YANAGI Keiko 柳圭子（石原圭子）

… Alternative Names

Researcher Number	70265990
Other IDs
Affiliation (Current)	2019: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2017: 久留米大学, 医学部, 准教授 2010 – 2012: 佐賀大学, 医学部, 准教授 2007 – 2008: Saga University, 医学部, 准教授 2003 – 2006: 佐賀大学, 医学部, 助教授 2000 – 2001: 佐賀医科大学, 医学部, 助教授 1995 – 1997: 佐賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General physiology / General physiology Except Principal Investigator Circulatory organs internal medicine
Keywords	Principal Investigator カリウムチャネル / イオンチャネル / ポリアミン / 内向き整流カリウム電流 / 内向き整流カリウムチャネル / マグネシウムイオン / IRK1 / Kir2 / スペルミン / Potassium channel … More Except Principal Investigator カルシウムチャネル / タンパク間相互作用 / 酸化修飾 / プロゲステロン / QT延長症候群 / カベオラ / ニトロシル化 / カルモデュリン / リン酸化 / カリウムチャネル / 不整脈 / 性ホルモン / エストロゲン / 性差医療 / 性差 / 一酸化窒素 / レドックス Less

K+の電気化学ポテンシャル依存的チャネル開閉機構の研究Principal InvestigatorOngoing
- Principal Investigator
  
  柳圭子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kurume University
Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockersPrincipal Investigator
- Principal Investigator
  
  YANAGI Keiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga University
Elucidation of the molecular mechanisms of the inward rectifier potassium channel function using electrophysiological and optical approachesPrincipal Investigator
- Principal Investigator
  
  YANAGI Keiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga University
性ホルモンによる心筋イオンチャネル制御の検討-不整脈の性差医療の基礎戦略
- Principal Investigator
  
  FURUKAWA Tetsushi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
A study on the regulation of the inward rectifier potassium current by polyamine.Principal Investigator
- Principal Investigator
  
  YANAGI Keiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga University
A study on the molecular basis of the cardiac inward rectifier potassium channelsPrincipal Investigator
- Principal Investigator
  
  YANAGI Keiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga University
  佐賀医科大学
Study on the diversity of the cardiac inward rectifier potassium channelsPrincipal Investigator
- Principal Investigator
  
  YANAGI(ISHIHARA)
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga Medical School
IRK1(Kir2.1)チャネルの内向き整流性のメカニズムに関する研究Principal Investigator
- Principal Investigator
  
  柳圭子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
カリウムチャネル内向き整流特性に果たすポリアミンの役割Principal Investigator
- Principal Investigator
  
  柳圭子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  佐賀医科大学
内向き整流カリウムチャネル蛋白の電気生理学的機能と構造の連関Principal Investigator
- Principal Investigator
  
  柳圭子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
心筋カリウムチャネル内向き整流特性の分子機構Principal Investigator
- Principal Investigator
  
  柳圭子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  佐賀医科大学

All 2017 2016 2013 2012 2011 2010 2009 2008 2007 2005 2004

All Journal Article Presentation

[Journal Article] Mg の電気生理学2013
- Author(s)
  石原圭子
- Journal Title
  
  日本心電学会誌心電図
- Data Source
  KAKENHI-PROJECT-22590208
[Journal Article] Role of Mg^<2+> block of the inward rectifier K^+ current in cardiac repol arization reserve : A quantitative simulation.2009
- Author(s)
  Ishihara Keiko
- Journal Title
  
  J. Mol. Cell. Cardiol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.42009
- Author(s)
  Ishihara K, Yamamoto T, Kubo Y.
- Journal Title
  
  Biochem Biophys Res Commun 380
  
  Pages: 832-837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Role of Mg^<2+> block of the inward rectifier K^+ current in cardiac repolarization reserve : A quantitative simulation2009
- Author(s)
  Ishihara K, Sarai N, Asakura K, Noma A, Matsuoka S.
- Journal Title
  
  J Mol Cell Cardiol 47
  
  Pages: 76-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.2009
- Author(s)
  Ishihara Keiko
- Journal Title
  
  Biochem. Biophys. Res. Commun. 380
  
  Pages: 832-837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] 心室筋内向き整流カリウム電流と細胞内マグネシウムイオン.2008
- Author(s)
  石原圭子
- Journal Title
  
