KOIDE Takaki 小出隆規

Researcher Number	70322253
Other IDs
External Links
Affiliation (Current)	2025: 早稲田大学, 理工学術院, 教授
Affiliation (based on the past Project Information) *help	2007 – 2024: Waseda University, 理工学術院, 教授 2010: 早稲田大学, 先進理工学部, 教授 2008: 早稲田大学, 先進理工学部, 教授 2006: 新潟薬科大学, 薬学部, 教授 2004 – 2005: 新潟薬科大学, 薬学部, 助教授 … More 2004: 国立大学法人香川大学, 医学部, 助教授 2000 – 2003: 徳島大学, 工学部, 講師 2000: 徳島大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Biological Sciences / Medium-sized Section 47:Pharmaceutical sciences and related fields / Pharmaceutical Sciences and related fields / Applied pharmacology / Structural biochemistry Except Principal Investigator Basic Section 56060:Ophthalmology-related / Bacteriology (including Mycology) / Basic Section 52020:Neurology-related / Basic Section 90120:Biomaterials-related … More / Basic Section 56020:Orthopedics-related / Basic Section 37030:Chemical biology-related / Pharmaceutical Sciences and related fields / Biomedical engineering/Biological material science / Biomedical engineering/Biomaterial science and engineering / Structural biochemistry / Science and Engineering Less
Keywords	Principal Investigator コラーゲン / ペプチド / 分子シャペロン / スクリーニング / 線維化 / 小胞体 / 蛋白質 / フォールディング / 創薬 / ライブラリ … More / モノクローナル抗体 / 3重らせん / がん / 薬物送達 / イメージング / シスプラチン / ドラッグデリバリー / タンパク質 / 医薬分子設計 / フォトアフィニティーラベリング / ビピリジン … More Except Principal Investigator コラーゲン / バイオマテリアル / 成長因子 / コラーゲン結合ドメイン / blood brain barrier / triple helix peptide / angiogenesis / stroke / 3次元細胞培養 / インジェクタブルゲル / 網膜 / 機能性アミノ酸配列 / 人工コラーゲン / 硝子体手術 / 人工コラーゲン様ポリペプチド / 黄斑円孔 / コラーゲンミメティックペプチド / 環状コラーゲンミメティックペプチド / コラーゲン結合型成長因子 / コラーゲン結合成長因子模倣ペプチド / 局所硬化ゲル / スフェロイド / 局所送達 / 運動器再生 / 環状コラーゲン結合ペプチド / オルガノイド / ランダムライブラリ / 3重らせん型ペプチド / 生物活性ペプチド / ペプチド創薬 / スクリーニング / 3重らせんペプチド / 神経麻痺生角膜症 / TRPチャネル / 角膜上皮創傷治癒 / マトリセルラー蛋白質 / 角膜創傷治癒 / テネイシンX / RNA aptamer / RNAアプタマー / substrate recognition / NMR analysis / collagen-binding domain / clostridial collagenases / 基質認識 / NMR解析 / 細菌性コラゲナーゼ / Biosignal Molecules / Immobilization / Material design / Cell design / Cell culture / EGFレセプター遺伝子 / 光リソグラフ法 / 光固定化 / 上皮細胞成長因子(EGF) / 情報伝達分子 / ハイブリッド人工臓器 / 臓器再生 / 細胞分化 / 細胞成長 / 光リソグラフィ / ゼラチン固定化 / ヘパリン固定化 / 成長因子固定化 / 細胞培養系 / 材料設計 / 生体分子固定化 / 細胞設計 / 遺伝子導入 / 細菌 / SNAP-25 / 疼痛抑制 / 神経障害性疼痛 / ボツリヌス神経毒素 / 重層扁平上皮 / 表皮成長因子 / スピン標識ペプチド / 再生医療 / 血管新生 / 血管内皮細胞成長因子 / 鼓膜穿孔 / 上皮細胞成長因子 / コラゲナーゼ / 人工皮膚 / 鼓膜閉鎖術 / 骨新生 / 構造活性相関 / 毒素 / ガス壊疽菌群 / 共進化 / HSP47 / 分子シャペロン / フォールディング / 孔径制御 / 物質透過性 / ポリペプチド / 核酸 / DDS / 刺激応答性 / インテリジェント材料 / 物質透過制御 / 多孔性膜 / 自己集積化 / 高分子ブラシ / 高分子電解質 Less

