KASHIWAGI Takahito 柏木孝仁

Researcher Number	70320158
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 久留米大学, 医学部, 准教授 2011 – 2017: 久留米大学, 医学部, 講師 2009 – 2011: Kurume University, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 09020:Sociology of education-related / Basic Section 09050:Tertiary education-related / Pediatrics
Keywords	Principal Investigator 阻害薬 / PA / PB2 / ポリメラーゼ / PAサブユニット / 抗ウイルス薬 / RNAポリメラーゼ / インフルエンザウイルス / 感染症 / ウイルス … More / 生理活性 / 酵素 / 核酸 / Small RNA / インフルエンザ / PB2サブユニット / 遺伝子複製 / 内科 / 呼吸器 / 小児科 / 微生物 / 医療・福祉 / 小児感染症学 … More Except Principal Investigator Pタンパク質 / RNAポリメラーゼ / 抗ウイルス薬 / RSV / パラミクソウイルス / モノネガウイルス / P / RSウイルス / ナノ粒子 / ペプチドベース阻害薬 / PFr / 4量体形成部位 / ペプチド阻害薬 / 動機づけ因子 / 見える化 / AI解析 / ライフイベント / 性別役割分担 / 女性医師 / キャリア形成 / ジェンダー / ダイバーシティ・インクルージョン / well-being / 医師のキャリア形成 / ダイバーシチィ・インクルージョン / ワークモチベーション / 男女共同参画 / ３次元コンピューターグラフックス画像 / 肺音聴診シミュレーター / 医学教育 / 次世代型シミュレーター / AR技術 / 下気道感染症 / 乳幼児 / ペプチド薬剤 / Lポリメラーゼ / ポリメラーゼ / ペプチド / 相互作用 / RNP / 非翻訳領域 / 欠損変異型 / 抗ウイルス作用 / ミニゲノムアッセイ系 / RNA複製酵素 / Lタンパク質 / ルシフェラーゼ / ミニゲノム Less

Pタンパク質の4量体を破壊する広域抗モノネガウイルス薬の開発研究
- Principal Investigator
  
  原好勇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Development of next-generation simulator using augmented reality
- Principal Investigator
  
  山田圭
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09050:Tertiary education-related
- Research Institution
  Kurume University
A universal design of nanoparticle-based antivirals against paramyxoviruses
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
女性医師のワークモチベーションを上昇させる動機づけモデルの樹立
- Principal Investigator
  
  守屋普久子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09020:Sociology of education-related
- Research Institution
  Kurume University
A novel antiviral strategy against respiratory syncytial virus disrupting protein-protein interactions
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Development of new drug based on the self or non-self distinctional mechanism of the influenza virusPrincipal Investigator
- Principal Investigator
  
  KASHIWAGI TAKAHITO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Establishment of a new therapeutic for the treatment of paramyxoviruses by using a mimic of viral genomic RNA.
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
New strategy of the therapy that applied antigenic-shift of the influenza virus.Principal Investigator
- Principal Investigator
  
  KASHIWAGI takahito
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Novel strategies and basic approaches for the study of the treatment against highly pathogenic influenza virus.Principal Investigator
- Principal Investigator
  
  KASHIWAGI Takahito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein.2020
- Author(s)
  Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eleouet JF, Rameix-Welti MA, Watanabe H.
- Journal Title
  
  J Gen Virol
  
  Volume: 101 Issue: 1 Pages: 21-32
- DOI
  10.1099/jgv.0.001350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07834
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017
- Author(s)
  K. Hara, T. Kashiwagi, N. Hamada, H. Watanabe
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10047
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication2017
- Author(s)
  Hara Koyu、Kashiwagi Takahito、Hamada Nobuyuki、Watanabe Hiroshi
- Journal Title
  
  Journal of General Virology
  
  Volume: 98 Issue: 5 Pages: 900-905
- DOI
  10.1099/jgv.0.000750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10047
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017
- Author(s)
  Hara K, Kashiwagi T, Hamada N, and Watanabe H.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09672
[Journal Article] The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Journal Title
  
  J Infect Chemother
  
  Volume: 21 Issue: 4 Pages: 296-301
- DOI
  10.1016/j.jiac.2014.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Journal Title
  
  J Infect Chemother
  
  Volume: 21 Pages: 296-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09672
[Journal Article] The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication.2014
- Author(s)
  Kashiwagi T, Hara K, Nakazono Y, Uemura Y, Imamura Y, Hamada N, and Watanabe H.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 12 Pages: e114502-e114502
- DOI
  10.1371/journal.pone.0114502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care facility.2014
- Author(s)
  Hamada N, Hara K, Matsuo Y, Imamura Y, Kashiwagi T, Nakazono Y, Gotoh K, Ohtsu Y, Ohtaki E, Motohiro T and Watanabe H.
- Journal Title
  
