YAMAMOTO Chika 山本千夏

… Alternative Names

山本千夏ヤマモトチカ

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Researcher Number	70230571
Other IDs
Affiliation (Current)	2025: 東邦大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 東邦大学, 薬学部, 教授 2013 – 2020: 東邦大学, 薬学部, 教授 2011 – 2012: 北陸大学, 薬学部, 准教授 2006 – 2009: 北陸大学, 薬学部, 准教授 2005 – 2006: Hokuriku University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 … More 2002 – 2004: 北陸大学, 薬学部, 講師 2000: Hokuriku University, Faculty of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 1994 – 1999: 北陸大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Environmental pharmacy / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Biological pharmacy / Environmental pharmacy / Biological pharmacy
Keywords	Principal Investigator 血管内皮細胞 / 血管平滑筋細胞 / カドミウム / 線溶 / 鉛 / 線維芽細胞 / バイオオルガノメタリクス / TNF-α / プロテオグリカン / ハイブリッド分子 … More / PAI-1 / t-PA / 線溶系 / 血管 / 組織プラスミノーゲンアクチベータ- / プラスミノーゲンアクチベーターインヒビター1型 / プラスミノーゲンアクチベーターインヒビター1型 / 組織型プラスミノーゲンアクチベーター / プラスミノーゲンアクチベータインヒビター1 / パールカン / atherosclerosis / decorin / versican / homocysteine / adiponectin / proteoglycan / vascular smooth muscle cells / 動脈硬化 / デコリン / バーシカン / ホモシステイン / アディポネクチン / 内皮細胞 / 毒性 / 有機化学物質 / CHO細胞 / ジーントラップ法 / 有機金属化合物 / アンチモン / ビスマス / 細胞毒性 / 脳 / トロンビン / 周皮細胞 / 微小血管内皮細胞 / VEGF / u-PA / 脳微小血管 / プラスミノーゲンアクチベータ-インヒビター-1 / プラミスノーゲンアクチベータ-インヒビター1 / 組織プラミスノーゲンアクチベータ- / プラスミノーゲンアクチベータ-インヒビター … More Except Principal Investigator プロテオグリカン / 周皮細胞 / 血管 / Proteoglycan / グリコサミノグリカン / パールカン / デコリン / ビグリカン / 内皮細胞 / Glycosaminoglycan / Pericyte / Endothelial cell / デルマタン硫酸 / ヘパラン硫酸 / CTGF / Vascular / Perlecan / コア蛋白 / 血管内皮細胞 / Dermatan sulfate / Chondroitin sulfate / Heparan sulfate / コンドロイチン硫酸 / Vascular endothelial growth factor / Syndecan-1 / Microvasculature / 脳微小血管 / シンデカン / 血管内皮増殖因子 / シンデカン-1 / 微小血管 / vascular / extracellular matrix / biglycan / decorin / growth factor / proteoglycan / vascular endothelial cell / トランスフォーミング増殖因子 / VEGF / 細胞外マトリックス / 細胞増殖因子 / Core protein / Decorin / Biglycan / Versican / Pericytes / バーシカン / 生理活性 / 金属生物学 / 毒性学 / トランスポーター / 整理活性 / 生体分子 / メタロチオネイン / 血管平滑筋細胞 / TGF-β / サイトカイン / 亜鉛輸送体 / 細胞毒性 / カドミウム / 亜鉛 / 金属輸送体 / 神経細胞 / 毒性 / 脳 / メチル水銀 Less

有機フッ素化合物PFASの血管毒性を担う分子としてのプロテオグリカンPrincipal Investigator
- Principal Investigator
  
  山本千夏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Toho University
Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toho University
Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallicesPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Toho University
Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
- Principal Investigator
  
  Kaji Toshiyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tokyo University of Science
Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicityPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Toho University
  Hokuriku University
Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Regulation of proteoglycan metabolism by adiponectin in vascular smooth muscle cellsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cells
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
脳毛細血管内皮細胞と周皮細胞における線溶蛋白の発現および増殖因子による調節Principal Investigator
- Principal Investigator
  
