OKAMURA Tomio 岡村富夫

Researcher Number	70152337
Other IDs
External Links
Affiliation (Current)	2023: 滋賀医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2011 – 2013: 滋賀医科大学, 医学部, 教授 2005 – 2006: 滋賀医科大学, 医学部, 教授 1999 – 2001: Shiga University of Medical Science, Phamacology, Professor, 医学部, 教授 1996 – 1998: 滋賀医科大学, 医学部, 助教授 1989 – 1992: 滋賀医科大学, 医学部, 助教授 1990: Shiga University of Medical Science, Department of Pharmacology, Assistant Profe, 医学部, 助教授
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / 応用薬理学・医療系薬学 Except Principal Investigator General pharmacology / General pharmacology / Anesthesiology/Resuscitation studies / 応用薬理学・医療系薬学
Keywords	Principal Investigator 一酸化窒素 / NO作動性神経 / 陰茎海綿体 / カルシウム拮抗薬 / EDRF / 脳動脈 / ＮＯ作動性神経 / 平滑筋支配神経 / 生活習慣病 / 活性酸素 … More / 末梢神経 / 血管内皮細胞 / 神経型NO合成酵素 / 血管内皮機能 / レニン / アンジオテンシン / アンジオテンシン変換酵素 / レニン抗体 / 免疫組織化学 / 血管内皮 / 瞳孔括約筋 / レニン阻害薬 / ヒト血管 / 血管壁 / 腎摘ラット / Renin / Angiotensin / Angiotensin-converting enzyme / Renin antibody / Immunohistochemistry / Vascular endothelium / Renin inhibitor / Human artery / フルナリジン / カルシウム・カルモデュリン依存性プロテインキナーゼII / サイクリックGMP / ノルアドレナリン / 一酸化窒素(NO) / 血管内皮由来弛緩因子(EDRF) / 血管緊張性調節 / 血管平滑筋 / Calcium antagonist / Nitric oxide / Nitroxidergic nerve / Flunarizine / Cyclic GMP / Calcium / calmodulin-dependent protein kinase / Noradrenaline / 翼口蓋神経節 / 血管拡張神経 / 脳および眼動脈 / スーパーオキシド / 低温 / Caged NO / 低酸素 / 眼動脈 / 神経伝達物質 / 血管造影 / Nitric Oxide (NO) / Nitroxidergic (Nitrergic) nerve / Pterygopalatine ganglion / Vasodilator nerve / Cerebral and ophthalmic artery / Superoxide / corpus cavernosum / Hypothermia … More Except Principal Investigator 陰茎海綿体 / 一酸化窒素(NO) / サル / 脳動脈 / 血管内皮 / NO作動性神経 / 一酸化窒素 / 内皮細胞 / Ca^<2+>感受性K^+チャネル / endothelium / nitric oxide (NO) / corpus cavernosum / 幹細胞 / インスリン抵抗性因子 / 糖尿病 / 幹細胞機能 / iPS細胞 / 再生医療 / 幹細胞移植 / カニクイザル / 麻薬 / モルヒネ / Tリンパ球 / オピオイド / 免疫抑制 / 血管平滑筋 / オピオイド受容体 / T細胞 / 血管弛緩 / オキシヘモグロビン / クモ膜下出血 / 脳血管攣縮 / プロスタグランディン / 内皮依存性収縮 / 赤血球溶血上清液 / 大脳動脈 / Cerebral vasospasm, / subarachnoid hemorrhage, / oxyhemoglobin, / prostaglandin, / endothelium, / cyclooxygenase inhibitor, / calcium entry blocker, / ascorbic acid / コリン作動性神経 / 蛋白リン酸化 / 舌動脈 / 網膜中心動脈 / 高血圧 / Nitric Oxide (NO) / Nitroxidergic nerve / Cerebral artery / Corpus cavernosum / Reciprocal innervation / Prejunctional inhibition / Vasodilator nerve / Blood pressure / 冠状および舌動脈 / 内皮由来過分極因子(EDHF) / アラキドン酸代謝物 / バイオカスケード装置 / チトクロームP450 / アラキドン酸 / サル舌動脈 / coronary of linguial artery / endotherium-derived hyperpolarization factor (EDHF) / metabolite(s) from arachidonic acid / nitroxidergic nerve / biocascade system / 舌,頚および脳動脈 / Ca2+依存症K+チャネル / チトクロームP450 3A4 / 高脂血症ウサギおよびサル / 動脈硬化 / Ca2+依存性K+チャネル / 動脈硬化モデル動物 / 血管支配神経 / lingual, carotid and cerebral arteries / Ca^<2+>-dependent K^+-channel / cytochrome P450 3A4 / hyperlipidemic rabbit and monkey / atherosclerosis / インスリン抵抗性 / 内皮機能障害 / 高脂血症 / アンジオテンシン / 酸化ストレス / 一酸化窒素合成酵素 / テトラヒドロピオプテリ / テトラヒドロビオプテリン / 血管内皮機能障害 / フィブラート / HMG-CoA還元酵素阻害薬 / Insulin resistance / Endothelial dysfunction / Hyperlipidemia / Angiotensin / Oxidative stress / Nitric oxide synthase / Tetrahydrobiopterin Less

