Sugiyama Tsuyoshi 杉山剛志

… Alternative Names

杉山剛志スギヤマツヨシ

SUGIYAMA Tsuyoshi 杉山剛志

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Researcher Number	70268001
Other IDs	https://orcid.org/0000-0002-8517-9067
Affiliation (Current)	2024: 岐阜医療科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2024: 岐阜医療科学大学, 薬学部, 教授 2019 – 2022: 岐阜医療科学大学, 薬学部, 教授 2018: 岐阜医療科学大学, 保健科学部, 教授 2016 – 2017: 岐阜薬科大学, 薬学部, 准教授 2009 – 2010: Gifu Pharmaceutical University, 薬学部, 准教授 … More 2004 – 2005: 岐阜薬科大学, 薬学部, 助教授 2001 – 2002: 愛知医科大学, 医学部, 助手 1995 – 1998: 愛知医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Bacteriology (including Mycology) / Biological pharmacy / Bacteriology (including Mycology) Except Principal Investigator Bacteriology (including Mycology)
Keywords	Principal Investigator Toll-like receptors / Lipopolysaccharides / poly I : C / Signaltransduction / Cytokines / Nitric Oxide / Bacterial CpG DNA / Signal transduction / アジュバント / IgA … More / 炎症性腸疾患 / 感染性腸炎 / 腸内細菌叢 / 免疫学 / Rho GTPase / RhoGEF / アクチン重合 / III型分泌機構 / シトロバクター・ローデンティウム / 腸管出血性大腸菌 / poly I:C / LiponolysaccharidesLiponolysaccharides / 感染免疫 / Macrophage / Morphological change / Mitogen-activated protein kinase / Interferon-γ / B-1 cell … More Except Principal Investigator HSP / LPS / エンドトキシン / アポトーシス / 肝細胞 / endotoxic shock / hepatocyte / TNF / stress response / apoptosis / endotoxin / lipopolysaccharide / エンドトキシンショック / マウス / ストレス蛋白 / TNFi / peroxynitrite / ニトロチロシン / iNOS / 一酸化窒素 / ストレスタンパク / D-ガラクトサミン / ストレス応答 / 熱ショック蛋白 Less

Analysis of Intestinal epithelial cell responses inducing secretory IgA as a basis for mucosal immune adjuvant developmentPrincipal Investigator
- Principal Investigator
  
  杉山剛志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gihu University of Medical Science
Establishment of intestinal flora modification method for prevention of enterohemorrhagic Escherichia coli infection and inflammatory enteritisPrincipal Investigator
- Principal Investigator
  
  杉山剛志
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gihu University of Medical Science
Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant developmentPrincipal Investigator
- Principal Investigator
  
  Sugiyama Tsuyoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gihu University of Medical Science
  Gifu Pharmaceutical University
コッホの原則を満たす実験的マウス潰瘍性大腸炎起炎菌の同定Principal Investigator
- Principal Investigator
  
  杉山剛志
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Gifu Pharmaceutical University
Inhibitory mechanism and the target of Toll like receptor signaling inhibitorsPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Tsuyoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Gifu Pharmaceutical University
低濃度LPSに反応するB-1細胞のCD14を介したシグナル伝達経路の解析Principal Investigator
- Principal Investigator
  
  杉山剛志
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University
THE ROLE OF STRESS PROTEINS IN ENDOTOXIN-INDUCED HEPATIC INJURY
- Principal Investigator
  
  YOKOCHI Takashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  AICHI MEDICAL UNIVERSITY
実験的エンドトキシンショックにおけるアポトーシスの関与
- Principal Investigator
  
  横地高志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University
細菌内毒素投与による熱ショック蛋白誘導機序
- Principal Investigator
  
  YOKOCHI Takashi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University

All 2019 2018 2017 2016 2004

All Journal Article Presentation Book

[Book] エンドトキシン・自然免疫研究　２１　エンドトキシン・自然免疫研究のフロンティアをめざして2018
- Author(s)
  早水良、杉山剛志
- Total Pages
  88
- Publisher
  医学図書出版株式会社
- Data Source
  KAKENHI-PROJECT-16K08241
[Journal Article] The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells2019
- Author(s)
  Nishikawa Masashi、Nakano Shun、Nakao Hiromu、Sato Katsuya、Sugiyama Tsuyoshi、Akao Yukihiro、Nagaoka Hitoshi、Yamakawa Hisashi、Nagase Takahiro、Ueda Hiroshi
- Journal Title
  
  Cellular Signalling
  
  Volume: 61 Pages: 93-107
- DOI
  10.1016/j.cellsig.2019.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-18K15045, KAKENHI-PROJECT-18J13111, KAKENHI-PROJECT-19K07043
[Journal Article] Peyer’s Patches as a Portal for DNA Delivery by <i>Lactococcus lactis</i> <i>in Vivo</i>2018
- Author(s)
  Ayumu Yano, Keita Takahashi, Yusuke Mori, Shiori Watanabe, Yuki Hanamura, Tsuyoshi Sugiyama, Naoki Inoue
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 2 Pages: 190-197
- DOI
  10.1248/bpb.b17-00657
- NAID
  130006329249
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-16K19127
[Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production2004
- Author(s)
  Sugiyama T. et al.
- Journal Title
  
