okamoto yasuo 岡本安雄

… Alternative Names

Researcher Number	80293877
Other IDs
External Links
Affiliation (Current)	2021: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 川崎医科大学, 医学部, 教授 2016 – 2017: 川崎医科大学, 医学部, 教授 2014 – 2015: 金沢大学, 医学系, 准教授 2008 – 2012: 金沢大学, 医学系, 准教授 2008: 金沢大学, 大学院・医学系研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General pharmacology / Emergency medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator General medical chemistry / General pharmacology / Biological Sciences / General physiology / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator スフィンゴシン1-リン酸 / N-アシルエタノールアミン / N-アシルホスファチジルエタノールアミン / アナンダミド / エンドカンナビノイド / ホスホリパーゼD / 脂質メディエーター / エンドセリン受容体 / 脱感作機構 / スフィンゴシン-1-リン酸 … More Except Principal Investigator 脂質メディエーター / がん / 血管新生 / N-アシルエタノールアミン / アナンダミド / エンドカンナビノイド / 酵素 / リン脂質 / ホスホリパーゼD / エンドセリン / スフィンゴシン-1-リン酸 / S1P_2 / 血管成熟 / ノックアウトマウス / SIP_2 / S1P / Edg受容体 / 浸潤 / 転移 / 遊走 / Rac / Rho / SIP / N-アシルトランスフェラーゼ / リソソーム / 酸素 / アシル基転移酸素 / スフィンゴシンー１－リン酸 / イノシトールリン脂質 / PI3-キナーゼ / シグナル伝達 / 血管障壁 / 血管医学 / 脂質 / 循環器・高血圧 / 生体分子 / 生理学 / 循環器疾患 / メラノーマ / アポトーシス / ニーマンピック / コレラ毒素 / 受容体 / 伊東細胞 / カベオラ / コレステロール / endothelin / receptor / cancer / melanoma / apoptosis / Niemann-Pick / cholesterol / 血管平滑筋 / 非選択的陽イオンチャンネル / ストア作動性Ca^<2+>チャンネル / SK＆F96365 / LOE908 / trp / カルシウムチャンネル / クローニング / ストア作動性カルシウムチャンネル / カルシウム / endothelin-1 / vascular smooth muscle cell / nonselective cation channels / store-operated Ca^<2+> channel / SK＆F 96365 / LOE 908 / transient receptor potential / ボスホリパーゼD / メタロ-βーラクタマーゼ・ファミリー / メタロ-β-ラクタマーゼ・ファミリー / N-acylethanolamine / anandamide / endocannabinoid / enzyme / lipid mediator / phospholipase D / metallo-□-lactamase family / phospholipid / 性差 / 糖尿病 / 血管機能 / ヒスチジン脱炭酸酵素 Less

A novel strategy for controlling lung fibrosis: Targeting bioactive lysophospholipid-degrading enzymePrincipal Investigator
- Principal Investigator
  
  岡本安雄
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
血管内皮機能に着目した糖尿病性血管障害発症機序の性差の解明と性差医療への応用
- Principal Investigator
  
  竹之内康広
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kawasaki Medical School
A novel strategy of acute lung injury: Targeting sphingolipid signalingPrincipal Investigator
- Principal Investigator
  
  Okamoto Yasuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Kawasaki Medical School
  Kanazawa University
Mechanisms for the regulation of vascular homeostasis by functional lipid molecules
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kanazawa University
Research of developmental engineering of the sphingosine-1-phosphate receptor as a target molecules of antiatherosclerotic drugPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yasuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kanazawa University
Analysis on the metabolism and physiological function of anandamide and related fatty acid amide compounds
- Principal Investigator
  
  UEDA Natsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kagawa University
Elucidation of physiological finction of anandamide, an endogenous marijuana-like substance, in mammalsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yasuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kanazawa University
  Kagawa University
Signaling for regulating hematogenous metastasis of tumors
- Principal Investigator
  
  TAKUWA Yoh
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Functional analysis of a novel enzyme of the phospholipase D type involved in the endocannabinoid
- Principal Investigator
  
  UEDA Natsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kagawa University
内因性マリファナ様物質アナンダミドの生合成に係る新規ホスホリパーゼDの解析Principal Investigator
- Principal Investigator
  
  岡本安雄
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagawa University
The structure and function of Ca^<2+>-permeable nonselective cation channels
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
  Kyoto University
エンドセリン受容体の脱感作機構Principal Investigator
- Principal Investigator
  
  岡本安雄
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Regulation of endothelin receptor expression through cancer cell differentiation
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tottori University

[Book] Bioactive Lipid Mediators2015
- Author(s)
  Noriko Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa
- Total Pages
  426
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15K10970
[Book] ミオシン軽鎖キナーゼ(血管生物医学事典)2011
- Author(s)
  岡本安雄
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22590284
[Book] 脂質メディエーター(血管生物医学事典)2011
- Author(s)
  岡本安雄
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22590284
[Book] 脂質メディエーター2011
- Author(s)
  岡本安雄
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts2020
- Author(s)
  Takenouchi Y, Kitakaze K, Tsuboi K, Okamoto Y
- Journal Title
  
  Experimental Cell Research
  
  Volume: in press Pages: 112010-112010
- DOI
  10.1016/j.yexcr.2020.112010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-20K11571
[Journal Article] Chronic Treatment with α-Lipoic Acid Improves Endothelium-Dependent Vasorelaxation of Aortas in High-Fat Diet-Fed Mice2019
- Author(s)
  Takenouchi Y, Tsuboi K, Ohsuka K, Nobe K, Ohtake K, Okamoto Y, Kasono K
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 9 Pages: 1456-1463
- DOI
  10.1248/bpb.b18-00800
- NAID
  130007700165
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-19K11731, KAKENHI-PROJECT-17K01852
[Journal Article] Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.2019
- Author(s)
  Ishimaru Kazuhiro、Yoshioka Kazuaki、Kano Kuniyuki、Kurano Makoto、Saigusa Daisuke、Aoki Junken、Yatomi Yutaka、Takuwa Noriko、Okamoto Yasuo、Proia Richard L.、Takuwa Yoh
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Pages: 18329-18329
- DOI
  10.1038/s41598-019-54877-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07864, KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542
[Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.2018
- Author(s)
  1.Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y
- Journal Title
  