Nitrergic function in life style-related diseasesPrincipal Investigator
- Principal Investigator
  
  OKAMURA Tomio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Effects of insulin resistance-related factors on the stem cell functions in vivo.
- Principal Investigator
  
  IMAMURA Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
The study on functions of opioid receptors expressed in T lymphocytes
- Principal Investigator
  
  SHODA Takehiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
Role of PPARα in Pathogenesis of Endothelial Dysfunction Associated with Insulin Resistance
- Principal Investigator
  
  SHINOZAKI Kazuya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Function of vascular endothelium and vasomotor nerve in atherosclerotic animals
- Principal Investigator
  
  AYAJIKI Kazuhide
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Shiga University of Medical Science
Analyses of projection route of nitroxidergic nerve and its transmission mechanismPrincipal Investigator
- Principal Investigator
  
  OKAMURA Tomio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Measurement of vasorelaxant substance derived from endothelium and innervating nerve by biocascade system
- Principal Investigator
  
  AYAJIKI Kazuhide
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Analysis of Mechanisms Underlying Vascular Nitroxidergic Innervation and its Pathogenic Implication
- Principal Investigator
  
  TODA Noboru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Effects of calcium antagonists on vascular endothelial, smooth muscle and sympathetic nerve functionsPrincipal Investigator
- Principal Investigator
  
  OKAMURA Tomio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
Basic Research on the vascular renin-angiotensin systemPrincipal Investigator
- Principal Investigator
  
  OKAMURA Tomio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
Basic Research on Cerebral Vasospasm and Its Prophylaxis
- Principal Investigator
  
  TODA Noboru
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science

All 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats2014
- Author(s)
  Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 124 Pages: 76-85
- NAID
  130003382630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.2014
- Author(s)
  Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 124 Pages: 76-85
- NAID
  130003382630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390056
[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.2014
- Author(s)
  Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 124 Pages: 76-85
- NAID
  130003382630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats2014
- Author(s)
  Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 124 Pages: 76-85
- NAID
  130003382630
- URL
  https://www.jstage.jst.go.jp/article/jphs/124/1/124_13178FP/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390056
[Journal Article] Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide : An overview2013
- Author(s)
  Toda N, Okamura T
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 53 Pages: 1228-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Influence of hypoxia on endothelium-derived NO-mediated relaxation in rat carotid, mesenteric and iliac arteries2013
- Author(s)
  Tawa M, Shimosato T, Geddawy A, Imamura T, Okamura T
- Journal Title
  
  Pharmacology
  
  Volume: 91 Pages: 322-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: An overview.2013
- Author(s)
  Toda N, Okamura T.
- Journal Title
  
  J Clin Pharmacol.
  
  Volume: 53 Pages: 1228-1239
- DOI
  10.1002/jcph.179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide.2013
- Author(s)
  Toda N, Toda H, Okamura T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 714 Pages: 414-423
- DOI
  10.1016/j.ejphar.2013.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Influence of hypoxia on endothelium-derived NO-mediated relaxation in rat carotid, mesenteric and iliac arteries2013
- Author(s)
  Tawa M, Shimosato T, Geddawy A, Imamura T, Okamura T.
- Journal Title
  
