Fukuhara Kiyoshi 福原潔

… Alternative Names

福原潔フクハラキヨシ

FUKUHARA Kiyoshi 福原潔

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Researcher Number	70189968
Other IDs
External Links
Affiliation (Current)	2025: 昭和医科大学, 薬学部, 教授 2025: 国立医薬品食品衛生研究所, 有機化学部, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 昭和大学, 薬学部, 教授 2014 – 2020: 昭和大学, 薬学部, 教授 2005 – 2012: 国立医薬品食品衛生研究所, 有機化学部, 室長 2005 – 2007: 国立医薬品食品衛生研究所, 有機化学部第一室, 室長 2001 – 2003: National Institute of Health Sciences, Division of Organic Chemistry, Section Chief, 有機化学部, 室長 … More 1997 – 2000: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 1993: 国立衛生試験所, 有機化学部, 研究員 1993: 国立衛生試験所, 有機化学部・第一室, 研究員 1992: 国立衛生試験所, 有機化学部第一室, 研究員 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / 医薬分子機能学 / Chemical pharmacy Except Principal Investigator 医薬分子機能学 / Hygiene and public health / Chemical pharmacy / Chemical pharmacy / 環境影響評価(含放射線生物学) / 化学系薬学
Keywords	Principal Investigator 活性酸素 / アルツハイマー病 / カテキン / アミロイドβ / ポリフェノール / 抗酸化剤 / アミロイド / 凝集阻害 / 生活習慣病 / ビタミンE … More / 酸化ストレス / 抗腫瘍化合物 / α-セクレターゼ / セクレターゼ / ペプチド / 神経細胞毒性 / 凝集阻害活性 / フィセチン / プロシアニジン / chemoorevention / oxidatiye stress / reactive oxygen species / polyphenol / flavonoid / catechin / antioxidant / アポトーシス / 予防物質 / フラボノイド / Cancer / Flavonoid / Polyphenol / Catechin / Reactive Oxygen Species / Antioxidant / ラジカル / DNA damage / cancer / hydroxyl radical / N-oxide / phenazine / ヒドロキシルラジカル / N-オキシド構造 / 神経細胞毒性抑制作用 / ペプチドモチーフ / カフェ酸 / トロロックス / 抗酸化物質 / アルツハイマー病治療薬 / レスベートロール / アルツハマー / アルツハイマー / DNA / フェナジン / 電気化学 / サイクリックボルタンメトリー / 変異原性 / ニトロレダクターゼ / アザアレーン / フェナンスレン / ニトロアレーン / 多環芳香族炭化水素 … More Except Principal Investigator 活性酸素 / 酸化ストレス / Amidoxime / Nitric Oxide / アミドオキシム / 一酸化窒素 / 早期診断法 / トランスジェニックマウス / エクソソーム / 高齢化 / 抗酸化剤 / バイオマーカー / プロテオミクス解析 / アルツハイマー病 / oxidative stress / reactive oxygen species / alkvlamine / fenfluramin / N-nitrsofenfluramine / N-nitrosocomnound / N-ニトロソ化合物 / アルキルアミン / フェンフルラミン / N-ニトロソフェンフルラミン / N-ニトロソ化合 / Nitosamine / Hydroxyl / DNA切断活性 / ニトロソアミン / ヒドロキシルラジカル / グルコースオキシダーゼ / ニトロサミン / ヒドロキシラジ / Smooth muscular relaxation action / Hydroxy-L-arginine / シアノトリアゼン / 平滑筋弛緩作用 / ヒドロキシアルギニン / 酵素 / DNA / CV法 / 酸化還元電位 / 相互作用 / レセプター / リガンド / DPV法 / 分子軌道計算 / フラーレン / 毒性評価 / 分子間相互作用 / 薬物代謝酵素 / ニトロアレーン / 環境化学物質 / 化学計算 / 電子移動 / 一電子還元 / 電気化学 / スーパーオキシド / ニトロアレーンアニオンラジカル / セミキノンアニオンラジカル / クロノクーロメトリー Less

Development of peptide derivatives with amyloid-beta cleaving activityPrincipal Investigator
- Principal Investigator
  
  福原潔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University
Catechin derivatives useful for the treatment of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Fukuhara Kiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University
Development of a PET imaging agent and disease biomarker for Alzheimer's disease.
- Principal Investigator
  
  OIKAWA Shinji
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Mie University
Development of amyloid beta C-terminal motifs conjugated with phenolic antioxidantPrincipal Investigator
- Principal Investigator
  
  Fukuhara Kiyoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Studies on synthetic antioxidants for prevention of oxidative stress-related diseasesPrincipal Investigator
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design and Synthesis of Antioxidant for a New Type of Chemopreventive AgentsPrincipal Investigator
- Principal Investigator
  
  KIYUOSHI Fukuhara
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen
- Principal Investigator
  
  OKUDA Haruhiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
Studies of Synthetic Catechin Analogues Useful for Antioxidant TherapyPrincipal Investigator
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences
Studies of Phenazine di N-Oxides as a New Type of Hydroxy Radical DonorPrincipal Investigator
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences
Synthesis of NO generating compounds with hydroxyl releasing ability
- Principal Investigator
  
  TANNO Masayuki, 末吉祥子
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences (NIHS)
DPV法を利用した簡便なリガンドーレセプター相互作用解析手法の開発
- Principal Investigator
  
  宮田直樹
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
Synthesis of NO-donors as Biotransformation Model Compounds
- Principal Investigator
  
  SUEYOSHI Shoko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences (NIHS)
DNA二重鎖構造巻き戻し機能を持つDNA切断化合物の合成Principal Investigator
- Principal Investigator
  
  福原潔
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
化学計算による環境化学物質の毒性評価の新手法の開発
- Principal Investigator
  
  宮田直樹
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  国立衛生試験所
新規環境汚染物質ニトロアザアレーンの合成と毒性発現機構の有機化学的解析Principal Investigator
- Principal Investigator
  
  福原潔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  国立衛生試験所
クロノクーロメトリー法を用いた活性酸素ラジカルの発生と消去反応の解析
- Principal Investigator
  
  MIYATA Naoki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  化学系薬学
- Research Institution
  国立衛生試験所

