modulating the Expression of Hypothalamic Feeding-Regulating Peptides.2007
- Author(s)
  H. Hashimoto, Y. Azuma, M. Kawasaki, H. Fujihara, E. Onuma, H. Yamada-Okabe, Y. Takuwa, E. Ogata, Y. Ueta
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 292-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Synthesis and SAR studies of a novel class of S1P(1) receptor antagonists.2007
- Author(s)
  T. Nakamura, K. Yonesu, Y. Mizuno, C. Suzuki, Y. Sakata, Y. Takuwa, F. Nara, S. Satoh
- Journal Title
  
  Bioorg Med Chem 15
  
  Pages: 3548-3564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Ca2+-independent, inhibitory effects of cyclic AMP on Ca2+ regulation of phosphoinositide 3-kinase C2a, Rho and myosin phosphatase in vascular smooth muscle.2006
- Author(s)
  MA.Azam, K.Yoshioka, S.Ohkura, N.Takuwa, N.Sugimoto, K.Sato, Y.Takuwa
- Journal Title
  
  J. Pharm.Exp.Ther 320(2)
  
  Pages: 907-916
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Takuwa Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor.2006
- Author(s)
  I.Inoki, N.Takuwa, N.Sugimoto, K.Yoshioka, S.Takata, S.Kaneko, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] カルシウムイオンによる血管収縮活性化機構の新展開2006
- Author(s)
  多久和陽
- Journal Title
  
  実験医学 24
  
  Pages: 2812-2816
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor.2006
- Author(s)
  I. Inoki, N. Takuwa, N. Sugimoto, K. Yoshioka, S. Takata, S. Kaneko, Y. Takuwa
- Journal Title
  
  Biochem. Biophys. Res. Commun. 346
  
  Pages: 293-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase.2006
- Author(s)
  R.Zheng, A.Iwase, R.Shen, OB.Goodman Jr, N.Sugimoto, Y.Takuwa, DJ.Lerner, DM.Nanus
- Journal Title
  
  Oncogene. 25(44)
  
  Pages: 5942-5952
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Takuwa Class II phosphoinositide 3-kinase alfa-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.2006
- Author(s)
  Y.Wang, K.Yoshioka, MA.Azam, N.Takuwa, S.Sakurada, Y.Kayaba, N.sugimoto, I.Inoki, T.Kimura, T.Kuwai, Y.
- Journal Title
  
  Biochem J 394
  
  Pages: 581-592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] A new frontier of investigation on the activation mechanisms for calcium ion-dependent enhancement of vascular smooth muscle contraction2006
- Author(s)
  Y. Takuwa
- Journal Title
  
  Jikken Igaku 24(18)
  
  Pages: 2812-2816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] カルシウムイオンによる血管収縮活性化機構の新展開2006
- Author(s)
  多久和陽
- Journal Title
  
  実験医学 24(18)
  
  Pages: 2812-2816
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.2006
- Author(s)
  Wang Y, Yoshioka K, Azam MA, Kimura T, Kuwaki T. Takuwa Y.
- Journal Title
  
  Biochem J. 394(Pr 3)
  
  Pages: 581-592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] PKC phosphorylates MARCKS Ser159 not only directly but also through RhoA/ROCK.2006
- Author(s)
  A. Tanabe, Y. Kamisuki, H. Hidaka, M. Suzuki, M. Negishi, Y. Takuwa
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 156-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA(1) receptor in G(i)-inactivated CHO cells.2006
- Author(s)
  Sugimoto N, Takuwa N, Yoshioka K, Takuwa Y.
- Journal Title
  
  Exp Cell Res. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.2006
- Author(s)
  Wang Y, Yoshioka K, Azam MA, Kimura T, Kuwaki T, Takuwa Y.
- Journal Title
  
  Biochem J. 394(Pt 3)
  
  Pages: 581-592
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] DM. Nanus Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase.2006
- Author(s)
  R. Zheng, A. Iwase, R. Shen, OB. Goodman Jr, N. Sugimoto, Y. Takuwa, DJ. Lerner
- Journal Title
  
  Oncogene 25(44)
  
  Pages: 5942-5952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] カルシウムイオンによる血管収縮活性化機構の新展開2006
- Author(s)
  多久和陽
- Journal Title
  
  24(18)
  
  Pages: 2812-2816
- Data Source
  KAKENHI-PROJECT-18590259
[Journal Article] Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO sells.2006
- Author(s)
  N.Sugimoto, N.Takuwa, K.Yoshioka, Y.Takuwa
- Journal Title
  
  Exp. Cell Res. 312
  
  Pages: 1899-1908
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Sugimoto Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle.2005
- Author(s)
  Y.Takuwa, K.Yoshioka, N.Takuwa, Y.Wang, MA.Azam, N.
- Journal Title
  
  Biomed. Res. 16
  
  Pages: 13-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] スフィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子機構2005
- Author(s)
  多久和典子, 杉本直俊, 多久和陽
- Journal Title
  
  実験医学(増刊号) 23巻6号
  
  Pages: 218-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP.2005
- Author(s)
  Nagasawa SY, Takuwa N, Sugimoto N, Mabuchi H, Takuwa Y.
- Journal Title
  
  Biochem J. 385(Pr 3)
  
  Pages: 737-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Maruyama. Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.2005
- Author(s)
  H.Ohkawara, T.Ishibashi, T.Sakamoto, K.Sugimoto, K.Nagata, K.Yokoyama, N.Sakamoto, M.Kamioka, I.Matsuoka, S.Fukuhara, N.Sugimoto, Y.Takuwa, Y.
- Journal Title
  
  J Biol Chem. 18;280(11)
  
  Pages: 10182-10188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Inhibition of Rac activation as a mechanism for negativeregulation of actin cytoskeletal reorganization and cell motility by cyclic AMP.2005
- Author(s)
  S.Nagasawa, N.Takuwa, N.Sugimoto, H.Mabuchi, Y.Takuwa.
- Journal Title
  
  Biochem J. 385
  
  Pages: 737-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] スフィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子構造2005
- Author(s)
  多久和典子, 杉本直俊, 多久和陽
- Journal Title
  
  実験医学 23
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] スフィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子構造2005
- Author(s)
  多久和典子
- Journal Title
  
  実験医学 23
  
  Pages: 218-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Statins suppress oxidized low-density lipoprotein-induced macrophage proliferation by inactivation of small G protein -p38 MAPK pathway.2005
- Author(s)
  T. Senokuchi, T. Matsumura, M. Sakai, M. Yano, T. Taguchi, K. Sonoda, D. Kukidome, K. Imoto, T. Nishikawa, S. Kim-Mitsuyama, Y. Takuwa, E. Araki
- Journal Title
  
  J. Biol. Chem. 280(8)
  
  Pages: 6627-6633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] RhoA and Rac mediate endothelial cell polarication and detachment induced by T-cadherin.2005
- Author(s)
  M.Philippova, D.Ivanov, R.Allenspach, Y.Takuwa, P.Erne, T.Resink.
- Journal Title
  
  FASEB J. 19(6)
  
  Pages: 588-890
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle.2005
- Author(s)
  Yoh Takuwa
- Journal Title
  
  Biomed. Res. 16
  
  Pages: 13-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] フィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子構造2005
- Author(s)
  多久和典子他
- Journal Title
  
  実験医学 23
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] スフィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子構造2005
- Author(s)
  多久和典子他
- Journal Title
  
  実験医学 23
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Maruyama Endogenous NO Blockade Enhances Tissue Factor Expression via Increased Ca2+ Influx through MCP-1 in Endothelial Cells by Monocyte Adhesion.2005
- Author(s)
  T.Sakamoto, T.Ishibashi, N.Sakamoto, K.Sugimoto, K.Egashira H.Ohkawara, K.Nagata, K.Yokoyama, M.Kamioka, T.Ichiki, N.Sugimoto, M.Kurabayashi, K.Suzuki, Y.Takuwa, Y.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 25(9)
  
  Pages: 2005-2011
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Eguchi Signal-Crosstalk between Rho/ROCK and JNK mediates Migration of Vascular Smooth Muscle Cells stimulated by Angiotensin.2005
- Author(s)
  H.Ohtsu, M.Mifune, G.D.Frank, S.Saito, T.Inagami, S.K.Mitsuyama, Y.Takuwa, T.Sasaki, J.D.Rothstein, H.Suzuki, H.Nakashima, E.A.Woolfolk, E.D.Motley, S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 25
  
  Pages: 1831-1836
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] Inhibition of Rac activation as a mechanism for negativeregulation of actin cytoskeletal reorganization and cell motility by cyclic AMP.2005
- Author(s)
  S. Nagasawa, N. Takuwa, N. Sugimoto, H. Mabuchi, Y. Takuwa
- Journal Title
  
