YOSHIHARA Daisuke 吉原大輔

Researcher Number	70454402
Other IDs
Affiliation (based on the past Project Information) *help	2017: 藤田保健衛生大学, 大学共同利用機関等の部局等, 助教 2015 – 2016: 藤田保健衛生大学, 疾患モデル教育研究センター, 助教 2012: 藤田保健衛生大学, 疾患モデル教育研究センター, 助教 2010 – 2011: 藤田保健衛生大学, 疾患モデル教育研究センター, 助手
Review Section/Research Field	Except Principal Investigator Experimental pathology
Keywords	Except Principal Investigator 多発性嚢胞腎 / 網羅的解析 / りん酸化タンパク質 / オミックス解析 / 塩分摂取 / 環境因子 / メタボローム / 多発性嚢胞腎症 / リン酸化 / プロテオミクス … More / メタボロミクス / 慢性腎臓病 / S6 / polycystic liver / polycystic kidney / 細胞内情報伝達 / 嚢胞 / 線維化 / 核内受容体 / 線維 / 細胞増殖 / SCD1 / TGF / mTOR / ERK / PPAR Less

Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-
- Principal Investigator
  
  Nagao Shizuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fujita Health University
A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade
- Principal Investigator
  
  SHIZUKO Nagao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fujita Health University

All 2017 2016 2015 2013 2012 2011 2010

All Journal Article Presentation Book

[Book] Annual Review 2013腎臓2013
- Author(s)
  長尾静子、釘田雅則、吉原大輔、山口太美雄　（分担）
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017
- Author(s)
  Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
- Journal Title
  
  Mol Cell Biol
  
  Volume: e-Pub Issue: 24
- DOI
  10.1128/mcb.00337-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08435, KAKENHI-PROJECT-15K09247, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465
[Journal Article] 多発性嚢胞腎発症のメカニズム2013
- Author(s)
  長尾静子、釘田雅則、吉原大輔、山口太美雄
- Journal Title
  
  Annual Review 2013 腎臓 (冨野康日己、柏原直樹、成田一衛編、中外医学社、東京)
  
  Pages: 101-108
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Structure and function of the pancreas in the polycystic kidney rat2012
- Author(s)
  Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H
- Journal Title
  
  Pancreas
  
  Volume: (in press) Issue: 8 Pages: 1292-8
- DOI
  10.1097/mpa.0b013e31824c12f9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590332, KAKENHI-PROJECT-22590351, KAKENHI-PROJECT-24591010
[Journal Article] Structure and Function of the Pancreas in the Polycystic Kidney Rat2012
- Author(s)
  Yi L., Naruse S., Furuya S., Yamamoto A., Nakakuki M., Nagao S., Yoshihara D., Ko S.B.H., Wei M, Kondo T., Ishiguro H.
- Journal Title
  
  Pancreas
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Global gene expression profiling in PPAR-γ agonist-treated kidneys in an orthologous rat model of human autosomal recessive polycystic kidney disease2012
- Author(s)
  Yoshihara D, Kugita M, Yamaguchi T, Aukema H.M., Kurahashi H., Morita M., Hiki Y., Calvet J.P., Wallace D.P., Toyohara T., TAbe T., Nagao S.
- Journal Title
  
  PPAR Research
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Animal models for human polycystic kidney disease.2012
- Author(s)
  Shizuko Nagao, Kugita M, Yoshihara D, Yamaguchi T.
- Journal Title
  
  Experimental Animal
  
  Volume: Vol.61, No.5 Pages: 477-488
- NAID
  10031121852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Global Gene ExpressionProfiling in PPAR-γ Agonist-TreatedKidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease.2012
- Author(s)
  Yoshihara D, Kugita M, Yamaguchi T, Aukema HM, Kurahashi H, Morita M, Hiki Y, Calvet JP, Wallace DP, Toyohara T, Abe T, Nagao S.
- Journal Title
  
  PPAR Res
  
  Volume: 2012 Pages: 695898-695898
- DOI
  10.1155/2012/695898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351, KAKENHI-PUBLICLY-23013019, KAKENHI-PROJECT-23659182, KAKENHI-PROJECT-24390085, KAKENHI-PROJECT-24790393
[Journal Article] Animal models for human polycystic kidney disease2012
- Author(s)
  Nagao S, Kugita M, Yoshihara D, Yamaguchi T
- Journal Title
  
  Exp Anim.
  
