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Yamaguchi Shigeru  山口 秀

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YAMAGUCHI Shigeru  山口 秀

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Researcher Number 70399939
Other IDs
Affiliation (Current) 2025: 北海道大学, 医学研究院, 講師
Affiliation (based on the past Project Information) *help 2021 – 2024: 北海道大学, 医学研究院, 講師
2019 – 2021: 北海道大学, 大学病院, 講師
2017: 北海道大学, 大学病院, 助教
2016: 北海道大学, 医学研究科, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 56010:Neurosurgery-related / Neurosurgery
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56010:Neurosurgery-related
Keywords
Principal Investigator
神経膠腫 / 膠芽腫 / G6PC3 / hypoxia / glioblastoma / photodynamic diagnosis / PpIX / IDH / lower-grade glioma / photodyanamic dianogisis … More / lower-grade gliomas / PEPT2 / 5-ALA / 蛍光診断 / 脳神経疾患 / マイクロRNA / メチオニン / 包括的遺伝子解析 / グリオーマ / gene expression analysis … More
Except Principal Investigator
PD-1 / EZH2 / ATRT / 神経鞘腫 / 疾患特異的iPS細胞 / neurofibromatosis type 2 / Schwann細胞 / 人工多能性幹細胞 / iPS細胞 / NF2 / 神経線維腫症2型 Less
  • Research Projects

    (5 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (8 People)
  •  Analysis of treatment effect of combination with EZH2 inhibitor and immune checkpoint inhibitor for aypical rhabdoid / teratoid tumors

    • Principal Investigator
      金子 貞洋
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Hokkaido University
  •  膠芽腫における低酸素内糖代謝亢進メカニズムの検証Principal Investigator

    • Principal Investigator
      山口 秀
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Photodynamic diagnosis for low-grade gliomas: functional analysis of porphyrin synthesis pathwayPrincipal Investigator

    • Principal Investigator
      Yamaguchi Shigeru
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Analysis of disease mechanism and discovery of novel treatment for neurofibromatosis type 2 using patient-derived induced pluripotent stem cell

    • Principal Investigator
      Shunsuke Terasaka
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Exploration of methionine uptake mechanism on glioma through microRNA analysisPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Shigeru
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University

All 2024 2022 2021 2019 2017

All Journal Article Presentation

  • [Journal Article] Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F-Fluoromisonidazole and 18F-Fluorodeoxyglucose Positron Emission Tomography2024

    • Author(s)
      Okamoto Michinari、Yamaguchi Shigeru、Sawaya Ryosuke、Echizenya Sumire、Ishi Yukitomo、Kaneko Sadahiro、Motegi Hiroaki、Toyonaga Takuya、Hirata Kenji、Fujimura Miki
    • Journal Title

      BioMed Research International

      Volume: 2024 Pages: 1-10

    • DOI

      10.1155/2024/2973407

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09225
  • [Journal Article] Analysis of induced pluripotent stem cell clones derived from a patient with mosaic neurofibromatosis type 22022

    • Author(s)
      Ishi Yukitomo、Era Takumi、Yuzawa Sayaka、Okamoto Michinari、Sawaya Ryosuke、Motegi Hiroaki、Yamaguchi Shigeru、Terasaka Shunsuke、Houkin Kiyohiro、Fujimura Miki
    • Journal Title

      American Journal of Medical Genetics Part A

      Volume: - Issue: 6 Pages: 1863-1867

    • DOI

      10.1002/ajmg.a.62700

    • Data Source
      KAKENHI-PROJECT-19K09519
  • [Journal Article] Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 22021

    • Author(s)
      Ishi Yukitomo、Harada Taisuke、Kameda Hiroyuki、Okada Hiromi、Yokota Isao、Okamoto Michinari、Sawaya Ryosuke、Motegi Hiroaki、Yamaguchi Shigeru、Terasaka Shunsuke、Kudo Kohsuke、Fujimura Miki
    • Journal Title

      Neuroradiology

      Volume: 64 Issue: 2 Pages: 393-396

    • DOI

      10.1007/s00234-021-02809-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09519, KAKENHI-PROJECT-21H02857, KAKENHI-PROJECT-19K17256
  • [Journal Article] Identification of PEPT2 as an Important Candidate Molecule in 5-ALA-mediated Fluorescence-Guided Surgery in WHO Grade II/III Gliomas2019

    • Author(s)
      Hou C, Yamaguchi S, Ishi Y, Terasaka S, Kobayashi H, Motegi H, Hatanaka KC, Houkin K.
    • Journal Title

      J Neurooncol

      Volume: 143 Issue: 2 Pages: 197-206

    • DOI

      10.1007/s11060-019-03158-3

    • NAID

      120006847764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09495
  • [Journal Article] PETの脳腫瘍への応用2017

    • Author(s)
      山口 秀
    • Journal Title

      脳神経外科

      Volume: 45 Pages: 1015-1024

    • Data Source
      KAKENHI-PROJECT-16K19991
  • [Presentation] 蛍光診断補助装置VLD-EXを用いた深部に存在する悪性神経膠腫の摘出術2021

    • Author(s)
      山口 秀
    • Organizer
      第30回日本脳神経外科手術と機器学会
    • Data Source
      KAKENHI-PROJECT-19K09495
  • [Presentation] BRAF V600変異を有する成人高悪性度神経膠腫の臨床病理学的検討2017

    • Author(s)
      伊師雪友 山口秀 吉田道春 茂木洋晃 小林浩之 寺坂俊介 寶金清博
    • Organizer
      第18回日本分子脳神経外科学会
    • Data Source
      KAKENHI-PROJECT-16K19991
  • [Presentation] Clinicopathological Analysis of Adult High-Grade Gliomas Harboring BRAF V600E Mutation2017

    • Author(s)
      Yukitomo Ishi, Shigeru Yamaguchi, Michiharu Yoshida, Hiroaki Motegi, Hiryuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
    • Organizer
      The meeting of the Asian Society of Neuro-Oncology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19991
  • [Presentation] MRIとメチオニンPET所見から神経膠腫の病理診断や予後予測は可能か?2017

    • Author(s)
      山口 秀、平田 健司、伊師 雪友、茂木 洋晃、小林 浩之、寺坂 俊介、寳金 清博
    • Organizer
      第35回日本脳腫瘍学会
    • Data Source
      KAKENHI-PROJECT-16K19991
  • 1.  伊師 雪友 (30812284)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 2.  小林 浩之 (70374478)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  茂木 洋晃 (40748844)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  Shunsuke Terasaka (10447055)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  江良 択実 (00273706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  平田 健司 (30431365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  金子 貞洋 (40811237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KO Suken
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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