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TSUNODA Toshiyuki  角田 俊之

… Alternative Names

角田 俊之  ツノダ トシユキ

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Researcher Number 70444817
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8751-7576
Affiliation (Current) 2025: 福岡大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2012 – 2024: 福岡大学, 医学部, 准教授
2014: 福岡大学, 大学院医学研究科, 准教授
2008: 九大, 大学病院
2007: Kyushu University, 大学病院, 臨床助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Tumor biology / Tumor biology / Urology
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 54030:Infectious disease medicine-related / Digestive surgery / Experimental pathology / Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related / Thoracic surgery
Keywords
Principal Investigator
KRAS / 3次元培養 / 低分子化合物 / 大腸癌 / 3次元培養 / エクソソーム / エンドサイトーシス / シャペロン / 癌免疫微少環境 / PMCD … More / VDAC / BiP / TAM / ゴルジ体 / 薬剤抵抗性 / KDELR / マクロファージ / PMC / 免疫チェックポイント / 免役チェックポイント / 細胞内小器官 / 免疫逃避 / 化合物スクリーニング / 大腸がん / フィールドエフェクト / 薬剤スクリーニング / 微小環境 / 高分化癌 / TGF-BI / EGF / In silico 解析 / マイクロアレイ / 正常上皮 / 前立腺 … More
Except Principal Investigator
浸潤 / 癌 / 肺癌 / CD73 / 細胞間コミュニケーション / アスペルギルス / 遺伝子解析 / 癌化 / 潰瘍性大腸炎 / micropapillary pattern / 重複感染 / 微生物間インタラクション解析 / 病原細菌 / バイオフィルム形成 / 細菌 / 癌関連線維芽細胞 / NT5E / 腫瘍間質相互作用 / MMP-2 / MMP / tumor-stroma interaction / tumor invasion / Emmprin / tumor microenvironment / stromal cells / emmprin / cancer invasion / 接着性侵襲性大腸菌 / CAC / CHI3L1 / claudin-2 / CLDN2 / CH3L1 / CEACAM6 / 相互作用 / 非結核性抗酸菌 / 炎症性腸疾患 / 造腫瘍機構 / 炎症促進因子 / 潰瘍性大腸炎の癌化 / 癌化ハイリスク症例の選別 / ポシティブフィードバック因子 / 外科 / 細胞・組織 / Gemcitabine耐性株 / 膵癌 / microdissection / Micropapillary pattern / 頭頸部癌 / 大腸癌 / sprouting / tumor budding / miRNA / 簇出型浸潤 / 末梢分泌型miRNA / 変異KRAS / 縦隔リンパ節サンプル / 腫瘍組織サンプル / 患者血清サンプル / 微小浸潤肺癌 / 微小浸潤癌 / KRAS / T細胞 / ZFAT Less
  • Research Projects

    (17 results)
  • Research Products

    (78 results)
  • Co-Researchers

    (36 People)
  •  Development of a novel cancer therapy utilizing the intracellular and extracellular cycle of the chaperone complex controlled by mutant KRASPrincipal Investigator

    • Principal Investigator
      角田 俊之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Fukuoka University
  •  癌間質におけるCD73/NT5Eをターゲットとした腫瘍浸潤抑制機構の解明と治療法の開発

    • Principal Investigator
      青木 光希子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Fukuoka University
  •  In vitro modeling of spread through air spaces (STAS) in lung cancer and its mechanism.