医療用材料を指向した新規コラーゲン金属錯体架橋ゲルの応用検討
- Principal Investigator
  
  市瀬慎一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kitasato University
Cerebral infarction treatment strategy using collagen-like "triple helix peptide" containing functional amino acid sequence
- Principal Investigator
  
  ケレベールオレリアン
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Basic research for optimizing new macular hole treatments with artificial collagen-like polypeptides
- Principal Investigator
  
  小嶋健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of Musculoskeletal Regeneration Techniques through the Construction of a Platform for Functional Organoid Fabrication and Local Delivery
- Principal Investigator
  
  Uchida Kentaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
Discovery of drug leads from a random triple-helical peptide library constructed in yeast cells
- Principal Investigator
  
  MASUDA Ryo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Waseda University
Development of an efficient strategy for obtaining drug leads from expanded random peptide librariesPrincipal Investigator
- Principal Investigator
  
  Koide Takaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Waseda University
Establishment of a Novel Therapeutic Strategy for Neurotrophic Keratopathy by Targeting the Tenesin X-TRP Channel System
- Principal Investigator
  
  Sumioka Takayoshi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Wakayama Medical University
Selection of RNA aptamer against collagen and apply to new drug discovery
- Principal Investigator
  
  Hirayoshi Kazunori
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Kyoto University
Development of novel cyclic peptides that detect molecular states of collagen in vitro and in vivoPrincipal Investigator
- Principal Investigator
  
  KOIDE Takaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Waseda University
Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied study
- Principal Investigator
  
  YAMAMOTO YUMIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Okayama University
Development of a peptidic HSP47 inhibitor as an antifibrotic agentPrincipal Investigator
- Principal Investigator
  
  Koide Takaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
Potential of cisplatin derivatives as antifibrotic drugsPrincipal Investigator
- Principal Investigator
  
  KOIDE Takaki
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
A novel drug carrier based on the collagen-like triple-helical peptidePrincipal Investigator
- Principal Investigator
  
  KOIDE Takaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Waseda University
Translational research on a drug delivery system using substrate binding domain derived from bacterial collagenases
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
Chemical biology of collagen toward drug developmentPrincipal Investigator
- Principal Investigator
  
  KOIDE Takaki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
Coevolved ability of Collagen and its molecular chaperon HSP47.
- Principal Investigator
  
  ASADA Shiniti
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
HSP47はいかにしてコラーゲンの構造形成を助けているのかPrincipal Investigator
- Principal Investigator
  
  小出隆規
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
線維化疾患治療薬を目指した分子シャペロン阻害剤の創製Principal Investigator
- Principal Investigator
  
  小出隆規
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
A study on the molecular mechanism of substrate recognition by Clostridial collagenases
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KAGAWA UNIVERSITY
体温では折り畳み不能なコラーゲンの生合成を実現する小胞体シャペロンシステムPrincipal Investigator
- Principal Investigator
  
  小出隆規
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
  The University of Tokushima
HSP47のプロコラーゲンに対するシャペロン機能の分子基盤Principal Investigator
- Principal Investigator
  
  小出隆規
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
ペプチドモデルを用いた構成的アプローチによるコラーゲンの3本らせん形成過程の解明Principal Investigator
- Principal Investigator
  
  小出隆規
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
物質輸送を精密に制御できる高分子ブラシ自己集積化多孔性膜の設計と合成
- Principal Investigator
  
