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Sashida Goro  指田 吾郎

… Alternative Names

SASHIDA Goro  指田 吾郎

指田 吾郎  サシダ ゴロウ

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Researcher Number 70349447
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8050-1558
Affiliation (Current) 2025: 熊本大学, 国際先端医学研究機構, 特定事業教員(教授)
Affiliation (based on the past Project Information) *help 2016 – 2024: 熊本大学, 国際先端医学研究機構, 特別招聘教授
2014 – 2015: 熊本大学, 国際先端医学研究機構, 特別招聘准教授
2014: 千葉大学, 大学院医学研究科, 助教
2014: 熊本大学, 国際先端医学研究機構, 特別招聘準教授
2011 – 2014: 千葉大学, 医学(系)研究科(研究院), 助教
2003 – 2004: 東京医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Hematology / Complex Systems Disease Theory / Laboratory medicine
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Hematology / Basic Section 42040:Laboratory animal science-related / Broad Section I / Basic Section 49010:Pathological biochemistry-related / Biological Sciences
Keywords
Principal Investigator
骨髄異形成症候群 / 造血幹細胞 / クロマチン / クローン造血 / エピゲノム / ストレス / 転写因子 / トリソミー8 / 数的染色体異常 / トリソミー8 … More / 感染 / DNAメチル化 / 老化 / TET2 / RUNX1 / 自然免疫 / 白血病 / IGF2BP2 / 炎症応答 / HMGA1 / 骨髄移植術 / 炎症 / Casein Kinase 2 / TNF-a / HMGA2 / CK2 / RFX5 / 5-FU / TNFa / HMGA2 / キメラマウス / 感染ストレス / クロナール造血 / クローナル造血 / TET2 / ゲノム変異 / 感染症 / ヒストン修飾 / 環境ストレス / EZH2 / がん幹細胞 / ポリコーム / JAK2 / ポリコーム複合体 / 骨髄線維症 / 慢性骨髄増殖性腫瘍 / エピジェネティクス / MDS / 国際情報交換 / 急性骨髄性白血病 / MLL-PTD / PNA / テロメラーゼ / フローサイトメーター / PNAプローブ / テロメア … More
Except Principal Investigator
白血病 / エピジェネティクス / RUNX / 分子標的治療 / 造血幹細胞 / 造血器腫瘍 / 分指標的治療 / マウスモデ / マウスモデル / AYA世代がん / 機能獲得方変異 / 遺伝子変異 / マイクロRNA / 造血幹細胞腫瘍 / エイジング / Stress / Epigenetics / SETD2 / TLR / MYD88 / Hematopoietic stem cell / Histone methylation / Regeneration / Transformation / Toll-like receptor / Inflammation / Hematopoietic stem cells / 癌 / がん幹細胞 / 抗体医薬 / ITGA9 / トランスレーショナルリサーチ / チロシンリン酸化 / 血液学 / TIF1 / TIF1beta / KAP1 / CML / BCR-ABL / ポリコーム群複合体 / 骨随異形成症候群 / 骨髄異形成症候群 / ポリコーム群遺伝子 / 前駆細胞 / T細胞分化 / 転写因子ネットワーク / チェックポイント / 自己複製 / 分化停止 / 遺伝子 / 細胞・組織 / 発生・分化 / 免疫学 / B細胞系列 / T細胞系列 / 転写因子 / 系列決定 Less
  • Research Projects

    (17 results)
  • Research Products

    (74 results)
  • Co-Researchers

    (26 People)
  •  骨髄異形成症候群・がん幹細胞の発生と拡大の分子基盤解明Principal Investigator

    • Principal Investigator
      指田 吾郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Pathogenec implication of hematopoietic stem cell aging in age-associated hematological malignancies

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy

    • Principal Investigator
      大里 元美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  Epigenetic regulation and cell fate determination of hematopoietic stem cell in stress conditionsPrincipal Investigator

    • Principal Investigator
      Sashida Goro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  A Crosstalk Between Inflammation and Epigenetics in Regulating HSC Fitness