    • Principal Investigator
      中島 裕康
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Fukuoka University
  •  アスペルギルスと細菌の微生物間インタラクション解析による重複感染病態の解明と制御

    • Principal Investigator
      泉川 公一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Nagasaki University
  •  Foundational research for developing inhibitors targeting the interaction between Emmprin and CD73

    • Principal Investigator
      Aoki Mikiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Fukuoka University
  •  Control of KRAS signals in cancer-immune microenvironmentPrincipal Investigator

    • Principal Investigator
      Tsunoda Toshiyuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Fukuoka University
  •  Mechanism of refractoriness via cell-to-cell communication between Aspergillus and non-tuberculous Mycobacterium

    • Principal Investigator
      Izumikawa Koichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Nagasaki University
  •  Analysis of inflammation-induced colon cancer development mechanism by adhesive invasive Escherichia coli (AIEC) related molecule

    • Principal Investigator
      KINUGASA TETSUSHI
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      International University of Health and Welfare
  •  Elucidation of in vivo-like signal regulated by mutated KRAS in colorectal cancer spheroid and development of inhibitor.Principal Investigator

    • Principal Investigator
      Tsunoda Toshiyuki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Fukuoka University
  •  Elucidation and clinical application of tumorigenic machinery mediated by proinflammatory factors originating from ulcerative colitis

    • Principal Investigator
      KINUGASA TETSUSHI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kurume University
  •  膵臓癌特異的な微小環境構築能に対する変異KRAS関連シグナル阻害剤の開発

    • Principal Investigator
      佐々木 隆光
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Fukuoka University
  •  Elucidation of the mechanism for regulating microenvironment and cancer development by mutant KRASPrincipal Investigator

    • Principal Investigator
      Tsunoda Toshiyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Fukuoka University
  •  Elucidation of Field Effect in Colorectal Cancer with Mutant KRASPrincipal Investigator

    • Principal Investigator
      TSUNODA Toshiyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Fukuoka University
  •  Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse model

    • Principal Investigator
      DOI Keiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Fukuoka University
  •  Analyse of peripheral secreted microRNA controlled by mutations KRAS in lung cancer.

    • Principal Investigator
      YOSHIDA Yasuhiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Fukuoka University
  •  Comprehensive study on the mechanisms involved in micropapillary or budding type tumor invasion

    • Principal Investigator
      Nabeshima Kazuki
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Fukuoka University
  •  3次元培養を用いた前立腺癌新規バイオマーカーの検索Principal Investigator

    • Principal Investigator
      角田 俊之
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2007 Other

All Journal Article Presentation Patent

  • [Journal Article] MMP-2 Regulation of Emmprin on Tumour Cells and CD73 on Fibroblasts During Tumour-Stromal Interaction2023

    • Author(s)
      Aoki M, Tsunoda T, Koga K, Nabeshima K, Hamasaki M
    • Journal Title

      Anticancer Res

      Volume: 43 Issue: 8 Pages: 3735-3745

    • DOI

      10.21873/anticanres.16558

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06703, KAKENHI-PROJECT-21K07110
  • [Journal Article] Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis2022

    • Author(s)
      KINUGASA TETSUSHI、TSUNODA TOSHIYUKI、MIZOGUCHI EMIKO、OKADA TOSHIYUKI、SUDO TOMOYA、KAWAHARA AKIHIKO、AKIBA JUN、AKAGI YOSHITO
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 8 Pages: 4119-4127

    • DOI

      10.21873/anticanres.15910

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08318, KAKENHI-PROJECT-20K09114
  • [Journal Article] Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment2021

    • Author(s)
      Kushima Hisako、Tsunoda Toshiyuki、Matsumoto Taichi、Kinoshita Yoshiaki、Izumikawa Koichi、Shirasawa Senji、Fujita Masaki、Ishii Hiroshi
    • Journal Title

      Microorganisms

      Volume: 9 Issue: 7 Pages: 1435-1435

    • DOI

      10.3390/microorganisms9071435

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08840, KAKENHI-PROJECT-21K06703, KAKENHI-PROJECT-21K07161, KAKENHI-PROJECT-18K15154
  • [Journal Article] The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes2021

    • Author(s)
      Shuhei Ishikura Masayoshi Nagai Toshiyuki Tsunoda Kensuke Nishi Yoko Tanaka Midori Koyanagi Senji Shirasawa
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: NA Issue: 6 Pages: 626-638

