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Isobe Masaharu  磯部 正治

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… Alternative Names

磯部 正治  イソベ マサハル

ISOBE Masaharu  磯部 正治

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Researcher Number 70211050
Other IDs
External Links
Affiliation (Current) 2025: 富山大学, 学術研究部工学系, 特別研究教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 富山大学, 学術研究部工学系, 特別研究教授
2021: 富山大学, 学術研究部工学系, 教授
2012 – 2016: 富山大学, 大学院理工学研究部(工学), 教授
2012: 富山大学, 大学院・理工学研究部, 教授
2011: 富山大学, 大学院理工学研究部, 教授 … More
2010: 富山大学, 大学院・理工学研究部(工学), 教授
2009 – 2010: 富山大学, 理工学研究部(工学), 教授
2008: 富山大学, 理工学研究部, 教授
2007: University of Toyama, Faculty of Science and Engineering Graduate School, Professor
2006: 富山大学, 大学院・理工学研究部(工学), 教授
2006: University of Toyama, Grad. Sch. of Sci and Eng., Prof.
1999 – 2005: Toyama University・Faculty of Engineering, Professor, 工学部, 教授
1996 – 1998: 富山大学, 工学部, 助教授
1994: 富山大学, 工学部, 助教授
1992 – 1993: 富山医科薬科大学, 和漢薬研究所, 助手
1991: 富山医科薬科大学, 和漢薬研, 助手
1990: 富山医科薬科大学和漢薬研究所, 助手
1989: 富山医科薬科大学, 和漢薬研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Human genetics / Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / 基礎ゲノム科学 / 環境生理学(含体力医学・栄養生理学) / Tumor diagnostics / Tumor immunology
Except Principal Investigator
Applied health science / Environmental physiology (including Physical medicine and Nutritional physiology) / Environmental physiology (including Physical medicine and Nutritional physiology) / 環境生理学(含体力医学・栄養生理学)
Keywords
Principal Investigator
成人T細胞白血病 / 14番染色体 / ATL1 / 染色体異常 / T細胞白血病 / TCL1 / 染色体転座 / JF1 / SAM P8 / PCR … More / HTLV-1 / adult T-cell leukemia / central nervous system / Brain / FGF / がん幹細胞 / ヒトモノクローナル抗体 / TCL1遺伝子 / T細胞受容体 / がん治療用抗体 / T細胞受容体様抗体 / MR1 / がん抗原 / モノクローナル抗体 / TCR様抗体 / MHC class I / Tumor stem cell / Antibody / T-cell receptor / Senescence / Learning and Memory Dysfunction / QTL analysis / 老化 / 記憶学習障害 / 連鎖解析 / chromosome translocation / chromosome abnormality / SNP / BAC / ATLl / chromosome abnormalities / chromosome 14 / ATL / 成人細胞白血病 / T-cell leukemia / T-cell receptor locus / T細胞受容体遺伝子 / バキュロウイルス / 長期増強 / 蛋白工学 / 線維芽細胞増殖因子 / 癌幹細胞 / 大腸がん / 抗体療法 / 腫瘍マーカー / がん細胞 / MAGrahd法 / 癌 / 免疫学 / HTLV-I / 大腸癌 / 第14番染色体 / elk / tclー1 … More
Except Principal Investigator
ストレス / ドーパミン / セロトニン / みどりの香り / 学習・記憶 / dopamine / serntonin / lateral hypothalamic area / cedrol / green odor / forest-bathing / stress / 神経科学 / 視床下部外側野 / セドロール / 森林浴 / immune system / endocrine system / learning and memory / acidic fibroblast growth factor / 遺伝子 / コルチコステロン / マクロファージ / アドレナリン / 老化促進モデルマウス / 線維芽細胞増殖因子 / 免疫 / 内分泌 / 酸性線維芽細胞増殖因子 / 脳・神経 / 視床下部ニューロン / 副交感神経系 / CRF / 不安 / 心理的ストレス / 遺伝子工学 / 免疫組織化学 / 虚血 / 線維芽細胞生長因子 / グルコ-スセンサ- / 長期増強 / 海馬 / 迷路学習 / 交感神経 / 摂食 / 線維芽細胞成長因子 Less
  • Research Projects