[Journal Article] In silico optimization of peptides that inhibit Wnt/β-catenin signaling2023
- Author(s)
  Fujita Minami、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 84 Pages: 117264-117264
- DOI
  10.1016/j.bmc.2023.117264
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06508, KAKENHI-PROJECT-20K06958
[Journal Article] DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination2023
- Author(s)
  Fukuhara Kiyoshi、Nakanishi Ikuo、Imai Kohei、Mizuno Mirei、Matsumoto Ken-ichiro、Ohno Akiko
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 2 Pages: 225-225
- DOI
  10.3390/antiox12020225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06620, KAKENHI-PROJECT-22K06508
[Journal Article] Antioxidant and Prooxidant Effects of Thymoquinone and Its Hydroquinone Metabolite2022
- Author(s)
  M. Mizuno, K. Fukuhara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 9 Pages: 1389-1393
- DOI
  10.1248/bpb.b22-00199
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06508, KAKENHI-PROJECT-20K15486
[Journal Article] Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling2022
- Author(s)
  Tsuchiya Keisuke、Kiyoshi Masato、Hashii Noritaka、Fujita Minami、Kurohara Takashi、Ishii-Watabe Akiko、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 73 Pages: 117021-117021
- DOI
  10.1016/j.bmc.2022.117021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06508, KAKENHI-PLANNED-18H05502
[Journal Article] Effects of reaction environments on radical-scavenging mechanisms of ascorbic acid2021
- Author(s)
  中西　郁夫，荘司　好美，大久保　敬，福原　潔，小澤　俊彦，松本　謙一郎，福住　俊一
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 68 Issue: 2 Pages: 116-122
- DOI
  10.3164/jcbn.20-147
- NAID
  130007993434
- ISSN
  0912-0009, 1880-5086
- Year and Date
  2021-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06620, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-20H02779, KAKENHI-PUBLICLY-20H04819
[Journal Article] Development of Photoswitchable Estrogen Receptor Ligands2020
- Author(s)
  K. Tsuchiya, T. Umeno, G. Tsuji, H. Yokoo, M. Tanaka, K. Fukuhara, Y. Demizu, T. Misawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 68 Issue: 4 Pages: 398-402
- DOI
  10.1248/cpb.c19-01108
- NAID
  130007824936
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06588, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin2020
- Author(s)
  Mizuno Mirei、Mori Kazunori、Tsuchiya Keisuke、Takaki Takashi、Misawa Takashi、Demizu Yosuke、Shibanuma Motoko、Fukuhara Kiyoshi
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 36 Pages: 23164-23174
- DOI
  10.1021/acsomega.0c02936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Relationship between the Radical-Scavenging Activity of Selected Flavonols and Thermodynamic Parameters Calculated by Density Functional Theory2020
- Author(s)
  中西　郁夫，大久保　敬，荘司　好美，藤高　侑也，下田　恵，松本　謙一郎，福原　潔，濱田　博喜
- Journal Title
  
  Free Radical Research
  
  Volume: 54 Issue: 7 Pages: 535-539
- DOI
  10.1080/10715762.2020.1813887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06620, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-20H02779
[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama and Hiroyuki Itabe
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1045-1045
- DOI
  10.3390/antiox9111045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Synthesis and radical-scavenging activity of C-methylated fisetin analogues2019
- Author(s)
  1.K. Imai, I. Nakanishi, K. Ohkubo, A. Ohno, M. Mizuno, S. Fukuzumi, K. Matsumoto, K. Fukuhara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 27 Issue: 8 Pages: 1720-1727
- DOI
  10.1016/j.bmc.2019.02.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-18K06620, KAKENHI-PUBLICLY-18H04650, KAKENHI-PROJECT-17H03010
[Journal Article] Anti-inflammatory effects of new catechin derivatives in a hapten-induced mouse contact dermatitis model2019
- Author(s)
  Nakano Eriko、Kamei Daisuke、Murase Remi、Taki Iori、Karasawa Koji、Fukuhara Kiyoshi、Iwai Shinichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 845 Pages: 40-47
- DOI
  10.1016/j.ejphar.2018.12.036
- NAID
  130007900581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08413, KAKENHI-PROJECT-18K06588
[Journal Article] Inhibition of beta-amyloid-induced neurotoxicity by planar analogues of procyanidin B32019
- Author(s)
  M. Mizuno, K. Mori, T. Misawa, Y. Demizu, M. Shibanuma, K. Fukuhara*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 18 Pages: 2659-2663
- DOI
  10.1016/j.bmcl.2019.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-19K07423
[Journal Article] Efficient protective activity of a planar catechin analogue against radiation-induced apoptosis in rat thymocytes2018
- Author(s)
  Sekine-Suzuki Emiko、Nakanishi Ikuo、Imai Kohei、Ueno Megumi、Shimokawa Takashi、Matsumoto Ken-ichiro、Fukuhara Kiyoshi
- Journal Title
  
  RSC Advances
  
  Volume: 8 Issue: 19 Pages: 10158-10162
- DOI
  10.1039/c7ra13111a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18375, KAKENHI-PROJECT-18K06588
[Journal Article] A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.2017
- Author(s)
  Hiroki Kumamoto, Misato Fukano, Shuhei Imoto, Satoru Kohgo, Yuki Odanaka, Masayuki Amano, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya, Kazuhiro Haraguchi & Kiyoshi Fukuhara.
- Journal Title
  
  Nucleosides, nucleotides & nucleic acids
  
  Volume: 36 Issue: 7 Pages: 463-473
- DOI
  10.1080/15257770.2017.1322209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-26460153
[Journal Article] A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using <sup>1</sup>H-NMR Spectroscopy2017
- Author(s)
  K. Fukuhara, A. Ohno, R. Kikura-Hanajiri
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 9 Pages: 1147-1154
- DOI
  10.1248/yakushi.17-00046
- NAID
  130006038236
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460153
[Journal Article] Synthesis and Antioxidant Activity of a Procyanidin B3 Analogue2017
- Author(s)
  水野　美麗，中西　郁夫，松林　智子，今井　耕平，荒井　卓也，松本　謙一郎，福原　潔
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 4 Pages: 1041-1044
- DOI
  10.1016/j.bmcl.2016.12.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460056, KAKENHI-PROJECT-26460153, KAKENHI-PROJECT-15K18901
[Journal Article] 52.Synthesis of Methylated Quercetin Analogues for Enhancement of Radical-Scavenging Activity2017
- Author(s)
  Kohei Imai, Ikuo Nakanishi, Kei Ohkubo, Yusuke Ohba, Takuya Arai, Mirei Mizuno, Shunichi Fukuzumi, Ken-ichiro, and Matsumoto, Kiyoshi Fukuhara
- Journal Title
  
  RSC Adv.
  