  Volume: 61(5) Pages: 477-88
- NAID
  10031121852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.2011
- Author(s)
  Buchholz B, Klanke B, Schley G, Bollag G, Tsai J, Kroening S, Yoshihara D, Wallace DP, Kraenzlin B, Gretz N, Hirth P, Eckardt KU, Bernhardt WM.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 26(11) Issue: 11 Pages: 3458-65
- DOI
  10.1093/ndt/gfr432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model2011
- Author(s)
  Toyohara T, Suzuki T, Akiyama Y, Yoshihara D, Takeuchi Y, Mishima E, Nagao S, Soga T, Abe T
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 15(5) Issue: 5 Pages: 676-87
- DOI
  10.1007/s10157-011-0467-4
- NAID
  10030340950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351, KAKENHI-PROJECT-22790144, KAKENHI-PROJECT-23590265
[Journal Article] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling.2011
- Author(s)
  Kugita M., Nishii K., Morita M., Yoshihara D., Kowa-Sugiyama H., Yamada K., Yamaguchi T., Wallace D.P., Calvet J.P., Kurahashi H., Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 300(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Yoshihara D, Kurahashi H, Morita M,Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 300(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Yoshihara D., Kurahashi H., Morita M., Kugita M., Hiki Y., Aukema HM., Yamaguchi T., Calvet JP., Wallace DP., Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 300(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling.2011
- Author(s)
  Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 300(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Polycystic kidney disease in Han : SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin.2010
- Author(s)
  Nagao S, Morita M, Kugita M, Yoshihara D, Yamaguchi T, Kurahashi H, Calvet JP, Wallace DP.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 299(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Polycystic kidney disease in Han : SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin.2010
- Author(s)
  Nagao S, Morita M, Kugita M, Yoshihara D, Yamaguchi T, Kurahashi H, Calvet JP, Wallace DP.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 299(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎症モデル動物の腎臓におけるレチノイドX受容体の解析2016
- Author(s)
  釘田雅則、吉原大輔、加藤由布、小木曽昇、下村恭代、西田修、長尾静子
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  神奈川県、川崎　　ミューザ川崎シンフォニーホール
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] Mitochondrial dysfunction contributes to cyst proliferation of autosomal dominant polycystic kidney disease.2016
- Author(s)
  Yu Ishimoto, Masaomi Nangaku, Shizuko Nagao, Daisuke Yoshihara, Masanori Kugita, Yoko Yoshida, Jing Zhou, Mike Murphy, Akira Shimizu, Reiko Inagi.
- Organizer
  The Asian Pacific Society of Nephrology
- Place of Presentation
  Perth, WA, Australia
- Year and Date
  2016-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] ミトコンドリア機能異常は多発性嚢胞腎の嚢胞形成に関与する2016
- Author(s)
  石本遊、南学正臣、吉原大輔、釘田雅則、長尾静子
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  神奈川県、横浜　パシフィコ横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] 多発性嚢胞腎症モデル動物の腎臓におけるRXRの発現と局在2016
- Author(s)
  吉原大輔、釘田雅則、長尾静子
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  神奈川県、横浜　パシフィコ横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] Beneficial effect of combined treatment of two somatostatin analogs in an orthologous model of human autosomal recessive polycystic kidney disease.2015
- Author(s)
  Yoshihara D, Kugita M, Sasaki M, Nishii K, Suzuki A, Higashihara E, Horie S, Yamaguchi T, Nagao S.
- Organizer
  1th ASPR Congress & the 118th Annual Meeting of the Japan Pediatric Society
- Place of Presentation
  Osaka, Japan
- Year and Date
  2015-04-15
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] 多発性嚢胞腎症のモデル動物であるPCKラットにおけるGi作動薬の病態進行抑制効果2015
- Author(s)
  釘田雅則、吉原大輔、西井一宏、鈴木敦詞、湯澤由紀夫、山口太美雄、堀江重郎、東原英二、長尾静子