  Biochem J 385
  
  Pages: 737-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.2005
- Author(s)
  H. Ohkawara, T. Ishibashi, T. Sakamoto, K. Sugimoto, K. Nagata, K. Yokoyama, N. Sakamoto, M. Kamioka, I. Matsuoka, S. Fukuhara, N. Sugimoto, Y. Takuwa, Y. Maruyama
- Journal Title
  
  J Biol Chem 18;280(11)
  
  Pages: 10182-10188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Statins suppress oxidized low-density lipoprotein-induced macrophage proliferation by inactivation of small G protein-p38 MAPK pathway.2005
- Author(s)
  T.Senokuchi, T.Matsumura, M.Sakai, M.Yano, T.Taguchi, K.Sonoda, D.Kukidome, K.Imoto, T.Nishikawa, S.Kim-Mitsuyama, Y.Takuwa, E.Araki.
- Journal Title
  
  J. Biol. Chem. Feb 25;280(8)
  
  Pages: 6627-6633
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390054
[Journal Article] RhoA and Rac mediate endothelial cell polarication and detachment induced by T-cadherin.2005
- Author(s)
  M. Philippova, D. Ivanov, R. Allenspach, Y. Takuwa, P. Erne, T. Resink
- Journal Title
  
  FASEB J 19(6)
  
  Pages: 588-890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] スフィンゴシン1リン酸受容体による癌浸潤・転移の制御とその分子構造2005
- Author(s)
  多久和典子他
- Journal Title
  
  実験医学 23(増刊)
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP.2005
- Author(s)
  Nagasawa SY, Takuwa N, Sugimoto N, Mabuchi H, Takuwa Y.
- Journal Title
  
  Biochem J 385(Pt 3)
  
  Pages: 737-744
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.2004
- Author(s)
  D.Shida, J.Kitayama, H.Yamaguchi, K.Hama, J.Aoki, H.Arai, H.Yamashita, K.Mori, A.Sako, T.Konishi, T.Watanabe, T.Sakai, R.Suzuki, H.Ohta, Y.Takuwa, H.Nagawa.
- Journal Title
  
  Exp Cell Res. 301(2)
  
  Pages: 168-178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Blood lipid mediator sphingosine-1-phosphate potently stimulates platelet derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of kruppel-like factor 5.2004
- Author(s)
  S.Usui, N.Sugimoto, N.Takuwa, S.Sakagami, S.Takata, S.Kaneko, Y.Takuwa.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 12300-12311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor2004
- Author(s)
  Usui S, Sugimoto N, Takuwa N, Sakagami S, Takata S, Kaneko S, Takuwa Y.
- Journal Title
  
  J Biol Chem. 279(13)
  
  Pages: 12300-12311
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.2004
- Author(s)
  D.Shida, T.Watanabe, T.Sakai, R.Suzuki, H.Ohta, Y.Takuwa, H.Nagawa
- Journal Title
  
  Exp Cell Res. 301
  
  Pages: 168-178
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] スフィンゴシン-1-リン酸受容体による癌浸潤・転移の制御受容体サブタイブ特異的な促進・抑制二方向性制御とその分子機構2004
- Author(s)
  多久和典子
- Journal Title
  
  金沢大学十全医学会雑誌 113(3・4)
  
  Pages: 93-97
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590221
[Journal Article] Overexpression of phospholopase D prevents actinomycin D induced apoptosis through potentiation of phosphoinositide 3-kinase signaling pathways in Chinese hamster ovary cells.2004
- Author(s)
  M.Yamada, Y.Banno, Y.Takuwa, M.Koda, A.Hara, Y.Nozawa.
- Journal Title
  
  Biochem.J. 378
  
  Pages: 649-656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Divergent signals and cytoskeletal Assemblies regulate self-organizing polarity in neutrophils.2003
- Author(s)
  J.Xu, F.Wang, A.V.Keymeulen, P.Herzmark, A.Straight, K.Kelly, Y.Takuwa, N.Sugimoto, T.Mitchison, H.R.Bourne.
- Journal Title
  
  Cell 114
  
  Pages: 201-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Antiproliferative action of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.2003
- Author(s)
  H.Ikeda, H.Satoh, M.Yanase, Y.Inoue, T.Tomiya, M.Arai, K.Tejima, K.Nagashima, H.Maekawa, N.Yahagi, Y.Tamtomi, S.Sakurada, Y.Takuwa, I.Ogara, S.Kimura, K.Fujiwara.
- Journal Title
  
  Gastroenterology. 124
  
  Pages: 459-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor requirement of inhibition of cellular Rac activity.2003
- Author(s)
  K.Arikawa, N.Takuwa, H.Yamaguchi, N.Sugimoto, J.Kitayama, H.Nagawa, K.Takehara, Y.Takuwa.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 32841-32851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Inhibitory and stimulatory regulation of Rac and cell motility by the G_<12/13>-Rho-and the G_i-pathways integrated downstream of a single G protein coupled sphingosine-1-phosphate receptor isoform.2003
- Author(s)
  N.Sugimoto, N.Takuwa, H.Okamoto, S.Sakurada, Y.Takuwa.
- Journal Title
  
  Mol.Cell.Biol. 23
  
  Pages: 1534-1545
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and hematogenous metastasis of melanoma cells.2003
- Author(s)
  H.Yamaguchi, J.Kitayama, N.Takuwa, K.Arikawa, I.Inoki, K.Takehara, H.Nagawa, Y.Takuwa.
- Journal Title
  
  Biochem.J. 374
  
  Pages: 715-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphatidylinositol 3-kinase or Akt, in chinese hamster ovary cells.2003
- Author(s)
  Y, Banno, Y.Takuwa, M.Yamada, N.Takuwa, K.Ohguchi, A.Hara, Y.Nozawa.
- Journal Title
  
  Biochem.J. 369
  
  Pages: 363-368
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Journal Article] Lysophosphatidic acid enhances metastatic potential of human colon carcinoma DLD1 cells through LPA1.2003
- Author(s)
  D.Shida, J.Kitayama, H.Yamaguchi, Y Okaji, NH.Tsuno, T.Watanabe, Y Takuwa, H.Nagawa.
- Journal Title
  