  Pharmacology
  
  Volume: 91 Pages: 322-30
- DOI
  10.1159/000351706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055, KAKENHI-PROJECT-23390056
[Journal Article] Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide2013
- Author(s)
  Toda N, Toda H, Okamura T
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 714 Pages: 414-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress2012
- Author(s)
  Shimosato, Geddawy, Tawa, Imamura, Okamura
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 118 Issue: 2 Pages: 206-214
- DOI
  10.1254/jphs.11187fp
  10.1254/jphs.11187FP
- NAID
  10030454848
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Neurogenic and endothelial nitric oxide regulates blood circulation in lingual and other oral tissues2012
- Author(s)
  Toda, Ayajiki, Okamura
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: 60 Pages: 100-108
- DOI
  10.1097/fjc.0b013e318252452a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Cerebral blood flow regulation by nitric oxide in Alzheimer's disease.2012
- Author(s)
  Toda, Okamura
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 32 Pages: 569-578
- DOI
  10.3233/jad-2012-120670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress2012
- Author(s)
  Shimosato T, Geddawy A, Tawa M, Imamura T, Okamura T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 206-214
- NAID
  10030454848
- URL
  https://www.jstage.jst.go.jp/article/jphs/118/2/118_11187FP/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390056
[Journal Article] Cerebral blood flow regulation by nitric oxide in Alzheimer's disease2012
- Author(s)
  Toda N, Okamura T
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 32 Pages: 569-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Chronic administration of micotine-free cigarette smoke extract impaired endothelium-dependent vascular relaxation in rats via increased vascular oxidative stress2012
- Author(s)
  Shimosato T, Geddawy A, Tawa M, Imamura T, Okamura T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 206-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Neurogenic and endothelial nitric oxide regulates blood circulation in lingual and other oral tissues2012
- Author(s)
  Toda N, Ayajiki K, Okamura T
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: 60 Pages: 100-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Neurogenic and endothelial nitric oxide regulates blood circulation in lingual and other oral tissues2012
- Author(s)
  Toda, Ayajiki, Okamura
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys2012
- Author(s)
  Ayajiki K, Kobuchi S, Tawa M, Okamura T
- Journal Title
  
  Hypertens Res
  
  Volume: 35 Pages: 88-92
- NAID
  10030643093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390055
[Journal Article] Impairment by hypoxia or hypoxia/reoxygenation of nitric oxide-mediated relaxation in isolated monkey coronary artery : the role of intracellular superoxide2011
- Author(s)
  Tawa M, Yamamizu K, Geddawy A, Shimosato T, Imamura T, Ayajiki K, Okamura T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 116 Pages: 188-196
- NAID
  10029894695
- URL
  https://www.jstage.jst.go.jp/article/jphs/116/2/116_11031FP/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390056
[Journal Article] Contribution of nitric oxide in big endothelin-1-induced cardioprotective effects on ischemia/ reperfusion injury in rat hearts2011
- Author(s)
  Tawa M, Fukumoto T, Ohkita M, Yamashita N, Geddawy A, Imamura T, Ayajiki K, Okamura T, Matsumura Y
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: 57 Pages: 575-578
- DOI
  10.1097/fjc.0b013e31821325ad
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390056
[Presentation] GSK3beta differentially modifies early and late stages of adipogenesis from the pluripotent stem cells to mature adipocytes2014
- Author(s)
  今村武史、岩崎広高、田和正志、下里貴、岡村富夫
- Organizer
  日本薬理学会
- Place of Presentation
  徳島大学
- Data Source
  KAKENHI-PROJECT-23390056
[Presentation] Effects of insulin resistance on adipogenic differentiation of the stem cells transplanted in cynomolgus monkeys.2013
- Author(s)
  今村武史、岩崎広高、田和正志、下里貴、岡村富夫
- Organizer
  日本薬理学会
- Place of Presentation
  福岡国際センター
- Data Source
  KAKENHI-PROJECT-23390056
[Presentation] インスリン抵抗性ラットにおける血管機能障害に及ぼすアトロバスタチンおよびアムロジピンの併用効果2013
- Author(s)
  田和正志, 下里貴, Geddawy Ayman, 新宅治夫, 政田正広, 今村武史, 岡村富夫
- Organizer
  第13回日本NO学会
- Place of Presentation
  沖縄県医師会館
- Data Source
  KAKENHI-PROJECT-23390055

1. AYAJIKI Kazuhide (10167968)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. IMAMURA Takeshi (00552093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. TAWA Masashi (10510274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. TODA Noboru (50025590)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Kazuhide (00210683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUJIOKA Hideyuki (50228970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MASADA Masahiro (00229353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. TORII Ryuzou (50106647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YOSHIDA Yoshinori (20447965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. SHODA Takehiro (60335263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHINOZAKI Kazuya (20324577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKAMURA Tomio 岡村 富夫

Research Projects

Research Products

Co-Researchers

Nitrergic function in life style-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of insulin resistance-related factors on the stem cell functions in vivo.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on functions of opioid receptors expressed in T lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of PPARα in Pathogenesis of Endothelial Dysfunction Associated with Insulin Resistance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of vascular endothelium and vasomotor nerve in atherosclerotic animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of projection route of nitroxidergic nerve and its transmission mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Measurement of vasorelaxant substance derived from endothelium and innervating nerve by biocascade system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Mechanisms Underlying Vascular Nitroxidergic Innervation and its Pathogenic Implication

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of calcium antagonists on vascular endothelial, smooth muscle and sympathetic nerve functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Research on the vascular renin-angiotensin systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Research on Cerebral Vasospasm and Its Prophylaxis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.2014

Author(s)

Journal Title

NAID

Data Source

OKAMURA Tomio 岡村富夫