Amano Naoko 天野直子

… Alternative Names

AMANO NAOKO 天野直子

AMANO Naoko 天野直子

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Researcher Number	70348689
Other IDs
Affiliation (Current)	2025: 地方独立行政法人東京都立病院機構東京都立小児総合医療センター(臨床研究部), 内分泌・代謝科, 医長
Affiliation (based on the past Project Information) *help	2018 – 2023: 慶應義塾大学, 医学部(信濃町), 共同研究員 2017: 慶應義塾大学, 医学部, 研究員 2016: 慶應義塾大学, 医学部(信濃町), 共同研究員 2015: 慶應義塾大学, 医学部, 研究員 2014 – 2015: 慶應義塾大学, 医学部, 共同研究員 2008 – 2009: Keio University, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Pediatrics
Keywords	Principal Investigator 副腎 / 発生分化 / 副腎低形成症 / 小児内分泌学 / モデルマウス / 副腎低形成 / 遺伝子 / 発生 / 副腎皮質 / 副腎機能低下症 … More / 内分泌学 / 小児内分泌 / ステロイド分析 / PCOS / ステロイドホルモン / 思春期 / 肥満 … More Except Principal Investigator MIRAGE症候群 / 副腎 / 遺伝子改変マウス / SAMD9 / 病理所見 / 表現型 / モデルマウス / ゲノム編集 / 疾患モデルマウス / 疾患モデルメダカ / 疾患モデル動物 / 疾患モデル細胞 / MIRAGEs症候群 Less

Pathogenesis of adrenal insufficiency in MIRAGE syndrome revealed by genetically modified mouse
- Principal Investigator
  
  Hasegawa Tomonobu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
The production and analyses of model mice having new genetic abnormality responsible for adrenal hypoplasiaPrincipal Investigator
- Principal Investigator
  
  AMANO Naoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
The pathogenesis of MIRAGE syndrome revealed by model mice using genome editing
- Principal Investigator
  
  Hasegawa Tomonobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
molecular basis and a new genetic cause of primary aderenal insufficiencyPrincipal Investigator
- Principal Investigator
  
  Amano Naoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Model cell-line and model animals of MIRAGE syndrome
- Principal Investigator
  
  Hasegawa Tomonobu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Identification and functional characterization of a novel causative gene for adrenal hypoplasiaPrincipal Investigator
- Principal Investigator
  
  AMANO NAOKO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Diagnostic usefulness of salivary steroid hormone measurement by LC-MS/MS in girls with PCOSPrincipal Investigator
- Principal Investigator
  
  AMANO Naoko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University

All 2021 2018 2017 2016 2015 2009

All Journal Article Presentation

[Journal Article] Clinical and Immunological Analyses of Ten Patients with MIRAGE Syndrome.2021
- Author(s)
  Mitsui-Sekinaka K, Narumi S, Sekinaka Y, Uematsu K, Yoshida Y, Amano N, Shima H, Hasegawa T, Nonoyama S.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 41 Issue: 3 Pages: 709-711
- DOI
  10.1007/s10875-020-00964-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03627, KAKENHI-PROJECT-20H03652, KAKENHI-PROJECT-18K08527, KAKENHI-PROJECT-20K22916, KAKENHI-PROJECT-20K16942
[Journal Article] MIRAGE syndrome is a rare cause of 46,XY DSD born SGA without adrenal insufficiency.2018
- Author(s)
  Shima H, Hayashi M, Tachibana T, Oshiro M, Amano N, Ishii T, Haruna H, Igarashi M, Kon M, Fukuzawa R, Tanaka Y, Fukami M, Hasegawa T, Narumi S.
- Journal Title
  
  PLoS One.
  
