Yamashita Taku 山下沢

… Alternative Names

YAMASHITA Taku 山下沢

山下沢ヤマシタタク

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Researcher Number	70398246
Other IDs
Affiliation (Current)	2025: 武庫川女子大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 武庫川女子大学, 薬学部, 教授 2015 – 2021: 武庫川女子大学, 薬学部, 准教授 2014: 大阪大学, 薬学研究科(研究院), 准教授 2013: 大阪大学, 大学院・薬学研究科, 招聘准教授 2013: 大阪大学, 薬学研究科(研究院), 招へい准教授 … More 2013: 大阪大学, 薬学研究科(研究院), 招聘准教授 2011 – 2012: 大阪大学, 薬学研究科(研究院), 助教 2011: 大阪大学, 薬学研究科, 助教 2006: 熊本大, 研究員 2005: 熊本大学, 大学院医学薬学研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Basic Section 21040:Control and system engineering-related / Control engineering/System engineering / Physical pharmacy
Keywords	Principal Investigator 創薬 / ドッキングシミュレーション / 構造解析 / 結核菌 / シミュレーション / 相互作用 / X線結晶構造解析 / 結晶構造解析 / 作用機序解明 / 抗結核薬 … More / 共鳴ラマン分光法 / 時間分解測定 / CPR / フランス / 国際研究者交流 / 2C9 / 2C19 / CYP / 薬物代謝酵素 / 部位特異的変異 / 薬物代謝 / 結合親和性 / 基質認識 / 時間分解スペクトル測定 / 代謝活性 / シトクロムP450 / 標的配列 / CooA / 一酸化炭素 / 転写因子 / 変異体 / 安定性 / 結晶化 / ガスセンサー … More Except Principal Investigator 確率 / 機械学習 / 薬学 / 情報通信工学 / 制御工学 / 確率統計 / 確率論 / X線結晶構造解析 / シトクロムP450 / 共鳴ラマン分光 / 一塩基多型 / シトクロムＰ４５０ / 薬物代謝 Less

Application to elucidate the function of targets for novel anti-tuberculosis drugs and to develop detection kitsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Mukogawa Women's University
Interpretability of Machine Learning-Assisted Control Methods through Stochastic Controllability Analysis
- Principal Investigator
  
  Kashima Kenji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 21040:Control and system engineering-related
- Research Institution
  Kyoto University
Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteinsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Mukogawa Women's University
Control systems that utilize interaction with environmental fluctuation
- Principal Investigator
  
  Kashima Kenji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Control engineering/System engineering
- Research Institution
  Kyoto University
Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
The Elucidation on mechanism of drug metabolism by a statistic and dynamics approaches.Principal Investigator
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
ガスセンサータンパク質におけるガス分子認識および機能発現機構解明Principal Investigator
- Principal Investigator
  