    • Principal Investigator
      Huang Gang
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kumamoto University
  •  Analysis of hematopoietic stem cell regulation by numerical chromosome anomaly and the mechanism of MDS pathogenesisPrincipal Investigator

    • Principal Investigator
      Sashida Goro
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  マイクロRNA miR-142の機能獲得型変異による白血病発症メカニズムの解明

    • Principal Investigator
      荒木 喜美
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Kumamoto University
  •  Development of novel antibodies against leukemia and elucidation of their blocking mechanisms

    • Principal Investigator
      Osato Motomi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  Understanding of pathogenesis of Trisomy 8-induced myelodysplastic syndromePrincipal Investigator

    • Principal Investigator
      Sashida Goro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  Infection stresses promote the pathogenesis of myelodysplastic syndromePrincipal Investigator

    • Principal Investigator
      Sashida Goro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Molecular mechanisms in the pathogenesis of myelodysplastic syndromePrincipal Investigator

    • Principal Investigator
      Sashida Goro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Complex Systems Disease Theory
    • Research Institution
      Kumamoto University
  •  Roles of tyrosine phosphorylation of KAP1 in leukemogenesis

    • Principal Investigator
      Kubota Sho
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Epigenetic dysregulation in myelodysplastic syndromes in the absence of Ezh2Principal Investigator

    • Principal Investigator
      SASHIDA GORO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Role of epigenetic dysregulation in the pathogenesis of hematological malignancies

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Molecular mechanism of MLL mutant-induced MDSPrincipal Investigator

    • Principal Investigator
      SASHIDA Goro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Clarification of molecular mechanisms regulating lineage commitment taking place on the way from multipotent hematopoietic progenitors to unipotent T cell progenitors

    • Principal Investigator
      KAWAMOTO Hiroshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
      The Institute of Physical and Chemical Research
  •  PNAプローブを用いた簡便なテロメア長測定法の開発Principal Investigator

    • Principal Investigator
      指田 吾郎
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Tokyo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] A gain‐of‐function mutation in microRNA-142 is sufficient to cause the development of T‐cell leukemia in mice.2023

    • Author(s)
      Kawano Shingo、Araki Kimi、Bai Jie、Furukawa Imari、Tateishi Keigo、Yoshinobu Kumiko、Usuki Shingo、Nimmo Rachael A.、Kaname Tadashi、Yoshihara Masaharu、Takahashi Satoru、Sashida Goro、Araki Masatake
    • Journal Title

      Cancer Science

      Volume: - Issue: 7 Pages: 2821-2834

    • DOI

      10.1111/cas.15794

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05999, KAKENHI-PROJECT-23K21285, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02952
  • [Journal Article] Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs2023

    • Author(s)
      Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G.
    • Journal Title

      Journal of Experimental Medicine (JEM)

      Volume: 220 (7) Issue: 7 Pages: 9999-9999

    • DOI

      10.1084/jem.20220962

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ2522, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-22K16304, KAKENHI-PROJECT-21K06870, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K08421, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H02952
  • [Journal Article] HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner2022

    • Author(s)
      Supannika Sorin, Sho Kubota, Sofiane Hamidi, Takako Yokomizo-Nakano, Kulthida Vaeteewoottacharn, Sopit Wongkham, Sakda Waraasawapati, Chawalit Pairojkul, Jie Bai, Mariko Morii, Guojun Sheng, Kanlayanee Sawanyawisuth, Goro Sashida
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 7

    • DOI

      10.1096/fj.202200386r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21H02490, KAKENHI-PROJECT-21H02952
  • [Journal Article] The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell.2022

    • Author(s)
      Sun Y, Kubota S, Iimori M, Hamashima A, Murakami H, Bai J, Morii M, Yokomizo-Nakano T, Osato M, Araki K, Sashida G.
    • Journal Title

      Int J Hematol.

