Ohno Akiko 大野彰子

… Alternative Names

大野彰子オオノアキコ

OHNO Akiko 大野彰子

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Researcher Number	70356236
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, ゲノム安全科学部, 主任研究官
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立医薬品食品衛生研究所, 安全性予測評価部, 主任研究官 2019 – 2020: 国立医薬品食品衛生研究所, 安全性予測評価部, 主任研究官 2017: 国立医薬品食品衛生研究所, 安全性予測評価部, 主任研究官 2010 – 2012: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 2009 – 2010: 国立医薬品食品衛生研究所, 有機化学部, 主任研究員
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry
Keywords	Principal Investigator 医薬品化学 / MRI / フォスファチジルセリン / ガドリニウム / 新規抗がん剤 Except Principal Investigator アルツハイマー病 / アミロイドβ / アミロイド / 凝集阻害 / ビタミンE … More / カテキン / α-セクレターゼ / セクレターゼ / ペプチド / 神経細胞毒性 / 凝集阻害活性 / フィセチン / プロシアニジン / 神経細胞毒性抑制作用 / ペプチドモチーフ / カフェ酸 / トロロックス / 抗酸化物質 / アルツハイマー病治療薬 / 活性酸素 / レスベートロール / アルツハマー / アルツハイマー / 生活習慣病 / ポリフェノール / 酸化ストレス / 抗酸化剤 Less

Development of peptide derivatives with amyloid-beta cleaving activity
- Principal Investigator
  
  福原潔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University
Catechin derivatives useful for the treatment of Alzheimer's disease
- Principal Investigator
  
  Fukuhara Kiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University
Development of amyloid beta C-terminal motifs conjugated with phenolic antioxidant
- Principal Investigator
  
  Fukuhara Kiyoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Development of new cancer therapeutic agents targeting a selective induction of macrophage for cancer cellPrincipal Investigator
- Principal Investigator
  
  OHNO Akiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Studies on synthetic antioxidants for prevention of oxidative stress-related diseases
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences

[Journal Article] DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination2023
- Author(s)
  Fukuhara Kiyoshi、Nakanishi Ikuo、Imai Kohei、Mizuno Mirei、Matsumoto Ken-ichiro、Ohno Akiko
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 2 Pages: 225-225
- DOI
  10.3390/antiox12020225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06620, KAKENHI-PROJECT-22K06508
[Journal Article] Synthesis and radical-scavenging activity of C-methylated fisetin analogues2019
- Author(s)
  1.K. Imai, I. Nakanishi, K. Ohkubo, A. Ohno, M. Mizuno, S. Fukuzumi, K. Matsumoto, K. Fukuhara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 27 Issue: 8 Pages: 1720-1727
- DOI
  10.1016/j.bmc.2019.02.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-18K06620, KAKENHI-PUBLICLY-18H04650, KAKENHI-PROJECT-17H03010
[Journal Article] A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using <sup>1</sup>H-NMR Spectroscopy2017
- Author(s)
  K. Fukuhara, A. Ohno, R. Kikura-Hanajiri
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 9 Pages: 1147-1154
- DOI
  10.1248/yakushi.17-00046
- NAID
  130006038236
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460153
[Journal Article] Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-beta C-terminal peptides2016
- Author(s)
  Takuya Arai, Akiko Ohno, Kazunori Mori, Hiroshi Kuwata, Mirei Mizuno, Kohei Imai, Shuntaro Hara, Motoko Shibanuma, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 22 Pages: 5468-5471
- DOI
  10.1016/j.bmcl.2016.10.027
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26460153, KAKENHI-PROJECT-15K18901
[Journal Article] Design, synthesis, and evaluation of Trolox-conjugated amyloid-beta C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease2016
- Author(s)
  Takuya Arai, Akiko Ohno, Kazunori Mori, Taeko Kakizawa, Hiroshi Kuwata, Toshihiko Ozawa, Motoko Shibanuma, Shuntaro Hara, Seiichi Ishida, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 18 Pages: 4138-4143
- DOI
  10.1016/j.bmc.2016.06.057
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26460153
[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013
- Author(s)
  Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 52 Issue: 2 Pages: 133-138
- DOI
  10.3164/jcbn.12-118
- NAID
  130004466706
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24590397
[Journal Article] Reductive amination of glutaraldehyde 2,4-dinitrophenylhydrazone using 2-picoline borane and high-performance liquid chromatographic analysis.2012
- Author(s)
  Uchiyama. S..; Sakamoto, H.; Ohno, A.; Inaba, Y.; Nakagome, H.; Kunugita, N.
- Journal Title
  