  PLoS One
  
  Volume: 印刷中
- NAID
  120006605152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10970
[Journal Article] Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.2017
- Author(s)
  Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 12
- DOI
  10.1371/journal.pone.0182329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15K09135, KAKENHI-PROJECT-15K10970, KAKENHI-PROJECT-17H04166
[Journal Article] Sphingosine-1-phosphate receptor type 2 (S1P2) inhibits bleomycininduced cellular senescence in murine lung fibroblasts2016
- Author(s)
  Juanjuan Zhao, Yasuo Okamoto, Yoh Takuwa
- Journal Title
  
  十全医学会雑誌
  
  Volume: 125
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10970
[Journal Article] 脂質メディエータースフィンゴシン1-リン酸による血管障壁機能の制御2015
- Author(s)
  岡本安雄
- Journal Title
  
  十全医学会雑誌
  
  Volume: 123 Pages: 114-118
- NAID
  120005568313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10970
[Journal Article] Phosphatidylinositol 3-Kinase Class II α-Isoform PI3K-C2α Is Required for Transforming Growth Factor β-induced Smad Signaling in Endothelial Cells.2015
- Author(s)
  Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Pages: 6086-105
- DOI
  10.1074/jbc.m114.601484
- NAID
  120005593954
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26460374, KAKENHI-PROJECT-15K10970, KAKENHI-PROJECT-26460292, KAKENHI-PROJECT-15H04673
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis byinducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia.
  
  Volume: 57 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells.2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perstective
  
  Volume: 2 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice2013
- Author(s)
  Cui H, Okamoto Y, Yoshioka K, et al.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 132 Pages: 1205-1214
- DOI
  10.1016/j.jaci.2013.07.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25670162
[Journal Article] Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis.2013
- Author(s)
  Takuwa N, Okamoto Y, Yoshioka K, Takuwa Y.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 33 Pages: 96-108
- NAID
  130004943837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390051
[Journal Article] Essential role of class II PI3K-C2α in sphingosine-1-phosphate receptor-1 mediated signaling and migration in endothelial cells.2013
- Author(s)
  Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, TakuwaY
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 2325-2339
- DOI
  10.1074/jbc.m112.409656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-23116509
[Journal Article] Essential role of endothelial class II PI3K-C2a in angiogenesis and vascular barrier function.2012
- Author(s)
  Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz JR, Okamoto H, Sasaki T,Matsui O, Asano M, Adams HR, Takakura N, Takuwa Y.
- Journal Title
  
  Nat Med
  
  Volume: 18 Pages: 1560-1569
- DOI
  10.1038/nm.2928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-23500493, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PROJECT-24300330, KAKENHI-PROJECT-24390051, KAKENHI-PLANNED-22112005, KAKENHI-PUBLICLY-23116509
[Journal Article] Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novei Therapeutic Targets for Atherosclerosis2011
- Author(s)
  Okamoto Y
- Journal Title
  
  Pharmaceuticals
  
  Volume: 4 Pages: 117-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] スフィンゴシン1-リン酸シグナル伝達系2011
- Author(s)
  岡本安雄
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 138 Pages: 166-167
- NAID
  10029768003
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate spastic radial artery in coronary artery bypass grafting surgery2011
- Author(s)
  Takagi T, Okamoto Y, Tomita S, Sato A, Yamaguchi S, Takuwa Y, Watanabe G
- Journal Title
  
  J Thorac Cardiovasc Surg
  
  Volume: 142 Pages: 59-65
- URL
  http://dx.doi.org/10.1016/j.jtcvs.2011.01.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] スフィンゴシン1-リン酸シグナル伝達系の心血管系における機能2011
- Author(s)
  岡本安雄
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 536-544
- NAID
  10029069215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] スフィンゴシン-1-リン酸シグナル伝達系の新血管系における機能2011
- Author(s)
  岡本安雄,吉岡和晃,多久和典子,多久和陽
- Journal Title
  
  生化学
  
  Volume: 8 Pages: 536-544
- URL
  http://www.jbsoc.or.jp/event/magazine/pdf/83-06-10.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis Pharmaceuticals2011
- Author(s)
  Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y
- Volume
  4
- Pages
  117-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y
- Journal Title
  
  Cardiovascular Research
  
  Volume: 85(3) Pages: 484-493
- DOI
  10.1093/cvr/cvp312
- NAID
  120001939472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-21591414, KAKENHI-PROJECT-22590284
[Journal Article] Sustained delivery of sphingosine-1-phosphate usingpoly(lactic-co-glycolic acid)-based microparticles stimulatesAkt/ERK-eNOS mediated angiogenesis and vascular maturation restoringblood flow in ischemic limbs of mice2010
- Author(s)
  Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 634(1-3) Pages: 121-131
- DOI
  10.1016/j.ejphar.2010.02.038
- NAID
  120002086439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22590284
[Journal Article] the G protein-coupled receptor for sphingosine-1-phosphate, negativelyregulates tumor angiogenesis and tumor growth in vivo in mice2010
- Author(s)
  Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.
- Journal Title
  
  CancerRes.
  
