Okamoto Akiko 岡本晶子 (須賀晶子)

… Alternative Names

須賀

須賀晶子スガアキコ

SUGA Akiko 須賀晶子

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Researcher Number	70450400
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 特任講師 2025: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2024: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 2016: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 2015: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 2012: 独立行政法人理化学研究所, 網膜再生医療研究開発プロジェクト, 研究員 2009 – 2011: The Institute of Physical and Chemical Research, 網膜再生医療研究チーム, 研究員 2008: The Institute of Physical and Chemical Research, 中川独立主幹研究ユニット, ユニット研究員 2007: The Institute of Physical and Chemical Research, 中川独立主幹研究ユニット, ユニット研究員
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology / Neurochemistry/Neuropharmacology / Neuroscience in general
Keywords	Principal Investigator 網膜 / 遺伝性網膜疾患 / 再生 / ゲノム編集 / 病態解析 / 動物モデル / 疾患モデル動物 / 細胞増殖 / 神経 / ミュラーグリア細胞 … More / スプライシング / 構造変異 / 有害変異 / ゲノム解析 / プロテオーム解析 / 分子シャペロン / 視細胞 / シャペロニン / 疾患モデルマウス / レーベル黒内障 / モデル動物 / 分子生物学 / シナプス / ノックインマウス / 全ゲノム配列解析 / 変性 / 機能解析 / 変異 / 全ゲノム解析 / 全エクソーム解析 / 遺伝性疾患 / アデノ随伴ウイルス / 傷害 / 変性モデル / グリア細胞 / 神経幹細胞 / マウス系統 / ミュラーグリア / 前駆細胞 / LIMホメオドメイン型転写因子 / 細胞形態 / ニワトリ / 時期特異的遺伝子導入 / 発生 / 障害 / 転写因子 / 樹状突起形態 / サブタイプ / ニワトリ胚 / 神経発生 Less

Evaluation of structural variants and splice variants associated with IRDPrincipal Investigator
- Principal Investigator
  
  岡本晶子 (須賀)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
CCT2複合ヘテロ変異による網膜変性モデルマウスの病態と網羅的タンパク質定量解析Principal Investigator
- Principal Investigator
  
  岡本晶子 (須賀)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
in vivo and in vitro analysis of LRRTM4 mutation associated with dominant-inherited macular degeneration.Principal Investigator
- Principal Investigator
  
  Okamoto Akiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Induction of Muller glia-derived retinal regeneration by expressing regeneration promoting genesPrincipal Investigator
- Principal Investigator
  
  Okamoto Akiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Screening and functional screening of the genes which regulate the proliferation of Muller glia in damaged retina.Principal Investigator
- Principal Investigator
  
  SUGA Akiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research
LIM-homeobox transcription factors regulate neuronal dendritic morphogenesis in subtype-specific manner.Principal Investigator
- Principal Investigator
  
  SUGA Akiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Handbook of Laboratory Animal Science: Essential Principles and Practices2021
- Author(s)
  Akiko Suga and Takeshi Iwata (Edited by Jann Hau and Steven J. Schapiro)
- Total Pages
  1016
- Publisher
  CRC Press, Taylor & Francis Group
- ISBN
  9781138341807
- Data Source
  KAKENHI-PROJECT-18K09432
[Book] 臨床応用に向けた疾患シーケンス解析(遺伝子医学MOOK34号)2018
- Author(s)
  須賀晶子・吉武和敏・岩田岳
- Total Pages
  228
- Publisher
  メディカルドゥ
- ISBN
  4944157282
- Data Source
  KAKENHI-PROJECT-18K09432
[Book] 網膜の幹細胞再生医療叢書 4 巻2013
- Author(s)
  須賀晶子
- Data Source
  KAKENHI-PROJECT-22700403
[Book] 再生医療叢書　4巻　上皮・感覚器　網膜の幹細胞2013
- Author(s)
  須賀晶子
- Total Pages
  232
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22700403
[Journal Article] A homozygous structural variant of RPGRIP1 is frequently associated with achromatopsia in Japanese patients with IRD2024
- Author(s)
  Akiko Suga, Kei Mizobuchi, Taiga Inooka, Kazutoshi Yoshitake, Naoko Minematsu, Kazushige Tsunoda, Kazuki Kuniyoshi, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Takaaki Hayashi, Shinji Ueno, Takeshi Iwata
- Journal Title
  