  Cancer Res. 63
  
  Pages: 1706-1711
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390063
[Patent] 血管内皮関門障害に関連した疾患又は症状を予防及び/又は治療するための候補物質のスクリーニング方法2013
- Inventor(s)
  多久和陽
- Industrial Property Rights Holder
  多久和陽
- Industrial Property Number
  2013-033893
- Filing Date
  2013-02-22
- Data Source
  KAKENHI-PROJECT-24390051
[Patent] S1P2受容体アンタゴニストを含む、粥状動脈硬化治療薬2011
- Inventor(s)
  多久和陽、王飛、岡本安雄
- Industrial Property Rights Holder
  国立大学法人金沢大学
- Filing Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-21390057
[Patent] SIP_2受容体アンタゴニストを含む、粥状動脈硬化治療薬2011
- Inventor(s)
  多久和陽、王飛、岡本安雄
- Industrial Property Rights Holder
  国立大学法人金沢大学
- Filing Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-21390057
[Patent] 非ヒトノックアウト動物、並びにその用途およびその作製方法2011
- Inventor(s)
  多久和陽、吉岡和晃
- Industrial Property Rights Holder
  国立大学法人金沢大学
- Industrial Property Number
  2010-090078
- Filing Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-17014034
[Patent] 非ヒトノックアウト動物、並びにその用途およびその作製方法2010
- Inventor(s)
  吉岡和晃、多久和陽
- Industrial Property Rights Holder
  国立大学法人金沢大学
- Filing Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-21390057
[Patent] 癌細胞の転移を阻害する化合物をインビボの系でスクーリングする方法2009
- Inventor(s)
  多久和陽名川弘一
- Industrial Property Rights Holder
  国立大学法人金沢大学
- Acquisition Date
  2009-05-02
- Data Source
  KAKENHI-PROJECT-17014034
[Patent] スフィンゴシン-1-リン酸を用いた血管新生を促進する方法2005
- Inventor(s)
  多久和陽, 尾山治
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2005-145422
- Filing Date
  2005-05-18
- Data Source
  KAKENHI-PROJECT-17390054
[Presentation] Sequential phosphoinositide conversion is required for TGFβ-induced receptor endocytosis and endosomal receptor signaling in endothelial cells.2020
- Author(s)
  Aki S, Yoshioka K, Takuwa N, Takuwa Y.
- Organizer
  第97回日本生理学会大会　（誌上開催）
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Class II PI3Ks α and βare Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.　Symposium on Angiology Evolving into New Research Fields2020
- Author(s)
  Aki S, Sarker MAK, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y.
- Organizer
  第97回日本生理学会大会（誌上開催）(シンポジウム招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Differential roles of class II PI3-kinase-C2α and -C2αin clathrin-mediated fluid phase endocytosis in vascular endothelial cells.2020
- Author(s)
  Yoshioka K, Aki S, Takuwa N, Takuwa Y.
- Organizer
  第97回日本生理学会大会（誌上開催）
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Sphingosine kinase-2 is required for autophagic lipid degradation in macrophage and inhibits atherosclerosis.2019
- Author(s)
  Takuwa Y, Ishimaru K, Yoshioka K, Takuwa N, Okamoto Y.
- Organizer
  第97回日本生理学会大会（誌上開催）
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] イノシトールリン脂質3'-ホスファターゼMTMR4によるエンド-リソソームおよびオートファジー経路の制御メカニズム2019
- Author(s)
  吉岡和晃, Quynh Hoa Pham, 安藝翔, 多久和典子, 多久和陽
- Organizer
  日本生化学会北陸支部第37回大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Sequential phosphoinositide conversion is required for transforming growth factor β-induced receptor endocytosis and Smad2/3 activation in endothelial cell.2019
- Author(s)
  Aki S, Yoshioka K, Takuwa N, Takuwa Y.
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Regulation of intracellular clearance by 3'-phosphoinositide-specific phosphatase, myotubularin-relatedprotein-4 (MTMR4).2019
- Author(s)
  Yoshioka K, QH Pham, S Aki, N Takuwa, Y Takuwa
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Essential roles of class II PI3K isoforms in endocytosis and endosomal signaling.2019
- Author(s)
  Yoshioka K, Aung KT, Sarker MAK, Aki S, K Yoshioka, Biswas K, N Takuwa， Y Takuwa
- Organizer
  9th Congress of the Federation of the Asian and Oceanian Physiological Societies
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] 連続するホスホイノシタイド代謝がTGFβ受容体エンドサイトーシス及びSmad2/3活性化に必須である2019
- Author(s)
  安藝翔, 吉岡和晃, Islam Shahidu, 多久和典子, 多久和陽
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] 粥状動脈硬化におけるスフィンゴ脂質代謝酵素の役割2019
- Author(s)
  多久和典子, 石丸和宏, 多久和陽
- Organizer
  第29回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] イノシトールリン脂質3’脱リン酸化酵素MTMR4 による細胞内クリアランス制御メカニズム2019
- Author(s)
  吉岡和晃, Quynh Hoa Pham, 安藝翔, 多久和典子, 多久和陽
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] 連続するホスホイノシタイド代謝がTGFβ受容体エンドサイトーシス及びSmad2/3 活性化に必須である.2019
- Author(s)
  安藝翔, 吉岡和晃, 多久和典子, 多久和陽
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Sequential phosphoinositide conversion is required for transforming growth factor b-induced receptor endocytosis and Smad2/3 activation in endothelial cells.2019
- Author(s)
  Aki S, Yoshioka K, Takuwa N, Takuwa Y.
- Organizer
  9th Congress of the Federation of the Asian and Oceanian Physiological Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Differential roles of class II PI3K in endocytosis and endosomal signaling.2019
- Author(s)
  Yoshioka K, Aung KT, Sarker MAK, Aki S, Biswas K, Takuwa N, Takuwa Y.
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor.2018
- Author(s)
  Sarker MAK, S Aki , K Yoshioka, K Kuno, K Ishimaru , N Takuwa， Y Takuwa
- Organizer
  第54回北陸生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] S1P2によるブレオマイシン誘発肺線維症の増悪機構の検討：肺胞マクロファージの細胞廊下制御の関与2018
- Author(s)
  多久和典子，岡本安雄，石丸和宏，多久和陽
- Organizer
  第28回日本病態生理学会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Phosphoinositide-specific 3'-phosphatase, myotubularin-related protein 4 (MTMR4), regulates lysosomal activity and autophagy.2017
- Author(s)
  Pham Quynh Hoa, Kazuaki Yoshioka, Sato Nakamura, MD Azadul Kabir Sarker, Khin Thuzar Aung, Shahidul Islam, Sho Aki, Noriko Takuwa and Yoh Takuwa.
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor.2017
- Author(s)
  SK Azadul, S Aki, K Yoshioka , Kuno, Y Okamoto, AT Khin, PQ Hoa, S Islam, N Takuwa, Y Takuwa.
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] lass II phosphoinositide 3-kinase isoforms PI3K-C2αand PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells.2017
- Author(s)
  AT Khin, K Yoshioka, S Aki, PQ Hoa, SK Azadul, S Islam, K Ishimaru, N Takuwa, Y Takuwa.
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] 抗がん剤による臓器障害におけるスフィンゴシン-1-リン酸（S1P）情報伝達系の関与2017
- Author(s)
  多久和典子, 石丸和宏, 岡本安雄, 多久和陽
- Organizer
  第27回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Endothelial 　Class II PI3K-C2alpha is Necessary for Vasucular Formation and Integrity through Regulating Endocytic Membrane Trafficking.2017
- Author(s)
  Kazuaki Yoshioka, Sho Aki, Noriko Takuwa, Yoh Takuwa.
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells.2017
- Author(s)
  PQ Hoa, K Yoshioka, SK Azadul, AT Khin, S Islam, S Aki, S Nakamura, N Takuwa, Y Takuwa.
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] Phosphotidylinositol 3-kinase class II isoforms, PI3K-C2alpha and PI3K-C2beta are necessary for pinocytosis in endothelial cells.2017
- Author(s)
  Khin Thuzar Aung, Sho Aki, Kazuaki Yoshioka, Pham Hoa Quynh , MD Azadul Kabir Sarker, Islam Shahidul, Noriko Takuwa, Yoh Takuwa.
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells.2017
- Author(s)
  PQ Hoa, K Yoshioka, SK Azadul, AT Khin, S Islam, S Aki, S Nakamura, N Takuwa, Y Takuwa.
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08542
[Presentation] 宿主細胞のスフィンゴシン-1-リン酸受容体を介するがん血行性転移の制御2016
- Author(s)
  多久和典子, 岡本安雄, 多久和　陽
- Organizer
  第26回日本病態生理学会大会
- Place of Presentation
  石川
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Phosphatidylinositol 3-kinase class IIalpha isoform PI3K-C 2alpha is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells.2016
- Author(s)
  Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa , Pham Quynh Hoa, MD Azadul Kabir Sarker, Khin Thuzar Aung, Shahidul Islam, Yoh Takuwa.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] S1P2 による血管新生と血管障壁機能の制御 (シンポジウム　招待講演)2016
- Author(s)
  岡本安雄、杜娃、崔弘、吉岡和晃、多久和典子、多久和陽.
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田
- Year and Date
  2016-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Phosphatidylinositol 3-kinase class IIαisoform PI3K-C2alpha is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells.2016
- Author(s)
  Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa and Yoh Takuwa
- Organizer
  The 2nd Spring Special Symposium of the Japanese Vascular Biology and Medicine Organization
- Place of Presentation
  大阪
- Year and Date
  2016-06-03
- Invited
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] 血管内皮細胞においてクラスII 型PI3K-C2α はTGFβ/Smad シグナル伝達系に必須である2016
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第93回日本生理学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] S1P2, a receptor for the lysophospholipid mediator sphingosine 1-phosphate,2016
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa.
- Organizer
  International Shock Congress Symposium "Microcirculation and endothelial damage in sepsis and shock"
- Place of Presentation
  東京
- Year and Date
  2016-10-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Phosphatidylinositol 3-kinase class II a isoform PI3K-C2a is required for transforming growth factor b-induced receptor endocytosis and endosomal signaling in endothelial cells.2015
- Author(s)
  Sho Aki, Kazuaki Yoshioka, Yasuo, Okamoto, Noriko Takuwa and Yoh Takuwa.
- Organizer
  14 th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
- Place of Presentation
  Sofitel Chain Bridge Hotel（ハンガリー　ブタペスト）
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P-2-) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice.2015