    • DOI

      10.1002/jcb.29890

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07317, KAKENHI-PROJECT-21K07161
  • [Journal Article] Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP12021

    • Author(s)
      Kandasamy Palanivel、Zlobec Inti、Nydegger Damian T.、Pujol‐Gimenez Jonai、Bhardwaj Rajesh、Shirasawa Senji、Tsunoda Toshiyuki、Hediger Matthias A.
    • Journal Title

      Molecular Oncology

      Volume: 15 Issue: 10 Pages: 2782-2800

    • DOI

      10.1002/1878-0261.12999

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07161
  • [Journal Article] CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA2021

    • Author(s)
      Shuhei Ishikura, Kazumasa Yoshida, Sayuri Hashimoto, Kazuhiko Nakabayashi, Toshiyuki Tsunoda, Senji Shirasawa
    • Journal Title

      Journal of Biological Chemistry

      Volume: 297(4) Issue: 4 Pages: 101213-101213

    • DOI

      10.1016/j.jbc.2021.101213

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07317, KAKENHI-PROJECT-21K07161
  • [Journal Article] Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products2021

    • Author(s)
      HASHIMOTO SAYURI、NAGAI MASAYOSHI、NISHI KENSUKE、ISHIKURA SHUHEI、NAKABAYASHI KAZUHIKO、YAZAKI RYO、OHSHIMA TAKASHI、SUENAGA MASAHIKO、SHIRASAWA SENJI、TSUNODA TOSHIYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 8 Pages: 4061-4070

    • DOI

      10.21873/anticanres.15207

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07161
  • [Journal Article] Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion2020

    • Author(s)
      NISHI KENSUKE、ISHIKURA SHUHEI、UMEBAYASHI MASAYO、MORISAKI TAKASHI、INOZUME TAKASHI、KINUGASA TETSUSHI、AOKI MIKIKO、NIMURA SATOSHI、SWAIN ANTHONY、YOSHIDA YOICHIRO、HASEGAWA SUGURU、NABESHIMA KAZUKI、SAKATA TOSHIFUMI、SHIRASAWA SENJI、TSUNODA TOSHIYUKI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 8 Pages: 4663-4674

    • DOI

      10.21873/anticanres.14465

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-20K09114, KAKENHI-PROJECT-18K07215
  • [Journal Article] MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS2020

    • Author(s)
      NISHI KENSUKE、TSUNODA TOSHIYUKI、UCHIDA YOSHINORI、SUETA TAKAYUKI、SAWATSUBASHI MOTOHIRO、YAMANO TAKAFUMI、HASHIGUCHI YASUKO、SWAIN ANTHONY、SHIRASAWA SENJI、SAKATA TOSHIFUMI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 8 Pages: 4687-4694

    • DOI

      10.21873/anticanres.14468

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Journal Article] A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.2019

    • Author(s)
      Sawata Y, Matsukawa T, Doi S, Tsunoda T, Arikawa N, Matsunaga N, Ohnuki K, Shirasawa S, Kotake Y.
    • Journal Title

      Mol Cell Biochem

      Volume: 462 Pages: 25-31

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10659
  • [Journal Article] Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation2019

    • Author(s)
      Charitou Theodosia、Srihari Sriganesh、Lynn Miriam A.、Jarboui Mohamed-Ali、Fasterius Erik、Moldovan Max、Shirasawa Senji、Tsunoda Toshiyuki、Ueffing Marius、Xie Jianling、Xin Jin、Wang Xuemin、Proud Christopher G.、Boldt Karsten、Al-Khalili Szigyarto Cristina、Kolch Walter、Lynn David J.
    • Journal Title

      British Journal of Cancer

      Volume: 121 Issue: 1 Pages: 37-50

    • DOI

      10.1038/s41416-019-0477-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07215, KAKENHI-PROJECT-17K10659
  • [Journal Article] Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver2019