  Analyst
  
  Volume: 137 Issue: 18 Pages: 4274-4279
- DOI
  10.1039/c2an35230c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510079, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24390172
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Demizu, Y., Okuhira, K., Motoi, H., Ohno, A., Shoda, T., Fukuhara, K., Okuda, H., Naito, M., Kurihara, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Pages: 1793-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790126
[Journal Article] A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis2012
- Author(s)
  A. Ohno, T. Kawanishi, H. Okuda, K. Fukuhara, K.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 3 Pages: 320-324
- DOI
  10.1248/cpb.60.320
- NAID
  130001852416
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 4 Pages: 1793-1796
- DOI
  10.1016/j.bmcl.2011.11.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
[Journal Article] A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity2011
- Author(s)
  K. Fukuhara, A. Ohno, Y. Ando, T. Yamoto, H. Okuda
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 4 Pages: 399-406
- DOI
  10.2133/dmpk.DMPK-11-RG-005
- NAID
  130004463199
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] アスピリンの抗腫瘍効果:NSAIDsへの期待2011
- Author(s)
  大野彰子
- Journal Title
  
  ファルマシア
  
  Volume: 47 Pages: 669-670
- Data Source
  KAKENHI-PROJECT-22790126
[Journal Article] Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics2011
- Author(s)
  A. Ohno, K. Oka, C. Sakuma, H. Okuda, K. Fukuhara
- Journal Title
  
  J. Agric. Food Chem
  
  Volume: 59 Issue: 10 Pages: 5181-5187
- DOI
  10.1021/jf200204y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Complete NMR analysis of oxytocin in phosphate buffer2010
- Author(s)
  A.Ohno
- Journal Title
  
  Magn.Reson.Chem.
  
  Volume: 48 Pages: 168-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790126
[Journal Article] Complete NMR analysis of oxytocin in phosphate buffer2010
- Author(s)
  A.Ohno
- Journal Title
  
  Magn.Reson.Chem. 48
  
  Pages: 168-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Complete NMR analysis of oxytocin in phosphate buffer2010
- Author(s)
  A. Ohno, N. Kawasaki, K. Fukuahra, H. Okuda, T. Yamaguchi
- Journal Title
  
  Magn. Reson. Chem
  
  Volume: 48 Issue: 2 Pages: 168-172
- DOI
  10.1002/mrc.2557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126
[Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity2009
- Author(s)
  K.Fukuhara, A.Ohno, I.Nakanishi, K.Imai, A.Nakamura, K.Anzai, N.Miyata, H.Okuda
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 6989-6992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Time-dependent changes of oxytocin using 1H NMR coupled with multivariate an alysis : a new approach for quality evaluation of protein/peptide biologic drugs2009
- Author(s)
  A.Ohno
- Journal Title
  
  Chem.Pharm.Bull. 57
  
  Pages: 1396-1399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Intramolecular base-accelerated radicalscavenging reaction of a planar catechin derivative having a lysine moiety2009
- Author(s)
  K. Fukuahra, I. Nakanishi, K. Ohkubo, Y. Obara, A. Tada, K. Imai, A. Ohno, A. Nakamura, T. Ozawa, S. Urano, S. Saito, S. Fukuzumi, K. Anzai, N. Miyata, H. Okuda
- Journal Title
  
  Chem. Comm.
  
  Issue: 41 Pages: 6180-6182
- DOI
  10.1039/b913714a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative having a lysine moiety2009
- Author(s)
  K.Fukuahra, I.Nakanishi, K.Ohkubo, Y.Obara, A.Tada, K.Imai, A.Ohno, A.Nakamura, T.Ozawa, S.Urano, S.Saito, S.Fukuzumi, K.Anzai, N.Miyata, H.Okuda
- Journal Title
  
  Chem.Comm.
  