      Volume: 115 Issue: 4 Pages: 553-562

    • DOI

      10.1007/s12185-021-03274-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21H02952, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-23K21285
  • [Journal Article] RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner2021

    • Author(s)
      Abdallah Mohamed Gaber、Niibori-Nambu Akiko、Morii Mariko、Yokomizo Takako、Yokomizo Tomomasa, at al.
    • Journal Title

      Leukemia

      Volume: 35 Issue: 10 Pages: 2983-2988

    • DOI

      10.1038/s41375-021-01268-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02952, KAKENHI-PROJECT-19J40166, KAKENHI-PROJECT-17K07199, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-20K08758, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-18KK0440, KAKENHI-PROJECT-23K21285
  • [Journal Article] Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation2021

    • Author(s)
      Bai Jie、Yokomizo-Nakano Takako、Kubota Sho、Sun Yuqi、Kanai Akinori、Iimori Mihoko、Harada Hironori、Iwama Atsushi、Sashida Goro
    • Journal Title

      Oncogene

      Volume: 40 Issue: 8 Pages: 1531-1541

    • DOI

      10.1038/s41388-020-01629-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K08842, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-21K19512
  • [Journal Article] Two faces of RUNX3 in myeloid transformation2021

    • Author(s)
      Yokomizo-Nakano Takako、Sashida Goro
    • Journal Title

      Experimental Hematology

      Volume: 97 Pages: 14-20

    • DOI

      10.1016/j.exphem.2021.02.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-21H02952
  • [Journal Article] Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome2020

    • Author(s)
      Yokomizo-Nakano Takako、Kubota Sho、Bai Jie、Hamashima Ai、Morii Mariko、Sun Yuqi、Katagiri Seiichiro、Iimori Mihoko、Kanai Akinori、Tanaka Daiki、Oshima Motohiko、Harada Yuka、Ohyashiki Kazuma、Iwama Atsushi、Harada Hironori、Osato Motomi、Sashida Goro
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 12 Pages: 2523-2536

    • DOI

      10.1158/0008-5472.can-19-3167

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07840, KAKENHI-PROJECT-19K16811, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196
  • [Journal Article] Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome.2020

    • Author(s)
      Yokomizo-Nakano T, Kubota S, Bai J, Hamashima A, Morii M, Sun Y, Katagiri S, Iimori M, Kanai A, Tanaka D, Oshima M, Harada Y, Ohyashiki K, Iwama A, Harada H, Osato M, Sashida G.
    • Journal Title

      Cancer Research

      Volume: Epub

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668
  • [Journal Article] Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.2020

    • Author(s)
      Kuan JW, Su AT, Tay SP, Fong IL, Kubota S, Su'ut L, Osato M, Sashida G.
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 2 Pages: 217-224

    • DOI

      10.1007/s12185-019-02768-x

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019

    • Author(s)
      Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 1653-1653

    • DOI

      10.1038/s41467-019-09710-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K07244, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019

    • Author(s)
      Tenjin Yuki、Kudoh Shinji、Kubota Sho、Yamada Tatsuya、Matsuo Akira、Sato Younosuke、Ichimura Takaya、Kohrogi Hirotsugu、Sashida Goro、Sakagami Takuro、Ito Takaaki
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 11 Pages: 1622-1635

    • DOI

      10.1038/s41374-019-0277-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-18K19480, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Deregulated Polycomb functions in myeloproliferative neoplasms.2019

    • Author(s)
      Sashida G, Oshima M, Iwama A.
    • Journal Title

      Int J Hematol

      Volume: 110 Issue: 2 Pages: 170-178

    • DOI

      10.1007/s12185-019-02600-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18H02842
  • [Journal Article] Systematic Review of Normal Subjects Harbouring <b><i>BCR-ABL1</i></b> Fusion Gene2019

    • Author(s)
      Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
    • Journal Title

      Acta Haematologica

      Volume: 143 Issue: 2 Pages: 96-111

    • DOI

      10.1159/000501146

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668
  • [Journal Article] RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance2019

    • Author(s)
      Balogh Peter、Adelman Emmalee R.、Pluvinage John V.、Capaldo Brian J.、Freeman Katie C.、Singh Sandeep、Elagib Kamaleldin E.、Nakamura Yukio、Kurita Ryo、Sashida Goro、Zunder Eli R.、Li Hui、Gru Alejandro A.、Price Elizabeth A.、Schrier Stanley L.、Weissman Irving L.、Figueroa Maria E.、Pang Wendy W.、Goldfarb Adam N.
    • Journal Title