    • Author(s)
      DOI KEIKO、TSUNODA TOSHIYUKI、KOYANAGI MIDORI、TANAKA YOKO、YAMANO SHIORI、FUJIKANE AYA、NISHI KENSUKE、ISHIKURA SHUHEI、SHIRASAWA SENJI
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 8 Pages: 4495-4502

    • DOI

      10.21873/anticanres.13625

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Journal Article] A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells2019

    • Author(s)
      Sawata Yuuga、Matsukawa Taiji、Doi Satoshi、Tsunoda Toshiyuki、Arikawa Nagisa、Matsunaga Natsumi、Ohnuki Koichiro、Shirasawa Senji、Kotake Yojiro
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 462 Issue: 1-2 Pages: 25-31

    • DOI

      10.1007/s11010-019-03606-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07215, KAKENHI-PROJECT-17K07184
  • [Journal Article] Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture2018

    • Author(s)
      Luo, H.; Nishi, K.; Ishikura, S.; Swain, A.; Morishige, N.; Yazaki, R.; Ohshima, T.; Shirasawa, S.; Tsunoda, T.
    • Journal Title

      Anticancer research

      Volume: 38 Issue: 7 Pages: 4247-4256

    • DOI

      10.21873/anticanres.12721

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05846, KAKENHI-PROJECT-17H03972, KAKENHI-PROJECT-18K07215
  • [Journal Article] The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation.2018

    • Author(s)
      Naemura M, Kuroki M, Tsunoda T, Arikawa N, Sawata Y, Shirasawa S, Kotake Y.
    • Journal Title

      Anticancer Res

      Volume: 38 Pages: 77-81

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Journal Article] Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line2018

    • Author(s)
      Inozume T, Tsunoda T, Morisaki T, Harada K, Shirasawa S, Kawamura T
    • Journal Title

      Journal of Dermatology

      Volume: 45 Issue: 12 Pages: 1434-1439

    • DOI

      10.1111/1346-8138.14651

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10148, KAKENHI-PROJECT-18K07215
  • [Journal Article] A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.2018

    • Author(s)
      Okamoto H, Matsukawa T, Doi S, Tsunoda T, Sawata Y, Naemura M, Ohnuki K, Shirasawa S, Kotake Y
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 442(1-2) Issue: 1-2 Pages: 39-45

    • DOI

      10.1007/s11010-017-3191-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07184, KAKENHI-PROJECT-18K07215
  • [Journal Article] The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation2018

    • Author(s)
      Naemura M, Kuroki M, Tsunoda T, Arikawa N, Sawata Y, Shirasawa S, Kotake Y.
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 1 Pages: 77-81

    • DOI

      10.21873/anticanres.12194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] Zfat expression in ZsGreen reporter gene knoc;in mice: Implications for a novel function of Zfat in definitive erythropoiesis.2018

    • Author(s)
      Tsunoda T, Doi K, Ishikura S, Luo H, Nishi K, Matsuzaki H, Koyanagi M, Tanaka Y, Okamura T, Shirasawa S
    • Journal Title

      Int J Mol Med.

      Volume: 42 Pages: 2595-2603

    • DOI

      10.3892/ijmm.2018.3806

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08166, KAKENHI-PROJECT-18K07215
  • [Journal Article] Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS2017

    • Author(s)
      Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L, Baillie GS, Sakata T, Shirasawa S, Tsunoda T.
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 7 Pages: 3833-3839

    • DOI

      10.21873/anticanres.11762

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line2017

    • Author(s)
      Nishi Kensuke、Iwaihara Yuri、Tsunoda Toshiyuki、Doi Keiko、Sakata Toshifumi、Shirasawa Senji、Ishikura Shuhei
    • Journal Title

      Cell Death & Disease

      Volume: 8 Issue: 12 Pages: 3218-3231

    • DOI

      10.1038/s41419-017-0006-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids2017

    • Author(s)
      12.Nishi K, Luo H, Nakabayashi K, Doi K, Ishikura S, Iwaihara Y, Yoshida Y, Tanisawa K, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M, Sakata T, Shirasawa S, Tsunoda T
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 7 Pages: 3855-3862

    • DOI

      10.21873/anticanres.11765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H01872, KAKENHI-PROJECT-15K06847
  • [Journal Article] The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.2016

    • Author(s)
      Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura T, Tsunoda T, Shirasawa S.
    • Journal Title

      J Biol Chem.