  Volume: 7 Issue: 29 Pages: 17968-17979
- DOI
  10.1039/c7ra02329d
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02268, KAKENHI-PROJECT-26460056, KAKENHI-PROJECT-15K18901, KAKENHI-PROJECT-26460153
[Journal Article] Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-beta C-terminal peptides2016
- Author(s)
  Takuya Arai, Akiko Ohno, Kazunori Mori, Hiroshi Kuwata, Mirei Mizuno, Kohei Imai, Shuntaro Hara, Motoko Shibanuma, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 22 Pages: 5468-5471
- DOI
  10.1016/j.bmcl.2016.10.027
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26460153, KAKENHI-PROJECT-15K18901
[Journal Article] Design, synthesis, and evaluation of Trolox-conjugated amyloid-beta C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease2016
- Author(s)
  Takuya Arai, Akiko Ohno, Kazunori Mori, Taeko Kakizawa, Hiroshi Kuwata, Toshihiko Ozawa, Motoko Shibanuma, Shuntaro Hara, Seiichi Ishida, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 18 Pages: 4138-4143
- DOI
  10.1016/j.bmc.2016.06.057
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26460153
[Journal Article] A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section2015
- Author(s)
  1.N. Ieda, K. Hishikawa, K. Eto, K. Kitamura, M. Kawaguchi, T. Suzuki, K. Fukuhara, N. Miyata, T. Furuta, J. Nabekura, H. Nakagawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 16 Pages: 3172-3175
- DOI
  10.1016/j.bmcl.2015.05.095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460153, KAKENHI-PROJECT-15K18899, KAKENHI-PROJECT-15K21603, KAKENHI-PLANNED-26111012, KAKENHI-PUBLICLY-26115524, KAKENHI-PROJECT-25293028, KAKENHI-PROJECT-26282219
[Journal Article] The hydroxy group of resveratrol is functionally important for direct activation of PPARalpha2015
- Author(s)
  Yoshie Takizawa, Rieko Nakata, Hiroyasu Inoue
- Journal Title
  
  PLOS ONE
  
  Volume: 印刷中 Issue: 3 Pages: 1-8
- DOI
  10.1371/journal.pone.0120865
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300255, KAKENHI-PROJECT-26460153
[Journal Article] Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore2014
- Author(s)
  Kai Kitamura, Hidehiko Nakagawa et al.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 24 Pages: 5660-5662
- DOI
  10.1016/j.bmcl.2014.10.075
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293028, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26460153
[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013
- Author(s)
  Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 52 Issue: 2 Pages: 133-138
- DOI
  10.3164/jcbn.12-118
- NAID
  130004466706
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24590397
[Journal Article] Chlorine atom substitution infuluences radical scavenging activity of 6-chromanol2012
- Author(s)
  K. Inami, Y. Ishizuka, M. Furukawa, I. Nakanishi, K. Ohkubo, K. Fukuhara, S. Fukuzumi, M. Mochizuki
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 20 Issue: 13 Pages: 4049-4055
- DOI
  10.1016/j.bmc.2012.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-23590064, KAKENHI-PROJECT-23590152, KAKENHI-PROJECT-23750014, KAKENHI-PLANNED-20108010
[Journal Article] A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis2012
- Author(s)
  A. Ohno, T. Kawanishi, H. Okuda, K. Fukuhara, K.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 3 Pages: 320-324
- DOI
  10.1248/cpb.60.320
- NAID
  130001852416
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Kinetics and Mechanism for the Scavenging Reaction of the 2,2-Diphenyl-1-picrylhydrazyl Radical by Synthetic Artepillin C Analogues2012
- Author(s)
  T. Kawashima, S. Manda, Y. Uto, K. Ohkubo, H. Hori, K. Matsumoto, K. Fukuhara, N. Ikota, S. Fukuzumi, T. Ozawa, K. Anzai, I. Nakanishi
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 85 Issue: 8 Pages: 877-883
- DOI
  10.1246/bcsj.20120005
- NAID
  130004153096
- ISSN
  0009-2673, 1348-0634
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-23590064, KAKENHI-PROJECT-23750014, KAKENHI-PLANNED-20108010
[Journal Article] Determination of Lusidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given Lucidin-3-O-primeveroside2012
- Author(s)
  Y. Ishii, K. Inoue, S. Takasu, M. Jin, K. Matsushita, K. Kuroda, K. Fukuhara, A. Nishikawa, T. Umemura
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 25 Issue: 5 Pages: 1112-1118
- DOI
  10.1021/tx300084p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 4 Pages: 1793-1796
- DOI
  10.1016/j.bmcl.2011.11.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
[Journal Article] Detection and quantification of specific-DNA adducts by LC-MS/MS in the livers of rats given estragole at the carcinogenic dose2011
- Author(s)
  Y. Ishii, Y, Suzuki, D. Hibi, M. Jin, K. Fukuhara, T. Umemura, A. Nishikawa
- Journal Title
  
  Chem. Res. Toxico
  
  Volume: 24 Issue: 4 Pages: 532-541
- DOI
  10.1021/tx100410y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity2011
- Author(s)
  K. Fukuhara, A. Ohno, Y. Ando, T. Yamoto, H. Okuda
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 4 Pages: 399-406
- DOI
  10.2133/dmpk.DMPK-11-RG-005
- NAID
  130004463199
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation2011
- Author(s)
  N. Ieda, H. Nakagawa, T. Horinouchi, T. Peng, D. Yang, H. Tsumoto, T. Suzuki, K. Fukuhara, N. Miyata
- Journal Title
  
  Chem. Comm.
  