  Volume: 70(2) Pages: 772-781
- DOI
  10.1158/0008-5472.can-09-2722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22590284
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
- Author(s)
  N. Takuwa, S. Ohkura, S. Takashima, K. Ohtani, Y. Okamoto, T. Tanaka, K, Hirano, S. Usui, F. Wang, W. Du, K. Yoshioka, Y. Banno, M. Sasaki, I. Ichi, M. Okamura, N. Sugimoto, K. Mizugishi, Y. Nakanuma, I. Ishii, M. Takamura, S. Kaneko, S. Kojo, K. Satouchi, K. Mitumori, J. Chun, Y. Takuwa
- Journal Title
  
  Cardiovasc Res 85(3)
  
  Pages: 484-493
- NAID
  120001939472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Enhanced Ca2+-Dependent Activation of PI3K class IIα isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats2010
- Author(s)
  Seok YM, Azam MA, Okamoto Y, Sato A, Yoshioka K, Maeda M, Kim IK, Takuw Y.
- Journal Title
  
  Hypertension
  
  Volume: 56(5) Pages: 934-941
- DOI
  10.1161/hypertensionaha.110.160853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390057, KAKENHI-PROJECT-22590284
[Journal Article] Y Takuwa S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.2010
- Author(s)
  W Du, N Takuwa, K Yoshioka, Y Okamoto, K Gonda, K Sugihara, A Fukamizu, M Asano
- Journal Title
  
  Cancer Res 70(2)
  
  Pages: 772-781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.2010
- Author(s)
  X Qi, Y Okamoto, T Murakawa, F Wang, O Oyama, R Ohkawa, K Yoshioka, W Du, N Sugimoto, Y Yatomi, N Takuwa, Y Takuwa
- Journal Title
  
  Eur J Pharmacol 634
  
  Pages: 121-131
- NAID
  120002086439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] cDNA cloning and characterization of human and mouse Ca^<2+>-independent phosphatidylethanolamine N-acyltransferases2009
- Author(s)
  Jin X-H, Uyama T, Wang J, Okamoto Y, Tonai T, Ueda N
- Journal Title
  
  Biochim Biophys Acta-Mol Cell Biol Lipids 1791
  
  Pages: 32-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-d nsity lipoprotein in endothelial cells2009
- Author(s)
  K. Sugimoto, T. Ishibashi, T. Sawamura, N. Inoue, M. Kamioka, H. Uekita, H. Ohkawara, T. Sakamoto, N. Sakamoto, Y. Okamoto, Y. Takuwa, A. Kakino, Y. Fujita, T. Tanaka, T. Teramoto, Y. Maruyama, Y. Takeishi
- Journal Title
  
  Cardiovasc Res 84(1)
  
  Pages: 127-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent-graft.2009
- Author(s)
  H. Zhong, O. Matsui, K. Xu, T. Ogi, J. Sanada, Y. Okamoto, Y. Tabata, Y. Takuwa
- Journal Title
  
  J Vasc Surg 50(6)
  
  Pages: 1433-1443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc422009
- Author(s)
  Shiratsuchi A, Ichiki M, Okamoto Y, Ueda N, Sugimoto N, Takuwa Y, Nakanishi Y
- Journal Title
  
  J Biochem 145
  
  Pages: 43-50
- NAID
  10024914309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] 生体におけるスフィンゴシン-1-リン酸シグナル系の機能2009
- Author(s)
  多久和陽、岡本安雄、杜娃、戚〓、吉岡和晃、多久和典子
- Journal Title
  
  実験医学 27(13)
  
  Pages: 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc422009
- Author(s)
  A. Shiratsuchi, M. Ichiki, Y. Okamoto, N. Ueda, N. Sugimoto, Y. Takuwa, Y. Nakanishi
- Journal Title
  
  J. Biochem. 145(1)
  
  Pages: 43-50
- NAID
  10024914309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependenton Rho but not Rho kinase.2008
- Author(s)
  S. Takashima, N. Sugimoto, N. Takuwa, Y. Okamoto, K. Yoshioka, M. Takamura, S. Takata, S. Kanekob, Y. Takuwa
- Journal Title
  
  Cardiovasc Res 79(4)
  
  Pages: 689-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol2008
- Author(s)
  Placzek EA, Okamoto Y, Ueda N, Barker EL
- Journal Title
  
  J Neurochem 107
  
  Pages: 987-1000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown2008
- Author(s)
  Placzek EA, Okamoto Y, Ueda N, Barker EL
- Journal Title
  
  Neuropharmacology 55
  
  Pages: 1095-1104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] The stimulatory effect of phosphatidylethanolamine on N-acyl- phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD)2008
- Author(s)
  Wang J, Okamoto Y, Tsuboi K, Ueda N
- Journal Title
  
  Neuropharmacology 54
  
  Pages: 8-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] Sphingosine-1-phosphatesignaling and biological activitiesin the cardiovascular system.2008
- Author(s)
  Y. Takuwa, Y. Okamoto, K. Yoshioka, N. Takuwa
- Journal Title
  
  Biochim. Biophys. Acta 1781(9)
  
  Pages: 483-488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014034
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide.2007
- Author(s)
  Okamoto, Y.
- Journal Title
  
  Chem. Biodivers. 4
  
  Pages: 1842-1857
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590297
[Journal Article] Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism2007
- Author(s)
  Zhao L-Y, Tsuboi K, Okamoto Y, Nagahata S, Ueda N
- Journal Title
  
  Biochim Biophys Acta - Mol Cell Biol Lipids 1771
  
  Pages: 1397-1405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide2007
- Author(s)
  Okamoto, Y.
- Journal Title
  
  Chem.Biodivers 4
  
  Pages: 1842-1857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590297
[Journal Article] Predominant expression of N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies2007
- Author(s)
  Tsuboi K, Zhao L-Y, Okamoto Y, Araki N, Ueno M, Sakamoto H, Ueda N
- Journal Title
  
  Biochim Biophys Acta - Mol Cell Biol Lipids 1771
  
  Pages: 623-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide2007
- Author(s)
  Okamoto, Y
- Journal Title
  
  Chem. Biodivers 4
  
  Pages: 1842-1857
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide2007
- Author(s)
  Okamoto, Y. et al.
- Journal Title
  