      Volume: 291(29) Issue: 29 Pages: 15282-91

    • DOI

      10.1074/jbc.m116.723734

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
  • [Journal Article] Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.2016

    • Author(s)
      Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, Kawai T, Tanaka Y, Iwaihara Y, Luo H, Nishi K, Okamura T, Shirasawa S.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1859(11) Issue: 11 Pages: 1398-1410

    • DOI

      10.1016/j.bbagrm.2016.08.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
  • [Journal Article] Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells.2016

    • Author(s)
      Luo H, Umebayashi M, Doi K, Morisaki T, Shirasawa S, Tsunoda T.
    • Journal Title

      Anticancer Res.

      Volume: 36(7) Pages: 3585-9

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture2016

    • Author(s)
      Naemura M, Tsunoda T, Inoue Y, Okamoto H, Shirakawa S, and Kotake Y
    • Journal Title

      Molecular and cellular biochemistry.

      Volume: 412 Issue: 1-2 Pages: 141-146

    • DOI

      10.1007/s11010-015-2618-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26430127, KAKENHI-PROJECT-15K06847
  • [Journal Article] Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.2016

    • Author(s)
      Lapa GB, Tsunoda T, Shirasawa S, Baryshnikova MA, Evseev GG, Afanasyeva DA, Chigorina EA.
    • Journal Title

      Chem Biol Drug Des.

      Volume: 87(4) Issue: 4 Pages: 575-82

    • DOI

      10.1111/cbdd.12691

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.2015

    • Author(s)
      Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.
    • Journal Title

      J Cell Biochem.

      Volume: 16(1) Issue: 1 Pages: 149-57

    • DOI

      10.1002/jcb.24954

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24501322, KAKENHI-PROJECT-24590465, KAKENHI-PROJECT-15K08166
  • [Journal Article] Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.2015

    • Author(s)
      Tsunoda T, Ishikura S, Doi K, Iwaihara Y, Hidesima H, Luo H, Hirose Y, Shirasawa S.
    • Journal Title

      Anticancer Res.

      Volume: 35(8) Pages: 4453-9

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.2015

    • Author(s)
      Iwaihara Y, Ishikura S, Doi K, Tsunoda T, Fujimoto T, Okamura T, Shirasawa S.
    • Journal Title

      Anticancer Res.

      Volume: 35(8) Pages: 4419-23

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Journal Article] Oncogenic Ras influences the expression of multiple lncRNAs.2014

    • Author(s)
      Kotake Y, Naemura M, Kitagawa K, Niida H, Tsunoda T, Shirasawa S, Kitagawa M.
    • Journal Title

      Cytotechnology.

      Volume: Dec.14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Journal Article] Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.2014

    • Author(s)
      Tsunoda T, Ishikura S, Doi K, Matsuzaki H, Iwaihara Y, Shirasawa S.
    • Journal Title

      Anticancer Res.

      Volume: 34(8) Pages: 4551-5

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013

    • Author(s)
      Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e76254-e76254

    • DOI

      10.1371/journal.pone.0076254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590465
  • [Journal Article] Roles of ZFAT in haematopoiesis, angiogenesis and cancer development.2013

    • Author(s)
      Tsunoda T, Shirasawa S.
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 2833-2837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Journal Article] Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013

    • Author(s)
      Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T and Shirasawa S
    • Journal Title

      PLoS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Journal Article] KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.2012

    • Author(s)
      Ota T, Doi K, Fujimoto T, Tanaka Y, Ogawa M, Matsuzaki H, Kuroki M, Miyamoto S, Shirasawa S, Tsunoda T.
    • Journal Title

      Anticancer Res.