  ITO Yoshihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Construction of cell culture system by combining cell design using transfection of genes and material design using immobilization of biological molecules
- Principal Investigator
  
  ITO Yoshihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokushima

[Journal Article] The Thermal Stability of the Collagen Triple Helix Is Tuned According to the Environmental Temperature.2022
- Author(s)
  K.K. Fujii, Y. Taga, Y.K. Takagi, R. Masuda, S. Hattori, T. Koide
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 4 Pages: 2040-2040
- DOI
  10.3390/ijms23042040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05756
[Journal Article] Cyclic Peptides for Efficient Detection of Collagen2018
- Author(s)
  Takita Koh K.、Fujii Kazunori K.、Kadonosono Tetsuya、Masuda Ryo、Koide Takaki
- Journal Title
  
  ChemBioChem
  
  Volume: 19 Issue: 15 Pages: 1613-1617
- DOI
  10.1002/cbic.201800166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19502
[Journal Article] High-throughput turbidimetric screening for heparin-neutralizing agents and low-molecular-weight heparin mimetics2012
- Author(s)
  A. Sekiya, S. Oishi, N. Fujii, T. Koide
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 60(3) Pages: 371-376
- NAID
  130001852423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659112
[Journal Article] Identification of angiogenic regulatory domains of fibril-forming collagens using collagen-like triple helical peptides2012
- Author(s)
  A. Sekiya, H. Okano-Kosugi, C. M. Yamazaki, T. Koide
- Journal Title
  
  Peptide Science 2011
  
  Pages: 29-32
- NAID
  10030203958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659112
[Journal Article] コラーゲン三重らせんペプチドのデザイン、合成と応用2012
- Author(s)
  小出隆規
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 21 Pages: 217-222
- Data Source
  KAKENHI-PROJECT-22659112
[Journal Article] Pigment epithelium-derived factor(PEDF) shares binding sites in collagen with heparin/heparan sulfate proteoglycans2011
- Author(s)
  A. Sekiya, H. Okano-Kosugi, C. M. Yamazaki, T. Koide
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 26364-26374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659112
[Journal Article] コラーゲン結合性多機能SERPIN、色素上皮由来因子(PEDF)の構造-機能相関2011
- Author(s)
  関谷敦志、小出隆規
- Journal Title
  
  酵素工学ニュース
  
  Volume: 66 Pages: 20-24
- Data Source
  KAKENHI-PROJECT-22659112
[Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010
- Author(s)
  小出隆規
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 474-483
- NAID
  10026899828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010
- Author(s)
  小出隆規
- Journal Title
  
  生化学 82(印刷中)
- NAID
  10026899828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010
- Author(s)
  小出隆規
- Journal Title
  
  生化学 82(in press)
- NAID
  10026899828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010
- Author(s)
  C.M.Yamazaki, T.Koide, et al.
- Journal Title
  
  Biomaterials 31
  
  Pages: 1925-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010
- Author(s)
  Y.Nishikawa, Y.Takahara, S.Asada, A.Shigenaga, A.Otaka, K.Kitagawa, T.Koide
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 3767-3775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010
- Author(s)
  小出隆規
- Journal Title
  
  生化学 82巻
  
  Pages: 474-483
- NAID
  10026899828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses2010
- Author(s)
  C.M.Yamazaki, Y.Kadoya, K.Hozumi, H.Okano-Kosugi, S.Asada, K.Kitagawa, M.Nomizu, T.Koide
- Journal Title
  
  Biomaterials 31
  
  Pages: 1925-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010
- Author(s)
  C.M. Yamazaki, Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, T. Koide
- Journal Title
  
  Biomaterials 31
  
  Pages: 1925-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H.Okano-Kosugi, O.Matsushita, S.Asada, A.B.Herr, K.Kitagawa, T.Koide
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates2009
- Author(s)
  S.T.L. Philominathan, T. Koide, K. Hamada, H. Yasui, S. Seifert, O. Matsushita, J. Sakon
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides.2009
- Author(s)
  C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Peptides 2008
  