  Epidemiol Infect
  
  Volume: 142 Issue: 2 Pages: 424-427
- DOI
  10.1017/s0950268813001246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexs2013
- Author(s)
  K Hara, Y Nakazono, T Kashiwagi, N Hamada and H Watanabe
- Journal Title
  
  Journal of general virology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care ficility2013
- Author(s)
  N Hamada, K Hara, Y Matsuo, Y Imamura, T Kashiwagi, Y Nakazono, K Gotoh, E Ohtaki, T Motohiro and H Watanabe
- Journal Title
  
  Epidemiology and infection
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] インフルエンザ（H1N1）2009発生時に地域に密着して実施した実験室内診断症例の検討2013
- Author(s)
  今村宜寛、濱田信之、原好勇、柏木孝仁、渡邊浩
- Journal Title
  
  感染症学雑誌
  
  Volume: 87(3) Pages: 368-374
- NAID
  10031189392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes.2013
- Author(s)
  Hara K, Nakazono Y, Kashiwagi T, Hamada N, and Watanabe H.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 94 Issue: 11 Pages: 2406-2416
- DOI
  10.1099/vir.0.053959-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997(H5N1) restricts the replication of reassortant ribonucleoprotein complexes ribonucleoprotein complexes2012
- Author(s)
  Nakazono Y, Hara K, Kashiwagi T, Hamada N, and Watanabe H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7(2)
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997 (H5N1) restricts the replication of reassortant ribonucleoprotein complexes2012
- Author(s)
  Nakazono Y Hara K, Kashiwagi T, Hamada N, Watanabe H
- Journal Title
  
  PLoS ONE
  
  Volume: 7(2) Issue: 2 Pages: e32634-e32634
- DOI
  10.1371/journal.pone.0032634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591305, KAKENHI-PROJECT-21791015, KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient.2012
- Author(s)
  N Hamada, Y Imamura, K Hara, T Kashiwagi, Y Imamura, Y Nakazono, K Chijiwa, and H Watanabe
- Journal Title
  
  Journal of infection and chemotherapy
  
  Volume: 18 Issue: 6 Pages: 865-871
- DOI
  10.1007/s10156-012-0429-0
- NAID
  10031143888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] Clinical study concerning the relationship between community-acquired pneumonia and viral infection in northern Thailand2011
- Author(s)
  Hara K, Yahara K, Gotoh K, Nakazono Y, Kashiwagi T, et al
- Journal Title
  
  Inter.Med.
  
  Volume: 50 Pages: 991-998
- NAID
  130000650101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] Clinical study concerning the relationship between community-acquired pneumonia and viral infection in northern Thailand2011
- Author(s)
  Hara K, Yahara K, Gotoh K, Nakazono Y, Kashiwagi T, Imamura Y, Hamada N, Khositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Maneekarn N, Sirisanthana T, and Watanabe H.
- Journal Title
  
  Intern Med
  
  Volume: 50 Pages: 991-998
- NAID
  130000650101
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] Artificial hybrids of influenza A virus RNA polymerase reveal PA subunit modulates its thermal sensitivity2010
- Author(s)
  Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Journal Title
  
  PLoS ONE
  
  Volume: 5(12)
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] Artificial Hybrids of Influenza A Virus RNA Polymerase Reveal PA Sub unit Modulates Its Thermal Sensitivity2010
- Author(s)
  柏木孝仁
- Journal Title
  
  PLoS ONE
  
  Volume: 5(12)e15140 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] The N-terminal of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 influences promoter binding2009
- Author(s)
  柏木孝仁
- Journal Title
  
  PLoS ONE 4(5)e5473
  
  Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791015
[Journal Article] The N-terminal of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 influences promoter binding2009
- Author(s)
  Kashiwagi T, Leung BW, Deng T, Chen H, and Brownlee GG.
- Journal Title
  