      Volume: 32 Pages: 2271-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Journal Article] Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.2012

    • Author(s)
      Tsunoda T.
    • Journal Title

      Mol Cancer

      Volume: 11(1) Issue: 1 Pages: 46-46

    • DOI

      10.1186/1476-4598-11-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24501322, KAKENHI-PROJECT-24590465
  • [Journal Article] ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.2012

    • Author(s)
      Yoshida Y, Tsunoda T, Doi K, Fujimoto T, Tanaka Y, Ota T, Ogawa M, Matsuzaki H, Kuroki M, Iwasaki A, Shirasawa S.
    • Journal Title

      Anticancer Res.

      Volume: 32 Pages: 2301-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Patent] ピラゾール誘導体及び医薬組成物2020

    • Inventor(s)
      白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
    • Industrial Property Rights Holder
      白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-017307
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Patent] フェニルテトラヒドロピリドインドール誘導体及び医薬組成物2018

    • Inventor(s)
      白澤 専二、角田 俊之、大嶋 孝志、矢崎 亮
    • Industrial Property Rights Holder
      白澤 専二、角田 俊之、大嶋 孝志、矢崎 亮
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-147801
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Patent] 変異KRAS関連シグナル阻害用組成物2017

    • Inventor(s)
      白澤専二、角田俊之
    • Industrial Property Rights Holder
      白澤専二、角田俊之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-140139
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] 腫瘍-間質相互作用におけるMMP-2制御を介した腫瘍細胞上のemmprinと線維芽細胞上のCD73の重要性2022

    • Author(s)
      青木光希子、古賀佳織、鍋島一樹、角田俊之、濱崎慎
    • Organizer
      第26回 日本バイオ治療法学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07110
  • [Presentation] Growth of Tumor with Mutated-KRAS Related Signals are inhibited by a dual VDAC1 and KDELR1 regulator.2021

    • Author(s)
      Tsunoda T and Shirasawa S.
    • Organizer
      The Third RAS Initiative Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07161
  • [Presentation] KRASが誘導する発癌性ROSはVDAC1およびKDELR1の2重調節剤により抑制される。2021

    • Author(s)
      角田俊之, 西憲祐, 白澤専二.
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K07161
  • [Presentation] VDACおよびKDELRを標的とする低分子化合物STAR2は変異KRAS関連シグナルを抑制する.2020

    • Author(s)
      角田俊之, 橋本小百合, 永井正義, 西憲祐, 石倉周平,白澤専二.
    • Organizer
      第24回バイオ治療法研究会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 変異KRAS関連シグナルが活性化した癌細胞の増殖はVDAC1およびKDELR1の2重調節剤により抑制される.2020

    • Author(s)
      角田俊之, 西憲祐, 白澤専二
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 難治性腫瘍に対する副作用の少ない抗がん剤2020

    • Author(s)
      角田俊之,
    • Organizer
      2020イノベーションジャパン
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 変異KRAS関連シグナルが活性化した癌細胞株の増殖を抑制する低毒性化合物2019

    • Author(s)
      角田俊之, 西憲祐, 白澤専二
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 変異KRASはTNK細胞の腫瘍内浸潤とCD155依存的な免疫逃避を誘導する.2019

    • Author(s)
      角田俊之, 西憲祐, 石倉周平, 梅林雅代, 森崎隆, 猪爪隆史, 衣笠哲史, 青木光希子, 二村聡, スウェイン・アンソニー, 吉田陽一郎, 長谷川傑, 鍋島一樹, 坂田俊文, 白澤専二.
    • Organizer
      第23回バイオ治療法研究会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 変異KRASはTNK細胞の腫瘍内浸潤とCD155依存的な免疫逃避を誘導する2019

    • Author(s)
      角田俊之、西憲祐、石倉周平、梅林雅代、森崎隆、猪爪隆史、衣笠哲史、青木光希子、二村聡、スウェイン アンソニー、吉田陽一郎、長谷川傑、鍋島一樹、坂田俊文、白澤専二
    • Organizer
      第23回バイオ治療研究会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10659
  • [Presentation] 難治性腫瘍に対する副作用のない抗がん剤2019