  Chem.Biodivers. (in press)
- Data Source
  KAKENHI-PROJECT-17590251
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide2007
- Author(s)
  Okamoto Y, Wang J, Morishita J, Ueda N
- Journal Title
  
  Chem Biodivers 4
  
  Pages: 1842-1857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590282
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide2007
- Author(s)
  Okamoto, Y. et al.
- Journal Title
  
  Chem. Biodivers. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590251
[Journal Article] Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolyzing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines2005
- Author(s)
  Okamoto, Y. et al.
- Journal Title
  
  Biochem.J. 389
  
  Pages: 241-247
- Data Source
  KAKENHI-PROJECT-17590251
[Journal Article] Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidylethanolamine-hydrolyzing phospholipase D2005
- Author(s)
  Ueda N, Okamoto Y, Tsuboi K
- Journal Title
  
  Current Medicinal Chemistry 12(in press)
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain2005
- Author(s)
  Morishita J, Okamoto Y, Tsuboi K, Ueno M, Sakamoto H, Maekawa N, Ueda N
- Journal Title
  
  Journal of Neurochemistry (in press)
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolyzing phospholipase D exhibit dramatically reduced levels of N-acylphosphatidylethanolamines2005
- Author(s)
  Okamoto Y, Morishita J, Wang J, Schmid PC, Krebsbach RJ, Schmid HHO, Ueda N
- Journal Title
  
  Biochemical Journal (in press)
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase2005
- Author(s)
  Tsuboi K, Sun Y-X, Okamoto Y, Araki N, Tonai T, Ueda N
- Journal Title
  
  Journal of Biological Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners2004
- Author(s)
  Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N
- Journal Title
  
  Journal of Biological Chemistry 279・7
  
  Pages: 5298-5305
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D2004
- Author(s)
  Sun X-Y, Tsuboi K, Okamoto Y, Tonai T, Murakami M, Kudo I, Ueda N
- Journal Title
  
  Biochemical Journal 380
  
  Pages: 749-756
- Data Source
  KAKENHI-PROJECT-16790189
[Journal Article] Biosynthetic pathways of the endocannabinoid anandamide
- Author(s)
  Okamoto, Y.et al.
- Journal Title
  