- Author(s)
  Juan juan Zhao Yasuo Okamoto Kazuaki Yoshioka Sho Aki Pham Quynh Hoa Azadul MD Kabir Sarker Khin Thuzar Aung Noriko Takuwa Yutaka Inagaki Chiaki Takahashi Takashi Wada Yoh Takuwa
- Organizer
  第38回日本分子生物学会・第88回日本生化学会
- Place of Presentation
  神戸ポートアイランド（神戸ポートピアホテル　神戸国際会議場　神戸国際展示場　神戸商工会議所）(兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] クラスII α型PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3 シグナリングに必須である2015
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂(東京)
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Role of S1P2 in inflammation and fibrosis.2015
- Author(s)
  Yoh Takuwa Juanjuan Zhao, Yasuo, Okamoto, Kazuaki Yoshioka and Noriko Takuwa.
- Organizer
  14 th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
- Place of Presentation
  Sofitel Chain Bridge Hotel（ハンガリー　ブタペスト）
- Year and Date
  2015-07-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] クラス II PI3-キナーゼ PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3シグナリングに必須である2015
- Author(s)
  安藝　翔、吉岡　和晃、岡本　安雄、多久和　典子、多久和　陽
- Organizer
  第62回中部日本生理学会
- Place of Presentation
  富山大学　五福キャンパス　黒田講堂(富山県富山市)
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Sphingosine 1-phosphate receptor-2 plays a protective role against anaphylaxis and acute lung injury2015
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
- Organizer
  第10回スフィンゴテラピィ（STC）研究会
- Place of Presentation
  ホテルアローレ（石川県）
- Year and Date
  2015-06-16
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through inhibiting eNOS.2014
- Author(s)
  Okamoto Y, Cui H, Yoshioka K, Takuwa N, Zao J, Takuwa Y.
- Organizer
  The 91th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3K-C2αはメンブレン・トラフィック調節を介して血管バリア機能を制御する2014
- Author(s)
  吉岡和晃, 岡本安雄, 多久和典子, 多久和陽
- Organizer
  (シンポジウム講演)第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Endothelial class II PI3K-C2a controls vascular barrier integrity through regulating membrane trafficking.2014
- Author(s)
  Yoshioka K, Takuwa N, Okamoto Y, Takuwa Y.
- Organizer
  The 91th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII 型PI3K-C2αはメンブレン・トラフィック調節を介して血管バリア機能を制御する2014
- Author(s)
  吉岡和晃，岡本安雄，多久和典子，多久和陽
- Organizer
  第91回日本生理学会大会　シンポジウム「心血管系の形態・機能研究の最前線」
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through inhibiting eNOS2014
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Juanjuan Zhao, Yoh Takuwa
- Organizer
  第91回日本生理学会大会　　Symposium “Mechanisms on distributive shock and other blood pressure control failures
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through inhibiting eNOS2014
- Author(s)
  Y Okamoto, H Cui, K Yoshioka, N Takuwa, J Zhao, Y Takuwa
- Organizer
  (シンポジウム講演)第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスIIα型PI3キナーゼ-C2αによる血管新生・バリア機能調節メカニズム2013
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  (シンポジウム講演)第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル(大阪府豊中市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] ClassII PI3-kinase, PI3K-C2alpha, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation2013
- Author(s)
  K Biswas, K Yoshioka, Y Okamoto, N Takuwa, Y Takuwa
- Organizer
  Gordon Reseach Conference Vascular Cell Biology
- Place of Presentation
  Four Points Sheraton / Holiday Inn Express Express Ventura, CA, U.S.A
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] スフィンゴシン1-リン酸特異的2型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く2013
- Author(s)
  崔弘, 岡本安雄, 吉岡和晃, 杜娃, 多久和典子, 張威, Kuntal Biswas, 安藝翔, 趙娟娟, 九田裕一, 浅野雅秀, 芝本利重, 多久和陽
- Organizer
  第90回日本生理学会
- Place of Presentation
  タワーホール船堀(東京)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く2013
- Author(s)
  岡本　安雄　崔　弘　吉岡　和晃　多久和　典子　多久和　陽
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘(宮城県宮城郡)
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く2013
- Author(s)
  岡本安雄, 崔弘, 吉岡和晃, 多久和典子, 多久和陽
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘(宮城県宮城郡)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Sphingosine-1-phosphate receptor-2 negatively regulates eNOS and protects against acute vascular barrier disruption2013
- Author(s)
  Yoh Takuwa
- Organizer
  2013FASEB Summer Research Conference Lysophospholipid and Other Related Mediators - From Bench to Clinic
- Place of Presentation
  Hilton Niseko Village（北海道虻田郡）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Endothelial P13K-C2a, a class II PI3K in angiogenesis and vascular barrier function2013
- Author(s)
  Yoh Takuwa
- Organizer
  Gordon Research Conference Vascular CeU Biology
- Place of Presentation
  Four Points Sheraton / Holiday Inn Express (USA)(招待講演)
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスIIα型PI3キナーゼ-C2αによる血管新生・バリア機能調節メカニズムシンポジウム「血管機能を抑制するシグナリング機構」2013
- Author(s)
  吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] TGFβ1-Smad2/3シグナル伝達系を介した血管新生調節におけるクラスIIαPI3キナーゼPI3K-C2αの機能的役割2013
- Author(s)
  安藝翔, 吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  (シンポジウム講演)第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル(大阪府豊中市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Phosphatidylinositol 3-kinase classII α-isoform contols vesicular trafficking in endothelial cells to serve the essential role in angiogenesis and vascular barrier integrity2013
- Author(s)
  Yoh Takuwa
- Organizer
  第45回動脈硬化学会
- Place of Presentation
  京王プラザホテル(東京都新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Endothelial PI3K-C2a, a class II PI3K, has an essential role in angiogenesis and vascular barrier function2013
- Author(s)
  Yoshioka K, Yoshida K, Biswas K, Takuwa N, et al
- Organizer
  Gordon Reseach Conference Vascular Cell Biology
- Place of Presentation
  Four Points Sheraton / Holiday Inn Express Express Ventura, CA, U.S.A
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] TGFβ1-Smad2/3シグナル伝達系を介した血管新生調節におけるクラスIIαPI3キナーゼPI3K-C2αの機能的役割2013
- Author(s)
  安藝　翔、吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスIIα型PI3キナーゼ-C2αによる血管新生・バリア機能調節メカニズム2013
- Author(s)
  吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会　シンポジウム「血管機能を抑制するシグナリング機構」
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスII型PI3キナーゼC2αはメンブレン・トラフィッキング調節を介する血管形成及び恒常性維持に必須である2013
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  第90回日本生理学会
- Place of Presentation
  タワーホール船堀(東京)
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII 型PI3K-C2αはSARA のエンドソームへの動員を制御しTGFß1-Smad2/3シグナル伝達系を介した血管新生を調節する2013
- Author(s)
  安藝翔，吉岡和晃，岡本安雄，多久和典子，多久和陽
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場/神戸国際展示場/神戸ポートピアホテル（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く2013
- Author(s)
  岡本安雄、崔弘、吉岡和晃、多久和典子、多久和陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く2013
- Author(s)
  岡本　安雄，　崔　弘，　吉岡　和晃，　多久和　典子，　多久和　陽．
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  松島
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く2013
- Author(s)
  岡本　安雄，　崔　弘，　吉岡　和晃，　多久和　典子，　多久和　陽．
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3キナーゼC2αはエンドソーム上でのS1PによるRac1活性化を制御して内皮細胞遊走を調節する2013
- Author(s)
  Kuntal Biswas, 吉岡和晃, 安藝翔, 崔弘, 趙娟娟, 九田裕一, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  第90回日本生理学会
- Place of Presentation
  タワーホール船堀(東京)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] TGFβ1-Smad2/3シグナル伝達系を介した血管新生調節におけるクラスIIαPI3キナーゼPI3K-C2αの機能的役割2013
- Author(s)
  安藝　翔、吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスII型PI3K-C2αはSARAのエンドソームへの動員を制御しTGFß1-Smad2/3シグナル伝達系を介した血管新生を調節する2013
- Author(s)
  安藝翔, 吉岡和晃, 岡本安雄, 多久和典子, 多久和陽
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場/神戸国際展示場/神戸ポートピアホテル(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く2013
- Author(s)
  岡本安雄, 崔弘, 吉岡和晃, 多久和典子, 多久和陽
- Organizer
  (シンポジウム講演)第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル(大阪府豊中市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII 型PI3K-C2αはSARA のエンドソームへの動員を制御しTGFß1-Smad2/3シグナル伝達系を介した血管新生を調節する2013
- Author(s)
  安藝翔，吉岡和晃，岡本安雄，多久和典子，多久和陽
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3キナーゼC2αはエンドソーム上でのRac1活性化を制御してスフィンゴシン-1-リン酸(S1P)による血管内皮細胞遊走・管腔形成を調節する2012
- Author(s)
  Kuntal Biswas, 吉岡和晃, 岡本安雄, 多久和典子, 多久和陽
- Organizer
  第35回日本分子生物学会20第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡(福岡県)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Class II PI3 kinase C2α has a crucial role in vascular formation and barrier integrity2012
- Author(s)
  Kazuaki Yoshioka, Kotaro Yoshida, Noriko Takuwa, Yasuo Okamoto, Yoh Takuwa
- Organizer
  第20回日本血管生物医学会
- Place of Presentation
  あわぎんホール(徳島県)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Essential role of class IIα-isoform PI3 kinase (PI3K-C2α) in sphingosine-1-phosphate (S1P)-induced endothelial cell migration2012
- Author(s)
  Biswas K, Yoshioka K, Takuwa N, Okamoto Y, Takuwa Y
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野県松本文化会館(長野県)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Defective vascular barrier integrity and aneurysm formation in PI3K class II α-isoform C2α-deficient mice2012
- Author(s)
  Yoshioka K, Yoshida K, Cui H, Aki S, Biswas K, Zhao JJ, Takuwa N, et al
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野県松本文化会館(長野県)
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Class II PI3K-C2α is essential for vascular barrier integrity2012
- Author(s)
  Kazuaki Yoshioka, Noriko Takuwa, Yasuo Okamoto, Yoh Takuwa
- Organizer
  International Endotoxin and Innate Immunity Society Meeting 2012 JST-CREST International Symposium "Frontiers in Immunology & Inflammation: From Molecules to Disease"