  Pages: 458-459
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates.2009
- Author(s)
  Philominathan, S.T., Koide, T., Hamada, K., Yasui, H., Seifert, S., Matsushita, O., Sakon, J.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H.Okano-Kosugi, T.Koide, et al.
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions.2009
- Author(s)
  Okano-Kosugi H, Matsushita O, Asada S, Herr AB, Kitagawa K, Koide T.
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Totally synthetic collagen-like gels by intermolecular folding of designed peptides, (Proceeding for 30th European Peptide Symposium)2009
- Author(s)
  C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
- Journal Title
  
  Peptides 2008
  
  Pages: 458-459
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates.2009
- Author(s)
  Philominathan ST, Koide T, Hamada K, Yasui H, Seifert S, Matsushita O, Sakon J.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates2009
- Author(s)
  S.T.L.Philominathan, T.Koide, K.Hamada, H.Yasui, S.Seifert, O.Matsushita, J.Sakon
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions.2009
- Author(s)
  Okano-Kosugi, H., Matsushita, O., Asada, S., Herr, A.B., Kitagawa, K., Koide, T.
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H. Okano-Kosugi, O. Matsushita, S. Asada, A. B. Herr, K. Kitagawa, T. Koide
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] nidirectional binding of clostridial collagenase to triple helical substrates2009
- Author(s)
  S. T. L. Philominathan, T. Koide, K. Hamada, et al
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial collagen gels via self-assembly of de novo designed peptides.2008
- Author(s)
  Yamazaki CM, Asada S, Kitagawa K, Koide T.
- Journal Title
  
  Biopolymers 90(6)
  
  Pages: 816-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770092
[Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008
- Author(s)
  C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Biopolyniers (Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008
- Author(s)
  C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
- Journal Title
  
  Biopolymers(Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial collagen gels via self-assembly of de novo designed peptides2008
- Author(s)
  C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Biopolymers (Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering2007
- Author(s)
  Takaki Koide
- Journal Title
  
  Philosophical Transaction of Royal Society.B (印刷中)
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering2007
- Author(s)
  Takaki Koide
- Journal Title
  
  Philosophical Transaction of Royal Society. B. (印刷中)
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281(印刷中)
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 11177-11185
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 11177-11185
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281(印刷中)
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. Minimal structural requirement and spatial molecular orientation2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 3432-3438
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. Minimal structural requirement and spatial molecular orientation2006
- Author(s)
  Takaki Koide
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 3432-3438
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Triple-helical collagen-like peptides : engineering and applications in matrix biology2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Connective Tissue Research 46
  
  Pages: 131-141
- NAID
  10018086783
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Triple-helical collagen-like peptides : engineering and applications in matrix biology2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Connective Tissue Research 46
  
  Pages: 131-141
- NAID
  10018086783
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Collagen biosynthesis2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Topics in Current Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-15032238
[Journal Article] Collagen biosynthesis2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Topics in Current Chemistry 247
  
  Pages: 85-114
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] self-complementary peptides for the formation of collagen-like triple helical supramolecules2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 15
  
  Pages: 5230-5233
- Data Source
  KAKENHI-PROJECT-17028051
[Journal Article] Collagen biosynthesis2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Topics in Current Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Collagen biosynthesis2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Topics in Current Chemistry 247
  
  Pages: 85-114
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] Self-complementary peptides for the formation of collagen-like triple helical supramolecules2005
- Author(s)
  Takaki Koide
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 15
  
  Pages: 5230-5233
- Data Source
  KAKENHI-PROJECT-16689004
[Journal Article] プロコラーゲンの構造形成を実現する分子シャペロンHsp472004
- Author(s)
  小出隆規
- Journal Title
  