  Chem.Biodivers. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590251
[Patent] マクロファージの増殖・分化阻害又はマクロファージの老化促進による肺線維症の抑制2015
- Inventor(s)
  多久和陽、岡本安雄
- Industrial Property Rights Holder
  多久和陽、岡本安雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-137937
- Filing Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K10970
[Patent] 血管内皮関門障害に関連した疾患又は予防及び/又は治療するための候補物質のスクリーニング法2013
- Inventor(s)
  多久和陽、岡本安雄
- Industrial Property Rights Holder
  多久和陽、岡本安雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-033893
- Filing Date
  2013-02-22
- Data Source
  KAKENHI-PROJECT-22590284
[Patent] 血管内皮関門障害に関連した疾患又は症状を予防及び/又は治療するための候補物質のスクリーニング方法2013
- Inventor(s)
  多久和陽,岡本安雄
- Industrial Property Rights Holder
  多久和陽,岡本安雄
- Industrial Property Number
  2013-033893
- Filing Date
  2013-02-22
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] 膵β細胞における小胞体ストレス応答転写因子ATF4の機能解明2020
- Author(s)
  北風圭介, 親泊美帆, 張君, 津川和江, 河野恵理, 三宅雅人, 竹之内康広, 坪井一人, 岡本安雄, 親泊政一
- Organizer
  第61回日本生化学中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] ホルボールエステル処理したTHP-1細胞におけるIL-4/IL-13刺激によるSTAT6リン酸化に対するスフィンゴシン1-リン酸2型受容体の役割2020
- Author(s)
  山本慎也, 北風圭介, 竹之内康広, 坪井一人, 岡本安雄
- Organizer
  第34回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 小胞体ストレス応答転写因子ATF4の機能不全は膵β細胞の脱分化を惹起する2020
- Author(s)
  北風圭介, 親泊美帆, 張君, 津川和江, 河野恵理, 三宅雅人, 竹之内康広, 坪井一人, 岡本安雄, 親泊政一
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 肺線維症で増加するGrowth/differentiation factor 15 (GDF15) はマクロファージと線維芽細胞を活性化する2020
- Author(s)
  竹之内　康広, 嶋田　大雅, 北風　圭介,　坪井　一人, 岡本　安雄
- Organizer
  第137回　日本薬理学会　近畿部会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Growth/differentiation factor 15 (GDF15)はマクロファージと線維芽細胞の活性化を介して肺の線維化を促進する2020
- Author(s)
  竹之内康広, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第61回日本生化学中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] p16強制発現細胞における線維化関連因子の発現変化2020
- Author(s)
  竹之内康広, 新山佳史, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] マウス虚血後再灌流腎間質線維化におけるリゾホスファチジン酸受容体の遺伝子発現変化2020
- Author(s)
  竹之内康広, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K11731
[Presentation] ホルボールエステル処理したTHP-1細胞におけるIL-4/IL-13刺激によるSTAT6リン酸化に対するスフィンゴシン1-リン酸2型受容体の役割2020
- Author(s)
  岡本安雄, 北風圭介, 竹之内康広, 山本慎也, 坪井一人
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 肺胞上皮細胞およびマクロファージにおける線維化関連因子の発現に対する老化遺伝子p16の役割2020
- Author(s)
  新山佳史, 竹之内康広, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第34回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 肺線維症で増加するGrowth/differentiation factor 15 (GDF15) は線維化促進に関与する2020
- Author(s)
  竹之内康広, 嶋田大雅, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Inhibition of sphingolipid metabolism has ceramide-induced anti-tumor effect on pancreatic cancer cells2020
- Author(s)
  Taniai Tomohiko, Shirai Yoshihiro, Shimada Yohta, Hamura Ryoga, Yanagaki Mitsuru, Takada Naoki, Tsuboi Kazuhito, Okamoto Yasuo, Ohashi Toya, Yanaga Katsuhiko
- Organizer
  ACS Clinical Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] p16の強制発現による肺胞上皮細胞およびマクロファージにおける線維化関連因子の発現の変化2020
- Author(s)
  竹之内康広, 新山佳史, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] N-アシルエタノールアミンの加水分解における内在性酸性セラミダーゼの関与2020
- Author(s)
  坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Transcription factor ATF4 maintains pancreatic β-cell identity during ER stress2020
- Author(s)
  北風圭介, 親泊美帆, 張君, 濱田良真, 竹之内康広, 坪井一人, 藤谷与士夫, 岡本安雄, 親泊政一
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 抗炎症・食欲抑制性脂質メディエーターであるN-アシルエタノールアミンの酸性セラミダーゼによる細胞・組織内での加水分解2020
- Author(s)
  坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 抗炎症・食欲抑制性メディエーターであるN-アシルエタノールアミンの酸性セラミダーゼによる加水分解2019
- Author(s)
  坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
- Organizer
  第32回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 虚血後再灌流腎間質線維化モデルマウスにおけるリゾホスファチジン酸の受容体および代謝酵素の遺伝子発現解析2019
- Author(s)
  竹之内康広, 中川靖仁, 山本優, 荒木啓吾, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19K11731
[Presentation] 抗炎症・食欲抑制作用を有する脂質メディエーターであるN-アシルエタノールアミンの分解における酸性セラミダーゼの役割2019
- Author(s)
  坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, ラフマンイッファットアラソニア, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 肺線維症で増加するgrowth/differentiation factor 15 (GDF15) が線維化へ及ぼす影響2019
- Author(s)
  竹之内康広, 坪井一人, 北風圭介, 岡本安雄
- Organizer
  第60回日本生化学中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Multiple pathways for N-acylethanolamine biosynthesis from N-acylphosphatidylethanolamine: tissue-dependent contribution of each pathway.2019
- Author(s)
  Tsuboi Kazuhito, Inoue Manami, Okamoto Yoko, Hidaka Mayumi, Uyama Toru, Tsutsumi Toshihiko, Tanaka Tamotsu, Okamoto Yasuo, Ueda Natsuo, Tokumura Akira
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 肺線維症で増加するgrowth/differentiation factor 15 (GDF15) が線維化へ及ぼす影響2019
- Author(s)
  竹之内康広, 坪井一人, 北風圭介, 岡本安雄
- Organizer
  第60回日本生化学中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K11731
[Presentation] マウス虚血後再灌流腎間質線維化におけるリゾホスファチジン酸受容体の遺伝子発現変化2019
- Author(s)
  竹之内康広, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice2019
- Author(s)
  Yasuhiro Takenouchi, Kazuhito Tsuboi, Keisuke Kitakaze, Yasuhito Nakagawa, Keigo Araki, Suguru Yamamoto, Yuji Kawai, Daichi Niiyama, Yasuo Okamoto
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11731
[Presentation] Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice.2019
- Author(s)
  Yasuhiro Takenouchi, Kazuhito Tsuboi, Keisuke Kitakaze, Yasuhito Nakagawa, Keigo Araki, Suguru Yamamoto, Yuji Kawai, Daichi Niiyama, Yasuo Okamoto
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 酸性セラミダーゼは抗炎症・食欲抑制性メディエーターであるN-アシルエタノールアミンを生体内で加水分解する2019
- Author(s)
  坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 虚血後再灌流腎間質線維化モデルにおける脂質メディエーターリゾホスファチジン酸受容体の遺伝子発現変化2019
- Author(s)
  中川靖仁, 山本優, 荒木啓吾, 竹之内康広, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] 虚血後再灌流腎間質線維化モデルマウスにおけるリゾホスファチジン酸の受容体および代謝酵素の遺伝子発現解析2019
- Author(s)
  竹之内康広, 中川靖仁, 山本優, 荒木啓吾, 北風圭介, 坪井一人, 岡本安雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08634
[Presentation] Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor.2018
- Author(s)
  Sarker Kabir Azadul, Sho Aki, Kazuaki Yoshioka, Koji Kuno, Yasuo Okamoto, Aung Thuzar Khin, Pham Quynh Hoa, Islam Shahidul, Noriko Takuwa, Yoh Takuwa
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] 脂質メディエーターであるN-アシルエタノールアミンとリゾホスファチジン酸の新規生合成機構2017
- Author(s)
  坪井一人, Rahman Iffat Ara Sonia, Hussain Zahir, 山下量平, 岡本蓉子, 宇山徹, 竹之内康広, 田中保, 岡本安雄, 徳村彰, 上田夏生
- Organizer
  第28回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] スフィンゴシン1-リン酸（S1P）2型受容体S1P2による腫瘍血管新生と血管障壁機能の制御2017
- Author(s)
  岡本安雄
- Organizer
  第27回創薬・薬理フォーラム岡山
- Invited
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] エイコサペンタエン酸による糖尿病性血管内皮機能障害に対する慢性投与の治療効果および血管への直接作用2017
- Author(s)
  竹之内康広, 坪井一人, 大竹一男, 加園恵三, 岡本安雄
- Organizer
  第132回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] マウス分娩過程におけるADAMTS-1の役割の解析2017
- Author(s)
  生水真紀夫、多久和陽、岡本安雄、松島綱治、久野耕嗣