  山本千夏
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesis
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytes
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
重金属による血液線溶系の撹乱を介在する細胞内情報電圧経路Principal Investigator
- Principal Investigator
  
  山本千夏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
重金属による血管内皮細胞線溶調節の傷害メカニズムPrincipal Investigator
- Principal Investigator
  
  山本千夏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
重金属による血管細胞線溶調節の傷害Principal Investigator
- Principal Investigator
  
  山本千夏
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University

[Journal Article] Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells2021
- Author(s)
  Hara Takato、Sakuma Miki、Fujie Tomoya、Kaji Toshiyuki、Yamamoto Chika
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 5 Pages: 249-253
- DOI
  10.2131/jts.46.249
- NAID
  130008033315
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06638
[Journal Article] Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2017
- Author(s)
  Nakamura T, Yoshida E, Fujie T, Ogata F, Yamamoto C, Kawasaki N, Kaji T
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 6 Pages: 683-687
- DOI
  10.2131/jts.42.683
- NAID
  130006206268
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08047
[Journal Article] Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells.2016
- Author(s)
  Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, Yamamoto C, Kumagai Y, Naka H, Kaji T.
- Journal Title
  
  Journal of Biological Inorganic Chemistry
  
  Volume: 21 Issue: 2 Pages: 263-273
- DOI
  10.1007/s00775-016-1337-z
- NAID
  120007135582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells2016
- Author(s)
  Fujie T, Segawa Y, Uehara A, Nakamura T, Kimura T, Yoshida E, Yamamoto C, Uchiyama M, Naka H, Kaji T.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 2 Pages: 217-224
- DOI
  10.2131/jts.41.217
- NAID
  130005132664
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2016
- Author(s)
  Hara T, Matsuzaki H, Nakamura T, Yoshida E, Ohkubo T, Maruyama H, Yamamoto C, Saito S, Kaji T.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 3 Issue: 3 Pages: 109-113
- DOI
  10.2131/fts.3.109
- NAID
  130005151853
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08047
[Journal Article] Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells.2016
- Author(s)
  Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 295 Pages: 37-46
- DOI
  10.1016/j.taap.2016.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034, KAKENHI-PUBLICLY-16H01190, KAKENHI-PROJECT-15KK0325
[Journal Article] Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells2016
- Author(s)
  Fujie T, Segawa Y, Yoshida E, Kimura T, Fujiwara Y, Yamamoto C, Satoh M, Naka H, Kaji T.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 2 Pages: 225-232
- DOI
  10.2131/jts.41.225
- NAID
  130005132663
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells.2015
- Author(s)
  Fujiwara Y, Yamamoto C, Yoshida A, Kumagai Y, Kaji T.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 印刷中 Issue: 2 Pages: 259-267
- DOI
  10.1007/s00204-014-1420-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034
[Journal Article] The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules2015
- Author(s)
  Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C., Kaji, T.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 40 Pages: 321-327
- NAID
  130005068415
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells2015
- Author(s)
  Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S., Kaji, T.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Pages: 61-66
- NAID
  130005083360
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] カドミウムに曝露した血管内皮細胞におけるZIP8の発現2014
- Author(s)
  髙橋涼香，山本千夏，鍜冶利幸
- Journal Title
  
  薬学雑誌
  
  Volume: 134 Pages: 805-807
- NAID
  130004756448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] Effect of a Congolese herbal medicine used in sickle cell anemia on the expression of plasminogen activators in human coronary aortic endothelial cell culture2013
- Author(s)
  Nsimba, M.M., Yamamoto, C., Lami, J.N., Hayakawa, Y., and Kaji, T.
- Journal Title
  