      Haematologica

      Volume: 105 Issue: 4 Pages: 905-913

    • DOI

      10.3324/haematol.2018.208918

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18H02842
  • [Journal Article] Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.2018

    • Author(s)
      Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, et al.
    • Journal Title

      Cancer Discovery

      Volume: 8 Issue: 11 Pages: 1438-57

    • DOI

      10.1158/2159-8290.cd-17-1203

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16H06276
  • [Journal Article] Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.2018

    • Author(s)
      Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
    • Journal Title

      iScience

      Volume: 9 Pages: 161-174

    • DOI

      10.1016/j.isci.2018.10.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16H06276
  • [Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018

    • Author(s)
      Wang Changshan、Oshima Motohiko、Sato Daisuke、Matsui Hirotaka、Kubota Sho、Aoyama Kazumasa、Nakajima-Takagi Yaeko、Koide Shuhei、Matsubayashi Jun、Mochizuki-Kashio Makiko、Nakano-Yokomizo Takako、Bai Jie、Nagao Toshitaka、Kanai Akinori、Iwama Atsushi、Sashida Goro
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 9 Pages: 3872-3886

    • DOI

      10.1172/jci94645

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
  • [Journal Article] Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies2017

    • Author(s)
      Sashida G, Iwama A
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 1 Pages: 23-30

    • DOI

      10.1007/s12185-016-2124-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-16KT0113
  • [Journal Article] Epigenetic dysregulation in myelodysplastic syndromes2017

    • Author(s)
      指田吾郎
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 10 Pages: 1809-1817

    • DOI

      10.11406/rinketsu.58.1809

    • NAID

      130006132647

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Journal Article] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016

    • Author(s)
      Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
    • Journal Title

      J Experimenta l Medicine

      Volume: 213 Issue: 8 Pages: 1459-1477

    • DOI

      10.1084/jem.20151121

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Journal Article] Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.2016

    • Author(s)
      Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
    • Journal Title

      Leukemia

      Volume: in press Issue: 4 Pages: 861-871

    • DOI

      10.1038/leu.2016.268

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H05412, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16K20959, KAKENHI-PROJECT-17K16530, KAKENHI-PUBLICLY-17H05649, KAKENHI-PROJECT-15K09478
  • [Journal Article] Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms.2015

    • Author(s)
      Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K
    • Journal Title

      Genom Data.

      Volume: 4 Pages: 102-108

    • DOI

      10.1016/j.gdata.2015.04.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09480, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-26860738
  • [Journal Article] Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.2015

    • Author(s)
      Wang C, Oshima M, Sashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132041-e0132041

    • DOI

      10.1371/journal.pone.0132041

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K19544, KAKENHI-PROJECT-14J40024, KAKENHI-PROJECT-14J40042
  • [Journal Article] Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.2015

    • Author(s)
      Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K.
    • Journal Title

      Blood

      Volume: 125 Issue: 2 Pages: 304-315

    • DOI

      10.1182/blood-2014-04-555508

    • NAID

      40020613861

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591401, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26860738
  • [Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015

    • Author(s)
      Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, Iwama A.
    • Journal Title

      Blood

      Volume: 126 Issue: 10 Pages: 1172-83

    • DOI

      10.1182/blood-2015-03-634428

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J40024
  • [Journal Article] Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.2015

    • Author(s)
      Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, Iwama A.
    • Journal Title

      Leuk Lymphoma.