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] 抗がん剤による臓器障害におけるスフィンゴシン-1-リン酸（S1P）情報伝達系の関与2017
- Author(s)
  多久和典子、石丸和宏、岡本安雄、多久和陽
- Organizer
  第27回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] S1P2, a receptor for the lysophospholipid mediator sphingosine 1-phosphate, protects against vascular barrier disruption.2016
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
- Organizer
  The 8th Congress of the International Federation of Shock Societies
- Place of Presentation
  Tokyo Dome Hotel, Tokyo, Japan
- Year and Date
  2016-10-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling in endothelia cells2016
- Author(s)
  Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa, Yoh Takuwa
- Organizer
  第93回日本生理学会
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] 宿主細胞のスフィンゴシン-1-リン酸受容体を介するがん血行性転移の制御2016
- Author(s)
  多久和典子、岡本安雄、多久和陽
- Organizer
  第26回日本病態生理学会大会
- Place of Presentation
  金沢医科大学、石川県河北郡内灘町
- Year and Date
  2016-08-06
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] S1P2による血管新生と血管障壁機能の制御2016
- Author(s)
  岡本安雄, 杜娃, 崔弘, 吉岡和晃, 多久和典子, 多久和陽
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  にぎわい交流館AU、秋田県秋田市
- Year and Date
  2016-06-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] クラスII PI3-キナーゼ PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3シグナリングに必須である2016
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、Hoa Quynh Pham、MD Azadul Kabir Sarker、Khin Thuzar Aung、Shahidul Islam、多久和陽
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] Sphingosine 1-phosphate (S1P) receptor-2 (S1P2) aggravates lung fibrosis through altering alveolar macrophage polarization and cellular senescence in mice2016
- Author(s)
  JuanJuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa, Takashi Wada, Yutaka Inagaki, Chiaki Takahashi, Yoh Takuwa
- Organizer
  日本生化学会北陸支部第３４回大会
- Place of Presentation
  金沢大学宝町キャンパス、石川県金沢市
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] マウス分娩時の子宮機能におけるADAMTS-1の役割の解析2016
- Author(s)
  生水真紀夫、多久和陽、岡本安雄、栗原裕基、松島綱治、久野耕司
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] Role of S1P2 in inflammation and fibrosis2015
- Author(s)
  Yoh Takuwa, Juanjuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
- Organizer
  14 th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases Plenary Lecture
- Place of Presentation
  ハンガリー　ブタペスト
- Year and Date
  2015-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] クラスII α型PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3 シグナリングに必須である2015
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P2) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice2015
- Author(s)
  Juanjuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Sho Aki, Pham Quynh Hoa, Azadul MD Kabir Sarker, Khin Thuzar Aung, Noriko Takuwa, Yutaka Inagaki, Chiaki Takahashi, Takashi Wada, Yoh Takuwa
- Organizer
  第38回日本分子生物学会・第88回日本生化学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] Sphingosine 1-phosphate receptor-2 plays a protective role against anaphylaxis and acute lung injury2015
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
- Organizer
  第10回スフィンゴテラピィ（STC）研究会
- Place of Presentation
  石川県片山津
- Year and Date
  2015-06-16
- Data Source
  KAKENHI-PROJECT-15K10970
[Presentation] クラスII 型PI3K-C2αはメンブレン・トラフィック調節を介して血管バリア機能を制御する2014
- Author(s)
  吉岡和晃，岡本安雄，多久和典子，多久和陽
- Organizer
  第91回日本生理学会大会　シンポジウム「心血管系の形態・機能研究の最前線」
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through inhibiting eNOS2014
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Juanjuan Zhao, Yoh Takuwa
- Organizer
  第91回日本生理学会大会　　Symposium “Mechanisms on distributive shock and other blood pressure control failures
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] TGFβ1-Smad2/3シグナル伝達系を介した血管新生調節におけるクラスIIαPI3キナーゼPI3K-C2αの機能的役割2013
- Author(s)
  安藝　翔、吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスII 型PI3K-C2αはSARA のエンドソームへの動員を制御しTGFß1-Smad2/3シグナル伝達系を介した血管新生を調節する2013
- Author(s)
  安藝翔，吉岡和晃，岡本安雄，多久和典子，多久和陽
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場/神戸国際展示場/神戸ポートピアホテル（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く2013
- Author(s)
  岡本安雄、崔弘、吉岡和晃、多久和典子、多久和陽
- Organizer
  第21回日本血管生物医学会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] スフィンゴシン1-リン酸特異的2 型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く2013
- Author(s)
  崔弘,岡本安雄,吉岡和晃,杜娃,多久和典子,張威,Kuntal Biswas,安藝翔,趙〓〓,九田裕一,浅野雅秀,芝本利重,多久和陽
- Organizer
  第90回日本生理学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く2013
- Author(s)
  岡本　安雄　崔　弘　吉岡　和晃　多久和　典子　多久和　陽
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘(宮城県宮城郡)
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスIIα型PI3キナーゼ-C2αによる血管新生・バリア機能調節メカニズム2013
- Author(s)
  吉岡　和晃、多久和　典子、岡本　安雄、多久和　陽
- Organizer
  第21回日本血管生物医学会　シンポジウム「血管機能を抑制するシグナリング機構」
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] SIP2受容体遺伝子欠損はマクロファージの炎症活性を抑え、apoE欠損マウスにおける粥状動脈硬化を抑制する2011
- Author(s)
  岡本安雄
- Organizer
  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術総会合同大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] ポリ乳酸-グリコール酸共重合体を基材としたスフィンゴシン-1-リン酸徐放微粒子製剤による持続性放出はマウス虚血肢においてAkt/ERK-eNOSを介して血管新生および血管成熟を促進し血流を回復させる2011
- Author(s)
  戚〓,岡本安雄,吉岡和晃,王飛,崔弘,Biswas Kuntal,安藝翔,Dandar Erdembileg,多久和典子,多久和陽
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県金沢市)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] S1P2受容体遺伝子の破壊はapoE欠損マウスにおける粥状動脈硬化を抑制する2011
- Author(s)
  岡本安雄
- Organizer
  第58回中部日本生理学会
- Place of Presentation
  福井県県民ホール(福井県)
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis2011
- Author(s)
  Yasuo Okamoto, Xun Qi, Wa Du, Noriko Takuwa, kazuaki Yoshioka, Yoh Takuwa
- Organizer
  The 1stAsia-Pacific Vascular Biology Meeting and 第19回日本血管生物医学会学術集会
- Place of Presentation
  東京ステーションコンファレ
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] Function role of sphingosine-1-phosphate signaling in angiogenesis2011
- Author(s)
  Okamoto Y
- Organizer
  The 1^<st> Asia-Pacific Vascular Biology Meeting and第19回日本血管生物医学会学術集会
- Place of Presentation
  東京ステーションコンファレンス(東京都)(招待講演)
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] Deletion of sphingosine-1-phosphate receptor-2 inhibits macrophages proinflammatory activities and atherosclerosis in apoE-deficient mice2011
- Author(s)
  Okamoto Y
- Organizer
  2011 FASEB Summer Research Conference : Lysophospholipid Mediators in Health and Disease
- Place of Presentation
  Ciocco Hotel & Resort(イタリア)
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] SIP2受容体遺伝子の破壊はapoE欠損マウスにおける粥状動脈硬化を抑制する2011
- Author(s)
  岡本安雄
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] 自然発症高血圧ラットにおける血管のCa^<2+>依存性PI3KC2α一Rho経路の役割2010
- Author(s)
  岡本安雄
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール(岩手県)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] 自然発症高血圧ラットにおける血管のCa2+依存性PI3KC2α-Rho経路の役割2010
- Author(s)
  岡本安雄,石英美,アザムモハメドアリ,佐藤篤志,吉岡和晃,王飛,崔弘,多久和典子,多久和陽
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール・いわて県民情報交流センター(岩手県盛岡市)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590284