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3キナーゼC2αは血管形成・血管恒常性維持に必須である2012
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  第35回日本分子生物学会20第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡(福岡県)
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3キナーゼC2は血管形成に必須である2012
- Author(s)
  吉岡和晃, 岡本安雄, 多久和典子, 多久和陽
- Organizer
  第54回日本脂質生化学会
- Place of Presentation
  九州大学医学部百年講堂(福岡市)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Essential role of class IIα-isoform P13 kinase (PI3K-C2a) in sphingosine-1-phosphate(SlP-induced endothelial cell migration2012
- Author(s)
  多久和陽
- Organizer
  第7回スフィンゴテラピィ研究会
- Place of Presentation
  能登ロイヤルホテル(石川県)
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] スフィンゴシン-1-リン酸による血管内皮細胞遊走におけるクラスII型PI3キナーゼC2αの役割2012
- Author(s)
  Kuntal Biswas、吉岡和晃、多久和典子、岡本安雄、多久和陽
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  日長野県松本文化会館(長野)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] クラスII型PI3キナーゼC2αは血管新生・恒常性維持に必須である2012
- Author(s)
  吉岡和晃, 吉田耕太朗, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  第59回中部生理学会
- Place of Presentation
  自然科学研究機構岡崎コンファレンスセンター(愛知県)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] クラスII型PI3キナーゼC2αノックアウトマウスにおける血管障壁機能の異常2012
- Author(s)
  吉岡和晃、吉田耕太朗、崔弘、安藝翔、Kuntal Biswas,趙娟娟、多久和典子、岡本安雄、多久和陽
- Organizer
  89回日本生理学会大会
- Place of Presentation
  日長野県松本文化会館(長野)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Role of sphingosine-1'phosphate in cardiac remodeling and protection2012
- Author(s)
  Yoh Takuwa
- Organizer
  The 1st International Symposium Oil Lipid Mediators
- Place of Presentation
  九州大学医学部百年講堂(福岡県)(招待講演)
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Role of Lysophospholipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis 1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration2011
- Author(s)
  Yoh Takuwa, Noriko Takuwa, Seiichiro Ohkura, Shin-ichiro Takashima, Soichiro Usui2, Shuichi Kaneko, Yasuo Okamoto, Kazuaki Yoshioka
- Organizer
  第32回日本日本炎症・再生医学会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] 血管平滑筋収縮における新しいCa2+標的-ミオシン軽鎖ホスファターゼ2011
- Author(s)
  多久和陽
- Organizer
  第27回スパズム・シンポジウム
- Place of Presentation
  国立京都国際会館(京都府)(招待講演)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] 血管平滑筋収縮における新しいCa2+標的-ミオシン軽鎖ホスファターゼ2011
- Author(s)
  多久和陽
- Organizer
  第27回スパズム・シンポジウム
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis2011
- Author(s)
  Y Okamoto, X Qi, W Du, N Takuwa, K Yoshioka, Y Takuwa
- Organizer
  The 1st Asia-Pacific Vascular Biology Meeting/第19回日本血管生物医学会学術集会
- Place of Presentation
  東京ステーションコンファレンス(東京都)
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis2011
- Author(s)
  Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Xun Qi, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Kazushi Sugihara, Sho Aki, Kuntal Biswas, Masahide Asano, Yoh Takuwa
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(金沢)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Role of Lysophospholipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis2011
- Author(s)
  Yoh Takuwa
- Organizer
  1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration and第32回日本日本炎症・再生医学会シンポジウム
- Place of Presentation
  国立京都国際会館(京都府)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis2011
- Author(s)
  Yasuo Okamoto, Xun Qi, Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yoh Takuwa
- Organizer
  第19回日本血管生物医学会学術集会
- Place of Presentation
  東京ステーションコンファレンス(東京)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] クラスII型PI3キナーゼC2αは血管新生と障壁機能に必須である2011
- Author(s)
  吉岡和晃、吉田耕太郎、崔弘、安藝翔、Kuntal Biswas、多久和典子、岡本安雄、多久和陽
- Organizer
  第88回日本生理学会ポスター
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] ポリ乳酸-グリコール酸共重合体を基材としたスフィンゴシン-1-リン酸徐放微粒子製剤による持続性放出はマウス虚血肢においてAkt/ERK-eNOSを介して血管新生および血管成熟を促進し血流を回復させる2011
- Author(s)
  戚〓、岡本安雄、吉岡和晃、王飛、崔弘、Biswas Kuntal、安藝翔、Dandar Erdembileg、多久和典子、多久和陽
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(金沢)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Class II PI 3 kinase-C2α is essential for angiogenesis and barrier function.2011
- Author(s)
  Yoshioka K, Yoshida K, Cui H, Aki S, Kuntal B, Takuwa N, Okamoto Y, Takuwa Y
- Organizer
  第88回日本生理学会(誌上開催)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Recent progress in lipid mediator sphingosine-1-phosphate research2011
- Author(s)
  Takuwa N, et al.
- Organizer
  First International Joint Meeting of Cellular and Molecular Physiology in Epithelia 　（Plenary lecture）(招待講演)
- Place of Presentation
  北里大学広尾キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis2011
- Author(s)
  K Yoshioka, K Yoshida, H Cui, X Qi, T Wakayama, N Takuwa, et al
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県金沢)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] ポリ乳酸―グリコール酸共重合体を基材としたスフィンゴシン-1-リン酸徐放微粒子製剤による持続性放出はマウス虚血肢においてAkt/ERK-eNOSを介して血管新生および血管成熟を促進し血流を回復させる2011
- Author(s)
  戚勛, 岡本安雄, 吉岡和晃, 崔弘, Biswas K Biswas K, 安藝翔, Dandar E, 多久和典子
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県金沢)
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Role of lysophospholipid mediator sphingosine-1-phosphate in cardiac fibrosis2011
- Author(s)
  Y Takuwa, N Takuwa, S Ohkura, et al
- Organizer
  1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration /第32回日本炎症・再生医学会
- Place of Presentation
  国立京都国際会館・京都府
- Invited
- Data Source
  KAKENHI-PROJECT-23590344
[Presentation] Deficiency of sphingosine-1-phosphate receptor-2 inhibits proinflammatory activities of macrophages and atherosclerosis in apoE-deficient mice.2011
- Author(s)
  Okamoto Y, Wang F, Inoki I, Yoshioka K, Takuwa N, Takuwa Y
- Organizer
  第88回日本生理学会(誌上開催)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] A novel Ca2+-and phosphoinositide 3-kinase-depend mechanism for myosin phosphatase inhibition and Ca2+-sensitization in vascular smooth muscle2011
- Author(s)
  Yoh Takuwa
- Organizer
  Winter workshop「Plenary Lecture」
- Place of Presentation
  光州(Gwanjn韓国)
- Year and Date
  2011-01-25
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Development of Cardiac Fibrosis in Sphingosine Kinase 1 Transgenic Mice through an S1P3 Receptor-mediated Reactive Oxygen Species-dependent Process2010
- Author(s)
  Noriko Takuwa, Seiichiro Ohkura, Shinichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Soichiro Usui, Kazuaki Yoshioka, Masayuki Takamura, Shuichi Kaneko, Yoh Takuwa
- Organizer
  第74回日本循環器学会総会
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] S1P2受容体によるがん血管新生抑制とそのメカニズム2010
- Author(s)
  Takuwa N, Du W, Yoshioka K, Okamoto Y, Takuwa Y.
- Organizer
  第52回日本脂質生化学会シンポジウム1「リゾ脂質受容体研究の新展開」
- Place of Presentation
  群馬
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] クラスIIα型PI3キナーゼC2αは血管新生及びバリアー機能に必須である2010
- Author(s)
  吉岡和晃、多久和典子、岡本安雄、多久和陽
- Organizer
  第18回血管生物医学会
- Place of Presentation
  梅田スカイビル(大阪)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] スフィンゴシン-1-リン酸と血管新生の制御2010
- Author(s)
  多久和陽
- Organizer
  第43回加齢医学研究所シンポジウム
- Place of Presentation
  加齢医学研究所 (宮城県)
- Year and Date
  2010-03-24
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] スフィンゴシン-1-リン酸と血管新生の制御2010
- Author(s)
  多久和陽
- Organizer
  第43回加齢医学研究所シンポジウム
- Place of Presentation
  東北大学加齢医学研究所(仙台)
- Year and Date
  2010-03-24
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] クラスII型PI3キナーゼC2αの血管形成における生理的役割:コンディショナルKOマウスを用いた解析2010
- Author(s)
  吉岡和晃、吉田耕太朗、安藝翔、Kuntal Biswas、Wa Du、Xun Qi、Fei Wang、多久和典子、岡本安雄、多久和陽
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  日盛岡市民文化ホールいわて県民情報交流センター(岩手)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Cardiac remodeling and fibrosis in sphingosine kinase 1 transgenic mice through an S1P_3 receptor-mediated, reactive oxygen species-dependent process2010
- Author(s)
  N.Takuwa, S.Ohkura, S.Takashima, K.Ohtani, Y.Okamoto, S.Usui, K.Yoshioka, M.Takamura, S.Kaneko, Y.Takuwa
- Organizer
  The 74^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] The host cell sphingosine-1-phosphate receptor SIP2 negatively regulates tumor angiogenesis and tumor progression in vivo.2010
- Author(s)
  Takuwa N, Du W, Yoshioka K, Okamoto Y, Takuwa Y.
- Organizer
  第69回日本癌学会学術総会ワークショップ講演
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Signaling of vascular smooth muscle contraction2010
- Author(s)
  Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa.
- Organizer
  1st International Conference on Biorheology
- Place of Presentation
  和光市
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Sphingosine-1-phosphate receptor-2 inhibits tumor angiogenesis and tumor growth in vivo in mice Keystone Symposia Bioactive Lipids2010
- Author(s)
  Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, and Yoh Takuwa
- Organizer
  Biochemistry and Diseases
- Place of Presentation
  ウエステン都ホテル京都(京都)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] スフィンゴシン-1-リン酸と血管新生の制御2010
- Author(s)
  多久和陽
- Organizer
  第43回加齢医学研究所シンポジウム
- Place of Presentation
  加齢医学研究所大会議室(仙台)シンポジウム発表
- Year and Date
  2010-03-24
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] S1P2受容体によるがん血管新生抑制とそのメカニズム2010
- Author(s)
  多久和典子, 杜娃, 吉岡和晃, 岡本安雄, 多久和陽
- Organizer
  第52回日本脂質生化学会シンポジウム1「リゾ脂質受容体研究の新展開」
- Place of Presentation
  伊香保(招待講演)
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Class II PI 3-kinase C2α is required for angiogenesis and barrier integrity.2010
- Author(s)
  Yoshioka K, Takuwa N, Okamoto Y, Takuwa Y.
- Organizer