  Volume: 13 Issue: 11 Pages: e0206184-e0206184
- DOI
  10.1371/journal.pone.0206184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11194, KAKENHI-PROJECT-18K08527, KAKENHI-PLANNED-17H06428, KAKENHI-PROJECT-17J40246, KAKENHI-PROJECT-16K09979
[Journal Article] Pubertal Development and Pregnancy Outcomes in 46,XX Patients with Nonclassic Lipoid Congenital Adrenal Hyperplasia.2018
- Author(s)
  Hatabu N, Amano N, Mori J, Hasegawa Y, Matsuura H, Sumitomo N, Nishizawa K, Suzuki M, Katakura S, Kanamoto N, Kamimaki T, Ishii T, Hasegawa T
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: ePub ahead Issue: 5 Pages: 1866-1870
- DOI
  10.1210/jc.2018-01752
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09817, KAKENHI-PROJECT-16K09996, KAKENHI-PROJECT-16K09998, KAKENHI-PROJECT-19K08987
[Journal Article] Comment on: Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features of dyskeratosis congenita and IMAGe association.2018
- Author(s)
  Wilson DB, Bessler M, Ferkol TW, Shenoy S, Amano N, Ishii T, Shima H, Narumi S.
- Journal Title
  
  Pediatric Blood and Cancer
  
  Volume: 65 Issue: 1
- DOI
  10.1002/pbc.26747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09998
[Journal Article] Genetic Defects in Pediatric-onset Adrenal Insufficiency in Japan2017
- Author(s)
  Amano N, Narumi S, Hayashi M, Takagi M, Imai K, Nakamura T, Hachiya R, Sasaki G, Homma K, Ishii T, Hasegawa T
- Journal Title
  
  Eur J Endocrinol
  
  Volume: 177 Issue: 2 Pages: 187-194
- DOI
  10.1530/eje-17-0027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09996, KAKENHI-PROJECT-16K09998
[Journal Article] A novel case of somatic KCNJ5 mutation in pediatric-onset aldosterone- producing adenoma2017
- Author(s)
  Uchida N, Amano N, Yamaoka Y, Uematsu A, Sekine Y, Suzuki M, Watanabe J, Nishimoto K, Mukai K, Fukuzawa R, Hasegawa T, Ishii T
- Journal Title
  
  J Endocrine Soc
  
  Volume: 1 Issue: 8 Pages: 1056-1061
- DOI
  10.1210/js.2017-00210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09996, KAKENHI-PROJECT-16K09998, KAKENHI-PROJECT-17K09890
[Journal Article] 全身症状を生じる新たな遺伝子疾患「MIRAGE症候群」2017
- Author(s)
  天野直子、長谷川奉延
- Journal Title
  
  感染・免疫・炎症
  
  Volume: 47 Pages: 142-143
- Data Source
  KAKENHI-PROJECT-15K09599
[Journal Article] SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 72016
- Author(s)
  Narumi S*, et al., Matsumoto N, et al.
- Journal Title
  
  Nat Genet
  
  Volume: 48 Issue: 7 Pages: 792-797
- DOI
  10.1038/ng.3569
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-16H05357, KAKENHI-PROJECT-24591515, KAKENHI-PROJECT-26462714, KAKENHI-PROJECT-15K09599
[Journal Article] SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.2016
- Author(s)
  Narumi S, Amano N, Ishii T, Katsumata N, Hasegawa T, et al
- Journal Title
  