[Presentation] 膜成分およびホスファチジルエタノールアミンはアナンダミド生成ホスホリパーゼDを活性化する2009
- Author(s)
  王俊, 趙麗頴, 岡本安雄, 宇山徹, 坪井一人, 上田夏生
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] Masahide Asano and Yoh Takuwa HOST CELL S1P2 RECEPTOR NEGATIVELY REGULATES TUMOR GROWTH AND ANGIOGENESIS IN VIVO International Conference on Phospholipase A2 and Lipid Mediators2009
- Author(s)
  Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto
- Place of Presentation
  National Center of Sciences(東京)
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] Regulation of N-acylethanolamine-hydrolyzing acid amidase (NAAA) by proteolysis and glycosylation2008
- Author(s)
  Uyama T, Zhao L-Y, Tsuboi K, Okamoto Y, Nagahata S, Ueda N
- Organizer
  18th Annual Symposium of the International Cannabinoid Research Society
- Place of Presentation
  Aviemore, Scotland, UK
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] Sphingosine-1-phosphate signaling in tumor biology THE U.S. -JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP2008
- Author(s)
  Yoh Takuwa, Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto
- Place of Presentation
  (平安会館)京都
- Year and Date
  2008-03-20
- Data Source
  KAKENHI-PROJECT-17014034
[Presentation] ヒト及びマウスのCa2+非依存性ホスファチジルエタノールアミンN-アシル転移酵素の機能解析2008
- Author(s)
  金星華, 宇山徹, 王俊, 岡本安雄, 藤内武春, 上田夏生
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] Immunochemical studies reveal predominant expression of lysosomal N-acylethanolamine- hydrolyzing acid amidase in macrophages2007
- Author(s)
  Tsuboi K, Zhao L-Y, Okamoto Y, Araki N, Ueno M, Sakamoto H, Ueda N
- Organizer
  International Cannabinoid Research Society 17th Annual Symposium on the Cannabinoids
- Place of Presentation
  Saint-Sauveur, Quebec, Canada
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] N-アシルエタノールアミン水解酸性アミダーゼの免疫化学的解析2007
- Author(s)
  趙麗頴, 坪井一人, 岡本安雄, 荒木伸一, 上野正樹, 阪本晴彦, 上田夏生
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] レシチン・レチノール・アシル転移酵素構造類似タンパク質のホスファチジルエタノールアミンN-アシル転移酵素としての同定2007
- Author(s)
  金星華, 岡本安雄, 森下淳, 坪井一人, 宇山徹, 藤内武春, 上田夏生
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] 生体膜成分とリン脂質によるN-アシルホスファチジルエタノールアミン水解ホスホリパーゼD(NAPE-PLD)の活性化2007
- Author(s)
  王俊, 岡本安雄, 坪井一人, 上田夏生
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] N-アシルPEを生成する新規N-アシル転移酵素の同定と性状解析2007
- Author(s)
  岡本安雄,金星華,森下淳,坪井一人,藤内武春,上田夏生
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] アナンダミド前駆体N-アシルホスファチジルエタノールアミンのマクロファージ貧食抑制効果2007
- Author(s)
  一木万奈美, 白土明子, 岡本安雄, 上田夏生, 中西義信
- Organizer
  日本生化学会北陸支部第25回例会
- Place of Presentation
  金沢市
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] N-アシルPEを生成する新規N-アシル転移酵素の同定と性状解析2007
- Author(s)
  岡本安雄
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  札幌市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] 新規リソソーム酵素としてのN-アシルエタノールアミン水解酸性アミダーゼの性状解析2007
- Author(s)
  上田夏生, 趙麗頴, 坪井一人, 岡本安雄, 荒木伸一, 上野正樹
- Organizer
  第318回脂溶性ビタミン総合研究委員会
- Place of Presentation
  香川県さぬき市
- Year and Date
  2007-12-07
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] 内因性マリファナ様物質アナンダミドの生合成に係わる新規N-アシル転移酵素の同定と性状解析2007
- Author(s)
  金星華, 岡本安雄, 森下淳, 坪井一人, 藤内武春, 上田夏生
- Organizer
  第48回日本生化学会中国・四国支部例会
- Place of Presentation
  高知市
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] 抗炎症脂質N-アシルエタノールアミンを加水分解する酸性アミダーゼのマクロファージにおける発現2007
- Author(s)
  上田夏生, 坪井一人, 趙麗頴, 岡本安雄, 荒木伸一, 上野正樹, 阪本晴彦
- Organizer
  第28回日本炎症・再生医学会
- Place of Presentation
  東京都新宿区
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] Discovery of a calcium-independent phosphatidylethanolamine N-acyltransferase (iNAT)2007
- Author(s)
  Ueda N, Jin X-H, Okamoto Y, Morishita J, Tsuboi K, Tonai T
- Organizer
  International Cannabinoid Research Society 17th Annual Symposium on the Cannabinoids
- Place of Presentation
  Saint-Sauveur, Quebec, Canada
- Data Source
  KAKENHI-PROJECT-19590282
[Presentation] Identification and characterization of a novel phosphatidylethanolamine Nacyltransferase generating N-acylphosphatidylethanolamine2007
- Author(s)
  Okamoto, Y
- Organizer
  The 49th Japanese conference on the biochemistry of lipids
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] アナンダミドを遊離する新規ホスホリパーゼDの組換え体の精製と性状解析2006
- Author(s)
  岡本安雄
- Organizer
  日本ビタミン学会第58回大会
- Place of Presentation
  徳島市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] アナンダミドを含むN-アシルエタノールアミンを遊離する新規ホスホリパーゼDの組換え酵素の大腸菌からの精製と性状解析2006
- Author(s)
  岡本安雄
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  東京都江東区
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] Purification and characterization of the recombinant enzyme of a novel phospholipase D releasing anadamide and other N-acylethanolamine from Escherichia coli2006
- Author(s)
  Okamoto, Y
- Organizer
  The 48th Japanese conference on the biochemistry of lipids
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] Purification and characterization of recombinant NAPE-PLD expressed in Escherichiacoli2006
- Author(s)
  Okamoto, Y.
- Organizer
  International Cannabinoid Research Society 16th Annual Symposium on the Cannabinoids
- Place of Presentation
  Tihany, Hungary
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] Purification and characterization of the recombinant enzyme of a novel phospholipase D releasing anadamide2006
- Author(s)
  Okamoto, Y
- Organizer
  The 58th Annual Meeting of the Vitamin Society of Japan
- Place of Presentation
  Tokushima
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] Purification and characterization of recombinant NAPE-PLD expressed in Escherichia coli2006
- Author(s)
  Okamoto, Y
- Organizer
  International Cannabinoid Research Society 16th Annual Symposium on the Cannabinoids
- Place of Presentation
  Tihany, Hungary
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590297
[Presentation] Distinct role of S1P2 in the functional regulation of vascular endothelium and smooth muscle
- Author(s)
  Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates eNOS and protects against acute vascular barrier disruption
- Author(s)
  Yasuo Okamoto, Cui Hong, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
- Organizer
  The 18th International Vascular Biology Meeting 2014 (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] Sphingosine 1-phosphate receptor-2 plays a protective role against lipopolysaccharide (LPS)-induced acute lung injury
- Author(s)
  Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Sho Aki, JuanJuan Zhao, Hoa Quynh Pham, Md. Azadul Kabir Sarker, Saori Koizumi, Yoh Takuwa
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県・神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24390051
[Presentation] クラスIIα型PI3K-C2αはALK5 内在化及び足場タンパクSARA のエンドソームへの動員を制御しTGF-1-Smad2/3 を介した血管新生を調節する
- Author(s)
  安藝翔、吉岡和晃、岡本安雄、多久和典子、多久和陽
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府・東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24390051