    • Author(s)
      角田 俊之
    • Organizer
      2019イノベーションジャパン
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] Inhibition of PDE4 Triggers Luminal Apoptosis in Human Colorectal Cancer Spheroids.2018

    • Author(s)
      Toshiyuki Tsunoda.
    • Organizer
      Gordon Research Conference: Cyclic Nucleotide Phosphodiesterases. Newry, ME, US. June 10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] KRAS変異大腸癌細胞塊とCytokine-activated killer細胞の共培養系におけるCD155/TIGIT経路の役割の解析2018

    • Author(s)
      角田俊之, 西憲祐, 羅昊, 梅林雅代, 森崎隆, 白澤専二
    • Organizer
      第22回バイオ治療法研究会学術集会,東京,12月8日
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 3-deaza-cytarabineは3次元浮遊培養において変異KRAS陽性大腸癌細胞塊の増殖を抑制する2018

    • Author(s)
      角田俊之, 西憲祐, 白澤専二
    • Organizer
      第77回日本癌学会学術総会,大阪,9月27-29日
    • Data Source
      KAKENHI-PROJECT-18K07215
  • [Presentation] 三次元共培養法を用いた、KRAS変異大腸癌に対するCytokine-activated killer細胞と免疫チェックポイント阻害薬併用効果の検討2017

    • Author(s)
      西 憲祐、羅 昊、梅林 雅代、森崎 隆、白澤 専二、角田 俊之
    • Organizer
      第21回バイオ治療法研究会学術集会
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] PDE4 阻害剤アプレミラストは変異KRAS 陽性大腸癌細胞株にアポトーシスを誘導する.2017

    • Author(s)
      角田俊之, 白澤専二
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] レスベラトロールはAKTを脱リン酸化しBRAF変異メラノーマのベムラフェニブ耐性化を抑制する2016

    • Author(s)
      角田俊之, 白澤専二
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] PDE4阻害剤Apremilastの抗腫瘍効果の検討2016

    • Author(s)
      羅 昊、西 憲祐、角田 俊之、白澤 専二
    • Organizer
      第20回バイオ治療法研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-12-10
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] ALPK2のQ1853E変異は大腸癌の造腫瘍活性を促進する2016

    • Author(s)
      西 憲祐、羅 昊、角田 俊之、白澤 専二
    • Organizer
      第20回バイオ治療法研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-12-10
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] 変異KRAS制御シグナル関連分子を標的とする薬剤をスクリーニングするための3次元浮遊培養システムの構築2015

    • Author(s)
      角田俊之, 白澤専二
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] 3次元特異的変異KRAS制御分子KRAPの造腫瘍メカニズムの解明2015

    • Author(s)
      角田俊之,土井佳子, 白澤専二
    • Organizer
      第19回バイオ治療法研究会学術集会
    • Place of Presentation
      東京 東京理科大学 森戸記念館
    • Year and Date
      2015-12-05
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] 大腸癌造腫瘍能におけるALPK2遺伝子変異の機能的解析2015

    • Author(s)
      角田俊之, 新井冨生、森聖二郎、沢辺元司、村松正明、田中雅嗣、白澤専二
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京 新宿 京王プラザホテル
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-15K06847
  • [Presentation] 膵臓癌のジェムシタビン耐性化には3次元特異的変異KRAS制御分子群が関与する2014

    • Author(s)
      角田俊之, 佐々木隆光, 土井佳子, 石倉周平, 白澤専二
    • Organizer
      第18回バイオ治療法研究会学術集会
    • Place of Presentation
      高松
    • Year and Date
      2014-12-13
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] 大腸癌スフェロイドにおける変異KRASカスケードの解明とその応用2014