  JOURNAL OF ETHNOPHARMACOLOGY
  
  Volume: 146 Issue: 2 Pages: 594-599
- DOI
  10.1016/j.jep.2013.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058
[Journal Article] Decreased thrombin activity by a Congolese herbal medicine used in sicklecellanemia2013
- Author(s)
  Nsimba, M.M., Lami, J.N., Hayakawa, Y., Yamamoto, C., and Kaji, T.
- Journal Title
  
  JOURNAL OF ETHNOPHARMACOLOGY
  
  Volume: 148 Issue: 3 Pages: 895-900
- DOI
  10.1016/j.jep.2013.05.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058
[Journal Article] Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury2013
- Author(s)
  Hirooka, T., Yamamoto, C., Yasutake, A., Eto, K., and Kaji, T.
- Journal Title
  
  JOURNAL OF TOXICOLOGICAL SCIENCES
  
  Volume: 38 Pages: 837-845
- NAID
  130004447087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway.2010
- Author(s)
  Shinkai, Y., Yamamoto, C., Kaji, T.
- Journal Title
  
  Toxicol. Sci. 114
  
  Pages: 378-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010
- Author(s)
  Hirooka, T., Fujiwara, Y., Minami, Y., Ishii, A., Ishigooka, M., Shinkai, Y., Yamamoto, C., Satoh, M., Yasutake, A., Eto, K., Kaji, T.
- Journal Title
  
  Toxicol.In Vitro 24
  
  Pages: 835-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury: Cell-density-dependent defense mechanisms.2010
- Author(s)
  Hirooka, T., Fujiwara, Y., Shinkai, Y., Yamamoto, C., Yasutake,, A., Satoh, M., Eto, K., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. (in press)
- NAID
  10026469510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Suppression of fibroblast growth facor-2 expression : Possible mechanism underlying the methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells2009
- Author(s)
  Hirooka, T., Fujiwara, Y., Inoue, S., Shinkai, Y., Yamamoto, C., Masahiko, S., Yasutake, A., Eto, K.and Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 433-439
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Suppression of fibroblast growth facor-2 expression: Possible mechanism underlying the methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.2009
- Author(s)
  Hirooka, T., Fujiwara, Y., Inoue, S., Shinkai, Y., Yamamoto, C., Masahiko, S., Yasutake, A., Eto, K., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 433-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Biological activities of exogenous polysaccharides via controlling endogenous proteoglycan metabolism in vascular endothelial cells.2008
- Author(s)
  Sato T, Yamamoto C, Fujiwara Y, Kaji T.
- Journal Title
  
  Yakugakuzashi 128(5)
  
  Pages: 717-723
- NAID
  110006668266
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.2008
- Author(s)
  Fujiwara, Y., Yamamoto, C., Hirooka, T., Terada, N., Satoh, M., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 33
  
  Pages: 487-492
- NAID
  110006950529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Proteoglycan as a key molecule in atherosclerosis progression : Characteristics of the structure and regulation of the synthesis.2008
- Author(s)
  Urano A, Yamamoto C, Fujiwara Y, Kaji T.
- Journal Title
  
  Yakugakuzashi 128(3)
  
  Pages: 365-375
- NAID
  110006646589
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells2008
- Author(s)
  Fujiwara, Y., Yamamoto, C., Hirooka,T., Terada, N., Satoh, M.and Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 33
  
  Pages: 487-492
- NAID
  110006950529
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis2008
- Author(s)
  Chika Yamamoto
- Journal Title
  
  J.Health Sci 54
  
  Pages: 56-65
- NAID
  110006251367
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Adiponectin as an inducer of decorin synthesis in cultured vascular smoothmuscle cells2008
- Author(s)
  Chika Yamamoto
- Journal Title
  
  Life Sciences 83
  
  Pages: 447-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Homocysteine Inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells.2008
- Author(s)
  Fujiwara Y, Mikami C, Nagai M, Yamamoto C, Hirooka T, satoh M, Kaji T.
- Journal Title
  