1. TAKUWA Noriko (70150290)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. TSUBOI Kazuhito (80346642)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
3. TAKUWA Yoh (60171592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
4. YOSHIOKA Kazuaki (80333368)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
5. SUGIMOTO Naotoshi (80272954)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. UEDA Natsuo (20193807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
7. 竹之内康広 (30582233)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
8. NINOMIYA Haruaki (80212124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MIWA Soichi (40157706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUKAO Mitsuhiro (10250432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. UEKI Masaaki (20213332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UENO Masaki (30322267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 眞崎知生 (60009991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 北風圭介 (80840545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
15. MIZUGISHI Kiyomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. OTA Tsuguhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. KOSAKA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. HASHIMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. AKI Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. USUI Soichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 木戸屋浩康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 斎藤芳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 高橋和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 御簾博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 竹下有美枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 五十嵐淳介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 窪田泰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 榊原紀和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 塚本郁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 王英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 成瀬恵治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 石丸和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 高村雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

okamoto yasuo 岡本 安雄

岡本 安雄 オカモト ヤスオ

OKAMOTO Yasuo 岡本 安雄

Research Projects

Research Products

Co-Researchers

A novel strategy for controlling lung fibrosis: Targeting bioactive lysophospholipid-degrading enzymePrincipal Investigator

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血管内皮機能に着目した糖尿病性血管障害発症機序の性差の解明と性差医療への応用

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A novel strategy of acute lung injury: Targeting sphingolipid signalingPrincipal Investigator

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Mechanisms for the regulation of vascular homeostasis by functional lipid molecules

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Research of developmental engineering of the sphingosine-1-phosphate receptor as a target molecules of antiatherosclerotic drugPrincipal Investigator

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Analysis on the metabolism and physiological function of anandamide and related fatty acid amide compounds

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Elucidation of physiological finction of anandamide, an endogenous marijuana-like substance, in mammalsPrincipal Investigator

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Signaling for regulating hematogenous metastasis of tumors

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Functional analysis of a novel enzyme of the phospholipase D type involved in the endocannabinoid

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内因性マリファナ様物質アナンダミドの生合成に係る新規ホスホリパーゼDの解析Principal Investigator

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The structure and function of Ca^<2+>-permeable nonselective cation channels

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エンドセリン受容体の脱感作機構Principal Investigator

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Regulation of endothelin receptor expression through cancer cell differentiation

Principal Investigator

okamoto yasuo 岡本安雄

岡本安雄オカモトヤスオ

OKAMOTO Yasuo 岡本安雄