ISHIGURO AKIRA 石黒亮

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ISHIGURO Akira 石黒亮

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Researcher Number	70373264
Other IDs	https://orcid.org/0000-0003-1867-3134
Affiliation (Current)	2025: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2017 – 2020: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2016: 法政大学, 付置研究所, 研究員 2014 – 2015: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2013: 法政大学, 付置研究所, 研究員 … More 2013: 東京大学, 医科学研究所, 特任准教授 2008: The University of Tokyo, 医科学研究所, 特任助教 2007: The Institute of Physical and Chemical Research, 比較神経発生研究チーム, 研究員 2004 – 2006: 独立行政法人理化学研究所, 比較神経発生研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Neuroscience in general / Transformative Research Areas, Section (III) / Molecular biology / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator General medical chemistry / Life / Health / Medical informatics / Biological Sciences
Keywords	Principal Investigator RNA / FUS / TDP-43 / 筋萎縮性側索硬化症 / グアニン四重鎖 / PDI / 液液相分離 / 神経変性疾患 / リン酸化 / 全前脳症 … More / 転写 / 低複雑領域 / 液-液相分離 / 天然変性タンパク質 / シャペロン / 天然変性領域 / RNAシャペロン / ローカルトランスレーション / ALS / mRNA輸送 / RNA立体構造 / 前頭側頭葉変性症 / 局所翻訳 / 核酸医薬 / FGF2 / アプタマー / DNA-PK / TGIF / Zic2 / 発生・発達・再生神経科学 / Zic / 転写開始複合体 / Zicファミリータンパク質 / 転写因子 / 神経発生 / 遺伝子発現 … More Except Principal Investigator Zic / 遺伝子発現調節 / zincフィンガー / zincフィンガータンパク質 / 遺伝子発現制御 / 神経発生 / congenital anomaly / protein modification / transcriptional complex / gene targeting / neural development / cell differentiation / transcription factor / 細胞内局在 / 蛋白質間相互作用 / 構造生物学 / 動物発生 / 転写調節 / タンパク質間相互作用 / 先天性奇形 / タンパク質修飾 / 転写複合体 / 遺伝子ターゲッティング / 細胞分化 / 転写因子 / RNA2次構造 / RNA立体構造 / RNA・タンパク質相互作用 / RNAタンパク質相互作用 / ドッキング計算 / RNA-タンパク質相互作用 / RNA２次構造 / 脳の多様性 / エンハンサー / 比較ゲノム / 系統発生 / 進化 Less

ALS発症機序におけるRNA酸化の分子機構Principal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hosei University
G-quadruplex-dependent phase transitions of ALS-associated RNA-binding proteinsPrincipal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hosei University
Study of molecular mechanisms of ALS-linked FUS protein and dysregulation.Principal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hosei University
Study of interaction between TDP-43 and RNA guanine quadruplex and its disruptionPrincipal Investigator
- Principal Investigator
  
  Ishiguro Akira
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Hosei University
Comprehensive prediction of RNA-protein interactinos
- Principal Investigator
  
  Asai Kiyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  The University of Tokyo
Anti- fibroblast growth factor 2 aptamer improves existing arthritis in murine modelsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hosei University
  The University of Tokyo
Identification of Holoprosencephaly related gene regulationsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research
動物の進化系統発生におけるZicファミリーの意義
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経発生における転写制御因子Zicファミリーの分子制御機構Principal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
Molecular basis of Zic-mediated developmental control
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  RIKEN

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2008 2007 2004 Other

All Journal Article Presentation

[Journal Article] ALS責任タンパク質のグアニン四重鎖依存的位相変化2024
- Author(s)
  石黒亮
- Journal Title
  
  月刊「細胞」
  
  Volume: 56 Pages: 30-32
- Data Source
  KAKENHI-PUBLICLY-23H04265
[Journal Article] ALS責任タンパク質のグアニン四重鎖依存的位相変化2024
- Author(s)
  石黒亮
- Journal Title
  
  月刊「細胞」
  
  Volume: 56 Pages: 30-32
- Data Source
  KAKENHI-PROJECT-22K07032
[Journal Article] FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD2023
- Author(s)
  Fujino Yuzo、Ueyama Morio、Ishiguro Taro、Ozawa Daisaku、Ito Hayato、Sugiki Toshihiko、Murata Asako、Ishiguro Akira et al.
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-31
- DOI
  10.7554/elife.84338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07032, KAKENHI-PROJECT-23K06836, KAKENHI-PROJECT-20K07737, KAKENHI-PROJECT-21K07432, KAKENHI-PUBLICLY-23H04265, KAKENHI-PROJECT-21H02840
[Journal Article] ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA2023
- Author(s)
  Ishiguro Akira、Ishihama Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-023-33172-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07032, KAKENHI-PUBLICLY-23H04265
[Journal Article] Essential Roles and Risks of G-Quadruplex Regulation: Recognition Targets of ALS-Linked TDP-43 and FUS2022
- Author(s)
  Ishiguro Akira、Ishihama Akira
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 9 Pages: 1-8
- DOI
  10.3389/fmolb.2022.957502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07032
[Journal Article] Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS2020
- Author(s)
  Ishiguro Akira、Katayama Akira、Ishihama Akira
- Journal Title
  