  Volume: 47 Issue: 22 Pages: 6449-6451
- DOI
  10.1039/c1cc11681a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PUBLICLY-23117715
[Journal Article] Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics2011
- Author(s)
  A. Ohno, K. Oka, C. Sakuma, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Agric. Food Chem
  
  Volume: 59 Issue: 10 Pages: 5181-5187
- DOI
  10.1021/jf200204y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue2011
- Author(s)
  K. Imai, I. Nakanishi, A. Anzai, T. Ozawa, N. Miyata, S. Urano, H. Okuda, A. Nakamura, K. Fukuhara
- Journal Title
  
  Chem. Lett.
  
  Volume: 40 Issue: 12 Pages: 1417-1419
- DOI
  10.1246/cl.2011.1417
- NAID
  10030221524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-23590064
[Journal Article] Photoinduced nitric oxide release from a nitrobenzene derivative in mitchondria2011
- Author(s)
  T. Horinouchi, H. Nakagawa, T. Suzuki, K. Fukuhara, N. Miyata
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 17 Issue: 17 Pages: 4809-4813
- DOI
  10.1002/chem.201001967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PUBLICLY-23117715
[Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity2009
- Author(s)
  K.Fukuhara, A.Ohno, I.Nakanishi, K.Imai, A.Nakamura, K.Anzai, N.Miyata, H.Okuda
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 6989-6992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation2009
- Author(s)
  K. Hishikawa, H. Nakagawa, K. Fukuhara, H. Tsumoto, T. Suzuki, N. Miyata
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 131 Issue: 22 Pages: 7488-7489
- DOI
  10.1021/ja8093668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity2009
- Author(s)
  K.Fukuhara
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 6989-6992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K.Fukuhara
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 282-287
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice2008
- Author(s)
  A. Matsuoka, K. Kodama, K. Fukuhara, et. al.
- Journal Title
  
  Food. Chem. Toxicol. 46
  
  Pages: 1125-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K.Fukuhara, I.Nakanishi, A.Matsuoka, T.Matsumura, S.Honda, M.Hayashi, T.Ozawa, N.Miyata, S.Saito, N.Ikota, H.Okuda
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 282-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease2008
- Author(s)
  H. Kobayashi, K. Fukuhara, S. Tada-Oikawa, Y. Yada, Y. Hiraku, M. Murata, S. Oikawa
- Journal Title
  
  J. Neurochem
  
  Volume: 108 Pages: 397-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives2008
- Author(s)
  S. Manda, I. Nakanishi, K. Ohkubo, Y. Uto, T. Kawashima, K. Fukuhara, H. Okuda, H. Hori, T. Ozawa, N. Ikota, S. Fukuzumi, K. Anzai
- Journal Title
  
  Chem. Commumn.
  
  Pages: 626-628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-monty feeding test in young adult mice2008
- Author(s)
  A. Matsuoka, Y. Kodama, K. Fukuhara, S. Honda, M. Hayashi, K. Sai, M. Hasebe, Y. fujiwara
- Journal Title
  
  Food Chem. Toxicol. 46
  
  Pages: 1125-1130
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K.Fukuhara
- Journal Title
  
  Chem.Res.Toxicol. 21
  
  Pages: 282-287
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 21 Issue: 2 Pages: 282-287
- DOI
  10.1021/tx7003008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives2008
- Author(s)
  S. Manda, I. Nakanishi, K. Ohkubo, Y. Uto, T. Kawashima. K. Fukuhara, H. Okuda, H. Hori, T. Ozawa, N. Ikota, S. Fukuzumi, K. Anzai
- Journal Title
  
  Chem. Commun.
  
  Pages: 626-628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, H Okuda, et. al.
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of MethyI Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives2008
- Author(s)
  S. Manda, I. Nakanishi, K. Fukuhara, et. al.
- Journal Title
  
  Chem. Commun.
  
  Pages: 626-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol2008
- Author(s)
  K. Fukuhara
- Journal Title
  
  Chem. Res. Toxicol. 21
  
  Pages: 282-287
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsal solinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease2008
- Author(s)
  H. Kobayashi, K. Fukuhara, M. Murata, S. Oikawa
- Journal Title
  
  J. Neurochem. 108
  
  Pages: 397-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Involvement of Electron Transfer in the Radical-Scavenging Reaction of Resveratrol2007
- Author(s)
  I. Nakanishi, T. Shimada, K. Ohkubo, T. Shimizu, S.Urano, H. Okuda, N. Miyata, T. Ozawa, K. Anzai, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Chem. Lett. 36
  
  Pages: 1276-1277
- NAID
  10019962015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraqiuone for photodynamic therapy2007
- Author(s)
  K.Fukuhara
- Journal Title
  
  Bioorg. Medi.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara, S. Oikawa, N. Hakota, Y. Sakai, Y. Hiraku. T. Shoda, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara, S. Oikawa, N. Hakota, Y. Sakai, Y. Hiraku, T. Shoda, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara
- Journal Title
  
  Bioorg. Medi. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodyn amic therapy2007
- Author(s)
  K. Fukuhara
- Journal Title
  
  Bioorg. Medi. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K.Fukuhara
- Journal Title
  
  Bioorg. Medi. Chem. (in press)
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K.Fukuhara
- Journal Title
  
  Bioorg.Med.Chem. 15
  
  Pages: 3869-3873
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] A planar vatechin analogue as a new type of synthetic antioxidant2006
- Author(s)
  K.Fukuhara
- Journal Title
  
  Genes and Environment 28
  
  Pages: 41-47
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Structural Basis for DNA Cleaving-Activity of Resveratrol om the Presence of Cu(II)2006
- Author(s)
  K. Fukuhara
- Journal Title
  
  Bioorg. Medi. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Structural Basis for DNA Cleaving-Activity of Resveratrol om the Presence of Cu(II)2006
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Bioorg.Medi.Chem. 14
  
  Pages: 1437-1443
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] N-linked oligosaccharide processing enzymes as molecular targets for drug discovery2006
- Author(s)
  W. Hakamata, M. Muroi, T. Nishio, T. Oku, A. Takatsuki, H. Osada, K. Fukuhara, H. Okuda, M. Kurihara
- Journal Title
  
  J. App. Glycosci 53
  
  Pages: 149-154
- NAID
  10016802897
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Structural basis for DNA cleaving-activity of resveratorl in the presence of Cu(II)2006
- Author(s)
  K. Fukuhara, M. Nagakawa, I. Nakanishi, K. Ohkubo, K. Imai, S. Urano. S. Fukuzumi, T. Ozawa, N. Ikota, M. Mochizuki, N. Miyata, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] A planar catechin analogue as a new type of synthetic antioxidant2006
- Author(s)
  K. Fukuhara
- Journal Title
  