  J. Health Sci 54(1)
  
  Pages: 56-65
- NAID
  110006570804
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage.2007
- Author(s)
  Hirooka, T., Fujiwara, Y., Yamamoto, C., Yasutake, A., Kaji, T.
- Journal Title
  
  J. Health Sci. 53
  
  Pages: 450-456
- NAID
  110006366926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage2007
- Author(s)
  Hirooka, T., Fujiwara, Y., Yamamoto, C., Yasutake, A.and Kaji, T.
- Journal Title
  
  J. Health Sci. 53
  
  Pages: 450-456
- NAID
  110006366926
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers:cell density-dependent effects prevented by sulfation2006
- Author(s)
  Chika Yamamoto
- Journal Title
  
  Life Sci. 78
  
  Pages: 205-210
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells2006
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A. H.and Wight, T.N.
- Journal Title
  
  Biochim. Biophys. Acta 1760
  
  Pages: 1465-1474
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A.H., Wight, T.N.
- Journal Title
  
  Biochim. Biophys. Acta 1760
  
  Pages: 1465-1474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injuries their monolayers : cell density-dependent effects prevented by sulfation2006
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Life Sciences 78
  
  Pages: 844-850
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006
- Author(s)
  Kaji T, Yamamoto C, Oh-i M, Fujiwara Y, Yamazaki Y, Morita T, Plaas AH, Wight TN
- Journal Title
  
  Biochim Biophys Acta. 1760(9)
  
  Pages: 1465-1474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injuries their monolayers : cell density-dependent effects prevented by sulfation2006
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Life Sciences 78
  
  Pages: 844-850
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The biological effects of depolymerized sodium spirulan and sul fated colominic acid on vascular cells are beneficial in preventing atherosclerosis2006
- Author(s)
  Yamamoto C. et al.
- Journal Title
  
  Journal of Health Scinece 52
  
  Pages: 205-210
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The biological effects of depolymerized sodium spirulan and sulfated colominic acid on vascular cells are beneficial in preventing atherosclerosis.2006
- Author(s)
  Chika Yamamoto
- Journal Title
  
  J. Health Sci. 52・3
  
  Pages: 205-210
- NAID
  110006251367
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis.2006
- Author(s)
  Yamamoto C, Fujiwara Y, Kaji T.
- Journal Title
  
  J. Health Sci 52(3)
  
  Pages: 205-210
- NAID
  110006251367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers : cell density-dependent effects prevented by sulfation.2006
- Author(s)
  Chika Yamamoto
- Journal Title
  
  Life Sci. 78・8
  
  Pages: 844-850
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Proteoglycans predominantly synthesized by human brain microvascular endothelial cells in culture are perlecan and biglycan.2005
- Author(s)
  Yamamoto, C., Deng, X., Fujiwara, Y., Kaji, T.
- Journal Title
  
  J.Health Sci. 51
  
  Pages: 576-583
- NAID
  110003666529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Induction of synthesis of a large heparan sulfate proteoglycan, perlecan, by thrombin in cultured human coronary smooth muscle cells.2005
- Author(s)
  Yamamoto, C., Wakata, T., Fujiwara, Y., Kaji, T.
- Journal Title
  
  Biochim.Biophys.Acta 1722
  
  Pages: 92-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Proteoglycans predominantly synthesized by human brain microvascular endothelial cells in culture are perlecan and biglycan2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Journal of Health Science 51
  
  Pages: 576-583
- NAID
  110003666529
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Selective promotion of plasminogen activator inhibitor-1 secretion by activation of protease-activated receptor-1 in cultured human brain microvascular pericytes : comparison with endothelial cells2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 28
  
  Pages: 2208-211
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Proteoglycans released from cultured bovine aortic endothelial cell layers by sodium spirulan are both perlecan and biglycan2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 28
  
  Pages: 32-36
- NAID
  110003665766
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Induction of synthesis of a large heparan sulfate proteoglycan, perlecan, by thrombin in cultured human coronary smooth muscle cells2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Biochemica et Biophysica Acta 1722
  