  Nat Genet
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] Znrf3エクソン2はマウスX-zoneの分化に重要である：ゲノム編集を用いたin vivo解析2021
- Author(s)
  内田登天野直子高田修治小林杏子村上智亮鳴海覚志石井智弘長谷川奉延
- Organizer
  第54回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08260
[Presentation] 小児期発症原発性副腎皮質機能低下症63例における遺伝子異常：STAR変異例の遺伝子型と臨床的特徴2017
- Author(s)
  天野直子、鳴海覚志、林美恵、蜂屋瑠見、高木優樹、佐々木悟郎、本間桂子、石井智弘、長谷川奉延
- Organizer
  第51回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09998
[Presentation] 副腎低形成はMIRAGE症候群の必発徴候ではない：SGA出生46,XY性分化疾患49例におけるSAMD9変異スクリーニング2017
- Author(s)
  島彦仁、林美恵、天野直子、石井智弘、長谷川奉延、立花貴史、大城誠、五十嵐麻希、今雅史、深見真紀、鳴海覚志
- Organizer
  第51回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE Syndrome: A New Form of Syndromic Adrenal Hypoplasia Caused by Activating SAMD9 Mutations.2016
- Author(s)
  Narumi S, Amano N, Ishii T, Katsumata N, Fukuzawa R, Shimizu A, Shibata S, Okano H, Miyake N, Matsumoto N, Hasegawa T.
- Organizer
  The Endocrine Society’s 98th Annual Meeting&Expo
- Place of Presentation
  Boston, USA
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE Syndrome: A New Adrenal Hypoplasia Syndrome Caused by Heterozygous SAMD9 Mutations.2016
- Author(s)
  Amano N, Narumi S, Ishii T, Katsumata N, Fukuzawa R, Shimizu A, Miyake N, Matsumoto N, Hasegawa T
- Organizer
  The 17th Adrenal Cortex Conference
- Place of Presentation
  Boston (U.S.A.)
- Year and Date
  2016-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE症候群：機能亢進型SAMD9変異を原因とする新規症候群の発見2015
- Author(s)
  鳴海覚志、天野直子、石井智弘、勝又規行、福澤龍二、清水厚志、三宅紀子、松本直道、長谷川奉延
- Organizer
  第25回臨床内分泌代謝Update
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE症候群：機能亢進型SAMD9変異を原因とする新規症候群の発見2015
- Author(s)
  鳴海覚志、天野直子、石井智弘、勝又規行、福澤龍二、芝田晋介、岡野栄之、清水厚志、三宅紀子、松本直通、長谷川奉延
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE症候群：副腎低形成を伴う新規症候群の疾患概念の確立と責任遺伝子の同定2015
- Author(s)
  天野直子、鳴海覚志、石井智弘、勝又規行、福澤龍二、清水厚志、三宅紀子、松本直通、長谷川奉延
- Organizer
  第49回日本小児内分泌学会学術集会
- Place of Presentation
  タワーホール船堀（東京江戸川区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] MIRAGE症候群の分子病態2015
- Author(s)
  鳴海覚志、天野直子、石井智弘、柴田晋介、岡野栄之、長谷川奉延
- Organizer
  第49回日本小児内分泌学会学術集会
- Place of Presentation
  タワーホール船堀（東京江戸川区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K09599
[Presentation] 肥満思春期女児の唾液中遊離型AndrostenedioneとTestosteroneは高値である-LC-MS/MS法による検討-2009
- Author(s)
  天野直子
- Organizer
  第43回日本小児内分泌学会
- Place of Presentation
  栃木
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20790745
[Presentation] 肥満思春期女児の唾液中遊離型AndrostenedioneとTestosteroneは高値である-LC-MS/MS法による検討-2009
- Author(s)
  天野直子
- Organizer
  第43回日本小児内分泌学会
- Place of Presentation
  栃木県総合文化センター
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20790745

1. Hasegawa Tomonobu (20189533)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 鳴海覚志 (40365317)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. 石井智弘 (70265867)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. 高田修治 (20382856)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. 木下政人 (60263125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HASEGAWA Yukihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 五十嵐麻希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Amano Naoko 天野 直子

AMANO NAOKO 天野 直子

AMANO Naoko 天野 直子

Research Projects

Research Products

Co-Researchers

Pathogenesis of adrenal insufficiency in MIRAGE syndrome revealed by genetically modified mouse

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The production and analyses of model mice having new genetic abnormality responsible for adrenal hypoplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The pathogenesis of MIRAGE syndrome revealed by model mice using genome editing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

molecular basis and a new genetic cause of primary aderenal insufficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Model cell-line and model animals of MIRAGE syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional characterization of a novel causative gene for adrenal hypoplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Diagnostic usefulness of salivary steroid hormone measurement by LC-MS/MS in girls with PCOSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical and Immunological Analyses of Ten Patients with MIRAGE Syndrome.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MIRAGE syndrome is a rare cause of 46,XY DSD born SGA without adrenal insufficiency.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pubertal Development and Pregnancy Outcomes in 46,XX Patients with Nonclassic Lipoid Congenital Adrenal Hyperplasia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comment on: Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features of dyskeratosis congenita and IMAGe association.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Defects in Pediatric-onset Adrenal Insufficiency in Japan2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel case of somatic KCNJ5 mutation in pediatric-onset aldosterone- producing adenoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 全身症状を生じる新たな遺伝子疾患「MIRAGE症候群」2017

Author(s)

Amano Naoko 天野直子

AMANO NAOKO 天野直子

AMANO Naoko 天野直子