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] であるPCKラットにおけるGi作動薬の病態進行2015
- Author(s)
  吉原大輔、釘田雅則、西井一宏、鈴木敦詞、湯澤由紀夫、東原英二、堀江重郎、山口太美雄、長尾静子
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] Expression and distribution of retinoid X receptor in rodent models of polycystic kidney disease.2015
- Author(s)
  Yoshihara D, Kugita M, Sasaki M, Nagao S.
- Organizer
  11th ASPR Congress & the 118th Annual Meeting of the Japan Pediatric Society
- Place of Presentation
  Osaka, Japan
- Year and Date
  2015-04-15
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] Retinoid X receptor pathway, a novel signaling cascade responsible for cystogenesis in three rodent models of polycystic kidney disease.2015
- Author(s)
  Yoshihara D, Kugita M, Aukema HM, Yamaguchi T, Nagao S.
- Organizer
  American Society of Nephrology Kidney Week 2015
- Place of Presentation
  San Diego, CA, U.S.A.
- Year and Date
  2015-11-03
- Data Source
  KAKENHI-PROJECT-15K08435
[Presentation] 多発性嚢胞腎の動物モデル2013
- Author(s)
  長尾静子 (枝澄香)、釘田雅則、吉原大輔、山口多美雄
- Organizer
  第60回日本実験動物学会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Ameliorative effect of telmisartan on fibrocystic liver disease progression in an orthologous rat model of human autosomal recessive polycystic kidney disease (ARPKD)2013
- Author(s)
  Daisuke Yoshihara, Masanori Kugita, Mai Sasaki, Shigeo Horie, Koichi Nakanishi, Takaaki Abe, Harold M. Aukema, Tamio Yamaguchi, Shizuko Nagao.
- Organizer
  World Congress of Nephrology 2013
- Place of Presentation
  Hong Kong, China
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] テルミサルタンによるヒト常染色体劣性多発性嚢胞腎症オーソログ遺伝子変異モデルにおける病態発現抑制効果2013
- Author(s)
  長尾静子(枝澄香)、吉原大輔、釘田雅則、佐々木麻衣、堀江重郎、中西浩一、阿部高明、山口太美雄
- Organizer
  第48回日本小児腎臓学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Ameliorative effect of telmisartan on fibrocystic liver disease progression in an orthologous rat model of human autosomal recessive polycystic kidney disease (ARPKD).2013
- Author(s)
  Daisuke Yoshihara, Masanori Kugita, Mai Sasaki, Shigeo Horie, Koichi Nakanishi, Takaaki Abe, Harold M. Aukema, Tamio Yamaguchi, Shizuko Nagao.
- Organizer
  World Congress of Nephrology2013
- Place of Presentation
  HongKong, China
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎の動物モデル.2013
- Author(s)
  長尾静子(枝澄香)、釘田雅則、吉原大輔、山口太美雄
- Organizer
  第60回日本実験動物学会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ラット多発性嚢胞腎におけるPPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング2012
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾静子 (枝澄香)
- Organizer
  第55回日本腎臓学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ラット多発性嚢胞腎における PPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング.2012
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾静子(枝澄香)
- Organizer
  第55回日本腎臓学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラットPCKにおけるテルミサルタンの病態発現抑制効果2012
- Author(s)
  吉原大輔、釘田雅則、山口太美雄、長尾静子 (枝澄香)
- Organizer
  第20回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎症モデル動物の腎臓におけるretinoid X receptor (RXR)の発現と局在2012
- Author(s)
  釘田雅則、吉原大輔、山口太美雄、長尾静子 (枝澄香)
- Organizer
  日本実験動物科学・技術九州2012
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎症モデル動物の腎臓における retinoid X receptor (RXR)の発現と局在2012
- Author(s)
  釘田雅則、吉原大輔、山口太美雄、長尾静子(枝澄香)
- Organizer
  日本実験動物科学・技術九州 2012
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Telmisartan ameliorates fibrocystic liver disease in PCK rats, an orthologous model of human ARPKD2012
- Author(s)
  Masanori Kugita, Daisuke Yoshihara, Shigeo Horie, Harold M Aukema, Tamio Yamaguchi, Shizuko Nagao
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞性疾患におけるPPARγ部分作動薬の治療効果2012
- Author(s)
  吉原大輔, 釘田雅則, 山口太美雄, 長尾静子 (枝澄香)
- Organizer
  第44回藤田医学会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Telmisartan Ameliorates Fibrocystic Liver Disease in an Orthologous Rat Model of Human ARPKD2012
- Author(s)