  PLoS ONE
  
  Volume: 4(5)
- Data Source
  KAKENHI-PROJECT-21791015
[Patent] インフルエンザウイルス阻害薬2014
- Inventor(s)
  柏木孝仁、上村勇作、渡邊浩
- Industrial Property Rights Holder
  久留米大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-094681
- Filing Date
  2014-05-01
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] ウイルスRNAポリメラーゼ複合体由来のP断片は抗RSウイルス活性を示す2019
- Author(s)
  原好勇、柏木孝仁、渡邊浩
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] 精製したRSウイルスのP断片はRSウイルスの増殖を抑制する2019
- Author(s)
  原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第93回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] 精製したRSウイルスのP断片はRSウイルスの増殖を抑制する2019
- Author(s)
  原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第 93回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] The C-terminal fragment of the respiratory syncytial virus phosphoprotein inhibits the viral polymerase activity.2018
- Author(s)
  Koyu Hara, Kenichiro Yaita, Takahito Kashiwagi and Hiroshi Watanabe
- Organizer
  Negative Strand Virus meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第92回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] The C-terminal fragment of the respiratory syncytial virus phosphoprotein inhibits the viral polymerase activity.2018
- Author(s)
  Koyu Hara, Kenichiro Yaita, Takahito Kashiwagi and Hiroshi Watanabe
- Organizer
  Negative Strand RNA Virus meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第92回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原好勇、柏木孝仁、渡邊浩
- Organizer
  第92回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] 次世代シーケンサーによる病原体不明検体からのコロナウイルスの検出2017
- Author(s)
  濱田信之、原　好勇、柏木孝仁、八板謙一郎、後藤憲志、大津　寧、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスのPタンパク質C末端領域はウイルスRNPの合成を抑制する2017
- Author(s)
  八板謙一郎, 原　好勇, 柏木孝仁, 濱田信之, 渡邊　浩
- Organizer
  第91回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] RSウイルスのPタンパク質C末端領域はウイルスRNPの合成を抑制する2017
- Author(s)
  八板謙一郎, 原　好勇, 柏木孝仁, 濱田信之, 渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスの欠損型PはRSウイルスのポリメラーゼ活性を阻害する2017
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第87回日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] The C-terminal region of the respiratory syncytial virus phosphoprotein has an inhibitory effect on the polymerase activity.2017
- Author(s)
  Yaita K, Hara K, Khamrin P, Kashiwagi T, Hamada N, and Watanabe H.
- Organizer
  International Union of Microbiological Sciences 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットの転写および複製における役割2017
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスの欠損型PはRSウイルスのポリメラーゼ活性を阻害する2017
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第87回日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] インフルエンザウイルスのPA断片が持つエンドヌクレアーゼ活性は自身の遺伝子複製阻害に関与する2017
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] 新作用機序によるインフルエンザウイルス阻害剤への応用2016
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第86回日本感染症学会西日本地方会学術集会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] 新作用機序によるインフルエンザウイルス阻害剤への応用2016
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第59回日本感染症学会中日本地方会学術集会
- Place of Presentation
  沖縄（沖縄コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットのRNA結合部位の同定2015
- Author(s)
  原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] Identification of amino acids critical for polymerase activity in the N-terminal region of the PB2 subunit of influenza virus RNA polymerase.2015
- Author(s)
  Hara K, Kashiwagi T, Hamada N, and Watanabe H.
- Organizer
  Negative Strand Virus Meeting
- Place of Presentation
  Siena, Italy
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] The N-terminal fragments of the PB2 and PA subunits severely inhibit a ribonucleoprotein (RNP) activity of influenza A virus.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Organizer
  Negative Strand Virus Meeting
- Place of Presentation
  Siena, Italy
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスのN末端PAによるRNP合成阻害とその特異性について2015
- Author(s)
  柏木孝仁、原好勇、上村勇作、今村宜寛、濱田信之、渡邊浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] ンフルエンザウイルスのN末端PAによるRNP合成阻害とその特異性について2015
- Author(s)
  柏木孝仁、原　好勇、上村勇作、今村宜寛、濱田信之、渡邊　浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットのRNA結合部位の同定2015
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスPAサブユニットのN末端断片はRNPの合成を抑制する2014
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPA サブユニットによる RNP 合成阻害の特異性の検証2014
- Author(s)
  柏木孝仁，上村勇作，原好勇，今村宜寛，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合ではPB2とPAの同時移行が重要である2014
- Author(s)
  原好勇，柏木孝仁，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合ではPB2とPAの同時移行が重要である2014
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPAサブユニットによるRNP合成阻害の特異性の検証2014
- Author(s)
  柏木孝仁、上村勇作、原　好勇、今村宜寛、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPA サブユニットのN 末端断片はRNP の合成を抑制する2014
- Author(s)
  上村勇作，柏木孝仁，原好勇，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The PA subunit of the influenza A virus RNA polymerase contributes its stable activity on thermal stress through the promoter binding2011
- Author(s)
  Kashiwagi T, Hara K, Hamada N and Watanabe H.
- Organizer
  15th US-Japan Acute Respiratory Infections Panel Meeting
- Place of Presentation
  Wakayama, Japan
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] Mutational analysis of the PB2 subunit of H5N1 influenza virus RNA polymerase required for the assembly of the functional hybrid ribonucleoprotein2011
- Author(s)
  中園陽子、原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第15回国際ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] オセルタミビル感受性株と抵抗性株がそれぞれ左右剖検肺から検出された新型インフルエンザウイルスA(H1N1/2009)のクローン解析2011
- Author(s)
  濱田信之、今村豊、原好勇、柏木孝仁、今村宜寛、千々和勝己、渡邊浩
- Organizer
  第85回日本感染症学会学術総会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルス遺伝子複製酵素から見た温度への適応について2011
- Author(s)
  柏木孝仁、原好勇、今村宜寛、濱田信之、渡邊浩
- Organizer