  Pages: 6180-6182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] Characterization of tea cultivated at four different altitudes using 1H NMR analysis coupled with multivariate statistics
- Author(s)
  A.Ohno, K.Oka, C.Sakuma, H.Okuda, K.Fukuhara
- Journal Title
  
  J.Agri.Food Chem. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen induced hepatotoxicity
- Author(s)
  K.Fukuhara, A.Ohno, Y.Ando, T.Yamato, H.Okuda
- Journal Title
  
  Drug.Metab.Pharm. in press.
- NAID
  130004463199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] フラバノール誘導体‐アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ 蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔,大野彰子,奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-22790126
[Patent] フラバノール誘導体-アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔, 大野彰子, 奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2011-183246
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Patent] フラバノール誘導体-アセトン誘導体付加物、その製造方法並びにそれを利用したアミロイドβ蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔、大野彰子、奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2011-183246
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-22790126
[Patent] フラバノール誘導体‐アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ 蛋白凝集阻害剤及びアルツハイマー予防又は治療剤2011
- Inventor(s)
  福原潔,大野彰子,奥田晴宏
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] アミロイドβの神経毒製を抑制する新規ペプチドの開発2023
- Author(s)
  福原潔、沖山佳生、森一憲、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  酸化ストレス学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06508
[Presentation] Effects of the nitro-group on the mutagenicity of nitrated benzo[a]pyrenes2022
- Author(s)
  A. Ohno, Y. Okiyama, A. Hirose, K. Fukuhara
- Organizer
  264th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06508
[Presentation] C-メチルフィセチンのラジカル消去作用2021
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] ニトロ多環芳香族炭化水素の構造と変異原性に関するドッキングスタディ2021
- Author(s)
  大野彰子、沖山佳生、広瀬明彦、福原潔
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフラボノイドのラジカル消去作用2020
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 鉄錯体形成をトリガーとした新規抗酸化物質の開発2019
- Author(s)
  福原　潔，今井耕平，中西郁夫，松本謙一郎，大野彰子
- Organizer
  第43回鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフィセチンのラジカル消去活性2019
- Author(s)
  福原　潔，今井耕平，中西郁夫，大久保敬，大野彰子，水野美麗，福住俊一，松本謙一郎
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Planar catechin conjugated with DTPA as a promising antioxidant triggered by Fe3+ coordination2019
- Author(s)
  K. Fukuhara, K. Imai, I. Nakanishi, K. Matsumoto, A. Ohno
- Organizer
  258th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Potential lead compounds for the treatment of Alzheimer’s disease: a peptide that blocks amyloid beta induced neurotoxicity2018
- Author(s)
  K. Fukuhara, T. Arai, A. Ohno, K. Mori, M. Shibanuma, N. Miyata, H. Nakagawa
- Organizer
  256th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβのC末端モチーフを有するアルツハイマー病予防・治療薬の開発2018
- Author(s)
  福原　潔，荒井卓也，大野彰子，森一憲，柴沼質子，宮田直樹，中川秀彦
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 金属錯体形成をトリガーとした新規抗酸化物質の開発2018
- Author(s)
  福原　潔，今井耕平，中西郁夫，松本謙一郎，大野彰子
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アルツハイマー病治療薬を目指したアミロイドβのC末端ペプチドモチーフを有するフェノール性抗酸化剤の開発2017
- Author(s)
  福原潔、荒井卓也、大野彰子、森一憲、芝沼質子、宮田直樹、中川秀彦
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] AβのC末端もチーフを含有したトロロックス誘導体によるAβの細胞毒性および酸化ストレスの抑制2016
- Author(s)
  荒井卓也、大野彰子、森一憲、柿澤多恵子、石田誠一、桑田浩、小澤俊彦、原俊太郎、柴沼質子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] アミロイドβの C 末端モチーフを有する新規アルツハイマー病治療薬の開発2016
- Author(s)
  荒井卓也、大野彰子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] 新規アルツハイマー病治療薬の開発を目指したAβ1-42のC末端モチーフ含有ジヒドロカフェ酸誘導体の合成2015
- Author(s)
  荒井卓也、大野彰子、須賀真里奈、栗原正明、小澤俊彦、宮田直樹、中川秀彦、福原潔
- Organizer
  日本酸化ストレス学会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-26460153
[Presentation] AD 治療薬を指向した Aβ の C末端モチーフを有する Trolox 誘導体の開発2013
- Author(s)
  大野彰子
- Organizer
  第24回ビタミン E 研究会
- Place of Presentation
  東京
- Year and Date
  2013-01-10
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] カテキンをテンプレートとしたアルツハイマー病予防薬の開発2013
- Author(s)
  大野彰子
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] AD 治療薬を指向した Aβ の C末端モチーフを有する Trolox 誘導体の開発2013
- Author(s)
  大野彰子
- Organizer
  第24回ビタミン E 研究会
- Place of Presentation
  東京
- Year and Date
  2013-01-10
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] カテキンをテンプレートとしたアルツハイマー治療薬の開発2013
- Author(s)
  大野彰子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] カテキンをテンプレートとしたアルツハイマー病予防薬の開発2013
- Author(s)
  大野彰子
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] カテキンをテンプレートとしたアルツハイマー病予防薬の開発2013
- Author(s)
  大野彰子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drug2012
- Author(s)
  Ohno, A
- Organizer
  244^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-08-19
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drugs2012
- Author(s)
  Ohno, A.
- Organizer
  244th American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] アミロイドβを標的としたアルツハイマー予防薬の開発2012
- Author(s)
  大野彰子
- Organizer
  第23回ビタミンE研究会
- Place of Presentation
  東京
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR法による紅茶葉の品質評価2012