      Volume: 56 Issue: 2 Pages: 520-523

    • DOI

      10.3109/10428194.2014.924120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591401, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.2014

    • Author(s)
      Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.
    • Journal Title

      Nature Communications

      Volume: 18 Issue: 1 Pages: 5872-5882

    • DOI

      10.1038/ncomms6872

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-25460599, KAKENHI-PROJECT-25860351, KAKENHI-PUBLICLY-26114720, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-26460569, KAKENHI-PROJECT-26461396
  • [Journal Article] Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukemic transformation.2014

    • Author(s)
      Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayasi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 5177-5177

    • DOI

      10.1038/ncomms5177

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25461422, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26257501, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461460
  • [Journal Article] MDS with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.2014

    • Author(s)
      Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K and Iwama A.
    • Journal Title

      Leukemia and Lymphoma

      Volume: 17 Issue: 21 Pages: 1-4

    • DOI

      10.1182/blood-2013-12-544544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249054, KAKENHI-PUBLICLY-25130702, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26461396
  • [Journal Article] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders2013

    • Author(s)
      Muto T, Sashida G, Oshima M, et al.
    • Journal Title

      J Exp Med

      Volume: 18 Pages: 2627-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Journal Article] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.2013

    • Author(s)
      Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 210(12) Issue: 12 Pages: 2627-39

    • DOI

      10.1084/jem.20131144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04875, KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23591397, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24659458, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25670446, KAKENHI-PROJECT-25860521
  • [Journal Article] Epigenetic regulation of hematopoiesis.2012

    • Author(s)
      Sashida G, Iwama A.
    • Journal Title

      Int J Hematol.

      Volume: 96 Issue: 4 Pages: 405-12

    • DOI

      10.1007/s12185-012-1183-x

    • NAID

      10031126731

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Journal Article] Ezh2 augments leukemogenecity by reinforcing differentiation blockage in acute myeloid leukemia2012

    • Author(s)
      Tanaka S
    • Journal Title

      Blood

      Volume: 120 Issue: 5 Pages: 1107-17

    • DOI

      10.1182/blood-2011-11-394932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591367, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-221S0002, KAKENHI-PUBLICLY-23130502
  • [Journal Article] Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.2012

    • Author(s)
      Zhang Y, Yan X, Sashida G et al.
    • Journal Title

      Blood

      Volume: 120 Issue: 5 Pages: 1118-29

    • DOI

      10.1182/blood-2012-02-412379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] miRNA-142の機能獲得型点変異による白血病発症について2024

    • Author(s)
      荒木正健 河野慎吾 吉信公美子 要 匡 吉原雅大 高橋智 白潔 指田吾郎 荒木喜美
    • Organizer
      先端モデル動物支援プラットフォーム成果発表会
    • Data Source
      KAKENHI-PROJECT-23K21285
  • [Presentation] Inflammatory stress activates the Hmga2 protein to remodel chromatin and expand hematopoietic stem cell2023

    • Author(s)
      指田吾郎
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02952
  • [Presentation] microRNA-142の機能獲得型変異による白血病発症メカニズムの解析2022

    • Author(s)
      河野慎吾、荒木正健、荒木喜美、指田吾郎
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K21285
  • [Presentation] Hmga2 activates Igf2bp2 but also represses expression of inflammatory response genes in stress hematopoiesis2022

    • Author(s)
      Sho Kubota, Goro Sashida
    • Organizer
      51st ISEH Annual Scientific Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02952
  • [Presentation] miR-142の機能獲得型変異による白血病発症メカニズムの解析2022

    • Author(s)
      河野慎吾、白潔、指田吾郎、古河いまり、吉信公美子、北元優梨、高橋智、要匡、荒木喜美、荒木正健
    • Organizer
      第69回日本実験動物学会総会
    • Data Source
      KAKENHI-PROJECT-23K21285
  • [Presentation] HMGA2 maintains hematopoietic stem cell via pleiotropic regulation of the transcription in stress conditions2021

    • Author(s)
      Sho Kubota, Yuqi Sun, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Takako Ideue, Motomi Osato, Terumasa Umemoto, Kimi Araki, Goro Sashida
    • Organizer
      63rd ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02952
  • [Presentation] Earlier infection stresses and a driver genetic mutation facilitate myeloid transformation2021

    • Author(s)
      Goro Sashida
    • Organizer
      第94回生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19512
  • [Presentation] Genetics/epigenetics-mediated enhancer activation in myeloid transformation.2021

    • Author(s)
      Goro Sashida
    • Organizer
      80回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19512
  • [Presentation] HMGA2 maintains hematopoietic stem cell via pleiotropic regulation of the transcription in stress conditions2021