  第18回日本血管生物医学会学術集会/第8回日韓合同血管生物学シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] The role of vascular Ca2+-PI3KC2 alpha-Rho axis in hypertension of spontaneously hypertensive rats.2010
- Author(s)
  Okamoto Y, Seok Y-M, Azam MA, Sato A, Yoshioka K, Wang F, Hong C, Takuwa N, Takuwa Y.
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Bimodal actions of the cardiac sphingosine-1-phosphate signaling revealed in sphingosine kinase 1 transgenic mice : S1P3-mediated, Rho-and active oxygen- dependent, chronic progression of spontaneous cardiac remodeling and cardioprotection against acutely imposed ischemia/reperfusion injury in sphingosine kinase 1 transgenic mice.2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Usui S, Okamoto Y, Wang F, Du W, Yoahioka K, Takuwa Y
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] S1P2受容体によるがん血管新生抑制とそのメカニズム2010
- Author(s)
  多久和典子、杜娃、吉岡和晃、岡本安雄、多久和陽
- Organizer
  日本脂質生化学会
- Place of Presentation
  森秋旅館(群馬伊香保)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Bimodal actions of the cardiac sphingosine-1-phosphate signaling revealed in sphingosine kinase 1 transgenic mice : S1P3-mediated, Rho-and active oxygen-dependent, chronic progression of spontaneous cardiac remodeling and cardioprotection against acutely imposed ischemia/reperfusion injury.2010
- Author(s)
  多久和典子.
- Organizer
  The 27th Naito Conference "Membrane Dynamics and Lipid Biology [I]"
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Bimodal actions of the cardiac sphingosine-1-phosphate signaling revealed in sphingosine kinase 1 transgenic mice : S1P3-mediated, Rho-and active oxygen-dependent, chronic progression of spontaneous cardiac remodeling and cardioprotection against acutely imposed ischemia/reperfusion injury2010
- Author(s)
  Takuwa N.
- Organizer
  The 27th Naito Conference "Membrane Dynamics and Llipid Biology[I]"
- Place of Presentation
  札幌
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] The host cell sphingosine-1-phosphate receptor S1P2 negatively regulates tumor angiogenesis and tumor progression in vivo.2010
- Author(s)
  多久和典子, 杜娃, 吉岡和晃, 岡本安雄, 多久和陽
- Organizer
  第69回日本癌学会学術総会ワークショップ
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] The role of vascular Ca^<2+>-PI3KC2alpha-Rho axis in hypertension of spontaneously hypertensive rats.2010
- Author(s)
  Okamoto Y, Seok Y-M, Azam MA, Sato A, Yoshioka K, Wang F, Hong C, Takuwa N, Takuwa Y
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Class II PI 3-kinase C2α is required for angiogenesis and barrier integrity.2010
- Author(s)
  吉岡和晃, 多久和典子, 岡本安雄, 多久和陽
- Organizer
  第18回日本血管生物医学会学術集会/第8回日韓合同血管生物学シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Bimodal actions of the cardiac sphingosine-1-phosphate signaling revealed in sphingosine kinase 1 transgenic mice : S1P3-mediated, Rho-and active oxygen-dependent, chronic progression of spontaneous cardiac remodeling and cardioprotection against acutely imposed ischemia/reperfusion injury in sphingosine kinase 1 transgenic mice.2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Usui S, .Okamoto Y, Wang F, Du W, Yoahioka K, Takuwa Y.
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Cardiac remodeling and fibrosis in sphingosine kinase 1 transgenic mice through an S1P_3 receptor-mediated, reactive oxygen species-dependent process.2010
- Author(s)
  Takuwa N., S.Ohkura, S.Takashima, K.Ohtani, Y.Okamoto, S.Usui, K.Yoshioka, M.Takamura, S.Kaneko, Y.Takuwa
- Organizer
  The 74^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Physiological role of class II PI3K-C2alpha for vascular formation : conditional knockout mouse study.2010
- Author(s)
  Yoshioka K, Yoshida K, Aki S, Kuntal B, Du W, Qi, X, Wang F, Takuwa N, Okamoto Y, Takuwa Y
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] スフィンゴシン-1-リン酸と血管新生の制御2010
- Author(s)
  多久和陽
- Organizer
  第43回加齢医学研究所シンポジウム
- Place of Presentation
  加齢医学研究所(宮城県)
- Year and Date
  2010-03-24
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] マウス後肢虚血モデルにおける徐放化S1P製剤を用いた血管新生療法2009
- Author(s)
  戚〓、岡本安雄、村川智美、王飛、尾山治、吉岡和晃、杜娃、多久和典子、多久和陽
- Organizer
  第17回日本血管生物医学会
- Place of Presentation
  東京大学(東京)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Host cell S1P_2 receptor negatively regulates tumor growth and angiogenesis in vivo.2009
- Author(s)
  杜娃, 多久和典子, 吉岡和晃, 岡本安雄, 浅野雅秀, 多久和陽
- Organizer
  4^<th> Interbnational Conference on Phospholopase A_2 and Lipid Mediators
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] マウス後肢虚血モデルにおける徐放化S1P製剤を用いた血管新生療法2009
- Author(s)
  戚〓, 岡本安雄, 村川智美, 尾山治, 王飛, 吉岡和晃, 杜娃, 杉本直俊, 多久和典子, 多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 心筋リモデリングにおけるスフィンゴシン-1-リン酸情報伝達系の病態生理学的役割-スフィンゴシンキナーゼ1トランスジェニックマウスを用いた検討-2009
- Author(s)
  多久和典子,大倉誓一郎,高島伸一郎,大谷啓輔,薄井荘一郎,岡本安雄,王飛,杜娃,吉岡和晃,多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  石川県立音楽堂(金沢)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] 脂質メディェーターS1PによるS1P2受容体を介した腫瘍血管新生の抑制2009
- Author(s)
  杜娃, 多久和典子, 吉岡和晃, 岡本安雄, 多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 血管内皮細胞のTGFb1-Smadシグナル伝達系におけるクラスIIa型PI3キナーゼC2aの役割2009
- Author(s)
  安藝翔,吉岡和晃,岡本安雄,多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  石川県立音楽堂(金沢)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] RHOMLC PHOSPHATASE PATHWAY IN HYPERTENSION2009
- Author(s)
  Yasuo Okamoto, Mohammed Ali Azam, Kazuaki Yoshioka, Yoh Takuwa
- Organizer
  The 36th Congress of the International Union of Physiological Sciences
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] マウス後肢虚血モデルにおける徐放化S1P製剤を用いた血管新生療法2009
- Author(s)
  戚〓、岡本安雄、村川智美、王飛、尾山治、吉岡和晃、杜娃、多久和典子、多久和陽
- Organizer
  第17回日本血管生物医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR2009
- Author(s)
  多久和陽
- Organizer
  International Conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  学術総合センター (東京都)
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR2009
- Author(s)
  Yoh Takuwa
- Organizer
  International Conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] G_<(12)/(13)> and G_q coordinately mediate S1P_2-induced inhibition of Rac and migration in vascular smooth muscle in a Rho-dependent manner.2009
- Author(s)
  Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M, Kaneko S, Takuwa Y
- Organizer
  第73回日本循環器学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Host cell S1P_2 receptor negatively regulates tumor growth and angiogenesis in vivo2009
- Author(s)
  Du W, Takuwa N, Yoshioka K, Okamoto Y, Asano M, Takuwa Y.
- Organizer
  4^<th> Interbnational Conference on Phospholopase A_2 and Lipid Mediators
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR2009
- Author(s)
  多久和陽
- Organizer
  International Conference on Phospholipase A2 and Linid Mediators
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Masahide Asano and Yoh Takuwa HOST CELL S1P2 RECEPTOR NEGATIVELY REGULATES TUMOR GROWTH AND ANGIOGENESIS IN VIVO International Conference on Phospholipase A2 and Lipid Mediators2009
- Author(s)
  Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto
- Place of Presentation
  National Center of Sciences(東京)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] HOST CELL S1P2 RECEPTOR NEGATIVELY REGULATES TUMOR GROWTH AND ANGIOGENESIS IN VIVO2009
- Author(s)
  Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Masahide Asano and Yoh Takuwa.
- Organizer
  International Conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] 腫瘍血管新生におけるスフィンゴシンー1-リン酸受容体S1P2の役割2009
- Author(s)
  Wa Du,多久和典子,吉岡和晃,岡本安雄, Xun Qi, Fei Wang, Hong Cui, Kuntal Biswas,杉原一司,浅野雅秀,多久和陽
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] INVOLVEMENT OF THE Ca2+-PI3K-C2ALPHARHO-MLC PHOSPHATASE PATHWAY IN HYPERTENSION2009
- Author(s)
  Yasuo Okamoto, Mohammed Ali Azam, Kazuaki Yoshioka, Yoh Takuwa
- Organizer
  The 36th Congress of the International Union of Physiological Sciences
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] The role of S1P_2, the angiogenesis inhibitory receptor for sphingosine-1-phosphate, in tumor growth and angiogenesis in vivo.2009
- Author(s)
  Wa Du, 多久和典子, 吉岡和晃, 岡本安雄, Xun Qi, Fei Wang, Hong Cui, Kuntal Biswas, 杉原一司, 浅野雅秀, 多久和陽
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸(招待講演)
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 心筋リモデリングにおけるスフィンゴシン-1-リン酸情報伝達系の病態生理学的役割-スフィンゴシンキナーゼ1トランスジェニックマウスを用いた検討-2009
- Author(s)
  多久和典子, 大倉誓一郎, 高島伸一郎, 大谷啓輔, 薄井荘一郎, 岡本安雄, 王飛, 杜娃, 吉岡和晃, 多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 脂質メディエーターS1PによるS1P2受容体を介した腫瘍血管新生の抑制2009
- Author(s)
  杜娃、多久和典子、吉岡和晃、岡本安雄, 多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 心筋リモデリングにおけるスフィンゴシン-1-リン酸情報伝達系の病態生理学的役割 ―スフィンゴシンキナーゼ1トランスジェニックマウスを用いた検討―2009
- Author(s)
  多久和典子, 大倉誓一郎, 高島伸一郎, 大谷啓輔, 薄井荘一郎, 岡本安雄, 王飛, 杜娃, 吉岡和晃, 多久和陽
- Organizer
  第56回中部日本生理学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 血管平滑筋のシグナル伝達2009
- Author(s)
  多久和陽
- Organizer
  第24回日本ショック学会
- Place of Presentation
  金沢市文化ホール(金沢)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] S1P2 IS AN ANGIOGENESIS-SUPPRESSIVE RECEPTOR International Conference on Phospholipase A2 and Lipid Mediators2009
- Author(s)
  Yoh Takuwa
- Place of Presentation
  National Center of Sciences(東京)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] The role of S1P_2, the angiogenesis inhibitory receptor for sphingosine-1-phosphate, in tumor growth and angiogenesis in vivo2009
- Author(s)
  Wa Du, 多久和典子, 吉岡和晃, 岡本安雄, Xun Qi, Fei Wang, Hong Cui, Kuntal Biswas, 杉原一司, 浅野雅秀, 多久和陽
