ISHIGURO AKIRA 石黒亮

… Alternative Names

ISHIGURO Akira 石黒亮

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Researcher Number	70373264
Other IDs	https://orcid.org/0000-0003-1867-3134
Affiliation (Current)	2024: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2017 – 2020: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2016: 法政大学, 付置研究所, 研究員 2014 – 2015: 法政大学, マイクロ・ナノテクノロジー研究センター, 研究員 2013: 法政大学, 付置研究所, 研究員 … More 2013: 東京大学, 医科学研究所, 特任准教授 2008: The University of Tokyo, 医科学研究所, 特任助教 2007: The Institute of Physical and Chemical Research, 比較神経発生研究チーム, 研究員 2004 – 2006: 独立行政法人理化学研究所, 比較神経発生研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Neuroscience in general / Basic Section 49030:Experimental pathology-related / Transformative Research Areas, Section (III) / Molecular biology / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator General medical chemistry / Life / Health / Medical informatics / Biological Sciences
Keywords	Principal Investigator RNA / 筋萎縮性側索硬化症 / グアニン四重鎖 / 神経変性疾患 / FUS / TDP-43 / リン酸化 / 全前脳症 / 転写 / 液液相分離 … More / シャペロン / 天然変性領域 / 液-液相分離 / 天然変性タンパク質 / ローカルトランスレーション / ALS / mRNA輸送 / RNA立体構造 / 前頭側頭葉変性症 / 局所翻訳 / 核酸医薬 / FGF2 / アプタマー / DNA-PK / TGIF / Zic2 / 発生・発達・再生神経科学 / Zic / 転写開始複合体 / Zicファミリータンパク質 / 転写因子 / 神経発生 / 遺伝子発現 … More Except Principal Investigator Zic / 遺伝子発現調節 / zincフィンガー / zincフィンガータンパク質 / 遺伝子発現制御 / 神経発生 / congenital anomaly / protein modification / transcriptional complex / gene targeting / neural development / cell differentiation / transcription factor / 細胞内局在 / 蛋白質間相互作用 / 構造生物学 / 動物発生 / 転写調節 / タンパク質間相互作用 / 先天性奇形 / タンパク質修飾 / 転写複合体 / 遺伝子ターゲッティング / 細胞分化 / 転写因子 / RNA2次構造 / RNA立体構造 / RNA・タンパク質相互作用 / RNAタンパク質相互作用 / ドッキング計算 / RNA-タンパク質相互作用 / RNA２次構造 / 脳の多様性 / エンハンサー / 比較ゲノム / 系統発生 / 進化 Less

G-quadruplex-dependent phase transitions of ALS-associated RNA-binding proteinsPrincipal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hosei University
Study of molecular mechanisms of ALS-linked FUS protein and dysregulation.Principal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hosei University
Study of interaction between TDP-43 and RNA guanine quadruplex and its disruptionPrincipal Investigator
- Principal Investigator
  
  Ishiguro Akira
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Hosei University
Comprehensive prediction of RNA-protein interactinos
- Principal Investigator
  
  Asai Kiyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  The University of Tokyo
Anti- fibroblast growth factor 2 aptamer improves existing arthritis in murine modelsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hosei University
  The University of Tokyo
Identification of Holoprosencephaly related gene regulationsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research
動物の進化系統発生におけるZicファミリーの意義
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経発生における転写制御因子Zicファミリーの分子制御機構Principal Investigator
- Principal Investigator
  
  石黒亮
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
Molecular basis of Zic-mediated developmental control
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  RIKEN

All 2022 2020 2019 2018 2017 2016 2015 2008 2007 2004 Other

All Journal Article Presentation

[Journal Article] Essential Roles and Risks of G-Quadruplex Regulation: Recognition Targets of ALS-Linked TDP-43 and FUS2022
- Author(s)
  Ishiguro Akira、Ishihama Akira
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 9 Pages: 1-8
- DOI
  10.3389/fmolb.2022.957502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07032
[Journal Article] Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS2020
- Author(s)
  Ishiguro Akira、Katayama Akira、Ishihama Akira
- Journal Title
  