  Daisuke Yoshihara, Masanori Kugita, Shigeo Horie, Harold M. Aukema,Tamio Yamaguchi, Shizuko Nagao.
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Telmisartan ameliorates fibrocystic liver disease in PCK rats, an orthologous model ofhuman ARPKD.2012
- Author(s)
  Masanori Kugita, Daisuke Yoshihara,Shigeo Horie, Harold M Aukema, Tamio Yamaguchi, Shizuko Nagao
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞性疾患における PPARγ部分作動薬の治療効果2012
- Author(s)
  吉原大輔、釘田雅則、山口太美雄、長尾静子(枝澄香)
- Organizer
  第44回藤田医学会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラット PCKにおけるテルミサルタンの病態発現抑制効果.2012
- Author(s)
  吉原大輔、釘田雅則、山口太美雄、長尾静子(枝澄香)
- Organizer
  第20回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 網羅的遺伝子発現解析を用いた多発性嚢胞腎ラットPCKにおけるPPARγアゴニストによる治療機序の検証2011
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾枝澄香(静子)
- Organizer
  第19回嚢胞性腎疾患研究会
- Place of Presentation
  東京、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PPAE-γ agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Daisuke Yoshihara., Hiroki Kurahashi., Miwa Morita., Masanori Kugita., Yoshiyuki Hiki., Harold M.Aukema., Tamio Yamaguchi., James P.Calvet, Darren P.Wallace., Shizuko Nagao.
- Organizer
  World Congress of Nephrology 2011
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] RXR は嚢胞形成機序における共通の因子か?2011
- Author(s)
  釘田雅則、吉原大輔、山口太美雄、長尾枝澄香(静子)
- Organizer
  第43回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Global gene expression profiling in kidneys of PPAR-γ agonist-treated PCK rats, an orthologous model of human ARPKD.2011
- Author(s)
  Yoshihara D, Kugita M, Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T, Abe T, Nagao S.
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition 2011
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラット PCK の腎臓における PPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング2011
- Author(s)
  吉原大輔、釘田雅則、山口太美雄、倉橋浩樹、長尾枝澄香(静子)
- Organizer
  第43回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] RXRは嚢胞形成機序における共通の因子か?2011
- Author(s)
  釘田雅則、吉原大輔、山口太美雄、長尾枝澄香(静子)
- Organizer
  第43回藤田医学会総会
- Place of Presentation
  豊明、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎症モデルであるjckマウスの特徴2011
- Author(s)
  長尾枝澄香(静子)、吉原大輔、釘田雅則、森田美和、山口太美雄、Wallace Darren
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  東京、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Global gene expression profiling in kidneys of PPAR-gamma agonist-treated PCK rats, an orthologous model of human ARPKD2011
- Author(s)
  Yoshihara D., Kugita M., Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T., Abe T., Nagao S.
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Wallace Darren 多発性嚢胞腎症モデルであるj ckマウスの特徴.2011
- Author(s)
  長尾枝澄香(静子)、吉原大輔、釘田雅則、森田美和、山口太美雄
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラットPCKの腎臓におけるPPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング2011
- Author(s)
  吉原大輔、釘田雅則、山口太美雄、倉橋浩樹、長尾枝澄香(静子)
- Organizer
  第43回藤田医学会総会
- Place of Presentation
  豊明、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Metabolomic Profiling of the Autosomal Dominant Polycystic Kidney Disease Rat Model2011
- Author(s)
  Takafumi Toyohara, Takehiro Suzuki, Yasutoshi Akiyama, Daisuke Yoshihara, Eikan Mishima, Yoichi Takeuchi, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Metabolomic Profiling of the Autosomal Dominant Polycystic Kidney Disease Rat Model.2011
- Author(s)
  Takafumi Toyohara, Takehiro Suzuki,Yasutoshi Akiyama, Daisuke Yoshihara, Eikan Mishima, Yoichi Takeuchi, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition 2011
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 羅的遺伝子発現解析を用いた多発性嚢胞腎ラット PCK における PPAR-γアゴニストによる治療機序の検証2011
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾枝澄香(静子)
- Organizer
  第19回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト多発性嚢胞腎症のラットモデルにおけるPPAE-γアゴニストの治療効果2011
- Author(s)
  吉原大輔、倉橋浩樹、森田美和、釘田雅則、比企能之、Aukema Harold、山口太美雄、Calvet James、Wallace Darren、長尾枝澄香(静子)