  日本心電学会誌心電図 29
  
  Pages: 307-315
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] 心室筋内向き整流カリウム電流と細胞内マグネシウムイオン2008
- Author(s)
  石原圭子
- Journal Title
  
  日本心電学会誌心電図 29
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels2007
- Author(s)
  Ishihara K、Yan D-H.
- Journal Title
  
  J Physiol(Lond) 583
  
  Pages: 891-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels2007
- Author(s)
  Keiko Ishihara
- Journal Title
  
  J Physiol (Lond) 583
  
  Pages: 891-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590209
[Journal Article] Different intracellular polyamine concentrations underlie the difference in the inward rectifier K^+ currents in atria and ventricles of the guinea-pig heart.2005
- Author(s)
  Yan D-H, Nishimura K, Yoshida K, Nakahira K, Ehara T, Igarashi K, Ishihara K.
- Journal Title
  
  Journal of Physiology (London) 563
  
  Pages: 713-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590187
[Journal Article] Two Kir2.1 channel populations with different sensitivities to Mg^<2+> and polyamine block : a model for the cardiac strong inward rectifier K^+ channel.2005
- Author(s)
  Yan D-H, Ishihara K.
- Journal Title
  
  Journal of Physiology (London) 563
  
  Pages: 725-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590187
[Journal Article] Two modes of polyamine block regulating the cardiac inward rectifier K^+ Current I_<K1> as revealed by a study of the Kir2.1 channel expressed in a human cell line.2004
- Author(s)
  Ishihara K
- Journal Title
  
  Journal of Physiology(London) 556
  
  Pages: 61-78
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590187
[Journal Article] Cell-volume regulation by swelling-activated chloride current in guinea-pig ventricular myocytes.2004
- Author(s)
  Yamamoto, S, Ishihara, K, Ehara, T, Shioya, T.
- Journal Title
  
  Japanese Journal of Physiology 54
  
  Pages: 31-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590187
[Journal Article] Two modes of polyamine block regulating the cardiac inward rectifier K^+ current I_<K1> as revealed by a study of the Kir2.1 channel expressed in a human cell line.2004
- Author(s)
  Ishihara K, Ehara T.
- Journal Title
  
  Journal of Physiology (London) 556
  
  Pages: 61-78
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590187
[Journal Article] Two modes of polyamine block regulating the cardiac inward rectifier K^+ current I_<K1> as revealed by a study of the Kir2.1 channel expressed in a human cell line.2004
- Author(s)
  Ishihara K
- Journal Title
  