- Author(s)
  大野彰子
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMRを用いた拡張型心筋症モデルハムスターのメタボローム解析2012
- Author(s)
  大野彰子
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR 法による紅茶葉の品質評価2012
- Author(s)
  大野彰子
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] NMR を用いた拡張型心筋症モデルハムスターのメタボローム解析2012
- Author(s)
  大野彰子
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drugs2012
- Author(s)
  Ohno, A.
- Organizer
  244th American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drug2012
- Author(s)
  Ohno, A
- Organizer
  244t^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-08-19
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR 法による紅茶葉の品質評価2012
- Author(s)
  大野彰子
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR を用いた拡張型心筋症モデルハムスターのメタボローム解析2012
- Author(s)
  大野彰子
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] NMR 法によるインスリンの種差の解析手法開発2011
- Author(s)
  大野彰子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] A new NMR-based quality evaluation of biopolymer drug2011
- Author(s)
  Ohno, A.
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] 抗酸化活性およびアミロイドβ蛋白凝集抑制作用を有する新規アルツハイマー病予防薬の開発2011
- Author(s)
  大野彰子
- Organizer
  第64回日本酸化ストレス学会学術集会
- Place of Presentation
  北海道留寿都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR 法によるインスリンの種差の解析手法開発2011
- Author(s)
  大野彰子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] A new NMR-based quality evaluation of biopolymer drug2011
- Author(s)
  Ohno, A.
- Organizer
  drug,8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR - 多変量解析法による異なる高度で栽培・製造された紅茶葉の成分解析2011
- Author(s)
  大野彰子
- Organizer
  第4回食品薬学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 1H NMR-多変量解析法による異なる高度で栽培・製造された紅茶葉の成分解析2011
- Author(s)
  大野彰子
- Organizer
  第4回食品薬学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR法によるインスリンの種差の解析手法開発2011
- Author(s)
  大野彰子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] 抗酸化活性およびアミロイドβ 蛋白凝集抑制作用を有する新規アルツハイマー病予防薬の開発2011
- Author(s)
  大野彰子
- Organizer
  第64回日本酸化ストレス学会学術集会
- Place of Presentation
  北海道留寿都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] A new NMR-based quality evaluation of biopolymer drugs2011
- Author(s)
  Ohno, A
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] 抗酸化活性およびアミロイドβ蛋白凝集抑制作用を有する新規アルツハイマー病予防薬の開発2011
- Author(s)
  大野彰子
- Organizer
  第64回日本酸化ストレス学会学術集会
- Place of Presentation
  北海道留寿都
- Year and Date
  2011-07-03
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] New approach for quality evaluation for insulins derived from different species using 1H NMR coupled with multivariate analysis2011
- Author(s)
  Ohno, A
- Organizer
  242^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Denver
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] New approach for quality evaluation for insulins derived from different species using 1H NMR coupled with multivariate analysis2011
- Author(s)
  Ohno, A
- Organizer
  242^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Denver,USA
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] 1H NMR - 多変量解析法による異なる高度で栽培・製造された紅茶葉の成分解析2011
- Author(s)
  大野彰子
- Organizer
  第4回食品薬学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] New approach for quality evaluation for insulins derived from different species using 1H NMR coupled with multivariate analysis2011
- Author(s)
  Ohno, A.
- Organizer
  242^<th> American Chemical Society National Meeting & Exposition
- Place of Presentation
  Denver,USA
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] Application of a multivariate analysis based on ^1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs2010
- Author(s)
  Ohno, A.
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] βアミロイドの凝集阻害を標的とした抗酸化活性を有する新規アルツハイマー治療薬の開発2010
- Author(s)
  大野彰子
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] NMR/主成分分析法を利用したオキシトシンの品質評価手法の開発2010
- Author(s)
  大野彰子
- Organizer
  日本薬学会第130 年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs2010
- Author(s)
  A.Ohno
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] βアミロイドの凝集阻害を標的とした抗酸化活性を有する新規アルツハイマー治療薬の開発2010
- Author(s)
  大野彰子
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs2010
- Author(s)
  Ohno, A
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] ^1H NMR-based metabolomics approach for analysis of APAP hepatotoxicity2010
- Author(s)
  Ohno, A.
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs2010
- Author(s)
  Ohno, A., Kawasaki, N., Fukuhara, K., Okuda, H., Yamaguchi, T.
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] NMR/主成分分析法を利用したオキシトシンの品質評価手法の開発2010
- Author(s)
  大野彰子
- Organizer
  日本薬学会第130 年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390038
[Presentation] βアミロイドの凝集阻害を標的とした抗酸化活性を有する新規アルツハイマー治療薬の開発2010
- Author(s)
  大野彰子
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] ^1H NMR を利用したAPAPによる肝障害のメタボロミクス2010
- Author(s)
  大野彰子
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-22790126
[Presentation] Aβ1-42のC末端モチーフを有するカフェ酸およびジヒドロカフェ酸誘導体の合成とAβ凝集阻害活性の解析
- Author(s)
  荒井卓也、大野彰子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460153