    • Author(s)
      Sho Kubota, Yuqi Sun, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Takako Ideue, Motomi Osato, Terumasa Umemoto, Kimi Araki, Goro Sashida
    • Organizer
      63rd ASH Annual Meeting and Exposition(国際学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06870
  • [Presentation] Understanding of Trisomy 8 hematopoietic stem cell function and transformation by generating a new Trisomy 8 model.2021

    • Author(s)
      Jie Bai, Kimi Araki, Sho Kubota, Takako Yokomizo-Nakano, Minetaro Ogawa, Narumi Uno, Yasuhiro Kazuki, Mitsuo Oshimura, Goro Sashida
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K19512
  • [Presentation] 感染記憶による骨髄異形成症候群の発症機序解析2020

    • Author(s)
      指田吾郎、横溝貴子、久保田翔、濱嶋愛、金井昭教、岩間厚志、滝澤仁、松井啓隆
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] HSCs-specific induction of Hmga2 ensures the enhanced self-renewal property2019

    • Author(s)
      Yuqi Sun, Sho Kubota, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Kimi Araki, Motomi Osato, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K22640
  • [Presentation] RUNX3 over-expression impedes RUNX1 function and promotes the development of myelodysplastic syndrome2019

    • Author(s)
      Takako Yokomizo, Sho Kubota, Atsushi Iwama, Hironori Harada, Motomi Osato, Goro Sashida
    • Organizer
      日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] Stress and aging impair the transcriptome of MLL-AF9 stem cells and impede the leukemic transformation2019

    • Author(s)
      Ayaka Maeda, Sho Kubota, Takako Yokomizo, Mihoko Iimori, Kimi Araki, Motomi Osato, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] Stress and aging impair the transcriptome of MLL-AF9 stem cells and impede the leukemic transformation2019

    • Author(s)
      Ayaka Maeda, Sho Kubota, Takako Yokomizo, Mihoko Iimori, Kimi Araki, Motomi Osato, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K22640
  • [Presentation] Loss of Tif1β suppressed the development of BCR-ABL-induced leukemia.2019

    • Author(s)
      Mariko Morii, Sho Kubota, Takako Yokomizo-Nakano, Masayoshi Tasaki, Kimi Araki, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] RUNX3 over-expression impedes RUNX1 function and promotes the development of myelodysplastic syndrome2019

    • Author(s)
      Takako Yokomizo, Sho Kubota, Atsushi Iwama, Hironori Harada, Motomi Osato, Goro Sashida
    • Organizer
      日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K22640
  • [Presentation] Loss of Tif1b suppressed the development of BCR-ABL-induced leukemia2019

    • Author(s)
      Mariko Morii, Sho Kubota, Takako Yokomizo-Nakano, Masayoshi Tasaki, Kimi Araki, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K22640
  • [Presentation] HSCs-specific induction of Hmga2 ensures the enhanced self-renewal property.2019

    • Author(s)
      Yuqi Sun, Sho Kubota, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Kimi Araki, Motomi Osato, Goro Sashida
    • Organizer
      日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] Hmga2 promotes the development of MDS/MPN in the absence of Tet22018

    • Author(s)
      Jie Bai, Takako Yokomizo, Sho Kubota, Atsushi Iwama, Hironori Harada, Goro Sashida
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] Hmga2 promotes the development of MDS/MPN in the absence of Tet22018

    • Author(s)
      Jie Bai, Takako Yokomizo, Sho Kubota, Atsushi Iwama, Hironori Harada, Goro Sashida
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-18H02842
  • [Presentation] 骨髄異形成症候群におけるエピジェネティック制御の破綻2017

    • Author(s)
      指田吾郎
    • Organizer
      日本血液学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] RUNX2 super enhancer promotes the development of blastic plasmacytoid dendritic cell neoplasm2017

    • Author(s)
      Sho Kubota, Kenji Tokunaga, Motohiko Oshima, Tomohiro Umezu, Akinori Kanai, Kar Ton Tan, Henry Yang, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, and Goro Sashida
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K19545
  • [Presentation] RUNX3 promotes the development of MDS/MPN overlap syndrome via enhancing expression of Myc in the absence of Tet22017