  Pages: 92-102
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Inhibition of cultured bovine aortic smooth muscle cell proliferation by colominic acid2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 28
  
  Pages: 944-997
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Proteoglycans predominantly synthesized by human brain microvascular endothelial cells in culture are perlecan and biglycan2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  J. Health Sci. 51
  
  Pages: 576-583
- NAID
  110003666529
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Induction of synthesis of a large heparan sulfate proteoglycan, perlecan. by thrombin in cultured human coronary smooth muscle cells2005
- Author(s)
  Yamamoto C et al.
- Journal Title
  
  Biochim. Biophys. Acta 1722
  
  Pages: 92-102
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers : cell density-dependent effects prevented by sulfation.2005
- Author(s)
  Yamamoto C, Morita Y, Yamaguchi S, Hayashi T, Kaji T.
- Journal Title
  
  Life Sci. 78(8)
  
  Pages: 844-850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590124
[Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture.2004
- Author(s)
  Kaji, T., Sakurai, S., Yamamoto, C., Fujiwara, Y., Yamagishi, S., Yamamoto, H., Kinsella, M.G., Wight, T.N.
- Journal Title
  
  Biol.Pharm.Bull. (Highlighted paper selected by Editor in-chief) 27
  
  Pages: 1763-1768
- NAID
  110003608693
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.2004
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Nishida, T., Takigawa, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 322
  