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PPAR-γagonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.2011
- Author(s)
  Daisuke Yoshihara, Hiroki Kurahashi, M iwa Morita, Masano r i K ugit a, Yoshiyuki Hiki, Harold M Aukema, Tamio Yamaguchi, James P Calvet, Darren PWallace, Shizuko Nagao.
- Organizer
  World Congress of Nephrology 2011
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト多発性嚢胞腎症のラットモデルにおける PPAR-γアゴニストの治療効果2011
- Author(s)
  吉原大輔、倉橋浩樹、森田美和、釘田雅則、比企能之、Aukema Harold、山口太美雄、Calvet James、Wallace Darren、長尾枝澄香(静子)
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 常染色体劣性多発性嚢胞腎(ARPKD)モデルcpkマウスの尿細管上皮細胞における上皮間葉移行(EMT)2010
- Author(s)
  戸川寛子、中西浩一、島友子、佐古まゆみ、向山、宮嶋正康、野津寛大、吉原大輔、長尾静子、飯島一誠、吉川徳茂
- Organizer
  第45回日本小児腎臓病学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 非侵襲的拒絶反応診断法としてのFDG-PETの有用性の検討2010
- Author(s)
  森田美和、辻厚至、釘田雅則、吉原大輔、李小康、杉岡篤, 長尾静子
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PCKラットの腎臓と肝臓におけるPPAR-γアゴニストの治療効果2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、山口太美雄、倉橋浩樹、長尾静子
- Organizer
  第18回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト ARPKD と相同遺伝子変異を有する PCK rat における上皮間葉移行.2010
- Author(s)
  戸川寛子、中西浩一、島友子、佐古まゆみ、向山弘展、宮嶋正康、野津寛大、吉原大輔、長尾静子、飯島一誠、吉川徳茂
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 嚢胞性腎臓疾患モデルCyラットにおける嚢胞形成とRXRとの関連性についての検討2010
- Author(s)
  釘田雅則、西井一宏、森田美和、吉原大輔、山口太美雄、日下守、倉橋浩樹、長尾静子
- Organizer
  第42回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Thiazolidinedione Ameliorates Autosomal Recessive Polycystic Kidney and Liver Disease in the PCK Rat, an Orthologous Model of Human ARPKD.2010
- Author(s)
  Yoshihara D., Kurahashi H., Morita M., Kugita M., Hiki Y., Aukema H.M., Yamaguchi T., Calvet J.P., Wallace D.P., Nagao S.
- Organizer
  American Society of Nephrology 43rd Annual Meeting & Scientific Exposition
- Place of Presentation
  Denver, CO USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 嚢胞性腎臓疾患モデル Cy ラットにおける嚢胞形成と RXR との関連性についての検討.2010
- Author(s)
  釘田雅則、西井一宏、森田美和、吉原大輔、山口太美雄、日下守、倉橋浩樹、長尾静子
- Organizer
  第42回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PCK ラットの腎臓と肝臓における PPAR-γアゴニストの治療効果2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、山口太美雄、倉橋浩樹、長尾静子
- Organizer
  第18回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒトARPKDとオーソログな遺伝子変異モデルであるPCKラットの腎・肝組織における情報伝達系の検討2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、倉橋浩樹、山口太美雄、長尾静子
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Thiazolidinedione Ameliorates Autosomal Recessive Polycystic Kidney and Liver Disease in the PCK Rat, an Orthologous Model of Human ARPKD.2010
- Author(s)
  Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
- Organizer
  American Society of Nephrology 43rd Annual Meeting & Scientific Exposition.
- Place of Presentation
  Denver, CO USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 非侵襲的拒絶反応診断法としての FDG-PET の有用性の検討.2010
- Author(s)
  森田美和、辻厚至、釘田雅則、吉原大輔、李小康、杉岡篤, 長尾静子
- Organizer
  第57回日本実験動物学会総会.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト ARPKDとオーソログな遺伝子変異モデルである PCK ラットの腎・肝組織における情報伝達系の検討.2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、倉橋浩樹、山口太美雄、長尾静子
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラットモデル PCK の腎臓と肝臓における細胞情報伝達系の解析.2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、山口太美雄、倉橋浩樹、長尾静子
- Organizer
  第42回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 多発性嚢胞腎ラットモデルPCKの腎臓と肝臓における細胞情報伝達系の解析2010
- Author(s)
  吉原大輔、森田美和、釘田雅則、山口太美雄、倉橋浩樹、長尾静子
- Organizer
  第42回藤田医学会総会
- Place of Presentation
  豊明
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒトARPKDと相同遺伝子変異を有するPCK ratにおける上皮間葉移行2010
- Author(s)
  戸川寛子、中西浩一、島友子、佐古まゆみ、向山弘展、宮嶋正康、野津寛大、吉原大輔、長尾静子、飯島一誠、吉川徳茂
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 常染色体劣性多発性嚢胞腎(ARPKD)モデル cpk マウスの尿細管上皮細胞における上皮間葉移行(EMT).2010
- Author(s)
  戸川寛子、中西浩一、島友子、佐古まゆみ、向山弘展、宮嶋正康、野津寛大、吉原大輔、長尾静子、飯島一誠、吉川徳茂
- Organizer
  第45回日本小児腎臓病学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590351