  Microbiology and Immunology 48・12
  
  Pages: 957-963
- NAID
  10014092321
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590367
[Journal Article] Inhibition of LPS-induced nitric oxide and cytokine production in RAW 264 cells by 2-aminopurine2004
- Author(s)
  Sugiyama T.et al.
- Journal Title
  
  Journal of Endotoxin Research 10・5
  
  Pages: 340-340
- Data Source
  KAKENHI-PROJECT-16590367
[Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production2004
- Author(s)
  Sugiyama T.et al.
- Journal Title
  
  Microbiology and Immunology 48・12
  
  Pages: 957-963
- NAID
  10014092321
- Data Source
  KAKENHI-PROJECT-16590367
[Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-beta production.2004
- Author(s)
  Sugiyama T. et al.
- Journal Title
  
  Microbiol Immunol 48(12)
  
  Pages: 957-963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590367
[Presentation] 上皮細胞でのⅢ型分泌装置を介したアクチン重合はCitrobacter rodentium特異的分泌型IgA産生誘導に必須ではない2019
- Author(s)
  鶴見駿、髙橋圭太、井上直樹、杉山剛志
- Organizer
  第31回　微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] KIAA0599 augments TRIF- and Myd88-dependent TLR signaling2018
- Author(s)
  Tsuyoshi Sugiyama, Kanna Nakao, Ryo Hayami, Takuya Hasegawa, Keita Takahashi, Naoki Inoue, Takahiro Nagase, Hiroshi Ueda
- Organizer
  Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] A/E病変に伴うアクチンの重合が制御する宿主遺伝子発現2017
- Author(s)
  安田祐里花、鶴見駿、早水良、惠西丈彦、高橋圭太、井上直樹、杉山剛志
- Organizer
  第21 回腸管出血性大腸菌感染症研究会参加
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 糞便移植を用いたデキストラン硫酸ナトリウム誘発マウス潰瘍性大腸炎モデルにおける腸内細菌叢と病態の関係の解析2017
- Author(s)
  惠西丈彦、西科冴香、安田祐里花、村岡夏実、加藤大樹、前川洋一、井上直樹、杉山剛志
- Organizer
  第54 回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] Rhoグアニンヌクレオチド交換因子KIAA0362のToll様受容体シグナルへの影響2017
- Author(s)
  早水良、杉山剛志
- Organizer
  第23回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] Rhoグアニンヌクレオチド交換因子PLEKHG3によるTRIF依存的シグナル増強作用2017
- Author(s)
  中尾莞奈、早水良、秋元奈央、長谷川拓也、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  第54 回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] ARHGEF15 augments TRIF-dependent pathway of TLR signaling via enhancing the phosphorylation of IRF-32016
- Author(s)
  Sugiyama T, Hasegawa T, Takahashi K, Inoue N., Nagase T., Ueda H.
- Organizer
  14th Biennial Meeting of International Endotoxin and Innate Immunity Society
- Place of Presentation
  ドイツ・ハンブルグ
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 腸管上皮細胞におけるRho GTPase活性化のToll様受容体シグナルへの影響2016
- Author(s)
  矢端文彦、中尾莞奈、早水良、田中秀幸、児玉雄大、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-16K08241

1. YOKOCHI Takashi (20126915)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KATO Yutaka (40267985)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 上田浩 (50253779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 高橋圭太 (50634929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 所俊志 (10551088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 村上泰介 (40384135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sugiyama Tsuyoshi 杉山 剛志

杉山 剛志 スギヤマ ツヨシ

SUGIYAMA Tsuyoshi 杉山 剛志

Research Projects

Research Products

Co-Researchers

Analysis of Intestinal epithelial cell responses inducing secretory IgA as a basis for mucosal immune adjuvant developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of intestinal flora modification method for prevention of enterohemorrhagic Escherichia coli infection and inflammatory enteritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

コッホの原則を満たす実験的マウス潰瘍性大腸炎起炎菌の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory mechanism and the target of Toll like receptor signaling inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

低濃度LPSに反応するB-1細胞のCD14を介したシグナル伝達経路の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE ROLE OF STRESS PROTEINS IN ENDOTOXIN-INDUCED HEPATIC INJURY

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

実験的エンドトキシンショックにおけるアポトーシスの関与

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細菌内毒素投与による熱ショック蛋白誘導機序

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] エンドトキシン・自然免疫研究 ２１ エンドトキシン・自然免疫研究のフロンティアをめざして2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peyer’s Patches as a Portal for DNA Delivery by <i>Lactococcus lactis</i> <i>in Vivo</i>2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production2004

Author(s)

Sugiyama Tsuyoshi 杉山剛志

杉山剛志スギヤマツヨシ

SUGIYAMA Tsuyoshi 杉山剛志

[Book] エンドトキシン・自然免疫研究　２１　エンドトキシン・自然免疫研究のフロンティアをめざして2018