    (17 results)
  • Research Products

    (74 results)
  • Co-Researchers

    (13 People)
  •  Elucidation of ligands of cancer-specific monomorphic major histocompatibility complexes and development of novel antibody therapiesPrincipal Investigator

    • Principal Investigator
      磯部 正治
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      University of Toyama
  •  Development of the system for isolation of T-cell receptor like antibodies against tumor stem cellsPrincipal Investigator

    • Principal Investigator
      Isobe Masaharu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      University of Toyama
  •  Development of methods for isolation of human monoclonal antibodies recognizing cancer stem cellsPrincipal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor diagnostics
    • Research Institution
      University of Toyama
  •  Development and analysis of human monoclonal antibodies derived from patients with cancerPrincipal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor immunology
    • Research Institution
      University of Toyama
  •  Brain mechanisms underlying the anti-stress effects of green odor that is emanated from green leaves

    • Principal Investigator
      SASAKI Kazuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      University of Toyama
  •  Anti-stress effects of green odor emanating from forest

    • Principal Investigator
      SASAKI Kazuo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied health science
    • Research Institution
      University of Toyama
  •  Identification and functional analysis of genes for learning and memory dysfunction by using Senescence Accelerating MousePrincipal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      基礎ゲノム科学
    • Research Institution
      University of Toyama
  •  染色体異常好発領域からの成人T細胞白血病原因遺伝子の単離Principal Investigator

    • Principal Investigator
      磯部 正治
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Toyama
  •  Methodological development for the identification of disease related genes by taking advantage of chromosome abnormalitiesPrincipal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Toyama University, Faculty of Engineering
  •  Searching for gene responsible for adult T-cell leukemia(ATL)from human chromosome 14 at q32 region.Principal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Toyama University, Faculty of Engineering
  •  Effects of acidic fibroblast growth factor released by feeding on learning and memory, endocrine and immune systems

    • Principal Investigator
      SASAKI Kazuo
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Toyama University
  •  ヒト第14番染色体のゲノム解析と疾患関連遺伝子の探索Principal Investigator

    • Principal Investigator
      磯部 正治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Toyama
  •  ABNORMALITIES IN T-CELL RECEPTOR LOCUS AND T-CELL LEUKEMIAPrincipal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Toyama University, Faculty of Engineering
  •  染色体転座による成人T細胞白血病発症機構の解析Principal Investigator

    • Principal Investigator
      磯部 正治
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Toyama
  •  Development of mcdified fibroblast growth factors which act in central nervcus system.Principal Investigator

    • Principal Investigator
      ISOBE Masaharu
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      環境生理学(含体力医学・栄養生理学)
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  線維芽細胞成長因子による本能及び情動行動,学習,老化制御機構

    • Principal Investigator
      SASAKI Kazuo
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      環境生理学(含体力医学・栄養生理学)
    • Research Institution
      University of Toyama
      Toyama Medical and Pharmaceutical University
  •  成人T細胞白血病の染色体転座による発癌機構の研究Principal Investigator

    • Principal Investigator
      磯部 正治
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Toyama Medical and Pharmaceutical University

All 2023 2022 2021 2016 2015 2014 2013 2012 2011 2008 2006 2005 2004 2002 2001 2000 Other

All Journal Article Presentation Book Patent

  • [Book] An Animal Model of Senescence, in: International Congress Series 12602004

    • Author(s)
      M. Isobe
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] The development of a highly sensitive and quantitative SARS-CoV-2 rapid antigen test applying newly developed monoclonal antibodies to an automated chemiluminescent flow-through membrane immunoassay device2023