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Atsusi Sato Noriko Takuwa The pathophysiolosical roles of phosphoinositide 3-kinase(PI3K) class II a-isoform, a Ca2+-dependent regulator of Rho in vascular smooth blood pressure regulation Post-Genomic Advances in the Physiology of Smooth2009
- Author(s)
  Yoh Takuwa, Kazuaki Yoshioka, Yasuo Okamoto Mohammed Ali Azam, Young Mi Seok
- Organizer
  Muscle Satellite Symposium of IUPS 2009
- Place of Presentation
  名古屋市立大学病院(名古屋)
- Data Source
  KAKENHI-PROJECT-21390057
[Presentation] Sphingosine-1-phosphate signaling in tumor biology2008
- Author(s)
  Yoh, Takuwa
- Organizer
  THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP 2008
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Sphingosine-1-phosphate signaling in tumor biology2008
- Author(s)
  Yoh Takuwa
- Organizer
  THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP 2008
- Place of Presentation
  京都
- Year and Date
  2008-03-20
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Sphingosine-1-phosphate signaling in tumor biology THE U.S. -JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP2008
- Author(s)
  Yoh Takuwa, Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto
- Place of Presentation
  (平安会館)京都
- Year and Date
  2008-03-20
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] スフィンゴシン-1-リン酸(S1P)シグナリングと血管新生Sphingosine-1-phosphate signaling and angiogenesis(シンポジウム、リゾリン脂質の新しい機能Novel roles of lysophsopholipids)2008
- Author(s)
  多久和陽, 杜娃, 戚〓, 尾山治, 岡本安雄, 吉岡和晃, 多久和典子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸(招待講演)
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 徐放化S1P製剤による虚血後血管新生の促進2008
- Author(s)
  戚〓、村川智美、尾山治、杉本直俊、王飛、杜娃、吉岡和晃、岡本安雄、多久和典子、水岸貴代美、多久和陽
- Organizer
  第50回日本脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Sphingosine-1-phosphate signaling in tumor biology2008
- Author(s)
  Yoh Takuwa
- Organizer
  THE U. S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP 2008
- Place of Presentation
  京都
- Year and Date
  2008-03-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates tumor growth and angiogenesis in vivo.2008
- Author(s)
  杜娃, 多久和典子, 吉岡和晃, 岡本安雄, 浅野雅秀, 多久和陽
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] Sphingosine-1-phosphate signaling in tumor biology2008
- Author(s)
  Takuwa, Y.
- Organizer
  The U.S.-JAPAN Cooperative Cancer Research Program Workshop 2008
- Place of Presentation
  京都
- Year and Date
  2008-03-20
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Sphingosine-1-phosphate receptor-2 (S1P2)negatively regulates tumor growth and angiogenesis in vivo.2008
- Author(s)
  Du W, Takuwa N, YoshiokaK, Okamoto Y, Asano M, Takuwa Y.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] 徐放化SIP製剤による虚血後血管新生の促進2008
- Author(s)
  戚〓, 村川智美, 尾山治, 杉本直俊, 王飛, 杜娃, 吉岡和晃, 岡本安雄, 多久和典子, 水岸貴代美, 多久和陽
- Organizer
  第50回日本脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20590288
[Presentation] スフィンゴシンキナーゼ1a トランスジェニックマウスにおける心筋線維化の発症2007
- Author(s)
  多久和典子
- Organizer
  第80回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Transgenic overexpression of sphingosine kinase 1a in mice provokes cardiac fibrosis but not increased spontaneous malignancy.2007
- Author(s)
  Y. Takuwa
- Organizer
  3ed International Cconference on Phospholopase A2 and Lipid Mediators Gland Hotel Vesuvio
- Place of Presentation
  イタリア
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] スフィンゴシンキナーゼ1aトランスジェニックマウスにおける心筋線維化の発症2007
- Author(s)
  多久和典子
- Organizer
  第80回日本生化学会シンポジウム『リゾリン脂質メディエーター研究の新展開』シンポジスト
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Transgenic overexpression of sphingosine kinase la in mice provokes cardiac fibrosis but not increased spontaneous malignancy2007
- Author(s)
  Y. Takuwa
- Organizer
  3rd International Conference on Phospholopase A2 and Lipid Mediators
- Place of Presentation
  イタリア
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] スフィンゴシンキナーゼ1a トランスジェニックマウスにおける心筋線維化の発症2007
- Author(s)
  多久和典子
- Organizer
  第80回日本生化学会シンポジウム『リゾリン脂質メディエーター研究の新展開』シンポジスト
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] 尾形悦郎癌悪液質モデルラットにおける視床下部摂食関連遺伝子発現とPTHrPの関与2007
- Author(s)
  上田陽一、橋本弘史、東由美子、小沼悦郎、岡部尚文、鈴木仁士、川崎展、藤原広明、多久和陽
- Organizer
  第80回日本内分泌学会東京国際フォーラム
- Place of Presentation
  東京
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Development of cardiac fibrosis but not spontaneous malignancy in mice transgenic for sphingosine kinase la Symposium : Frontiers of lysophospholipid mediator research2007
- Author(s)
  Noriko, Takuwa
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan ; The 80th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Transgenic overexpression of sphingosine kinase la in mice provokes cardiac fibrosis but not increased spontaneous malignancy2007
- Author(s)
  Y. Takuwa
- Organizer
  3ed International Cconference on Phospholopase A_2 and Lipid Mediators
- Place of Presentation
  Solent (Italy)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Transgenic overexpression of sphingosine kinase la in mice provokes cardiac fibrosis but not increased spontaneous malignancy2007
- Author(s)
  Y. Takuwa
- Organizer
  3ed International Cconference on Phosphol opase A_2 and Lipid Mediators
- Place of Presentation
  ソレント(イタリア)
- Year and Date
  2007-05-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Transgenic overexpression of sphingosine kinase la in mice provokes cardiac fibrosis but not increased spontaneous malign ancy2007
- Author(s)
  Takuwa Y.
- Organizer
  The Third lnternational Conference on Pbospholipase A_2 and Lipid Mediators
- Place of Presentation
  ソレント(イタリア)
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Age-dependent progression of cardiac fibrosis but not spontaneous malignancy in sphingosine kinase 1 transgenic mice2006
- Author(s)
  Noriko Takuwa
- Organizer
  第20回国際生化学・分子生物学会議/ 第11回アジア・オセアニア生化学者・分子生物学者連合会議第79回日本生化学会大会、第29回日本分子生物学会年会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Age-dependent progression of cardiac fibrosis but not spontaneous malignancy in sphingosine kinase 1 transgenic mice2006
- Author(s)
  Noriko, Takuwa
- Organizer
  The 20th International Congress on Biochemistry and Molecular Biology/The 11th Asia-Oceania Joint Meeting of Biochemists and Molecular Biologists ; The29th Annual Meeting of the Molecular Biology Society of Japan/The 79th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590259
[Presentation] Regulation of Akt activation and cell migration by Lysophosphatidic acid (LPA)2006
- Author(s)
  Naotoshi Sugimoto, Noriko Takuwa, Yoh Takuwa
- Organizer
  第20回国際生化学・分子生物学会議/第79回日本生化学会大会国立京都国際会館
- Place of Presentation
  京都宝ヶ池プリンスホテル(京都)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] S1P2受容体を介したB16メラノーマ細胞の制御2005
- Author(s)
  多久和典子, 杉本直俊, 尾山治, 多久和陽
- Organizer
  第82回日本生理学会大会
- Place of Presentation
  仙台国際センター(仙台)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Y. Lysophosphatidic acid (LPA) receptor LPA1/Edg2 generates both the stimulatory and inhibitory signals for Rac and cell migration.2005
- Author(s)
  Sugimoto. N, Takuwa. N, Takuwa
- Organizer
  International Union of Physiological Sciences 2005.
- Place of Presentation
  Pali Mountain, (アメリカ)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Sphingosine 1-phosphate receptor-2 plays a protective role against lipopolysaccharide (LPS)-induced acute lung injury.
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Sho Aki, JuanJuan Zhao, Hoa Quynh Pham, Md. Azadul Kabir Sarker, Saori Koizumi, Yoh Takuwa
- Organizer
  第92回日本生理学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] クラスIIα型PI3K-C2αはALK5 内在化及び足場タンパクSARA のエンドソームへの動員を制御しTGFβ1-Smad2/3 を介した血管新生を調節する
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] クラスIIα型PI3K-C2αはALK5 内在化及び足場タンパクSARA のエンドソームへの動員を制御しTGF-1-Smad2/3 を介した血管新生を調節する
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府・東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates eNOS and protects against acute vascular barrier disruption.
- Author(s)
  Yasuo Okamoto, Cui Hong, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Sphingosine 1-phosphate receptor-2 plays a protective role against lipopolysaccharide (LPS)-induced acute lung injury
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Sho Aki, JuanJuan Zhao, Hoa Quynh Pham, Md. Azadul Kabir Sarker, Saori Koizumi, Yoh Takuwa
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県・神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] 292.安藝翔、吉岡和晃、多久和典子、岡本安雄、多久和陽　クラスII 型PI3 キナーゼ-C2α によるTGFβ 血管内皮作用の調節機構
- Author(s)
  安藝翔、吉岡和晃、多久和典子、岡本安雄、多久和陽
- Organizer
  第61回中部日本生理学会
- Place of Presentation
  名古屋市立大学桜山キャンパス（愛知県名古屋市）
- Year and Date
  2014-11-06 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Distinct role of S1P2 in the functional regulation of vascular endothelium and smooth muscle
- Author(s)
  Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates eNOS and protects against acute vascular barrier disruption
- Author(s)
  Yasuo Okamoto, Cui Hong, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Distinct role of S1P2 in the functional regulation of vascular endothelium and smooth muscle.
- Author(s)
  Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-26460374
[Presentation] Essential role of PI3K class II α for endosomal signaling of S1P1 and other receptors
- Author(s)
  Yoh Takuwa
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Invited
- Data Source
  KAKENHI-PROJECT-24390051