  蛋白質核酸酵素増刊号「細胞における蛋白質の一生」 49
  
  Pages: 870-874
- Data Source
  KAKENHI-PROJECT-15032238
[Journal Article] Surface-modifiable free-floating films formed by multiway connection of collagen-like triple-helical peptides
- Author(s)
  S. Matsui, C. M. Yamazaki, T. Koide
- Journal Title
  
  Macromol. Rapid Commun
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659112
[Patent] NOVEL PEPTIDES2022
- Inventor(s)
  小出隆規，市瀬慎一郎，増田亮, 中村颯志, 能勢博
- Industrial Property Rights Holder
  小出隆規，市瀬慎一郎，増田亮, 中村颯志, 能勢博
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K05756
[Patent] コラーゲンへの結合活性を有する環状ペプチド2018
- Inventor(s)
  小出隆規、瀧田講、平和馬
- Industrial Property Rights Holder
  小出隆規、瀧田講、平和馬
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17K19502
[Patent] コラーゲンへの結合活性を有する環状ペプチド2017
- Inventor(s)
  小出隆規、瀧田講、平和馬
- Industrial Property Rights Holder
  小出隆規、瀧田講、平和馬
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-166687
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K19502
[Patent] コラーゲン様ペプチドからなる薬物担体2012
- Inventor(s)
  小出隆規, 他
- Industrial Property Rights Holder
  早稲田大学
- Filing Date
  2012-01-23
- Data Source
  KAKENHI-PROJECT-22659112
[Patent] コラーゲン様ペプチドからなる薬物担体2012
- Inventor(s)
  小出隆規、山崎ちさと、安井裕之、高尾敏文、粟田ちひろ
- Industrial Property Rights Holder
  早稲田大学
- Filing Date
  2012-01-23
- Data Source
  KAKENHI-PROJECT-22659112
[Presentation] 家兎黄斑円孔モデルに対する人工コラーゲン様ポリペプチドシート移植の有効性の検討2023
- Author(s)
  新開陽一郎、田中寛、能勢博、市瀬慎一郎、小嶋健太郎、小出隆規、外園千恵
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-22K09796
[Presentation] 機能性アミノ酸配列含有ポリペプチドのヒトミュラー細胞への接着メカニズムの解析2022
- Author(s)
  新開陽一郎、田中寛、市瀬慎一郎、能勢博、小嶋健太郎、外園千恵、小出隆規
- Organizer
  第126回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-22K09796
[Presentation] 酵母内に構築した3重らせん型ランダムペプチドライブラリからの新規生物活性ペプチドの取得2022
- Author(s)
  増田亮、Khine Phyu Phyu Thant、小出隆規
- Organizer
  第54回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-20K05756
[Presentation] 酵母内に構築した3重らせん型ランダムペプチドライブラリからの新規生物活性ペプチドの取得2022
- Author(s)
  Khine Phyu Phyu Thant、増田亮、小出隆規
- Organizer
  第54回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-20K05756
[Presentation] A METHOD FOR OBTAINING PROTEIN-BINDING PEPTIDES FROM A RANDOM TRIPLE-HELICAL PEPTIDE LIBRARY2021
- Author(s)
  Ryo Masuda, Khine Phyu Phyu Thant, Tetsuya Kadonosono, Takaki Koide
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K05756
[Presentation] Targeting Unfolded Collagen by Cyclic Collagen-Mimetic Peptides2018
- Author(s)
  Takaki Koide, Koh K. Takita, Kazunori K. Fujii, Ryo Masuda, Tetsuya Kadonosono, Hiroyuki Kimura
- Organizer
  10th International Peptide Sym
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19502
[Presentation] Development of a collagen-detecting peptide and its application in vivo.2018
- Author(s)
  K.K. Takita, K.K. Fujii, H. Kimura, T. Koide
- Organizer
  第50回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-17K19502
[Presentation] コラーゲン3重らせんにインスパイアされたペプチド創薬2018
- Author(s)
  小出隆規
- Organizer
  日本薬学会第138年回
- Data Source
  KAKENHI-PROJECT-17K19502
[Presentation] Cyclic peptides for efficient detection of collagen2017
- Author(s)
  Koh K. Takita, Kazunori K. Fujii, Takaki Koide
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K19502
[Presentation] Seamless cyclization of collagen-like peptides with Gly-X-Y-repeating sequences2017
- Author(s)
  Kazuki C. Kuroda, Fumiko Hisamatsu, Takaki Koide
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K19502
[Presentation] Collagen Triple Helix, A Unique Peptide Scaffold for Biotools and Biomaterials2015
- Author(s)
  Takaki Koide
- Organizer
  IMS Asian International Symposium「Supramolecular Dynamics at the Interface of Chemistry and Biology