  Pages: 22-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Presentation] ヒト血管内皮細胞株EA.hy926細胞におけるカドミウムによるPAI-1発現誘導メカニズムの探索2021
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 血管内皮細胞においてt-PA発現を誘導するターピリジン亜鉛錯体2021
- Author(s)
  藤江智也，原崇人，伊藤愛，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] カドミウムによるヒト血管内皮細胞株EA.hy926細胞のPAI-1発現の誘導2020
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  生命金属に関する合同年会（ConMetal 2020）
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 亜鉛錯体による血管内皮細胞特異的なグリコサミノグリカン合成の調節2018
- Author(s)
  原崇人，酒巻沙弥香，中村武浩，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 亜鉛錯体を用いた内皮細胞シンデカン-4の新規発現調節機構の解析2017
- Author(s)
  原崇人，中村武浩，松崎紘佳，吉田映子，山本千夏，鍜冶利幸
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 鉛による血管内皮細胞増殖の阻害に関与するヘパラン硫酸プロテオグリカンの大型分子種パールカンの発現抑制機構2017
- Author(s)
  熊谷玲衣奈，原崇人，吉田映子，藤原泰之，山本千夏，鍜冶利幸
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] ジチオカルバメート銅錯体Cu10による血管内皮細胞のシンデカン-4発現誘導2017
- Author(s)
  立石紘子，原崇人，藤江智也，吉田映子，山本千夏，中寛史，鍜冶利幸
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 銅錯体を用いた血管内皮細胞のプロテオグリカン発現調節機構の解析2017
- Author(s)
  立石紘子，原崇人，吉田映子，藤江智也，山本千夏，中寛史，鍜冶利幸
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] ジチオカルバメート銅錯体による血管内皮細胞のプロテオグリカン発現調節2016
- Author(s)
  立石紘子，原崇人，藤江智也，吉田映子，山本千夏，中寛史，鍜冶利幸
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都・品川区）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 有機ロジウム化合物を活用した血管内皮細胞のパールカン発現抑制機構の解明への試み2016
- Author(s)
  松崎紘佳，原崇人，吉田映子，藤原泰之，山本千夏，斎藤慎一，鍜冶利幸
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都・品川区）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 有機金属化合物の細胞毒性2015
- Author(s)
  山本千夏，安池修之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管平滑筋細胞におけるTGF-β1による亜鉛輸送体ZIP8遺伝子の発現調節機構2015
- Author(s)
  武正文子，吉田映子，山本千夏，藤原泰之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 脂肪細胞分化及び脂肪滴の蓄積を抑制する亜鉛錯体の同定2014
- Author(s)
  峯松真梨，小野寺章，石橋孝文，岡若奈，武田直也，弘内淳美，矢埜みなみ, 山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸 , 佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物の毒性発現に関与する遺伝子2014
- Author(s)
  中浴静香,郡久美子,山本千夏,安池修之,鍜冶利幸
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 血管内皮細胞に対する亜鉛とカドミウム相互作用は金属輸送体ZIP8の発現に介在される2014
- Author(s)
  上原茜，山本千夏，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物の毒性発現に関与する遺伝子2014
- Author(s)
  中浴静香，郡久美子，山本千夏，安池修之，鍜冶利幸
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 骨粗鬆症モデルマウスへの Zn(bpy)Cl2 の有効性評価2014
- Author(s)
  石橋孝文，小野寺章，岡若奈，武田直也，弘内淳美，峯松真梨，矢埜みなみ，山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸，佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞においてビグリカンはTGF-βと協調してSmad経路に介在されるシンデカン-4の発現を抑制する2014
- Author(s)
  原崇人，新開泰弘，山本千夏，熊谷嘉人，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機アンチモン化合物による血管内皮細胞のメタロチオネイン誘導2014
- Author(s)
  村上正樹，藤江智也，松村実生，藤原泰之，木村朋紀，安池修之，山本千夏，佐藤雅彦，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞においてNrf2およびメタロチオネインを誘導する有機-無機ハイブリッド分子2013
- Author(s)
  藤江智也，中寛史，立浪忠志，新開泰弘，山本千夏，藤原泰之，佐藤雅彦，熊谷嘉人，鍜冶利幸
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞におけるFGF-2による亜鉛トランスポーター発現の調節2013
- Author(s)
  蜂須賀絵美,山本千夏,鍜冶利幸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] カドミウムに曝露した血管内皮細胞におけるZIP8の発現誘導2013
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍜冶利幸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] カドミウムの血管内皮細胞毒性2013
- Author(s)
  山本千夏,鍜冶利幸
- Organizer
  日本衛生学会第83回学術総会
- Place of Presentation
  金沢(招待講演)
- Year and Date
  2013-03-24
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機カルコゲン化合物の細胞毒性2013
- Author(s)
  橋谷珠世,岡崎貴大,郡久美子,山本千夏,藤原泰之,信國好俊,栗田城治,鍜冶利幸
- Organizer
  フォーラム2013:衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] ビスマスまたはアンチモンを導入した有機金属化合物の毒性発現とそのメカニズム2013
- Author(s)
  郡久美子,中浴静香,山本千夏,安池修之,角澤直紀,栗田城治,鍜冶利幸
- Organizer
  第12回分子予防環境医学研究会大会
- Place of Presentation
  つくば
- Year and Date
  2013-02-01
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 有機ビスマス化合物の細胞毒性はそのアンチモン置換体では消失する2012
- Author(s)
  郡久美子,中浴静香,山本千夏,安池修之,角澤直紀,栗田城治,鍜冶利幸
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds2012
- Author(s)
  Kumiko Kohri,Chika Yamamoto,Shuji Yasuike,Naoki Kakusawa,Jyoji Kurita,Toshiyuki Kaji
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  Sendai
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 有機金属化合物の細胞毒性に及ぼす導入金属の影響2012
- Author(s)
  郡久美子,山本千夏,安池修之,角澤直紀,廣岡孝志,栗田城治,鍜冶利幸
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] FGF-2による血管内皮細胞の亜鉛トランスポーター発現の調節2012
- Author(s)
  蜂須賀絵美,山本千夏,鍛冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] カドミウムによる血管内皮細胞ZIP 8の誘導2012
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍛冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物とそのアンチモン置換体の細胞毒性の特徴2012
- Author(s)
  郡久美子,山本千夏,安池修之,角澤直紀,栗田城治,鍜冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 血管内皮細胞に対するカドミウムの毒性発現機構2012
- Author(s)
  山本千夏,鍜冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds in vitro2012
- Author(s)
  Kumiko Kohri,Chika Yamamoto,Shuji Yasuike,Naoki Kakusawa,Jyoji Kurita,Toshiyuki Kaji
- Organizer
  The 22nd Symposium on Role of Metals in Biological Reactions, Biology and Medicine