1. TAKUWA Yoh (60171592)

# of Collaborated Projects: 12 results

# of Collaborated Products: 171 results
2. YOSHIOKA Kazuaki (80333368)

# of Collaborated Projects: 8 results

# of Collaborated Products: 69 results
3. SUGIMOTO Naotoshi (80272954)

# of Collaborated Projects: 8 results

# of Collaborated Products: 33 results
4. SAKURADA Sotara (00215691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKAMOTO Yasuo (80293877)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
6. HAMADA Kyoko (20262024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HOSHI Takeshi (60004537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MARUYAMA Yoshio (00133942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUNAGA Hiroshi (50165841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. USUI Soichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. WADA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. KIDOYA Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. OTA Tsuguhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. KOSAKA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. HASHIMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. KITA Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. MIZUGISHI Kiyomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. AKI Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
21. 石丸和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
22. 池田均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 高村雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 大西英生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 上田陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 斎藤芳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 高橋和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 御簾博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 竹下有美枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 五十嵐淳介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 窪田泰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 榊原紀和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 塚本郁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 王英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 成瀬恵治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 竹石恭知

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKUWA Noriko 多久和 典子

多久和 典子 タクワ ノリコ

Research Projects

Research Products

Co-Researchers

Investigation on the roles for sphingolipid signaling in the regulation of macrophage functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Strategy for Controlling Chronic Inflammation and Fibrosis: Targeting Sphingolipid SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of tumor angiogenesis and metastasis, and postischemic angiogenesis by sphingosine-1-phosphate signaling systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiological roles of the sphingosine-1-phosphate signaling system in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisums for S1P_2 G protein coupled receptor-mediated inhibition of tumor progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological and pathophysiological roles of the S1P signaling system : an in vivo studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on physiological roles of sphingosine-1-phosphate signaling system using genetically engineered mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

TAKUWA Noriko 多久和典子

多久和典子タクワノリコ