  Genetics in Medicine Open
  
  Volume: - Pages: 101843-101843
- DOI
  10.1016/j.gimo.2024.101843
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09689, KAKENHI-PROJECT-21K09712
[Journal Article] 遺伝性網膜疾患のゲノム解析2023
- Author(s)
  須賀晶子・吉武和敏・岩田岳
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 67-72
- Data Source
  KAKENHI-PROJECT-18K09432
[Journal Article] Genetic characterization of 1210 Japanese pedigrees with inherited retinal diseases by whole‐exome sequencing2022
- Author(s)
  Suga Akiko、Yoshitake Kazutoshi、Fukuchi Takeo、Hatase Tetsuhisa、Horiguchi Masayuki、Shimada Yoshiaki、Tanikawa Atsuhiro、Yamamoto Shuichi、Miura Gen、Ito Nana、Murakami Akira、Fujimaki Takuro、Hotta Yoshihiro、Tanaka Koji、Iwata Takeshi、他
- Journal Title
  
  Human Mutation
  
  Volume: 43 Issue: 12 Pages: 2251-2264
- DOI
  10.1002/humu.24492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09825, KAKENHI-PROJECT-21K09756, KAKENHI-PROJECT-22K09764, KAKENHI-PROJECT-22K09788, KAKENHI-PROJECT-22K09825, KAKENHI-PROJECT-18K09432, KAKENHI-PROJECT-20K09818
[Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022
- Author(s)
  Pan Yang、Suga Akiko、Kimura Itaru、Kimura Chojiro、Minegishi Yuriko、Nakayama Mao、Yoshitake Kazutoshi、Iejima Daisuke、Minematsu Naoko、Yamamoto Megumi、Mabuchi Fumihiko、Takamoto Mitsuko、Shiga Yukihiro、Araie Makoto、Kashiwagi Kenji、Aihara Makoto、Nakazawa Toru、Iwata Takeshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 21
- DOI
  10.1172/jci153589
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09689, KAKENHI-PROJECT-22K09787, KAKENHI-PROJECT-20K09786, KAKENHI-PROJECT-20K18366
[Journal Article] Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in?vitro2021
- Author(s)
  Pan Yang、Iejima Daisuke、Nakayama Mao、Suga Akiko、Noda Toru、Kaur Inderjeet、Das Taraprasad、Chakrabarti Subhabrata、Guymer Robyn H.、DeAngelis Margaret M.、Yamamoto Megumi、Baird Paul N.、Iwata Takeshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100456-100456
- DOI
  10.1016/j.jbc.2021.100456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432, KAKENHI-PROJECT-20K18366
[Journal Article] Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.2020
- Author(s)
  Li H, Yuan S, Minegishi Y, Suga A, Yoshitake K, Sheng X, Ye J, Smith S, Bunkoczi G, Yamamoto M, Iwata T
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 3 Pages: 444-458
- DOI
  10.1093/hmg/ddz311
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432, KAKENHI-PROJECT-17H06276
[Journal Article] LRRTM4-C538Y novel gene mutation is associated with hereditary macular degeneration with novel dysfunction of ON-type bipolar cells2018
- Author(s)
  Yuichi Kawamura, Akiko Suga, Takuro Fujimaki, Kazutoshi Yoshitake, Kazushige Tsunoda, Akira Murakami, Takeshi Iwata
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Pages: 893-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09432
[Journal Article] Identification of novel mutations in the LRR-cap domain of C21orf2 in Japanese patients with retinitis pigmentosa and cone-rod dystrophy.2016
- Author(s)
  Suga A, Mizota A, Kato M, Kuniyoshi K, Yoshitake K, Sultan W, Yamazaki M, Shimomura Y, Ikeo K, Tsunoda K, Iwata T.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 57 Issue: 10 Pages: 4255-4263
- DOI
  10.1167/iovs.16-19450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293377, KAKENHI-PROJECT-15K10914
[Journal Article] 網膜再生とwntシグナル2010
- Author(s)
  須賀晶子
- Journal Title
  