    • Author(s)
      Kengo Nishimura, Hiroaki Kitazawa, Takashi Kawahata, Kosuke Yuhara, Takahiro Masuya, Toshihiro Kuroita, Kentarou Waki, Seiichi Koike, Masaharu Isobe, Nobuyuki Kurosawa
    • Journal Title

      BMC Immunology

      Volume: 24 Issue: 1 Pages: 34-34

    • DOI

      10.1186/s12865-023-00567-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07214, KAKENHI-PROJECT-23K24137
  • [Journal Article] Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants2022

    • Author(s)
      Ozawa T, Tani H, Anraku Y, Kita S, Igarashi E, Saga Y, Inasaki N, Kawasuji H, Yamada H, Sasaki S, Somekawa M, Sasaki J, Hayakawa Y, Yamamoto Y, Morinaga Y, Kurosawa N, Isobe M, Fukuhara H, Maenaka K, Hashiguchi T, Kishi H, Kitajima I, Saito S, Niimi H
    • Journal Title

      mAbs

      Volume: 14 Issue: 1 Pages: 2072455-2072455

    • DOI

      10.1080/19420862.2022.2072455

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07214, KAKENHI-PROJECT-21H02962, KAKENHI-PROJECT-23K21403
  • [Journal Article] Polymorphic SERPINA3-R124C reduces pathogenesis of its wild type by shortening the lifetime of oligomeric Aβ2021

    • Author(s)
      Akbor Maruf Mohammad、Kurosawa Nobuyuki、Tanaka Masashi、Isobe Masaharu
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 8 Pages: 1861-1868

    • DOI

      10.1093/bbb/zbab101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07214
  • [Journal Article] Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta2021

    • Author(s)
      Akbor Maruf Mohammad、Kurosawa Nobuyuki、Nakayama Hiroki、Nakatani Ayumi、Tomobe Koji、Chiba Yoichi、Ueno Masaki、Tanaka Masashi、Nomura Yasuyuki、Isobe Masaharu
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 3 Pages: e0248027-e0248027

    • DOI

      10.1371/journal.pone.0248027

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07508, KAKENHI-PROJECT-21K07214
  • [Journal Article] A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice2021

    • Author(s)
      Akbor Maruf Mohammad、Kim Juhyon、Nomura Mai、Sugioka Juno、Kurosawa Nobuyuki、Isobe Masaharu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 572 Pages: 112-117

    • DOI

      10.1016/j.bbrc.2021.07.095

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06716, KAKENHI-PROJECT-21K07214
  • [Journal Article] Novel method for the high-throughput production of phosphorylation site-specific monoclonal antibodies2016

    • Author(s)
      Nobuyuki Kurosawa, Yuka Wakata, Tomonao Inobe, Haruki Kitamura, Megumi Yoshioka, Shun Matsuzawa, Yoshihiro Kishi & Masaharu Isobe
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 25174-25174

    • DOI

      10.1038/srep25174

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14405, KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
  • [Journal Article] Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation.2014

    • Author(s)
      Kano Y, Ishii H, Konno M, Yamasaki M, Miyata H, Nishikawa S, Hamabe A, Ogawa H, Takahashi H, Ohta K, Hasegawa S, Tanaka K, Fukusumi T, Otsuka M, Kawamoto K, Haraguchi N, Fujimoto R, Isobe M, Tomita Y, Matsuura N, Takiguchi S, Mori M, Doki Y.
    • Journal Title

      Int J Oncol

      Volume: 44 Issue: 2 Pages: 443-50

    • DOI

      10.3892/ijo.2013.2206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590459, KAKENHI-PROJECT-25640075
  • [Journal Article] Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice2013

    • Author(s)
      Akbor, K. Tomobe, T. Yamada, J. Kim, H. Mano, N. Kurosawa, K. Sasaki, Y. Nomura and M. Isobe
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Issue: 1 Pages: 25-30