  Genes and Environment 28
  
  Pages: 41-47
- NAID
  110004749517
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] A Planar Catechin Analogue as a New Type of Synthetic Antioxidant2006
- Author(s)
  K. Fukuhara
- Journal Title
  
  Genes and Environment 28
  
  Pages: 41-47
- NAID
  110004749517
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Structural Basis for DNA Cleaving-Activity of Resveratrol om the Presence of Cu(II)2006
- Author(s)
  K. Fukuhara
- Journal Title
  
  Bioorg. Medi. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Planar catechin analogues with alkyl side chains, as a potent antioxidant and an α-glucosidase inhibitor2006
- Author(s)
  W. Hakamata, I. Nakanishi, Y. Masuda, T. Shimizu, H. Higuchi, Y. Nakamura, T. Oku, S. Saito, S. Urano, T. Ozawa, N. Ikota, N. Miyata, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Am. Chem. Soc. 128
  
  Pages: 6524-6525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Structural basis for DNA cleaving-activity of resveratrol in the presence of Cu(II)2006
- Author(s)
  K. Fukuhara, M. Nagakawa, I. Nakanishi, K. Ohkubo, K. Imai, S. Urano, S. Fukuzumi, T. Ozawa, N. Ikota, M. Mochizuki, N. Miyata, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 1437-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Structural Basis for DNA Cleaving-Activity of Resveratrol om the Presence of Cu(II)2006
- Author(s)
  K.Fukuhara
- Journal Title
  
  Bioorg.Med.Chem. 14
  
  Pages: 1437-1443
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Design and synthesis of α-glucosidase inhibitor having DNA cleaving activity2006
- Author(s)
  W. Hakamata, E. Yamamoto, M. Muroi, M. Mochizuki, M. Kurihara, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Appl. Glycosci 53
  
  Pages: 255-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Design and synthesis of α-glucosidase inhibitor having DNA cleaving activity2006
- Author(s)
  W. Hakamata, E. Yamamoto, M. Muroi, M. Mochizuki, M. Kurihara, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Appl. Glycosci 53
  
  Pages: 255-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Planar catechin analogues with alkyl side chains, as a potent antioxidant and an α-glucosidase inhibitor2006
- Author(s)
  W. Hakamata, I. Nakanishi, Y. Masuda, T. Shimizu, H. Higuchi, Y. Nakamura, T. Oku, S. Saito, S. Urano, T. Ozawa, N. Ikota, N. Miyata, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Am. Chem. Soc 128
  
  Pages: 6524-6525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue2005
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Org.Biomol.Chem 3
  
  Pages: 3263-3265
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Electron-Tansfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in a Protic Medium, Org.2005
- Author(s)
  I. Nakanishi, T. Kawashima, K. Ohkubo, H. Kanazawa, K. Inami, M. Mochizuki, K. Fukuhara, H. Okuda, T. Ozawa, S. Itoh, S. Fukuzumi, N. Ikota
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 626-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Photo-induced Nitric Oxide Release from Nitrobenzene Derivatives2005
- Author(s)
  T. Suzuki, O. Nagae, Y. Kato, H. Nakagawa, K. Fukuhara, N. Miyata
- Journal Title
  
  J. Am. Chem. Soc. 127
  
  Pages: 11720-11726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue, Org.2005
- Author(s)
  Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 3263-3265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Journal Article] Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-Oxide by an NADH Analogue, Org.2005
- Author(s)
  Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota, K. Fukuhara
- Journal Title
  
  Biomol. Chem 3
  
  Pages: 3263-3265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Electron-Tansfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in a Protic Medium2005
- Author(s)
  H.Okuda, K.Fukuhara et al.
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 626-629
- Data Source
  KAKENHI-PROJECT-17590028
[Journal Article] Characterization of tea cultivated at four different altitudes using 1H NMR analysis coupled with multivariate statistics
- Author(s)
  A.Ohno, K.Oka, C.Sakuma, H.Okuda, K.Fukuhara
- Journal Title
  
  J.Agri.Food Chem. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen induced hepatotoxicity
- Author(s)
  K.Fukuhara, A.Ohno, Y.Ando, T.Yamato, H.Okuda
- Journal Title
  