  医学の歩み
  
  Volume: 233 Pages: 1037-1043
- Data Source
  KAKENHI-PROJECT-22700403
[Journal Article] 網膜再生とwnt シグナル2010
- Author(s)
  須賀晶子、高橋政代
- Journal Title
  
  医学の歩み
  
  Volume: 233巻10号 Pages: 1037-1043
- Data Source
  KAKENHI-PROJECT-22700403
[Journal Article] LIM family transcription factors regulate the subtype-specific morphogenesis of retinal horizontal cells at post-migratory stages2009
- Author(s)
  Akiko Suga, Masanori Taira, Shinichi Nakagawa
- Journal Title
  
  Developmental Biology 330
  
  Pages: 318-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700313
[Journal Article] 網膜再生とWntシグナル
- Author(s)
  須賀晶子、高橋政代
- Journal Title
  
  医学のあゆみ (印刷中)
- Data Source
  KAKENHI-PROJECT-19700313
[Patent] 細胞膜透過性ダンベル型rna およびその製造方法2011
- Inventor(s)
  阿部洋 , 伊藤嘉浩, 阿部奈保子, 烏田美和子, 中嶋裕子, 須賀晶子, 高橋政代
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2011-03-11
- Overseas
- Data Source
  KAKENHI-PROJECT-22700403
[Presentation] The whole exome and genome analysis for inherited retinal diseases in Japanese population2023
- Author(s)
  Akiko Suga
- Organizer
  ISER2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] 劣性遺伝性視神経萎縮症の新規原因遺伝子MCAT変異の同定と機能解析2020
- Author(s)
  須賀　晶子
- Organizer
  第68回日本臨床視覚電気生理学会
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] Genome-edited mouse model with Lrrtm4 mutation found in human macular dystrophy patients, showed light-induced photoreceptor degeneration.2019
- Author(s)
  Akiko Suga
- Organizer
  ARVO 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] 家族性視神経萎縮症の新規原因遺伝子同定と機能解析2019
- Author(s)
  須賀晶子
- Organizer
  第12回Retina Research Meeting
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] 劣性遺伝性視神経萎縮症の新規原因遺伝子同定と機能解析2019
- Author(s)
  須賀晶子
- Organizer
  第24回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] Novel mutation in LRRTM4 is associated with dominantly inherited macular dystrophy with reduced ON-bipolar cell response.2018
- Author(s)
  Akiko Suga, Yuichi Kawamura, Kazutoshi Yoshitake, Kazushige Tsunoda, Akira Murakami, Taheshi Iwata
- Organizer
  ARVO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09432
[Presentation] Chracterization and Whole-Genome Analysis of Cynomolgus Monkeys with Hereditary Macular Drusen.2017
- Author(s)
  Akiko Suga, Mao Nakayama, Zai-Long Chi, Atsushi Mizota, Nobuhiro Shimozawa, Kazutoshi Yoshitake, Takeshi Iwata
- Organizer
  ARVO 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] Characterization and whole genome analysis of cynomolgus monkeys with hereditary macular drusen2016
- Author(s)
  Akiko Suga, Mao Nakayama, Zai-Long Chi, Nobuhiro Shimozawa, Kazutoshi Yoshitake, Takeshi Iwata
- Organizer
  XXII Biennial Meeting of the International Society for Eye Research
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] Identification of novel mutations in C21ORF2 from Japanese patients with early-onset retinitis pigmentosa.2016
- Author(s)
  Akiko Suga, Mitsuhiro Kato, Kazutoshi Yoshitake, Astushi Mizota, Kazuho Ikeo, Takeshi Iwata
- Organizer
  13th International Congress of Human Genetics (ICHG2016)
- Place of Presentation
  京都国際会館
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] 網膜色素変性と錐体杆体ジストロフィーそれぞれの患者から見つかった繊毛遺伝子C21orf2の新規変異2016
- Author(s)
  須賀晶子、溝田淳、加藤光広、国吉一樹、吉武和敏、William Sultan、山崎正志、下村嘉一、池尾一穂、角田和繁、岩田岳
- Organizer
  第9回　Retina Research Meeting (RRM)
- Place of Presentation
  JPタワー　ホール＆カンファレンス
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] 全エクソン解析による網膜色素変性の新規原因遺伝子の同定と変異の機能解析2015
- Author(s)
  須賀　晶子
- Organizer
  国立病院機構東京医療センター　若手研究者発表会2015
- Place of Presentation
  東京医療センター
- Year and Date
  2015-11-02
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] Proliferation potential of Muller glia after retinal damage varies between mouse strains2015
- Author(s)
  Akiko Suga
- Organizer
  ARVO 2015
- Place of Presentation
  Colorado convention center (Denver, Colorado)
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10914
[Presentation] Genetic difference in the proliferation of Muller glia after retinal damage in adult mouse2012
- Author(s)
  Suga A, Sadamoto K, Fujii M, and Takahashi M.
- Organizer
  ISSCR (International Society for Stem Cell Research) 10^<th> Annual Meeting
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22700403
[Presentation] Genetic difference in the proliferation of Müller glia after retinal damage in adult mouse2012
- Author(s)
  Suga A, Sadamoto K, Fujii M, and Takahashi M
- Organizer
  ISSCR (International Society for Stem Cell Research) 10th Annual Meeting
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22700403
[Presentation] Genetic influence on Muller glial cell proliferation after retinal damage in adult mouse2011
- Author(s)
  Suga A, Sadamoto K, and Takahashi M.
- Organizer
  Stem Cells in Development and Disease 2011
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-22700403
[Presentation] Genetic influence on Muller glial cell proliferation after retinal damage in adult mouse2011
- Author(s)
  須賀晶子
- Organizer
  Stem Cells in Development and Disease 2011
- Place of Presentation
  Max Delbruck Centrum fur Molekulare Medizin,ドイツ、ベルリン
- Data Source
  KAKENHI-PROJECT-22700403
[Presentation] 網膜水平細胞の形態形成における、サブタイプ特異的な転写因子の機能解析2007
- Author(s)
  須賀晶子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会 (合同大合)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19700313
[Presentation] Screening for the genes regulating neurite extension in the chick retina2007
- Author(s)
  須賀晶子
- Organizer
  第2回フロンティア研究システム研究成果発表会
- Place of Presentation
  理化学研究所
- Data Source
  KAKENHI-PROJECT-19700313
[Presentation] 網膜水平細胞の形態形成における、サブタイプ特異的な転写因子の機能解析2007
- Author(s)
  須賀晶子中川真一
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19700313