  FEBS Letters
  
  Volume: 595 Issue: 3 Pages: 310-323
- DOI
  10.1002/1873-3468.14013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07291
[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020
- Author(s)
  Ishiguro A, Kimura N, Noma T, Shimo-Kon R, Ishihama A, Kon T.
- Journal Title
  
  FEBS letters
  
  Volume: 594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07291
[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020
- Author(s)
  Ishiguro A, Kimura N, Noma T, Shimo-Kon R, Ishihama A, Kon T.
- Journal Title
  
  FEBS letter
  
  Volume: - Issue: 14 Pages: 2254-2265
- DOI
  10.1002/1873-3468.13800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-17H03665, KAKENHI-PROJECT-17K07291
[Journal Article] TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.2016
- Author(s)
  Ishiguro A, Kimura N, Watanabe Y, Watanabe S, & Akira Ishihama.
- Journal Title
  
  Genes to cells
  
  Volume: in press Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350522
[Journal Article] Functional roles of Zic2 phosphorylation in transcriptional regulations2008
- Author(s)
  Ishiguro A, & Aruga J.
- Journal Title
  
  FEBS Lett. 582
  
  Pages: 154-158
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J, & Utsonomiya-Tate N.
- Journal Title
  
  Biochimica. et Biophysica. Acta. 1784
  
  Pages: 1011-1019
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Functional roles of Zic2 phosphorylation in transcriptional regulations.2008
- Author(s)
  Ishiguro A, & Aruga J
- Journal Title
  
  FEBS Letter 582
  
  Pages: 154-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J & Utsunomiya-Tate N
- Journal Title
  
  Biochimica. et Biophysics. Acta 1784
  
  Pages: 1011-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Rines/RNF180, a novel RING finger protein, is a membrane-bound ubiquitin ligase2008
- Author(s)
  Ogawa M, Mizugishi K, Koyabu Y, Ishiguro A, Imai Y, Takahashi R, Mikoshiba K, & Aruga J.
- Journal Title
  
  Genes cells. 13
  
  Pages: 397-409
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J, & Utsunomiya-Tate N
- Journal Title
  
  Biochimica. et Biophysica. Acta. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Rines/RNF180, a novel RING finger protein, is a membrane-bound ubiquitin ligase2008
- Author(s)
  Ogawa M, Mizugishi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R, Mikoshiba K, & Aruga J.
- Journal Title
  
  Genes cells 13
  
  Pages: 397-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly (ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Zic2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, Poly-ADP ribose polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Data Source
  KAKENHI-PROJECT-16700293
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro, A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 324
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16027261
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family2004
- Author(s)
  Ishiguro A, Inoue T, Mikoshiba K, Aruga J.
- Journal Title
  