  FEBS Letters
  
  Volume: 595 Issue: 3 Pages: 310-323
- DOI
  10.1002/1873-3468.14013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07291
[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020
- Author(s)
  Ishiguro A, Kimura N, Noma T, Shimo-Kon R, Ishihama A, Kon T.
- Journal Title
  
  FEBS letters
  
  Volume: 594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07291
[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020
- Author(s)
  Ishiguro A, Kimura N, Noma T, Shimo-Kon R, Ishihama A, Kon T.
- Journal Title
  
  FEBS letter
  
  Volume: - Issue: 14 Pages: 2254-2265
- DOI
  10.1002/1873-3468.13800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-17H03665, KAKENHI-PROJECT-17K07291
[Journal Article] TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.2016
- Author(s)
  Ishiguro A, Kimura N, Watanabe Y, Watanabe S, & Akira Ishihama.
- Journal Title
  
  Genes to cells
  
  Volume: in press Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350522
[Journal Article] Functional roles of Zic2 phosphorylation in transcriptional regulations2008
- Author(s)
  Ishiguro A, & Aruga J.
- Journal Title
  
  FEBS Lett. 582
  
  Pages: 154-158
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J, & Utsonomiya-Tate N.
- Journal Title
  
  Biochimica. et Biophysica. Acta. 1784
  
  Pages: 1011-1019
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Functional roles of Zic2 phosphorylation in transcriptional regulations.2008
- Author(s)
  Ishiguro A, & Aruga J
- Journal Title
  
  FEBS Letter 582
  
  Pages: 154-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J & Utsunomiya-Tate N
- Journal Title
  
  Biochimica. et Biophysics. Acta 1784
  
  Pages: 1011-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Rines/RNF180, a novel RING finger protein, is a membrane-bound ubiquitin ligase2008
- Author(s)
  Ogawa M, Mizugishi K, Koyabu Y, Ishiguro A, Imai Y, Takahashi R, Mikoshiba K, & Aruga J.
- Journal Title
  
  Genes cells. 13
  
  Pages: 397-409
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.2008
- Author(s)
  Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J, & Utsunomiya-Tate N
- Journal Title
  
  Biochimica. et Biophysica. Acta. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] Rines/RNF180, a novel RING finger protein, is a membrane-bound ubiquitin ligase2008
- Author(s)
  Ogawa M, Mizugishi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R, Mikoshiba K, & Aruga J.
- Journal Title
  
  Genes cells 13
  
  Pages: 397-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700300
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly (ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Zic2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, Poly-ADP ribose polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Data Source
  KAKENHI-PROJECT-16700293
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro, A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 324
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16027261
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family2004
- Author(s)
  Ishiguro A, Inoue T, Mikoshiba K, Aruga J.
- Journal Title
  