  Drug.Metab.Pharm. in press.
- NAID
  130004463199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] 新規スチルベン誘導体2014
- Inventor(s)
  福原潔、熊本浩樹、樋口明弘、坪田一男
- Industrial Property Rights Holder
  福原潔、熊本浩樹、樋口明弘、坪田一男
- Industrial Property Rights Type
  特許
- Filing Date
  2014-08-29
- Data Source
  KAKENHI-PROJECT-26460153
[Patent] フラバノール誘導体-アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔, 大野彰子, 奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2011-183246
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] フラバノール誘導体‐アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ 蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔,大野彰子,奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] アミロイドβの神経毒製を抑制する新規ペプチドの開発2023
- Author(s)
  福原潔、沖山佳生、森一憲、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  酸化ストレス学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06508
[Presentation] Effects of the nitro-group on the mutagenicity of nitrated benzo[a]pyrenes2022
- Author(s)
  A. Ohno, Y. Okiyama, A. Hirose, K. Fukuhara
- Organizer
  264th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06508
[Presentation] シリビニンの高機能化を目指した創薬研究2021
- Author(s)
  水野美麗，森一憲，土屋圭輔，髙木孝士，三澤隆史，出水庸介，柴沼質子，福原潔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフィセチンのラジカル消去作用2021
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] プテロスチルベンのラジカル消去反応に対するマグネシウムイオンの効果2021
- Author(s)
  中西郁夫、荘司好美、大久保敬、上野恵美、下田恵、小澤俊彦、福原潔、濱田博喜、松本謙一郎
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] ニトロ多環芳香族炭化水素の構造と変異原性に関するドッキングスタディ2021
- Author(s)
  大野彰子、沖山佳生、広瀬明彦、福原潔
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 分子内環固定によるシリビニンの高機能化2020
- Author(s)
  水野美麗，森一憲，柴沼質子，福原潔
- Organizer
  本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフラボノイドのラジカル消去作用2020
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβを創薬標的としたシリビニン誘導体の開発2019
- Author(s)
  水野美麗,森一憲,三澤隆史,髙木孝士,出水庸介,柴沼質子,福原潔
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 鉄錯体形成をトリガーとした新規抗酸化物質の開発2019
- Author(s)
  福原　潔，今井耕平，中西郁夫，松本謙一郎，大野彰子
- Organizer
  第43回鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフィセチンのラジカル消去活性2019
- Author(s)
  福原　潔，今井耕平，中西郁夫，大久保敬，大野彰子，水野美麗，福住俊一，松本謙一郎
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Planar catechin conjugated with DTPA as a promising antioxidant triggered by Fe3+ coordination2019
- Author(s)
  K. Fukuhara, K. Imai, I. Nakanishi, K. Matsumoto, A. Ohno
- Organizer
  258th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Synthesis of silibinin analogues targeting amyloid β2019
- Author(s)
  M. Mizuno, K. Mori, M. Shibanuma, K. Fukuhara
- Organizer
  258th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβを創薬標的としたプロアントシアニジン誘導体の開発2018
- Author(s)
  水野美麗，森　一憲，柴沼質子，福原　潔
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Potential lead compounds for the treatment of Alzheimer’s disease: a peptide that blocks amyloid beta induced neurotoxicity2018
- Author(s)
  K. Fukuhara, T. Arai, A. Ohno, K. Mori, M. Shibanuma, N. Miyata, H. Nakagawa
- Organizer
  256th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] カテキンのプロオキシダント効果：キノン代謝を経由する活性酸素毒性の解析2018
- Author(s)
  水野美麗、阿部眞優奈、生澤瑞季、福原潔
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] アミロイドβのC末端モチーフを有するアルツハイマー病予防・治療薬の開発2018
- Author(s)
  福原　潔，荒井卓也，大野彰子，森一憲，柴沼質子，宮田直樹，中川秀彦
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβによる神経細胞毒性を抑制するプロアントシアニジン誘導体の開発2018
- Author(s)
  水野美麗、森一憲、中西郁夫、松本謙一郎、柴沼質子、福原潔
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] アミロイドβ凝集と神経細胞毒性を抑制するプロアントシアニジン誘導体の開発2018
- Author(s)
  水野美麗，森　一憲，柴沼質子，福原　潔
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 金属錯体形成をトリガーとした新規抗酸化物質の開発2018
- Author(s)
  福原　潔，今井耕平，中西郁夫，松本謙一郎，大野彰子
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβ凝集阻害作用を有するプロアントシアニジン誘導体の創製2017
- Author(s)
  水野美麗、森一憲、中西郁夫、松本謙一郎、柴沼質子、福原潔
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] アルツハイマー病治療薬を目指したアミロイドβのC末端ペプチドモチーフを有するフェノール性抗酸化剤の開発2017
- Author(s)
  福原潔、荒井卓也、大野彰子、森一憲、芝沼質子、宮田直樹、中川秀彦
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] カテキン類のラジカル消去反応機構の化学的解析2017
- Author(s)
  江部靖弘、堀内柊吾、水野美麗、福原潔
- Organizer
  第61回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] AβのC末端もチーフを含有したトロロックス誘導体によるAβの細胞毒性および酸化ストレスの抑制2016
- Author(s)
  荒井卓也、大野彰子、森一憲、柿澤多恵子、石田誠一、桑田浩、小澤俊彦、原俊太郎、柴沼質子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] アミロイドβの C 末端モチーフを有する新規アルツハイマー病治療薬の開発2016
- Author(s)
  荒井卓也、大野彰子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] 新規アルツハイマー病治療薬の開発を目指したAβ1-42のC末端モチーフ含有ジヒドロカフェ酸誘導体の合成2015
- Author(s)
  荒井卓也、大野彰子、須賀真里奈、栗原正明、小澤俊彦、宮田直樹、中川秀彦、福原潔
- Organizer
  日本酸化ストレス学会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] NMR を用いたアルツハイマー症モデルマウスのメタボローム解析2012
- Author(s)
  福原潔
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] アミロイドβを標的としたアルツハイマー予防薬の開発2012
- Author(s)
  福原潔
- Organizer
  第23回ビタミンE研究会
- Place of Presentation
  東京
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] メチル基を有するフラボノイド系抗酸化剤の合成とラジカル消去活性2012
- Author(s)
  福原　潔
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] メチル基を有するフラボノイド系抗酸化剤の合成とラジカル消去活性2012
- Author(s)
  福原潔
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-11-28
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] The application of NMR-based metabolomics in drug development2012
- Author(s)
  Fukuhara, K
- Organizer
  The 3^<rd> Internatilnal Symposium on Drug Discovery and Design by NMR
- Place of Presentation
  横浜
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] NMR によるメタボローム情報の創薬への利用:有効性・安全性評価のためのメタボロミクス2012
- Author(s)
  福原潔
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Methyl analogues of quercetin for improved radical-scavenging activities2012
- Author(s)
  Fukuhara, K
- Organizer
  244th American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Methyl analogues of quercetin for improved radical-scavenging activities2012
- Author(s)
  Fukuhara, K
- Organizer
  244^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-08-19
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR によるメタボロミクス:薬物代謝酵素阻害によるAPAP 誘発肝障害の軽減2011
- Author(s)
  福原潔
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases2011
- Author(s)
  K.Fukuhara
- Organizer
  International Symposium on Free Radical Research : Contribution to Medicine
- Place of Presentation
  京都
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Novel Trolox-C-termal motifs of Aβ42 as neuroprotective agents for the treatment of Alzheimer's diseases2011
- Author(s)
  Fukuhara, K.
- Organizer
  242^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Denver
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Potential lead for an Alzheimer drug: a peptide that blocks amyloid s induced neurotoxicity2011
- Author(s)
  Fukuhara,K
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases2011
- Author(s)
  Fukuhara, K
- Organizer
  International Symposium on Free Radical Research: Contribution to Medicine (FRCM 2011)
- Place of Presentation
  京都
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR によるアセトアミノフェン誘発肝障害のメタホロミクス2011
- Author(s)
  福原潔
- Organizer
  第64回日本酸化ストレス学会学術集会
- Place of Presentation
  北海道留寿都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases2011
- Author(s)
  K.Fukuhara
- Organizer
  International Symposium on Free Radical Research : Contribution to Medicine
- Place of Presentation
  Kyoto
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Potential lead for an Alzheimer Drug : A peptide that blocks amyloid β induced neurotoxicity2011
- Author(s)
  Fukuhara, K.
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Novel trolox.C.terminal motifs of As42 as neuroprotective agents for the treatment of Alzheimer's diseases2011
- Author(s)
  Fukuhara, K
- Organizer
  242^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Denver, USA
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation]2010
- Author(s)
  K.Fukuhara
- Organizer
  240^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Boston
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR を利用したAPAPによる肝障害のメタボロミクス2010
- Author(s)
  福原潔
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 分子内に塩基性アミノ酸を有する平面型カテキン誘導体の抗酸化活性2010
- Author(s)
  福原潔
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Synthesis of Conformationally Constrained Epigallocatechin Analogue as a Promising Antioxidant2010
- Author(s)
  K.Fukuhara
- Organizer
  SFRBM's 17th Annual Meeting
- Place of Presentation
  Orlando