- Place of Presentation
  Kanazawa
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] Induction of metal transporter SLC39A8 by cadmium in vascular endothelial cells2012
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍛冶利幸
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Cadmium selectively and strongly induces the expression of ZIP 8 1n vascular end othelial cells2012
- Author(s)
  Takahashi S., Fujie T., Yamamoto C., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Induction of SLC39A8 expression by FGF-2 in vascular endothelial cells2012
- Author(s)
  Hachisuka E., Yamamoto C., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] ハイブリッド分子を活用する新しいバイオロジー2011
- Author(s)
  山本千夏
- Organizer
  フォーラム2011:衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] メチル水銀は脳浮腫形成に関与する脳血管組織のVEGFシステムを活性化する.2010
- Author(s)
  廣岡孝志, 新開泰弘, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀のヒト脳微小血管内皮細胞への傷害性発現は低酸素環境下において増強される.2010
- Author(s)
  姫〓〓, 廣岡孝志, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] An organoantimony compound that selectively induces perlecan synthesis in vascularendothelial cells2009
- Author(s)
  Chika Yamamoto
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は培養ヒト脳微小血管内皮細胞および周皮細胞のヒアルロナン合成を促進する.2009
- Author(s)
  廣岡孝志, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀中毒ラットの小脳顆粒細胞層における炎症性変化を伴った退行性変化.2009
- Author(s)
  杜可, 廣岡孝志, 山本千夏, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀による小脳障害のメカニズムに関する新しい仮説.2009
- Author(s)
  廣岡孝志, 杜可, 山本千夏, 安武章, 衞藤光明, 勝田省吾, 鍜冶利幸
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀中毒ラットの小脳顆粒細胞層における炎症性変化を伴った退行性変化2009
- Author(s)
  杜可, 廣岡孝志, 山本千夏, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀はヒト脳微小血管周皮細胞においてシンデカン-4の発現を誘導する2008
- Author(s)
  田中満崇, 廣岡孝志, 藤原泰之, 井上頌子, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] VEGFの自己分泌/傍分泌型調節システムは脳微小血管組織におけるメチル水銀毒性の標的である.2008
- Author(s)
  廣岡孝志, 山本千夏, 石井明彦, 石郷岡美緒, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀投与ラット脳の病理組織学的変化:小脳障害のメカニズムに関する新しい仮説.2008
- Author(s)
  杜可, 山本千夏, 廣岡孝志, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀はヒト脳微小血管周皮細胞においてシンデカン-4の発現を誘導する.2008
- Author(s)
  田中満崇, 廣岡孝志, 藤原泰之, 井上頌子, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] ヒト脳微小血管周皮細胞に対するメチル水銀の細胞密度依存的な傷害性.2008
- Author(s)
  廣岡孝志, 藤原泰之, 南有香, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] VEGFの自己分泌/傍分泌型調節システムは脳微小血管組織におけるメチル水銀毒性の標的である2008
- Author(s)
  廣岡孝志, 山本千夏, 石井明彦, 石郷岡美緒, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は傷害した培養脳微小血管内皮細胞層の修復をFGF-2システムの抑制を通じて阻害する2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 南有香, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  メタロチオネインおよびメタロバイオサイエンス研究会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] アディポネクチンによる血管平滑筋細胞デコリン合成の誘導2007
- Author(s)
  山本千夏
- Organizer
  第8回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  金沢エクセルホテル東急
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-18590124
[Presentation] メチル水銀による傷害内皮細胞層の修復阻害:FGF-2系およびVEGF系は関与するか?2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2007衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は傷害した培養脳微小血管内皮細胞層の修復をFGF-2システムの抑制を通じて阻害する.2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 南有香, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  メタロチオネインおよびメタロバイオサイエンス研究会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] ヒト脳微小血管内皮細胞の維持に対するメチル水銀の毒性2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 安武章, 鍜冶利幸.
- Organizer
  第8回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] 血管内皮細胞において亜鉛は金属輸送体ZIP8の発現抑制を介してカドミウムの細胞毒性を防御する
- Author(s)
  上原茜，山本千夏，鍜冶利幸
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] ハイブリッド分子を活用する新しいバイオロジー
- Author(s)
  山本千夏
- Organizer
  フォーラム2011　衛生薬学・環境トキ師コロジー(招待講演)
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 有機カルコゲン化合物の細胞毒性
- Author(s)
  橋谷珠世，岡崎貴大，郡久美子，山本千夏、藤原泰之，信國好俊，栗田城治，鍜冶利幸
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds in vitro
- Author(s)
  郡久美子，山本千夏，安池修之，角澤直紀，栗田城治，鍜治利幸
- Organizer
  The 22nd Symposium on Role of Metals in Biological Reactions, Biology and Medicine
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 有機金属化合物の細胞毒性に及ぼす導入金属の影響
- Author(s)
  郡久美子，山本千夏，安池修之，角澤直紀，廣岡孝志，栗田城治，鍜冶利幸
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] ビスマスまたはアンチモンを導入した有機金属化合物の毒性発現とそのメカニズム
- Author(s)
  郡久美子，中浴静香，山本千夏，安池修之，角澤直紀，栗田城治，鍜治利幸
- Organizer
  第12回分子予防環境医学研究会大会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] カドミウムの内皮細胞毒性に対する亜鉛の防御機構への金属輸送体発現の関与
- Author(s)
  上原茜，吉田映子，山本千夏，鍜冶利幸
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物の細胞毒性はそのアンチモン置換体では消失する
- Author(s)
  郡久美子，中浴静香，山本千夏，安池修之，角澤直紀，栗田城治，鍜治利幸
- Organizer
  フォーラム2012衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 有機ビスマス化合物とそのアンチモン置換体の細胞毒性の特徴
- Author(s)
  郡久美子，山本千夏，安池修之，角澤直紀，栗田城治，鍜治利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds
- Author(s)
  Kohri K., Yamamoto C., Yasuike S., Kakusawa N., Kurita J., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-23590156