    • DOI

      10.1016/j.bbrc.2013.09.145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25640075
  • [Journal Article] Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma2013

    • Author(s)
      Kurosawa, N.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e55147-e55147

    • DOI

      10.1371/journal.pone.0055147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650607, KAKENHI-PROJECT-23790617, KAKENHI-PROJECT-25640075
  • [Journal Article] Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma2013

    • Author(s)
      Kurosawa, N., Fujimoto, R., Ozawa, T., Itoyama, T., Sadamori, N., and Isobe, M.
    • Journal Title

      PloS one 8

    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Fine Bubble Mixing (FBM) Culture of E. coli: A Highly Cost-effective Middle Scale-size Culture System2013

    • Author(s)
      H. Yasumitsu, H. Tajima, M. Isobe, S. Kutsuna, S. M. Kawsar, Y. Fujii, R. A. Kanaly, Y. Ozeki and E. Yokota
    • Journal Title

      Protein Pept Lett

      Volume: 20 Pages: 213-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25640075
  • [Journal Article] HELIOS-BCL11B fusion gene involvement in a t(2;14)(q34;q32) in an adult T-cell leukemia patient2012

    • Author(s)
      Fujimoto, R., Ozawa, T., Itoyama, T., Sadamori, N., Kurosawa, N., and Isobe, M.
    • Journal Title

      Cancer genetics

      Volume: 205 Pages: 356-364

    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Rapid production of antigen-specific monoclonal antibodies from a variety of animals2012

    • Author(s)
      Kurosawa, N., Yoshioka, M., Fujimoto, R., Yamagishi, F., and Isobe, M.
    • Journal Title

      BMC biology

      Volume: 10 Pages: 80-80

    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Target-selective joint polymerase chain reaction: a robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells2011

    • Author(s)
      Yoshioka, M., Kurosawa, N., and Isobe, M.
    • Journal Title

      BMC biotechnology

      Volume: 11 Pages: 75-75

    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Target-selective homologous recombination cloning for high-throughput generation of monoclonal antibodies from single plasma cells.2011

    • Author(s)
      Nobuyuki Kurosawa, Megumi Yoshioka and Masaharu Isobe
    • Journal Title

      BMC Biotechnology

      Volume: 11 Issue: 1 Pages: 39-39

    • DOI

      10.1186/1472-6750-11-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Target-selective joint polymerase chain reaction: a robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells.2011

    • Author(s)
      Megumi Yoshioka, Nobuyuki Kurosawa and Masaharu Isobe
    • Journal Title

      BMC Biotechnology

      Volume: 11 Issue: 1 Pages: 75-75

    • DOI

      10.1186/1472-6750-11-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] Target-selective homologous recombination cloning for high-throughput generation of monoclonal antibodies from single plasma cells2011

    • Author(s)
      Kurosawa, N., Yoshioka, M., and Isobe, M.
    • Journal Title

      BMC biotechnology

      Volume: 11 Pages: 39-39

    • Data Source
      KAKENHI-PROJECT-23650607
  • [Journal Article] TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia2006

    • Author(s)
      S, Haider, K,. Hayakawa, T,. Itoyama, N,. Sadamori, N,. Kurosawa, M, Isobe
    • Journal Title

      J. Hum. Genet 51(4)

      Pages: 326-334

    • NAID

      10017479812

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Molecular characterization of a novel translocation t(5;14)(q21;q32) in a patient with congenital abnormalities.2006

    • Author(s)
      Haider, S., Matsumoto, R., Kurosawa, N., Wakui, K., Fukushima, Y., Isobe, M.
    • Journal Title

      J Hum Genet (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia.2006

    • Author(s)
      Haider, S., Hayakawa, K.Itoyama, T.Sadamori, N.Kurosawa, N., Isobe.M.
    • Journal Title

      J Hum Genet (in press)

    • NAID

      10017479812

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Molecular characterization of a novel translocation t(5;14)(q21;q32)in a patient with congenital abnormalities.2006