1. SHIZUKO Nagao (20183527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 71 results
2. MASANORI Kugita (50440681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 62 results
3. KURAHASHI Hiroki (30243215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
4. MORITA Miwa (90329699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 32 results
5. YAGYU Shigeru (10200479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMAGUCHI Tamio (70536292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 52 results
7. HIKI Yoshiyuki (20156566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
8. Yuzawa Yukio (00191479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Suzuki Atsushi (90340265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. Saito Kuniaki (80262765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. NANGAKU Masaomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 石黒洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 近藤孝晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 武田憲彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIHARA Daisuke 吉原 大輔

Research Projects

Research Products

Co-Researchers

Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-

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A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade

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[Book] Annual Review 2013腎臓2013

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[Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017

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[Journal Article] 多発性嚢胞腎発症のメカニズム2013

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[Journal Article] Structure and function of the pancreas in the polycystic kidney rat2012

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[Journal Article] Structure and Function of the Pancreas in the Polycystic Kidney Rat2012

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[Journal Article] Global gene expression profiling in PPAR-γ agonist-treated kidneys in an orthologous rat model of human autosomal recessive polycystic kidney disease2012

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[Journal Article] Animal models for human polycystic kidney disease.2012

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NAID

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[Journal Article] Global Gene ExpressionProfiling in PPAR-γ Agonist-TreatedKidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease.2012

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DOI

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[Journal Article] Animal models for human polycystic kidney disease2012

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NAID

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[Journal Article] The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.2011

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[Journal Article] Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model2011

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NAID

Data Source

[Journal Article] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling.2011

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Data Source

[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011

Author(s)

Journal Title

Data Source

[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011

Author(s)

Journal Title

Data Source

YOSHIHARA Daisuke 吉原大輔