  第85回日本感染症学会学術総会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] Inhibitory effect of human metapneumovirus (HMPV) M2-2 on RNA synthesis2011
- Author(s)
  濱田信之、原好勇、中園陽子、柏木孝仁、渡邊浩
- Organizer
  第15回国際ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] Mutational analysis of the PB2 subunit of H5N1 influenza virus RNA polymerase required for the assembly of the functional hybrid ribonucleoprotein2011
- Author(s)
  中園陽子、原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第15回国際ウイルス学会(15th International Congress of Virology)
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] The PA subunit of the influenza A virus RNA polymerase contributes its stable activity on thermal stress through the promoter binding2011
- Author(s)
  Kashiwagi T, Hara K, Hamada N, Watanabe H
- Organizer
  United States-Japan Cooperative Medical Science Program. 15th US-Japan Acute Respiratory Infections Panel Meeting
- Place of Presentation
  Wakayama, Japan
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルス遺伝子複製酵素の亜型間親和性を決定するアミノ酸解析2011
- Author(s)
  原好勇、柏木孝仁、渡邊浩
- Organizer
  第85回日本感染症学会学術総会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルス遺伝子複製酵素の温度変化への適応2010
- Author(s)
  柏木孝仁、原好勇、中園陽子、濱田信之、岩橋潤、今村宜寛、渡邊浩
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] PA subunit of influenza A virus RNA polymerase is involved in the stable RNA replication at the high temperature2010
- Author(s)
  柏木孝仁
- Organizer
  Options for the Control of Influenza VII
- Place of Presentation
  香港、中華人民共和国
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] The N-terminal region of the PA subunit of influenza virus RNA polymerase contributes to the functional RNA formation2010
- Author(s)
  Hara K, Nakazono Y, Kashiwagi T, and Watanabe H.
- Organizer
  Options for the Control of Influenza VII
- Place of Presentation
  Hong Kong
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルスRNAポリメラーゼサブユニットの亜型間での親和性解析-PB2(H5N1)の親和性決定部位について-2010
- Author(s)
  中園陽子、原好勇、柏木孝仁、今村宜寛、濱田信之、渡邊浩
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] Infection control for the pandemic(H1N1) 2009 in Kurume university hospital2010
- Author(s)
  Watanabe H, Kashiwagi T, Hara K, Masunaga K, Kawano S, Miura M, Iwahashi J, Qin L, Imamura Y, and Hamada N.
- Organizer
  Meeting of the global outbreak alert and response network(GOARN) partners from the western pacific region
- Place of Presentation
  Siem Reap, Cambodia
- Year and Date
  2010-03-23
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルスRNAポリメラーゼサブユニットの亜型間での親和性解析-PA(H3N2)の親和性決定部位について-2010
- Author(s)
  原好勇、中園陽子、柏木孝仁、今村宜寛、濱田信之、渡邊浩
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] PA subunit of Influenza A virus RNA polymerae is involved in the stable RNA replication at high temperature2010
- Author(s)
  Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Organizer
  Options for the Control of Influenza VII
- Place of Presentation
  Hong Kong
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] A型インフルエンザウイルス遺伝子複製酵素の温度変化への適応2010
- Author(s)
  柏木孝仁
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] インフルエンザウイルスPAサブユニットのN末端はプロモーターとの結合を通じてポリメラーゼの活性に影響を与えている2009
- Author(s)
  柏木孝仁
- Organizer
  第57回日本ウイルス学会
- Place of Presentation
  都市センターホテル(東京)
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] Analysis of the hybrid trimeric complexes consisted of human and avian influenza virus RNA polymerase subunits2009
- Author(s)
  Nakazono Y, Hara K, Kashiwagi T, and Watanabe H.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] インフルエンザウイルス遺伝子複製酵素の研究2009
- Author(s)
  柏木孝仁、原好勇、岩橋潤、中園陽子、今村宜寛、濱田信之
- Organizer
  第57回日本ウイルス学会学術総会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21791015
[Presentation] インフルエンザウイルスRNPの活性発現にはPB2-PAの組み合わせが重要である
- Author(s)
  原好勇、中園陽子、柏木孝仁、今村宜寛、濱田信之、渡邊浩
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPB2サブユニットによるRNAポリメラーゼの阻害効果
- Author(s)
  柏木孝仁、原好勇、中園陽子、今村宜寛、濱田信之、渡邊浩
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The N-terminal fragment of influenza A virus (H5N1) PB2 subunit strongly inhibits its RNAdependent RNA polymerase.
- Author(s)
  T Kashiwagi, K Hara, Y Nakazono, Y Uemura, Y Imamura, N Hamada and H Watanabe
- Organizer
  United States-Japan Cooperative Medical Science Program. 16th US-Japan Acute Respiratory Infections Panel Meeting.
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPB2とPAは遺伝子再集合を制御する
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスの遺伝子再集合を応用した阻害薬の開発
- Author(s)
  柏木孝仁、原　好勇、今村宜寛、濱田信之
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合について
- Author(s)
  原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第56回日本感染症学会中日本地方会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] 重症心身障害児施設でのヒト・メタニューモウイルス集団感染における新規迅速診断キットの有用性
- Author(s)
  濱田信之、原　好勇、松尾勇作、今村宜寛、柏木孝仁、後藤憲志、大津　寧、本廣　孝、渡邊　浩
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The N-terminal fragment of influenza A virus (H5N1) PB2 subunit strongly inhibits its RNA-dependent RNA polymerase.
- Author(s)
  T Kashiwagi, K Hara, Y Nakazono, Y Uemura, Y Imamura, N Hamada and H Watanabe
- Organizer
  United States-Japan Cooperative Medical Science Program. 16th US-Japan Acute Respiratory Infections Panel Meeting.
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] Co-incorporation of the PB2 and PA polymerase subunits is a critical determinant for the generation of H3N2 reassortant viruses.
- Author(s)
  Hara K, Kashiwagi T, Nakazono Y, Hamada N and Watanabe H
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPAサブユニットによるＲＮＡポリメラーゼの阻害効果
- Author(s)
  上村勇作、柏木孝仁、原好勇、今村宜寛、濱田信之、渡邊浩
- Organizer
  第87回日本感染症学会学術講演会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] PB2サブユニットによるインフルエンザウイルス遺伝子複製酵素の阻害効果に関する研究
- Author(s)
  柏木孝仁、原好勇、上村勇作、今村宜寛、濱田信之、渡邊浩
- Organizer
  第87回日本感染症学会学術講演会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590