1. KAJI Toshiyuki (90204388)

# of Collaborated Projects: 7 results

# of Collaborated Products: 64 results
2. FUJIWARA Yasuyuki (40247482)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
3. NOBUKUNI Yoshitaka (80295641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YASUIKE Shuji (10230210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
5. MIYAJIMA Sawako (30278139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 周尾卓也 (90399006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 廣岡孝志 (50397519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
8. 藤江智也 (20780886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 原崇人 (90805681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. TAGUCHI Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 信国好俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

YAMAMOTO Chika 山本 千夏

山本 千夏 ヤマモト チカ

Research Projects

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Co-Researchers

有機フッ素化合物PFASの血管毒性を担う分子としてのプロテオグリカンPrincipal Investigator

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Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cellsPrincipal Investigator

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Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallicesPrincipal Investigator

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Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression

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Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicityPrincipal Investigator

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Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury

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Regulation of proteoglycan metabolism by adiponectin in vascular smooth muscle cellsPrincipal Investigator

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Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cells

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脳毛細血管内皮細胞と周皮細胞における線溶蛋白の発現および増殖因子による調節Principal Investigator

Principal Investigator

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Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesis

Principal Investigator

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細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節

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Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytes

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重金属による血液線溶系の撹乱を介在する細胞内情報電圧経路Principal Investigator

Principal Investigator

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YAMAMOTO Chika 山本千夏

山本千夏ヤマモトチカ