  Biochemical and Biophysical Research Communications 324・5
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16700293
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro A, Inoue T, Mikoshiba K, Aruga J
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 302-307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro, A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 324
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-16390086
[Presentation] ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA2022
- Author(s)
  Ishiguro A, Ishihama A.
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07032
[Presentation] Role of glycine-rich domain of ALS-linked TDP-43 and FUS proteins in G-quadruplex recognition for mRNA transport2019
- Author(s)
  Ishiguro A, Katayama A & Ishihama A
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] ALS-linked G-quadruplex binding proteins TDP-43 and FUS have common and distinct roles in the molecular interaction mechanisms.2019
- Author(s)
  Ishiguro A, Kimura N, Katayama A & Kon T.
- Organizer
  NEURO 2019
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between ALS causative proteins and an RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura Takashi Noma, and Takahide Kon
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between TDP-43 and RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro
- Organizer
  第４回神経難病治療学セミナー　大阪大学大学院医学系研究科
- Invited
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Guanine oxidization of G-quadruplex affects TDP-43 dependent mRNA transport.2018
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura Takashi Noma, and Takahide Kon
- Organizer
  5th RNA Metabolism in Neurological Disease Conference, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] Molecular mechanisms of interaction between TDP-43 and RNA G-quadruplex2018
- Author(s)
  Akira Ishiguro
- Organizer
  Hong Kong RNA club seminar, Hong Kong City University, Hong Kong
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] グアニン四重鎖の酸化は TDP-43による mRNA輸送機能を阻害する2017
- Author(s)
  石黒亮・野間崇志・木村展之・昆隆英
- Organizer
  生命科学系学科合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07291
[Presentation] TDP43 recognizes and transports G-quadruplex-containing mRNAs into neurites for local translation.2015
- Author(s)
  Akira Ishiguro, Akira Ishihama, Nobuyuki Kimura
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] TDP43 recognizes and transports G4-containing mRNAs into neurites for local translation.2015
- Author(s)
  Akira Ishiguro, Nobuyuki Kimura
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  埼玉県さいたま市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] C2H2型ジンクフィンガータンパク質、Zicタンパク質の構造とGli及びGlisタンパク質との系統樹的関係の解析2007
- Author(s)
  加藤(酒井)くみ子,石黒亮,有賀純、楯直子
- Organizer
  第45回生物物理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] 核タンパク質Zicの物性と構造2007
- Author(s)
  加藤(酒井)くみ子,河西亜希子,石黒亮,御子柴克彦,有賀純,楯直子
- Organizer
  第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Zicタンパク質の構造と物性2007
- Author(s)
  加藤(酒井)くみ子,河西亜希子,石黒亮,御子柴克彦,有賀純,楯直子
- Organizer
  第45回生物物理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Essential roles of Zic2 phosphorylation in the transcriptional regulation2007
- Author(s)
  Ishiguro A., Aruga J.
- Organizer
  (一般口頭発表)第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] Zic、Gli、及びGlisタンパク質の系統樹的関係の解析2007
- Author(s)
  加藤(酒井)くみ子、石黒亮、有賀純、楯直子
- Organizer
  第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19700300
[Presentation] 抗IL-17アプタマーはC57BL/6JマウスにおけるIL-23誘導乾癬様皮膚炎を抑制する
- Author(s)
  長嶺誠和、大瀧菜月、森重之、佐々木麻子、平本真介、春田和彦、石黒亮、中村義一
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25350522
[Presentation] 筋萎縮性側索硬化症の封入体成分TDP-43タンパク質はRNA立体構造を認識する
- Author(s)
  石黒亮、渡辺すみ子、渡邊裕斗、山本兼由、石浜明
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25350522

1. ARUGA Jun (10232076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Asai Kiyoshi (30356357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YURA Kei (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 浜田道昭 (00596538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 亀田倫史 (40415774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木村展之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIGURO AKIRA 石黒 亮

ISHIGURO Akira 石黒 亮

Research Projects

Research Products

Co-Researchers

G-quadruplex-dependent phase transitions of ALS-associated RNA-binding proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of molecular mechanisms of ALS-linked FUS protein and dysregulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of interaction between TDP-43 and RNA guanine quadruplex and its disruptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive prediction of RNA-protein interactinos

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti- fibroblast growth factor 2 aptamer improves existing arthritis in murine modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Holoprosencephaly related gene regulationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動物の進化系統発生におけるZicファミリーの意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経発生における転写制御因子Zicファミリーの分子制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of Zic-mediated developmental control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Essential Roles and Risks of G-Quadruplex Regulation: Recognition Targets of ALS-Linked TDP-43 and FUS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020

Author(s)

Journal Title

Data Source

[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.2016

Author(s)

ISHIGURO AKIRA 石黒亮

ISHIGURO Akira 石黒亮