  Journal of Physiology(London) 556
  
  Pages: 61-78
- Data Source
  KAKENHI-PROJECT-15590187
[Presentation] 内向き整流カリウムチャネルのKイオン透過の制御機構2017
- Author(s)
  柳（石原）　圭子
- Organizer
  平成29年度生理学研究所研究会「膜システムの機能的・構造的統合」
- Data Source
  KAKENHI-PROJECT-16K08509
[Presentation] Mechanisms for external K+ dependence of K+ permeation and gating of Kir2.1 inward rectifier K+ channel2017
- Author(s)
  Ishihara K, Matsuoka S, Takano M
- Organizer
  The 94th Annual Meeting of the Physiological Society of Japan, Symposium 12: Simulation studies of structures, dynamics, and functions of ion channels and transporters
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K08509
[Presentation] 心筋内向き整流K+チャネルのK+透過は細胞外K+に依存するのか2016
- Author(s)
  柳（石原）圭子、鷹野誠
- Organizer
  生理学研究所研究会2016「心臓・血管系の包括的な機能統合研究」
- Place of Presentation
  九州大学馬出キャンパス（福岡県）
- Year and Date
  2016-10-24
- Data Source
  KAKENHI-PROJECT-16K08509
[Presentation] Kir2.1チャネルの細胞外K+に依存する透過と開閉のメカニズム2016
- Author(s)
  柳（石原）圭子、鷹野誠
- Organizer
  平成28年度生理学研究所研究会「膜システムの機能的・構造的統合」
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-16K08509
[Presentation] Kir2.1チャネルの細胞外Kイオンに依存するKイオン透過のメカニズム2016
- Author(s)
  柳（石原）圭子、鷹野誠
- Organizer
  第67回西日本生理学会
- Place of Presentation
  国民宿舎レインボー桜島（鹿児島県）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K08509
[Presentation] Inhibition of Kir2.x inward rectifier K+channels by local anesthetics, bupivacaine and lidocaine2013
- Author(s)
  Nakahira K, Fujisawa A, Ishihara K
- Organizer
  The 90 th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Tokyo
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Inhibition of Kir2.x inward rectifier K+ channels by local anesthetics, bupivacaine and lidocaine.2013
- Author(s)
  K Nakahira, A Fujisawa, K Ishihara
- Organizer
  The 90 th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  東京（船堀）
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] 局所麻酔薬リドカインとブピバカインによるKir2.x内向き整流Kチャネル抑制機構2013
- Author(s)
  中平圭、坂口　嘉郎、石原圭子
- Organizer
  日本麻酔科学会　第60回学術集会
- Place of Presentation
  北海道（札幌）
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] 局所麻酔薬リドカインとブピバカインによるKir2.x 内向き整流 K チャネル抑制機構2013
- Author(s)
  中平圭、坂口嘉郎、石原圭子
- Organizer
  日本麻酔科学会第60回学術集会
- Place of Presentation
  北海道
- Year and Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Mg の電気生理学2012
- Author(s)
  石原圭子
- Organizer
  心電学フロンティア 2012「炎症と不整脈・Mg の多彩な心筋作用」第29回」日本心電学会学術集会(招待講演
- Place of Presentation
  千葉
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Mgの電気生理学　心電学フロンティア2012　「炎症と不整脈・Mgの多彩な心筋作用」2012
- Author(s)
  石原圭子
- Organizer
  第29回日本心電学会学術集会
- Place of Presentation
  千葉（幕張）
- Invited
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Regulation of cardiac Na/Ca exchanger by PMCA is mediated by local calcium2012
- Author(s)
  Shioya T, Ishihara K
- Organizer
  The 89th annual meeting of the physiological society of Japan
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] pH感受性内向き整流カリウムチャネルKir2.3の心臓における役割2011
- Author(s)
  石原圭子、村田祐造、山本友美、市島久仁彦、福留健司、塩谷孝夫、増子貞彦、久保義弘
- Organizer
  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  Journal of Physiological Sciences(誌上開催)
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Low affinity polyamine block of IK1facilitating the cardiac repolarization. Special Symposium "Ion channels, Arrhythmogenesis and Channelopathy,"2011
- Author(s)
  Ishihara K
- Organizer
  4th Asia Pacific Heart Rhythm Society (APHRS 2011)
- Place of Presentation
  Fukuoka
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Role of the pH-sensitive strong inward rectifier Kir2.3 in the heart2011
- Author(s)
  Ishihara K, Murata Y, Yamamoto T, Ichishima K, Fukudome K, Shioya T, Masuko S, Kubo Y
- Organizer
  The 88th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Low-affinity polyamine block of I_<K1> facilitating the cardiac Repolarization2011
- Author(s)
  Ishihara K
- Organizer
  Special Symposium "Ion channels, Arrhythmogenesis and Channelopathy", 4th Asia Pacific Heart Rhythm Society (APHRS 2011) in Conjunction with 7th Asia Pacific Atrial Fibrillation Symposium (7th APAFS)
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Kir2とKir3サブファミリーに属する内向き整流K^+チャネル・サブユニットは異種発現系においてヘテロ多量体を形成する2010
- Author(s)
  石原圭子、山本友美、久保義弘
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  岩手県盛岡市
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Kir2.1内向き整流カリウムチャネルのpH依存性開閉機構2008
- Author(s)
  石原圭子, Yan DH、頴原嗣尚
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流K^+チャネルKir2.1のゲーティングと細胞内pH2008
- Author(s)
  石原圭子, Yan DH.
- Organizer
  生理学研究所研究会「膜機能分子ダイナミクスの分子機構解明に向けて」
- Place of Presentation
  愛知県、岡崎市
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] Low-affinity spermine block of strong inward rectifier Kir2 channels : role of cytoplasmic pore region2008
- Author(s)
  Ishihara K.
- Organizer
  Biophysical Society Meeting 52nd Annual Meeting
- Place of Presentation
  米国 Long Beach
- Year and Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] Low-affinity spermine block of strong inward rectifier Kir2 channels:role of cytoplasmic pore region2008
- Author(s)
  石原圭子
- Organizer
  Biophysical Society Meeting 52nd Annual Meeting
- Place of Presentation
  米国、Long Beach
- Year and Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流K^+チャネルKir2.1のゲーティングと細胞内pH2008
- Author(s)
  石原圭子
- Organizer
  生理学研究所研究会「膜機能分子ダイナミクスの分子機構解明に向けて」
- Place of Presentation
  愛知県、岡崎市
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流K^+電流の細胞内Mg^<2+>およびスペルミンによるブロックと心筋再分極予備力 : シミュレーションによる定量的検討2008
- Author(s)
  石原圭子
- Organizer
  第59回西日本生理学会
- Place of Presentation
  熊本県、熊本市
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] Inward rectifier potassium current I_<K1> during the cardiac myocellular repolarization : An in silico study2007
- Author(s)
  石原圭子
- Organizer
  4th International Symposium of Cell/Biodynamics Simulation Project, Kyoto University(Medical Systems Biology of the Heart)
- Place of Presentation
  京都
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] Inward Rectifier Potassium Current I^<K1> During the Cardiac Myocellular Repolarization:an in Silico Study2007
- Author(s)
  石原圭子
- Organizer
  4th International Symposium of Cell/Biodynamics Simulation Project, Kyoto University "Medical Systems Biology of the Heart"
- Place of Presentation
  京都
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流カリウムチャネルの低親和性スペルミンブロック : 細胞内領域チャネルポアの役割2007
- Author(s)
  石原圭子, Yan DH.
- Organizer
  生理学研究所研究会「イオンチャネル・トランスポーターと心血管機能 : 学際的取り組みによる新戦略」
- Place of Presentation
  愛知県岡崎市
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流K^+チャネルKir2.1、Kir2.2およびKir2.1(D172N)の機能差異2007
- Author(s)
  石原圭子, Yan DH.
- Organizer
  第24回心電学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590209
[Presentation] 内向き整流カリウムチャネルの低親和性スペルミンブロック:細胞内領域チャネルポアの役割2007
- Author(s)
  石原圭子
- Organizer
  生理学研究所研究会「イオンチャネル・トランスポーターと心血管機能:学際的取り組みによる新戦略」
- Place of Presentation
  岡崎
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-19590209