    • Author(s)
      S, Haider, R, Matsumoto, N,Kurosawa, K, Wakui, Y, Fukushima, M, Isobe
    • Journal Title

      J. Hum. Genet 51(4)

      Pages: 335-340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Fragl, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis2005

    • Author(s)
      H, Ishii, T, Inageta, K, Mimori, T, Saito, H, Sasaki, M, Isobe, M, Mori, C, M, Croce, K, Huebner, K, Ozawa, Y, Furukawa
    • Journal Title

      Proc Natl Acad Sci USA 102(27)

      Pages: 9655-9660

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Genetic analysis of learning and memory deficits in senescence-accelerated mouse (SAM).2005

    • Author(s)
      Tomobe, K., Isobe, M., Okuma, Y., Kitamura, K., Oketani, Y., Nomura, Y.
    • Journal Title

      Physiol Behav 84(4)

      Pages: 505-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Genetic analysis of learning and memory deficits in senescence-accelerated mouse(SAM)2005

    • Author(s)
      K, Tomobe, M, Isobe, Y, Okuma, K, Kitamura, Y, Oketani, Y, Nomura
    • Journal Title

      Physiol. Behay 84

      Pages: 505-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.2005

    • Author(s)
      Ishii, H., Inageta, T., Mimori, K., Saito, T., Sasaki, H., Isobe, M., Mori, M., Croce, C.M., Huebner, K., Ozawa, K., Furukawa, Y.
    • Journal Title

      Proc Natl Acad Sci USA 102(27)

      Pages: 9655-9660

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Quantitative trait loci for age-related memory dysfunction in SAMP8 and JF1 mice2004

    • Author(s)
      M, Isobe, K, Tomobe, M, Sawada, A. Kondo, N, Kurosawa, Y, Nomura
    • Journal Title

      The Senescence-Accelerated Mouse(SAM) : An Animal Model of Senescence, in : International Congress Series 1260(Edited by Y. Nomura, T. Takeda and Y. Okuma, Elsevier)

      Pages: 29-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci.2004

    • Author(s)
      Ozawa, T., Itoyama, T., Sadamori, N., Yamada, Y., Hata, T., Tomonaga, M., Isobe, M.
    • Journal Title

      J Hum Genet 49(3)

      Pages: 154-165

    • NAID

      10012891202

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci2004

    • Author(s)
      T, Ozawa, T, Itoyama, N, Sadamori, Y, Yamada, T, Hata, M, Tomonaga, M, Isobe
    • Journal Title

      J. Hum. Genet 49

      Pages: 154-165

    • NAID

      10012891202

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] Quantitative trait loci for age-related memory dysfunction in SAMP8 and JF1 mice.2004

    • Author(s)
      M.Isobe
    • Journal Title

      International Congress Series 1260

      Pages: 29-34

    • Data Source
      KAKENHI-PROJECT-16310133
  • [Journal Article] 3' rapid amplification of cDNA ends (RACE) walking for rapid structural analysis of large transcripts.2004

    • Author(s)
      Ozawa, T., Kondo, M., Isobe, M.
    • Journal Title

      J Hum Genet 49(2)

      Pages: 102-105

    • NAID

      10012114900

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Quantitative trait loci for age-related memory dysfunction in SAMP8 and JF1 mice.2004

    • Author(s)
      M.Isobe
    • Journal Title

      International Congress Series 1260

      Pages: 29-34

    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Allelic imbalance of 14q32 in esophageal carcinoma.2002

    • Author(s)
      Ihara, Y., Kato, Y., Bando, T., Yamagishi, F., Minamimura, T., Sakamoto, T., Tsukada, K., Isobe, M.
    • Journal Title

      Cancer Genet Cytogenet 135(2)

      Pages: 177-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Identification of an aberrant type of rearrangement in the T-cell receptor alpha/delta locus in adult T-cell leukemia.2001