1. FUKUHARA Kiyoshi (70189968)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. 水野美麗 (60766195)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. OKUDA Haruhiro (30160807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. UMEMURA Takashi (50185071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SYODA Takuji (60435708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. UCHIYAMA Shigehisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. NAKAGOME Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中川秀彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ohno Akiko 大野 彰子

大野 彰子 オオノ アキコ

OHNO Akiko 大野 彰子

Research Projects

Research Products

Co-Researchers

Development of peptide derivatives with amyloid-beta cleaving activity

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Catechin derivatives useful for the treatment of Alzheimer's disease

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Development of amyloid beta C-terminal motifs conjugated with phenolic antioxidant

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Development of new cancer therapeutic agents targeting a selective induction of macrophage for cancer cellPrincipal Investigator

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Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

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Research Institution

[Journal Article] DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination2023

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[Journal Article] Synthesis and radical-scavenging activity of C-methylated fisetin analogues2019

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Data Source

[Journal Article] A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using <sup>1</sup>H-NMR Spectroscopy2017

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[Journal Article] Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-beta C-terminal peptides2016

Author(s)

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Data Source

[Journal Article] Design, synthesis, and evaluation of Trolox-conjugated amyloid-beta C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease2016

Author(s)

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Data Source

[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013

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[Journal Article] Reductive amination of glutaraldehyde 2,4-dinitrophenylhydrazone using 2-picoline borane and high-performance liquid chromatographic analysis.2012

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[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012

Author(s)

Ohno Akiko 大野彰子

大野彰子オオノアキコ

OHNO Akiko 大野彰子