1. YAMAMOTO Shintaro (40336110)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. EHARA Tsuguhisa (50037446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 中谷晴昭 (60113594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 大江透 (70263556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUBO Yoshihiro (80211887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 黒川洵子 (40396982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YANAGI Keiko 柳 圭子（石原圭子）

柳 圭子 ヤナギ ケイコ

石原圭子

ISHIHARA Keiko 石原 圭子

石原 圭子 イシハラ ケイコ

YANAGI(ISHIHARA) 柳 圭子

Research Projects

Research Products

Co-Researchers

K+の電気化学ポテンシャル依存的チャネル開閉機構の研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockersPrincipal Investigator

Principal Investigator

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Elucidation of the molecular mechanisms of the inward rectifier potassium channel function using electrophysiological and optical approachesPrincipal Investigator

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性ホルモンによる心筋イオンチャネル制御の検討-不整脈の性差医療の基礎戦略

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A study on the regulation of the inward rectifier potassium current by polyamine.Principal Investigator

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A study on the molecular basis of the cardiac inward rectifier potassium channelsPrincipal Investigator

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Study on the diversity of the cardiac inward rectifier potassium channelsPrincipal Investigator

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IRK1(Kir2.1)チャネルの内向き整流性のメカニズムに関する研究Principal Investigator

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カリウムチャネル内向き整流特性に果たすポリアミンの役割Principal Investigator

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内向き整流カリウムチャネル蛋白の電気生理学的機能と構造の連関Principal Investigator

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心筋カリウムチャネル内向き整流特性の分子機構Principal Investigator

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[Journal Article] Mg の電気生理学2013

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[Journal Article] Role of Mg^<2+> block of the inward rectifier K^+ current in cardiac repol arization reserve : A quantitative simulation.2009

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YANAGI Keiko 柳圭子（石原圭子）

柳圭子ヤナギケイコ

ISHIHARA Keiko 石原圭子

石原圭子イシハラケイコ

YANAGI(ISHIHARA) 柳圭子