    • Author(s)
      Saitou, M., Sadamori, N., Isobe.M.
    • Journal Title

      J Hum Genet 46(12)

      Pages: 706-711

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.2000

    • Author(s)
      Saitou, M., Sugimoto, J., Hatakeyama, T., Russo, G., Isobe, M.
    • Journal Title

      Oncogene 19(23)

      Pages: 2796-2802

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Genetic heterogeneity of ribosomal RNA gene and matK gene in Panax notoginseng.2000

    • Author(s)
      Fushimi, H., Komatsu, K., Namba, T., Isobe, M.
    • Journal Title

      Planta Med 66(7)

      Pages: 659-661

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia.2000

    • Author(s)
      Akao, Y., Isobe, M.
    • Journal Title

      Genes Chromosomes Cancer 27(4)

      Pages: 412-417

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Journal Article] Cryopreservation of competent intact yeast cells for efficient electroporation.2000

    • Author(s)
      Suga, M., Isobe, M., Hatakeyama, T.
    • Journal Title

      Yeast 16(10)

      Pages: 889-896

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12204005
  • [Patent] 抗原特異的モノクローナル抗体作製方法2016

    • Inventor(s)
      黒澤信幸、磯部正治
    • Industrial Property Rights Holder
      国立大学法人富山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-10
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15K14405
  • [Patent] 抗原特異的モノクローナル抗体作製方法2015

    • Inventor(s)
      黒澤信幸、磯部正治
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-08-10
    • Data Source
      KAKENHI-PROJECT-15K14405
  • [Patent] 反応治具及び反応方法、並びにcDNA合成方法2013

    • Inventor(s)
      磯部正治、黒澤信幸
    • Industrial Property Rights Holder
      立大学法人富山大学
    • Acquisition Date
      2013-04-12
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Patent] 形質細胞または形質芽細胞の選択方法,目的抗原特異的な抗体の製造方法,新規モノクローナル抗体2012

    • Inventor(s)
      黒澤信幸、磯部正治
    • Industrial Property Rights Holder
      国立大学法人富山大学
    • Filing Date
      2012-03-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Patent] 形質細胞または形質芽細胞の選択方法,目的抗原特異的な抗体の製造方法,新規モノクローナル抗体2012

    • Inventor(s)
      黒澤信幸、磯部正治
    • Industrial Property Rights Holder
      国立大学法人富山大学
    • Filing Date
      2012
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Patent] 相同組換え方法およびクローニング方法2008

    • Inventor(s)
      磯部 正治, 黒澤 信幸
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Number
      2008-057995
    • Filing Date
      2008-03-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Patent] 反応治具及び反応方法、並びにcDNAの合成方法2008

    • Inventor(s)
      磯部正治, 黒澤信幸
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Number
      2008-008767
    • Filing Date
      2008-01-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Patent] 相同組換え方法およびクローニング方法2008

    • Inventor(s)
      磯部正治, 黒澤信幸
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Number
      2008-057995
    • Filing Date
      2008-03-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Patent] 反応治具及び反応方法、並びにcDNAの合成方法2008

    • Inventor(s)
      磯部 正治, 黒澤 信幸
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Number
      2008-008767
    • Filing Date
      2008-01-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Presentation] SARS-CoV-2スパイクタンパク質経鼻免疫マウス鼻粘膜組織由来モノクローナルIgA抗体の網羅的解析2022

    • Author(s)
      和氣 健太郎, 谷 英樹, 岡田 茉那, 磯部 正治, 黒澤 信幸
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K07214
  • [Presentation] 多形型SERPINA3はamyloidβ42のオリゴマー状態を延長させることで神経毒性を増強させる2021

    • Author(s)
      磯部正治, AKBOR Maruf, 中山弘暉, 中谷亜佑未, 友部浩二, 黒澤信幸
    • Organizer
      日本分子生物学会第44年会
    • Data Source
      KAKENHI-PROJECT-21K07214
  • [Presentation] SARS-COV2スパイクタンパク質の経鼻免疫で誘導されるマウス鼻腔粘膜由来IgAモノクローナル抗体取の特異性解析2021