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 2-ニトロイミダゾールの光増感作用の解析,2010
- Author(s)
  福原潔
- Organizer
  講演ハイライト(タイトル:活性酸素が薬になる～身体にやさしい癌治療を目指して～)日本薬学会第130 年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR-based metabolomics approach for analysis of APAP hepatotoxicity2010
- Author(s)
  Fukuhara, K
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 1H NMR-based metabolomics approach for analysis of APAP hepatotoxicity2010
- Author(s)
  K.Fukuhara
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Enhanced radical scavenging activities of catechin derivatives incorporating basic amino acids2010
- Author(s)
  Fukuhara, K
- Organizer
  240^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Boston, USA
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Synthesis of β-galactose-conjugated porphyrin analog with high affinity to cancer cell for photodynamic therapy2010
- Author(s)
  K.Fukuhara
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 分子内に塩基性アミノ酸を有する平面型カテキン誘導体の抗酸化活性2010
- Author(s)
  福原潔
- Organizer
  29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] I1H NMRを利用したAPAPによる肝障害のメタボロミクス2010
- Author(s)
  福原潔
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ラジオイムノテラピーに有効なニトロイミダゾール?抗体コンジュゲートの作成2009
- Author(s)
  福原潔
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ラジオイムノテラピーに有効なニトロイミダゾール-抗体コンジュゲートの作成2009
- Author(s)
  福原潔
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ニンヒドリンの反応特性を利用した新規カテキン誘導体の合成2009
- Author(s)
  福原潔
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 天然カテキンの生物活性制御を目的とした化学修飾法の開発2009
- Author(s)
  福原潔
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 天然カテキンの生物活性制御を目的とした化学修飾法の開発2009
- Author(s)
  福原潔
- Organizer
  第62回日本酸化ストレス学会
- Place of Presentation
  福岡
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンE誘導体の開発2008
- Author(s)
  中西郁夫, 乳井美奈子, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  日本環境変異原学会第37回大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 金属イオン存在下におけるヒドロキノン類のラジカル消去反応2008
- Author(s)
  中西郁夫, 大久保敬, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 天然抗酸化物質の生合成前駆体およびその類縁体のラジカル消去活性2008
- Author(s)
  中西郁夫, 宇都義浩, 大久保敬, 福原潔, 奥田晴宏
- Organizer
  第8回AOB(Antioxidant Biofactor)研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] レスベラトロールをテンプレートとした新規化学予防物質の開発2008
- Author(s)
  福原潔
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ラジカル消去活性の増強と遺伝毒性の軽減を目的としたレスベラトロールの誘導化2008
- Author(s)
  福原潔, 中西郁夫, 宮田直樹, 奥田晴宏
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] リジン側鎖を有する平面型カテキン誘導体の合成とラジカル消去活性2008
- Author(s)
  福原潔
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] エピカテキンの抗酸化作用の増強を目的とした立体構造固定化2008
- Author(s)
  今井耕平, 中西郁夫, 奥田晴宏, 福原潔
- Organizer
  日本環境変異原学会第37回大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Structure-Activity Relationships in the Radical-scavenging Reaction of Polyphenolic Flavones, Oxgen Club of Californai 2008 World Congress, California2008
- Author(s)
  I. Kahanishi, K. Ohkubo, K. Miyazaki, S. Urano, H. Okuda, N. Ikota, K. Anzai, S. Fukuzumi, T. Ozawa, K. Fukuhara
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] ブラジル産プロポリスに含まれるフェノール性抗酸化物質およびその誘導体のラジカル消去活性2008
- Author(s)
  中西郁夫, 大久保敬, 奥田晴宏, 福原潔, 安西和紀
- Organizer
  第41回酸化反応討論会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ヒドロキノン類によるラジカル消去速度に及ぼす金属イオンの効果2008
- Author(s)
  中西郁夫, 宇都義浩, 福原潔, 奥田晴宏, 安西和紀
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen2007
- Author(s)
  K. Fukuhara, A. Ishikawa, W. Hakamata, S. Saito, H. Okuda
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen2007
- Author(s)
  K. Fukuhara, A. Ishikawa, W. Hakamata, S. Saito, H. Okuda
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] N-ニトロソフェンフルラミンの毒性反応機構の解析-活性酸素毒性の可能性-2007
- Author(s)
  福原潔
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Effect of Methyl Substitution of Antioxidative Properties and Genotoxicity of Resveratrol2007
- Author(s)
  K. Fukuhara
- Organizer
  International Conference on Food Factors for Health Promotion (ICoFF2007)
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Intramolecular Base-Accelerated Radical-Scavenging Reaction of a Planar Catechin Derivative having a Lysine Moiety, 14th Annual Meeting of the Society for Free Radical Biology and Medicine(Sfrbm), Washington, D. C.2007
- Author(s)
  K. Fukuhara, I. Nakanishi, M. Obara, K. Ohbubo, T. Kawashima, T. Ozawa, N. Ikota, K. Anzai, S. Fukuzumi, N. Miyata, S. Saito, H. Okuda
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Effect of Methyl Substitution of Antioxidative Properties and Genotoxicity of Resveratrol, International Conference on Food Factors for Health Promotion(ICoFF2007)2007
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Ozawa, N. Miyata, N. Ikota, H. Okuda
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Electron-Transfer Mechanism in the Radical-Scavenging Reaction of Resveratrol, 14th Annual Meeting of the Society for Free Radical Biology and Medicin(SFRBM), Washington, D. C.2007
- Author(s)
  I. Nakanishi, T. Shimada, K. Ohkubo, S. Manda, S. Urano, H. Okuda, n. Miyata, t. Ozawa K. Anzai, S. Fukuzumi, N. Ikota, K. Fukuhara
- Place of Presentation
  USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Intramolecular Base-Accelerated Radical-Scavenging Reaction of a Planar Catechin Derivative Having a Lysine Moiety2007
- Author(s)
  K. Fukuhara
- Organizer
  14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM)
- Place of Presentation
  Washington
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] N-ニトロソフェンフルラミンの毒性反応機構の解析-活性酸素毒性の可能性-2007
- Author(s)
  福原潔
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] レスベラトロールをテンプレートとした新規抗酸化剤の開発2007
- Author(s)
  福原潔
- Organizer
  第29回日本フリーラジカル学会学術集会、日本過酸化脂質・フリーラジカル学会第31回大会合同学会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] DNA cleaving activity of nitroimidazole under photoirradiation2007
- Author(s)
  T. Shoda, K. Miura, Y. Sakai, S. Saito, H. Okuda, K. Fukuhara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Enhanced radical-scavenging activities of methyl resveratrol, Annual Meeting of SFRR Japan2007
- Author(s)
  K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Ozawa, N. Ikota N. Miyata, H. Okuda
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 光線力学療法剤の開発:9-ニトロアントラセン誘導体からのアントラキノンの生成とDNA切断反応2006
- Author(s)
  福原潔
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Involvement of Electron Transfer in the Radical-Scavenging Reaction of Resveratrol128th Annual Meeting of the Pharmaceutical Society of Japan2006
- Author(s)
  I. Nakanishi, T. Shimada, K. Okubo, S. Manda, T. shimizu, S. Urano, H. Okuda, N. Miyata, T.Ozawa K. Anzai, S. Fukuzami, N. Ikota, K. Fukuhara
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Enhanced radical-scavenging activities of planar catechin derivatives having Lysine Moiety, 128th Annual Meeting of the Phamaceutical Society of Japan2006
- Author(s)
  K. Fukuhara, I. Nakanishi, K. Okubo, N. Fukai, T. Ozawa, N. Miyata, S. Urano, S. Fukuzami, K. Anzai, H. Okuda
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 光線力学療法剤の開発 : 9-ニトロアントラセン誘導体からのアントラキノンの生成とDNA切断反応2006
- Author(s)
  福原潔
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2006
- Author(s)
  K. Fukuhara, N. Hakota, S. Oikawa, Y. Hiraku, Y. Sakai, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Organizer
  126th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2006
- Author(s)
  K. Fukuhara, N. Hakota, S. Oikawa, Y. Hiraku, Y. Sakai, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Organizer
  126th Annual Meeting of the Phamnaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590028
[Presentation] Enhanced radical-scavenging activities of planar catechin derivatives having alkyl side chains2005
- Author(s)
  K. Fukuhara, I. Nakanishi, T. Kawashima, H. Yakumaru, H. Kanazawa, H. Okuda, K. Ohkubo, T. Ozawa, S. Fukuzumi, N. Ikota
- Organizer
  Pacifichem 2005
- Place of Presentation
  Honolulu, Hawaii, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Enhanced radical-scavengin activities of planar catechin derivatives having alkyl side chains2005
- Author(s)
  K. Fukuhara
- Organizer
  Pacifichem 2005
- Place of Presentation
  Honolulu
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] Aβ1-42のC末端モチーフを有するカフェ酸およびジヒドロカフェ酸誘導体の合成とAβ凝集阻害活性の解析
- Author(s)
  荒井卓也、大野彰子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460153