    • Author(s)
      Yokomizo T, Tanaka D, Sho Kubota S, Oshima M, Harada Y, Kanai A, Iwama A, Harada H, Osato M, Sashida G
    • Organizer
      American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency2016

    • Author(s)
      Aoyama K, Mochizuki-Kashio M, Oshima M, Koide S, Nakajima-Takagi Y, Maeda M, Sashida G, Iwama A
    • Organizer
      American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition2016

    • Author(s)
      Sashida G, Wang C, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A
    • Organizer
      International Society for Experimental Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-08-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] Ezh2 loss promotes the transformation of ETP-ALL via suppressing T-cell differentiation regulators2016

    • Author(s)
      Sashida G, Wang C, Sato D, Oshima M, Matsui H, Nakajima-Takagi Y, Mochizuki-Kashio M, Iwama A
    • Organizer
      日本血液学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition2016

    • Author(s)
      Sashida G, Wang C, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A
    • Organizer
      International Society for Experimental Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-08-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] Ezh2 loss promotes the transformation of ETP-ALL via suppressing T-cell differentiation regulators2016

    • Author(s)
      Sashida G, Wang C, Sato D, Oshima M, Matsui H, Nakajima-Takagi Y, Mochizuki-Kashio M, Iwama A
    • Organizer
      日本血液学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-16KT0113
  • [Presentation] Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation2015

    • Author(s)
      Goro Sashida, Changshan Wang, Daisuke Sato, Motohiko Oshima, Atsushi Iwama
    • Organizer
      アメリカ血液学会年次総会
    • Place of Presentation
      米国オーランド
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML In Mouse2013

    • Author(s)
      Yue Zhang, Xiaomei Yan, Aili Chen, Goro Sashida, Zhijian Xiao, and Gang Huang
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      ニューオリンズ、米国(Blood 2013 122:2746)
    • Year and Date
      2013-12-06
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Ezh2 Loss Accelerates JAK2V617F-Driven Primary Myelofibrosis2013

    • Author(s)
      Tomioka T, Sashida G, et al.
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML In Mouse2013

    • Author(s)
      Zhang Y, Yan X, Chen A, Sashida G, et al.
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Modeling MLL-PTD Related Myelodysplastic Syndromes in Mouse2012

    • Author(s)
      Xiaomei Yan, Yue Zhang, Goro Sashida, Aili Chen, Xinghui Zhao, Susan Whitman, Qianfei Wang, Michael A. Caligiuri, Zhijian Xiao, and Gang Huang
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      アトランタ、米国(Blood 2012; 120: 2811)
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells2012

    • Author(s)
      Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan Whitman, Nicholas Zorko, Kelsie M. Bernot, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, H. Leighton Grimes, Michael A. Caligiuri, and Gang Huang
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      アトランタ、米国(Blood 2012; 120: 3501)
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Modeling MLL-PTD Related Myelodysplastic Syndromes in Mouse2012

    • Author(s)
      Yan X, Zhang Y, Sashida G, et al.
    • Organizer
      American Society of Hematology
    • Place of Presentation
      米国アトランタ
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Loss of Ezh2 Promotes the Development of Mutant-RUNX1 Induced MDS2012

    • Author(s)
      Sashida G, Tanaka S, et al.
    • Organizer
      American Society of Hematology
    • Place of Presentation
      米国アトランタ
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion2011

    • Author(s)
      Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan P. Whitman, Nicholas Zorko, Kelsie M. Bernot, David Witte, Qian-fei Wang, Daniel G. Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, Michael A Caligiuri, and Gang Huang
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      サンディエゴ、米国(Blood 2011; 118: 2801)
    • Year and Date
      2011-12-10
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Presentation] Ezh2 loss accelerates JAK2V617F-driven primary myelofibrosis

    • Author(s)
      Sashida G, Tomioka T, Wang C, Shide K, Shimoda K, Iwama A.
    • Organizer
      日本血液学会総会
    • Place of Presentation
      大阪・大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-26461396
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