  山下沢
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University

All 2024 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] A large pocket structure surrounding the catalytic center in the BCG protein from Mycobacterium tuberculosis2024
- Author(s)
  Takeshita, K., Sakai, N., Ueno, G., Horie, M., Tsujino, H., Arisawa, M.,Yamamoto, M., Arai, M., and Yamashita, T.
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2024.05.14.591795
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06555
[Journal Article] Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs2014
- Author(s)
  T. Z. Attia, T. Yamashita, M. A. Hammad, A. Hayasaki, T. Sato, M. Miyamoto, Y. Yasuhara, T. Nakamura, Y. Kagawa, H. Tsujino, M. A. Omar, O. H. Abdelmageed, S. M. Derayea, and T. Uno
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 62(2) Pages: 176-81
- NAID
  130003390760
- Data Source
  KAKENHI-PROJECT-23790045
[Journal Article] Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs2014
- Author(s)
  Tamer Zekry Attia, Taku Yamashita, Mohamed Abdelkhalek Hammad, Akinori Hayasaki, Takumi Sato, Masayoshi Miyamoto, Yuki Yasuhara, Takashi Nakamura, Yusuke Kagawa, Hirofumi Tsujino, Mahmoud Ahmed Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, Tadayuki Uno
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 62 Issue: 2 Pages: 176-181
- DOI
  10.1248/cpb.c13-00800
- NAID
  130003390760
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390011, KAKENHI-PROJECT-23790045
[Journal Article] Comparison of Cytochrome P450 Mediated Metabolism of Three Central Nervous System Acting Drugs2012
- Author(s)
  Tamer Zekry Attia, Taku Yamashita, Masayoshi Miyamoto, Atsushi Koizumi, Yuki Yasuhara, Jun-ichi Node, Yumi Erikawa, Yumi Komiyama, Chiaki Horii, Mayu Yamada, Mahmoud Ahmad Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, Tadayuki Uno
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 12 Pages: 1544-1549
- DOI
  10.1248/cpb.c12-00719
- NAID
  130001852550
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390011, KAKENHI-PROJECT-23790045
[Journal Article] Comparison of cytochrome p450 mediated metabolism of three central nervous system acting drugs2012
- Author(s)
  T. Z. Attia, T. Yamashita, M. Miyamoto, A. Koizumi, Y. Yasuhara, J. Node, Y. Erikawa, Y. Komiyama, C. Horii, M. Yamada, M. A. Omar, O. H. Abdelmageed, S. M. Derayea, and T. Uno
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60(12) Pages: 1544-9
- NAID
  130001852550
- Data Source
  KAKENHI-PROJECT-23790045
[Presentation] Contribution of oppositely charged residues to the drug metabolism of cytochrome P450 2C9 and 2C192014
- Author(s)
  山下沢、T.Z.Attia、M. A. Hammad、佐藤匠、早崎瑛紀、宮本正芳、安原由樹、中村隆志、辻野博文、宇野公之
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790045
[Presentation] Contribution of oppositely charged residues to the drug metabolism of cytochrome P450 2C9 and 2C192014
- Author(s)
  Taku Yamashita
- Organizer
  第130回日本薬学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790045
[Presentation] Roles of Terminal Domains in the Ligand Binding Properties of Cytoglobin2013
- Author(s)
  花井舜平、辻野博文、山下沢、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] CYP3A4における薬物結合様式の分光学的解析2013
- Author(s)
  倉橋拓也, 小泉温史, 山下沢, 宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  西東京
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Spectroscopic Characterization of Drug Binding to Cytochrome P450 3A42013
- Author(s)
  倉橋拓也、小泉温史、山下沢、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Comparison of Cytochrome P450 Mediated Metabolism of Three CNS Acting Drugs2012
- Author(s)
  T. Yamashita, T. Z. Attia, M. Miyamoto, A. Koizumi, Y. Yasuhara, J. Node, Y. Erikawa, Y. Komiyama, C. Horii, M. Yamada, M. A. Omar, O. H. Abdelmageed, S. M. Derayea, and T. Uno
- Organizer
  50th Anniversary Symposium on Cytochrome P450
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790045
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on Drug Metabolism in Human CYP2C92012
- Author(s)
  Tadayuki Uno, Yumi Erikawa, Masayoshi Miyamoto, Yuki Yasuhara, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms(SNPs) on the Activation of Procarcinogens in Human CYP1A22012
- Author(s)
  Tadayuki Uno, Jun-ichi Node, Sakiko Morita, Akihide Tsujimoto, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on the Interaction of Human CYP reductase with CYP2C19 and Its Drug Metabolizing Properties2012
- Author(s)
  宮本正芳, 飯賀由実子, 松本麻希, 安原由樹, 青山浩, 山下沢, 宇野公之
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] The role of lipid membrane in the course of drug metabolism by cytochrome P4502012
- Author(s)
  宇野公之, 安原由樹, 宮本正芳, 山田麻由, 山下沢, 青山浩
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of SNPs on the metabolism of Amitriptyline in CYP2D62012
- Author(s)
  宇野公之, 堀井千明, 山田麻由, 上村真司, 青山浩, 山下沢
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Three Cytochrome P450s Responsible for the Metabolism of Amitriptyline and Imipramine2011
- Author(s)
  Tadayuki Uno, Mayu Yamada, Shinji Uemura, Sakiko Morita, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192011
- Author(s)
  Tadayuki Uno, Masayoshi Miyamoto, Yumiko Iiga, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011

1. UNO Tadayuki (00183020)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. 辻野博文 (10707144)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Kashima Kenji (60401551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKESHITA Kohei (80346808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. AOYAMA Hiroshi (60291910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. OHTA Yoshito (30160518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHKI Kentaro (40639233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASAYUKI Masayuki (80200301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOMINAMI DAICHI (00709678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ARAI Masayoshi (80311231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamashita Taku 山下 沢

YAMASHITA Taku 山下 沢

山下 沢 ヤマシタ タク

Research Projects

Research Products

Co-Researchers

Application to elucidate the function of targets for novel anti-tuberculosis drugs and to develop detection kitsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interpretability of Machine Learning-Assisted Control Methods through Stochastic Controllability Analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control systems that utilize interaction with environmental fluctuation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Elucidation on mechanism of drug metabolism by a statistic and dynamics approaches.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ガスセンサータンパク質におけるガス分子認識および機能発現機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A large pocket structure surrounding the catalytic center in the BCG protein from Mycobacterium tuberculosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Comparison of Cytochrome P450 Mediated Metabolism of Three Central Nervous System Acting Drugs2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Comparison of cytochrome p450 mediated metabolism of three central nervous system acting drugs2012

Author(s)

Journal Title

NAID

Data Source

[Presentation] Contribution of oppositely charged residues to the drug metabolism of cytochrome P450 2C9 and 2C192014

Yamashita Taku 山下沢

YAMASHITA Taku 山下沢

山下沢ヤマシタタク