1. MIYATA Naoki (50114674)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OHNO Akiko (70356236)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
3. TANNO Masayuki (60171914)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SUEYOSHI Shoko (80171114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OKUDA Haruhiro (30160807)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
6. UMEMURA Takashi (50185071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. SYODA Takuji (60435708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 中島葉子 (40239926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 水野美麗 (60766195)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
10. HAKAMATA Wataru (10333337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OIKAWA Shinji (10277006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 矢田健一郎 (40467361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 冨本秀和 (80324648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MISAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. KAMEI Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 天野将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 中川秀彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 関根絵美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中田理恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 井上裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 中西郁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 大久保敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 福住俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 板部洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 牧山智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukuhara Kiyoshi 福原 潔

福原 潔 フクハラ キヨシ

FUKUHARA Kiyoshi 福原 潔

Research Projects

Research Products

Co-Researchers

Development of peptide derivatives with amyloid-beta cleaving activityPrincipal Investigator

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Catechin derivatives useful for the treatment of Alzheimer's diseasePrincipal Investigator

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Development of a PET imaging agent and disease biomarker for Alzheimer's disease.

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Development of amyloid beta C-terminal motifs conjugated with phenolic antioxidantPrincipal Investigator

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Studies on synthetic antioxidants for prevention of oxidative stress-related diseasesPrincipal Investigator

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Design and Synthesis of Antioxidant for a New Type of Chemopreventive AgentsPrincipal Investigator

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Mechanism of hepatic toxicity induced by N-nitrosocompounds : Role of nitrogen monoxides and active oxygen

Principal Investigator

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Studies of Synthetic Catechin Analogues Useful for Antioxidant TherapyPrincipal Investigator

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Studies of Phenazine di N-Oxides as a New Type of Hydroxy Radical DonorPrincipal Investigator

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Synthesis of NO generating compounds with hydroxyl releasing ability

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DPV法を利用した簡便なリガンドーレセプター相互作用解析手法の開発

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Synthesis of NO-donors as Biotransformation Model Compounds

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DNA二重鎖構造巻き戻し機能を持つDNA切断化合物の合成Principal Investigator

Principal Investigator

Fukuhara Kiyoshi 福原潔

福原潔フクハラキヨシ

FUKUHARA Kiyoshi 福原潔