    • Author(s)
      和氣 健太郎, 黒澤 信幸, 磯部 正治
    • Organizer
      日本生化学会第94大会
    • Data Source
      KAKENHI-PROJECT-21K07214
  • [Presentation] 取得困難な修飾部位特異的モノクローナル抗体の新規効率的作製法の開発2016

    • Author(s)
      藤 聡志、黒澤 信幸、磯部 正治
    • Organizer
      第68回日本生物工学会
    • Place of Presentation
      富山市
    • Data Source
      KAKENHI-PROJECT-15K14405
  • [Presentation] テンプレートスイッチ反応と懸垂液滴アレイ式磁気ビーズ反応法を用いた抗体 cDNA 迅速合成システムの開発2016

    • Author(s)
      松原 悠紀、黒澤 信幸、磯部 正治
    • Organizer
      第68回日本生物工学会
    • Place of Presentation
      富山市
    • Data Source
      KAKENHI-PROJECT-15K14405
  • [Presentation] 形質細胞内発現抗体を利用した抗原特異的モノクローナル抗体新規単離法(FIXAA)の開発2016

    • Author(s)
      塚本 薫、黒澤 信幸、磯部 正治
    • Organizer
      第68回日本生物工学会
    • Place of Presentation
      富山市
    • Data Source
      KAKENHI-PROJECT-15K14405
  • [Presentation] 種々の免疫動物に由来するプラズマ細胞からの1細胞抗体遺伝子スクリーニンク2014

    • Author(s)
      磯部 正治、黒澤 信幸
    • Organizer
      第66回日本生物工学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25640075
  • [Presentation] BCLL11B蛋白質発現減少は成人T細胞白血病の発症に関与する2012

    • Author(s)
      黒澤 信幸, 藤本 理加, 磯部 正治
    • Organizer
      第71回日本癌学会学術総会
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Antigen-specific plasma/plasmablast cells identification from a variety of animals for the production of monoclonal antibodies.2012

    • Author(s)
      Nobuyuki Kurosawa , Megumi Yoshioka, Rika Fujimoto and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2012-12-03
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Semi-Automatic Cloning and Expression of Immunoglobulin Genes from Single-Plasma Cells for High-Throughput Generation of Monoclonal Antibodies2012

    • Author(s)
      Masaharu Isobe
    • Organizer
      PEP TALK The Protein Science Week PIPELINE4
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2012-01-09
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Semi-Automatic Cloning and Expression of Immunoglobulin Genes from Single- Plasma Cells for High-Throughput Generation of Monoclonal Antibodies.2012

    • Author(s)
      Masaharu Isobe
    • Organizer
      PEP TALK The Protein Science Week PIPELINE4(招待講演)
    • Place of Presentation
      San Diego, CA USA
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] 様々な動物からの迅速な抗原特異的モノクローナル抗体作製法の開発 (Rapid production of antigen-specific monoclonal antibodies from a variety of animals.)2012

    • Author(s)
      黒澤信幸, 吉岡 めぐみ, 藤本 理加, 磯部 正治
    • Organizer
      第85回日本生化学会大会
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] モルモット抗体可変領域遺伝子レパートリーの解析 (Analysis of immunoglobulin variable gene repertoire from the guinea pig.)2012

    • Author(s)
      吉岡 めぐみ, 成瀬 輝芳, 黒澤 信幸, 磯部 正治
    • Organizer
      5回日本生化学会大会
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Target-selective joint polymerase chain reaction (TS-jPCR): A robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells2011

    • Author(s)
      Megumi Yoshioka, Nobuyuki Kurosawa and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2011-12-04
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Target-selective joint polymerase chain reaction (TS-jPCR): A robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells.2011