1. WATANABE Hiroshi (90295080)

# of Collaborated Projects: 6 results

# of Collaborated Products: 54 results
2. HARA Koyu (40309753)

# of Collaborated Projects: 6 results

# of Collaborated Products: 50 results
3. 山田圭 (00299512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 片山礼司 (20834485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安達洋祐 (90221043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 守屋普久子 (80449917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 片岡仁美 (20420490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 石田万里 (30359898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 和久屋寛 (40264147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 角間辰之 (50341540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 城戸瑞穂 (60253457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 黒木祥光 (60290847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮田潤子 (20380412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KASHIWAGI Takahito 柏木 孝仁

Research Projects

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Co-Researchers

Pタンパク質の4量体を破壊する広域抗モノネガウイルス薬の開発研究

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Development of next-generation simulator using augmented reality

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A universal design of nanoparticle-based antivirals against paramyxoviruses

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女性医師のワークモチベーションを上昇させる動機づけモデルの樹立

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A novel antiviral strategy against respiratory syncytial virus disrupting protein-protein interactions

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Development of new drug based on the self or non-self distinctional mechanism of the influenza virusPrincipal Investigator

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Establishment of a new therapeutic for the treatment of paramyxoviruses by using a mimic of viral genomic RNA.

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New strategy of the therapy that applied antigenic-shift of the influenza virus.Principal Investigator

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Novel strategies and basic approaches for the study of the treatment against highly pathogenic influenza virus.Principal Investigator

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[Journal Article] A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein.2020

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[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017

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[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication2017

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[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017

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[Journal Article] The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression.2015

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KASHIWAGI Takahito 柏木孝仁