  Biochemical and Biophysical Research Communications 324・5
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16700293
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro A, Inoue T, Mikoshiba K, Aruga J
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 302-307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro, A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 324
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16390086
[Presentation] Essential roles of RNA recognition in liquid-liquid phase separation of ALS- linked proteins, TDP-43 and FUS2023
- Author(s)
  Akira Ishiguro
- Organizer
  2023年日本神経化学会年会
- Data Source
  KAKENHI-PUBLICLY-23H04265
[Presentation] Protein disulfide isomerase regulates G-quadruplex dependent liquid-liquid phase separation of TDP-432023
- Author(s)
  Akira Ishiguro, Keiko Nishijima, Yuta Murakami, Hiroshi Kimura, Shinji Hadano and Asako Otomo
- Organizer
  2023年日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07032
[Presentation] Essential roles of RNA recognition in liquid-liquid phase separation of ALS- linked proteins, TDP-43 and FUS2023
- Author(s)
  Akira Ishiguro
- Organizer
  2023年日本神経化学会年会
- Data Source
  KAKENHI-PROJECT-22K07032
[Presentation] Protein disulfide isomerase regulates G-quadruplex dependent liquid-liquid phase separation of TDP-432023
- Author(s)
  Akira Ishiguro, Keiko Nishijima, Yuta Murakami, Hiroshi Kimura, Shinji Hadano and Asako Otomo
- Organizer
  2023年日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-23H04265
[Presentation] ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA2022
- Author(s)
  Ishiguro A, Ishihama A.
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07032
[Presentation] Role of glycine-rich domain of ALS-linked TDP-43 and FUS proteins in G-quadruplex recognition for mRNA transport2019
- Author(s)
  Ishiguro A, Katayama A & Ishihama A
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] ALS-linked G-quadruplex binding proteins TDP-43 and FUS have common and distinct roles in the molecular interaction mechanisms.2019
- Author(s)
  Ishiguro A, Kimura N, Katayama A & Kon T.
- Organizer
  NEURO 2019
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between ALS causative proteins and an RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura Takashi Noma, and Takahide Kon
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between TDP-43 and RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro
- Organizer
  第４回神経難病治療学セミナー　大阪大学大学院医学系研究科
- Invited
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Guanine oxidization of G-quadruplex affects TDP-43 dependent mRNA transport.2018
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura Takashi Noma, and Takahide Kon
- Organizer
  5th RNA Metabolism in Neurological Disease Conference, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between TDP-43 and RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro
- Organizer
  Hong Kong RNA club seminar, Hong Kong City University, Hong Kong
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] グアニン四重鎖の酸化は TDP-43による mRNA輸送機能を阻害する2017
- Author(s)
  石黒亮・野間崇志・木村展之・昆隆英
- Organizer
  生命科学系学科合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] TDP43 recognizes and transports G-quadruplex-containing mRNAs into neurites for local translation.2015
- Author(s)
  Akira Ishiguro, Akira Ishihama, Nobuyuki Kimura
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] TDP43 recognizes and transports G4-containing mRNAs into neurites for local translation.2015
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  埼玉県さいたま市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] C2H2型ジンクフィンガータンパク質、Zicタンパク質の構造とGli及びGlisタンパク質との系統樹的関係の解析2007
- Author(s)
  加藤(酒井)くみ子,石黒亮,有賀純、楯直子
- Organizer
  第45回生物物理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] 核タンパク質Zicの物性と構造2007
- Author(s)
  加藤(酒井)くみ子,河西亜希子,石黒亮,御子柴克彦,有賀純,楯直子
- Organizer
  第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Zicタンパク質の構造と物性2007
- Author(s)
  加藤(酒井)くみ子,河西亜希子,石黒亮,御子柴克彦,有賀純,楯直子
- Organizer
  第45回生物物理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Essential roles of Zic2 phosphorylation in the transcriptional regulation2007
- Author(s)
  Ishiguro A., Aruga J.
- Organizer
  (一般口頭発表)第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Zic、Gli、及びGlisタンパク質の系統樹的関係の解析2007
- Author(s)
  加藤(酒井)くみ子、石黒亮、有賀純、楯直子
- Organizer
  第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] 抗IL-17アプタマーはC57BL/6JマウスにおけるIL-23誘導乾癬様皮膚炎を抑制する
- Author(s)
  長嶺誠和、大瀧菜月、森重之、佐々木麻子、平本真介、春田和彦、石黒亮、中村義一
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] 筋萎縮性側索硬化症の封入体成分TDP-43タンパク質はRNA立体構造を認識する
- Author(s)
  石黒亮、渡辺すみ子、渡邊裕斗、山本兼由、石浜明
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25350522

1. ARUGA Jun (10232076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Asai Kiyoshi (30356357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YURA Kei (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 浜田道昭 (00596538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 亀田倫史 (40415774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木村展之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIGURO AKIRA 石黒 亮

ISHIGURO Akira 石黒 亮

Research Projects

Research Products

Co-Researchers

ALS発症機序におけるRNA酸化の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

G-quadruplex-dependent phase transitions of ALS-associated RNA-binding proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of molecular mechanisms of ALS-linked FUS protein and dysregulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of interaction between TDP-43 and RNA guanine quadruplex and its disruptionPrincipal Investigator

Principal Investigator

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Comprehensive prediction of RNA-protein interactinos

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Anti- fibroblast growth factor 2 aptamer improves existing arthritis in murine modelsPrincipal Investigator

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Identification of Holoprosencephaly related gene regulationsPrincipal Investigator

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動物の進化系統発生におけるZicファミリーの意義

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神経発生における転写制御因子Zicファミリーの分子制御機構Principal Investigator

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Molecular basis of Zic-mediated developmental control

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[Journal Article] ALS責任タンパク質のグアニン四重鎖依存的位相変化2024

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[Journal Article] ALS責任タンパク質のグアニン四重鎖依存的位相変化2024

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[Journal Article] FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD2023

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[Journal Article] ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA2023

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ISHIGURO AKIRA 石黒亮

ISHIGURO Akira 石黒亮