    • Author(s)
      角田俊之, 白澤専二.
    • Organizer
      第2回細胞凝集研究会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] 変異KRASが制御する3次元特異的癌増殖経路阻害のためのドラッグスクリーニング法の開発2014

    • Author(s)
      角田俊之, 土井佳子, 石倉周平, 白澤専二.
    • Organizer
      化学療法基盤支援活動第3回シンポジウム
    • Place of Presentation
      名護
    • Year and Date
      2014-05-12
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進2014

    • Author(s)
      土井佳子、石倉周平、岡村匡史、角田俊之、田中陽子、白澤専二
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      船堀
    • Year and Date
      2014-11-21
    • Data Source
      KAKENHI-PROJECT-24590465
  • [Presentation] 大腸癌における3次元特異的変異KRAS制御microRNAの解析2013

    • Author(s)
      角田俊之, 土井佳子, 石倉周平, 白澤専二
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] PDE4の抑制は3次元大腸クリプトモデルにおいてアポトーシスとAKTの脱リン酸化を誘導する.2013

    • Author(s)
      角田俊之, 白澤専二
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] 転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明2013

    • Author(s)
      土井佳子、小川雅弘、岡村匡史、石倉周平、角田俊之、田中陽子、白澤専二
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24590465
  • [Presentation] 変異KRAS制御ALPK2は3次元大腸クリプトモデルにおいてアポトーシスとDNA修復関連遺伝子の発現を誘導する2012

    • Author(s)
      角田俊之
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌・ホテルロイトン札幌
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] Three dimensional(3-D) culture model showing pre-malignant state of prostatic cell.2007

    • Author(s)
      Tsunoda, T, Naito, S
    • Organizer
      The 24th Korea-Japan Urological Congress.
    • Place of Presentation
      Cheoungju, Korea
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19791114
  • [Presentation] Gen expression profiling of prostatic epithelial cells in two-dimensional versus three-dimensional cultures2007

    • Author(s)
      Tsunoda, T, Inokuchi, J, Tyson, DR, Naito, S, Ornstein, DK
    • Organizer
      The 102nd annual meeting AUA 2007
    • Place of Presentation
      Anaheim, USA
    • Year and Date
      2007-05-19
    • Data Source
      KAKENHI-PROJECT-19791114
  • [Presentation] 腺房を構築する前立腺3次元培養モデルシステムの開発とその特性2007

    • Author(s)
      角田俊之、内藤誠二
    • Organizer
      第16回泌尿器科分子・綱胞研究会
    • Place of Presentation
      福岡
    • Year and Date
      2007-02-23
    • Data Source
      KAKENHI-PROJECT-19791114
  • [Presentation] The dysregulation of three-dimensional specific genes play a significant role in prostate cancer debelopment.2007

    • Author(s)
      Tsunoda, T, Inokuchi, J, Tyson, DR, Naito, S, Ornstein, DK
    • Organizer
      7th World Basic Urological Research Congress.
    • Place of Presentation
      Dublin, lreland
    • Year and Date
      2007-09-27
    • Data Source
      KAKENHI-PROJECT-19791114
  • [Presentation] 腺房を構築する正常前立腺上皮3次元培養細胞のIn sihco解析.2007

    • Author(s)
      角田俊之、内藤誠二
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19791114
  • [Presentation] 大腸癌spheroidに対するPDE4阻害剤の効果検討

    • Author(s)
      角田俊之, 太田岳晴, 土井佳子, 石倉周平, 白澤専二
    • Organizer
      第17回バイオ治療法研究会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] 変異KRAS陽性癌を標的とする薬剤開発のためのスクリーニングシステム

    • Author(s)
      角田俊之, 白澤専二.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24501322
  • [Presentation] KRAS制御分子ALPK2の造腫瘍メカニズムの解析

    • Author(s)
      角田俊之, 土井佳子, 石倉周平, 白澤専二
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      船堀
    • Year and Date
      2014-11-19 – 2014-11-22
    • Data Source
      KAKENHI-PROJECT-24501322
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