    • Author(s)
      Megumi Yoshioka, Nobuyuki Kurosawa and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Target-selective homologous recombination cloning (TS-HR) for high- throughput generation of monoclonal antibodies from single plasma cells.2011

    • Author(s)
      Rika Fujimoto, Megumi Yoshioka, Nobuyuki Kurosawa and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] 単一細胞からのハイスループットな抗体遺伝子/T細胞受容体遺伝子のクローニング及び発現システムの開発(High throughput cloning and expression of immunoglobulin genes/T-cell receptor genes from single cells.)2011

    • Author(s)
      吉岡 めぐみ, 黒澤 信幸, 磯部 正治
    • Organizer
      第84回日本生化学会大会
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] 単一細胞からのハイスループットな抗体遺伝子/T細胞受容体遺伝子のクローニング及び発現システムの開発(High throughput cloning and expression of immunoglobulin genes/T-cell receptor genes from single cells.)2011

    • Author(s)
      吉岡 めぐみ,黒澤 信幸,磯部 正治
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] ホールボードテストにおけるマウスの不安様行動に対する緑の香りの作用2011

    • Author(s)
      原田史敏、中島一樹、磯部正治、佐々木和男
    • Organizer
      第33回日本神経科学学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-20590227
  • [Presentation] Magnetic-beads Reaction through Arrayed Hanging-Drops (MAGrahd) for high-throughput amplification of immunoglobulin genes from single B cells.2011

    • Author(s)
      Nobuyuki Kurosawa, Megumi Yoshioka and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] A robust and rapid system for high-throughput generation of recombinant monoclonal antibodies from a variety of species.2011

    • Author(s)
      Masaharu Isobe, Megumi Yoshioka, Rika Fujimoto and Nobuyuki Kurosawa
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Magnetic-beads Reaction through Arrayed Hanging-Drops (MAGrahd) for high-throughput amplification of immunoglobulin genes from single B cells2011

    • Author(s)
      Nobuyuki Kurosawa, Megumi Yoshioka and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2011-12-04
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] TS-jPCR法を用いた単一細胞からのハイスループットな組換えモノクローナル抗体作製法の開発(Target Selective-joint Polymerase Chain Reaction for High-throughput Generation of Recombinant Monoclonal Antibodies from Single Cells)2011

    • Author(s)
      吉岡 めぐみ,黒澤 信幸,磯部 正治
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] Target-selective homologous recombination cloning (TS-HR) for high-throughput generation of monoclonal antibodies from single plasma cells2011

    • Author(s)
      Rika Fujimoto, Megumi Yoshioka, Nobuyuki Kurosawa and Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2011-12-04
    • Data Source
      KAKENHI-PROJECT-23650607
  • [Presentation] QTL analysis of age-related memory dysfunction in SAM P8 mouse2005

    • Author(s)
      M, Isobe, K, Tomobe, M, Sawada, A. Kondo, N, Kurosawa, S, Wakana, Y, Nomura
    • Organizer
      HGM2005 Workshop
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Presentation] QTL analysis of age-related memory dysfunction in SAM P8 mouse.2005

    • Author(s)
      M. Isobe
    • Organizer
      HGM2005 Workshop
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16310133
  • [Presentation] A robust and rapid system for high-throughput generation of recombinant monoclonal antibodies from a variety of species.

    • Author(s)
      Masaharu Isobe
    • Organizer
      Antibody Engineering
    • Place of Presentation
      San Diego, CA USA
    • Data Source
      KAKENHI-PROJECT-23650607
  • 1.  SASAKI Kazuo (60042826)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  OOMURA Yutaka (30019517)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  NAKAJIMA Kazuki (50207776)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  TSUKADA Akira (40236849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KAWARADA Atsushi (80195164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KUROSAWA Nobuyuki (50241253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  八木 寛 (60019164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  木村 宏 (40079736)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  UENO Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  黒沢 信幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 11.  千葉 陽一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  富田 裕彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  金 主賢
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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