- Place of Presentation
  岡崎、愛知
- Year and Date
  2015-06-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460158
[Presentation] コラーゲン３重らせんを模倣するペプチドのエンジニアリングと応用2015
- Author(s)
  小出隆規
- Organizer
  第20回ペプチドフォーラム
- Place of Presentation
  長浜バイオ大学
- Year and Date
  2015-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-25460158
[Presentation] Collagen Triple Helix as Scaffold for Peptide-based Biotools and Medicines2015
- Author(s)
  Takaki Koide
- Organizer
  7th Peptide Engineering Meeting
- Place of Presentation
  IISR Pune, India
- Year and Date
  2015-12-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460158
[Presentation] コラーゲン3重らせんを模倣するペプチドの創薬およびバイオマテリアルへの応用2012
- Author(s)
  小出隆規
- Organizer
  薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659112
[Presentation] コラーゲン3重らせんを模倣するペプチドの創薬およびバイオマテリアルへの応用2012
- Author(s)
  小出隆規
- Organizer
  日本薬学会第132年回
- Place of Presentation
  北海道大学(北海道)(招待講演)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659112
[Presentation] シスプラチン誘導体はコラーゲンのin vitro線維化を阻害する2011
- Author(s)
  小出隆規
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] A facile high-throughput ccreening to obtain inhibitors of various collagen-binding macromolecules2011
- Author(s)
  Takaki Koide
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22659112
[Presentation] シスプラチン誘導体はコラーゲンのin vitro線維化を阻害する2011
- Author(s)
  小出隆規
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Design, synthesis, and biomedical applications of collagen-mimetic triple-helical peptides2011
- Author(s)
  小出隆規
- Organizer
  第14回ペプチドフォーラム
- Place of Presentation
  鹿児島
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22659112
[Presentation] ガス壊疽菌群コラゲナーゼの基質結合ドメインと再生医療への応用2010
- Author(s)
  松下治、西望、小杉日登美、小出隆規、安達栄治郎、坂本恵子、服部雅一
- Organizer
  第57回トキシンシンポジウム
- Place of Presentation
  長浜ロイヤルホテル(滋賀県)
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] 色素上皮由来因子(PEDF)の配列特異的なコラーゲン認識とその意義2010
- Author(s)
  小出隆規
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] 色素上皮由来因子 (PEDF) の配列特異的なコラーゲン認識とその意義2010
- Author(s)
  小出隆規, ら
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Collagen-like peptide supramolecules that regulate cell adhesion2010
- Author(s)
  小出隆規
- Organizer
  31'st European Peptide Symposium
- Place of Presentation
  Copenhagen
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] ガス壊疽菌群コラゲナーゼの基質結合ドメインと再生医療への応用2010
- Author(s)
  松下治、西望、小杉日登美、小出隆規、安達栄治郎、坂本恵子、服部雅一
- Organizer
  第57回トキシンシンポジウム
- Place of Presentation
  滋賀県長浜市
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] 色素上皮由来因子 (PEDF) による特異的なコラーゲン認識2009
- Author(s)
  関谷敦志, 小出隆規, ら
- Organizer
  第82回に本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Substrate recognition of collagen-binding domains derived from bacterial collagenases2009
- Author(s)
  Matsushita O, Nishi N, Koide T, Philominathan STL, Sakon J Gensure RC, Iwashiro H, Adachi E
- Organizer
  8th Pan-pacific connective tissue societies symposium, 41st Annual meeting of the Japanese society of connective tissue research, 56th Annual meeting of the Japan matrix club
- Place of Presentation
  神奈川県逗子市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Integrin-dependent cell adhesin to the peptide-based artificial collagen2009
- Author(s)
  C.M.Yamazaki, T.Koide, et al.
- Organizer
  8th Pan-Pacific Connective Tissue Societies Symposium
- Place of Presentation
  横須賀
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] A 384-plate screening of the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H. Kosugi, S. Asada, K. Kitagawa, T. Koide, et al.
- Organizer