1. IWATA Takeshi (90374157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 峯岸ゆり子 (20621832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HOTTA Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 溝田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamoto Akiko 岡本 晶子 (須賀 晶子)

須賀

須賀 晶子 スガ アキコ

SUGA Akiko 須賀 晶子

Research Projects

Research Products

Co-Researchers

Evaluation of structural variants and splice variants associated with IRDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CCT2複合ヘテロ変異による網膜変性モデルマウスの病態と網羅的タンパク質定量解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

in vivo and in vitro analysis of LRRTM4 mutation associated with dominant-inherited macular degeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of Muller glia-derived retinal regeneration by expressing regeneration promoting genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening and functional screening of the genes which regulate the proliferation of Muller glia in damaged retina.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LIM-homeobox transcription factors regulate neuronal dendritic morphogenesis in subtype-specific manner.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Handbook of Laboratory Animal Science: Essential Principles and Practices2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 臨床応用に向けた疾患シーケンス解析(遺伝子医学MOOK34号)2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 網膜の幹細胞 再生医療叢書 4 巻2013

Author(s)

Data Source

[Book] 再生医療叢書 4巻 上皮・感覚器 網膜の幹細胞2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A homozygous structural variant of RPGRIP1 is frequently associated with achromatopsia in Japanese patients with IRD2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 遺伝性網膜疾患のゲノム解析2023

Author(s)

Journal Title

Data Source

[Journal Article] Genetic characterization of 1210 Japanese pedigrees with inherited retinal diseases by whole‐exome sequencing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022

Author(s)

Journal Title

Okamoto Akiko 岡本晶子 (須賀晶子)

須賀晶子スガアキコ

SUGA Akiko 須賀晶子

[Book] 網膜の幹細胞再生医療叢書 4 巻2013

[Book] 再生医療叢書　4巻　上皮・感覚器　網膜の幹細胞2013