  8th Pan-Pacific Connective Tissue Societies Symposium
- Place of Presentation
  横須賀
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Arg-richなコラーゲン様ペプチドの細胞膜透過性2009
- Author(s)
  遠藤裕之,中瀬生彦,二木史朗,浅田真一,小出隆規
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19770092
[Presentation] 色素上皮由来因子(PEDF)による特異的なコラーゲン認識2009
- Author(s)
  関谷敦志, 小出隆規, ら
- Organizer
  第82回に本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] ガス壊疽菌群コラゲナーゼの基質認識機構と再生医学への応用2009
- Author(s)
  松下治、小出隆規、安達栄治郎
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Substrate recognition of collagen-binding domains derived from bacterial collagenases.2009
- Author(s)
  Matsushita O., Nishi N., Koide T., Philominathan S.T.L., Sakon J., Gensure R.C., Iwashiro H., Adachi E.
- Organizer
  8th Pan-pacific connective tissue societies symposium, 41st Annual meeting of the Japanese society of connective tissue research, 56th Annual meeting of the Japan matrix club
- Place of Presentation
  神奈川県逗子市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Totally synthetic collagen-like gels by intermolecular folding of designed peptides2008
- Author(s)
  C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  ヘルシンキ
- Year and Date
  2008-09-04
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides2008
- Author(s)
  Chisato M. Yamazaki, Shinichi Asada, Kouki Kitagawa, Takaki Koide
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] コラーゲン3重らせん上に存在するタンパク質結合配列の探索2008
- Author(s)
  小杉日登美,浅田真一,北川幸己,小出隆規
- Organizer
  第55回マトリックス研究会/第40回結合組織学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19770092
[Presentation] ペプチドの自己集合による人工コラーゲンゲルの創製2007
- Author(s)
  山崎ちさと,浅田真一,北川幸己,小出隆規
- Organizer
  第54回マトリックス研究会/第39回結合組織学会学術大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-19770092

1. MASUDA Ryo (90632159)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. MATSUSHITA Osamu (00209537)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. ASADA Shinichi (50424883)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
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# of Collaborated Projects: 1 results

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9. KOSUGI Hitomi (80454213)

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35. ケレベールオレリアン (70623594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. OGUMA Keiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. HOHMURA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. TOMINAGA Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. TAKITA Koh K.

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
40. FUJII Kazunori K.

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
41. 河村健二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOIDE Takaki 小出 隆規

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Development of an efficient strategy for obtaining drug leads from expanded random peptide librariesPrincipal Investigator

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Development of novel cyclic peptides that detect molecular states of collagen in vitro and in vivoPrincipal Investigator

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Development of a peptidic HSP47 inhibitor as an antifibrotic agentPrincipal Investigator

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Potential of cisplatin derivatives as antifibrotic drugsPrincipal Investigator

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A novel drug carrier based on the collagen-like triple-helical peptidePrincipal Investigator

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Chemical biology of collagen toward drug developmentPrincipal Investigator

KOIDE Takaki 小出隆規