KITAHARA HIROKO 北原寛子

Researcher Number	70507053
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2018 – 2019: 金沢大学, 附属病院, 医員 2017: 金沢大学, 附属病院, 助教 2016: 金沢大学, 附属病院, 医員 2015: 金沢大学, 大学病院, 助教 2013 – 2014: 金沢大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Surgical dentistry Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator 口腔扁平上皮癌 / 上皮間葉移行 / 臨床腫瘍 / 微小管 / 口腔癌 / 微小管阻害薬 / 血小板 / β-catenin / E-cadherin Except Principal Investigator 臨床腫瘍 / 口腔癌 / PD-L1 / MMP

Analysis of Tumor Immunosuppressive Mechanisms in the Oral Cancer Invasive Microenvironment.
- Principal Investigator
  
  Nakamura Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanazawa University
Association analysis of microtubules and the mechanism of highly invasive acquisition in oral cancerPrincipal Investigator
- Principal Investigator
  
  Kitahara Hiroko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanazawa University
Elucidation of permeation, metastaticity acquisition mechanism due to the platelet in the tissue in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KITAHARA HIROKO
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanazawa University
Role of the adhesion molecules between the cell in invasion, the metastasis of oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KITAHARA HIROKO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanazawa University

All 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Selectively high efficacy of eribulin against high?grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck2019
- Author(s)
  Kobayashi Yutaka、Kitahara Hiroko、Hirai Mariko、Tanaka Akira、Jokaji Rei、Kobayashi Kazuhiko、Bou?Gharios George、Nakamura Hiroyuki、Kawashiri Shuichi
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 5064-5072
- DOI
  10.3892/ol.2019.10165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11869, KAKENHI-PROJECT-17K11870, KAKENHI-PROJECT-18K17221
[Journal Article] Clinicopathological Significace of the ET Axis in Human Oral Squamous Cell Carcinoma.2019
- Author(s)
  Miyazawa H, Kato K, Kobayashi Y, Hirai M, Kimura I, Kitahara H, Noguchi N, Nakamura H, Kawashiri S
- Journal Title
  
  Pathol Oncol Res.
  
  Volume: 25(3) Issue: 3 Pages: 1083-1089
- DOI
  10.1007/s12253-018-0514-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11870
[Journal Article] Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage.2018
- Author(s)
  Hira-Miyazawa M, Nakamura H, Hirai M, Kobayashi Y, Kitahara H, Bou-Gharios G, Kawashiri S.
- Journal Title
  
  Int J Oncol.
  
  Volume: 52 Pages: 379-388
- DOI
  10.3892/ijo.2017.4221
- NAID
  130007595071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05042, KAKENHI-PROJECT-17K11869, KAKENHI-PROJECT-17K11870, KAKENHI-PROJECT-18K17221, KAKENHI-PROJECT-19K21394
[Journal Article] 56POral squamous cell carcinoma cells were sensitized to cetuximab by Eribulin via induction of the mesenchymal-to-epithelial transition2017
- Author(s)
  Kitahara H.、Hirai M.、Kawashiri S.、Nakamura H.
- Journal Title
  
  Annals of Oncology
  
  Volume: 28 Pages: v14-v15
- DOI
  10.1093/annonc/mdx361.051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11869
[Journal Article] Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment.2017
- Author(s)
  Hirai M, Kitahara H, Kobayashi Y, Kato K, Bou-Gharios G, Nakamura H, Kawashiri S.
- Journal Title
  
  Int J Oncol
  
  Volume: 50 Issue: 1 Pages: 41-48
- DOI
  10.3892/ijo.2016.3785
- NAID
  120005973600
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05042, KAKENHI-PROJECT-26670861, KAKENHI-PROJECT-15K20510, KAKENHI-PROJECT-26463038, KAKENHI-PROJECT-17K11869
[Journal Article] 1721PThe role of PD-L1 in a high-grade invasive human oral squamous cell carcinoma microenvironment2017
- Author(s)
  Hirai M.、kitahara H.、Kobayashi Y.、Kawashiri S.、Nakamura H.
- Journal Title
  
  Annals of Oncology
  
  Volume: 28 Pages: v601-v602
- DOI
  10.1093/annonc/mdx391.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11869
[Journal Article] Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition.2016
- Author(s)
  Kitahara H, Hirai M, Kato K, Bou-Gharios G, Nakamura H, Kawashiri S.
- Journal Title
  
  Oncol Rep
  
  Volume: 36 Issue: 6 Pages: 3139-3144
- DOI
  10.3892/or.2016.5189
- NAID
  120005973603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05042, KAKENHI-PROJECT-26670861, KAKENHI-PROJECT-15K20510, KAKENHI-PROJECT-26463038
[Journal Article] Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2016
- Author(s)
  Ito Kimura, Hiroko Kitahara, Kazuhiro Ooi, Koroku Kato, Natsuyo Noguchi, Kunio Yoshizawa, Hiroyuki Nakamura, Shuichi Kawashiri
- Journal Title
  
  Oncology Letters
  
  Volume: 11 Issue: 1 Pages: 201-207
- DOI
  10.3892/ol.2015.3833
- NAID
  120005973602
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463038, KAKENHI-PROJECT-26463039, KAKENHI-PROJECT-15K20510, KAKENHI-PROJECT-25462882
[Journal Article] Prognostic value of vascular endothelial growth factor A and C in oral squamous cell carcinoma2014
- Author(s)
  Yanase M., Kato K., Yoshizawa K., Noguchi N., Kitahara H., Nakamura H
- Journal Title
  
  Journal of Oral pathology and medicine
  
  Volume: (in press) Issue: 7 Pages: 43-43
- DOI
  10.1111/jop.12167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24792195, KAKENHI-PROJECT-25462882, KAKENHI-PROJECT-25861923, KAKENHI-PROJECT-26463038
[Journal Article] Loss of claudin-7 is a negative prognostic factor for invasion andmetastasis in oral squamous cell carcinoma2013
- Author(s)
  Yoshizawa K., Nozaki S., Kato A., Hirai M., Yanase M., Yoshimoto T., KimuraI., Sugiura .S, Okamune A., Kitahara H., Noguchi N., Kato K., Ueki K., Kawashiri S
- Journal Title
  
  Oncology Report
  
  Volume: 29 Issue: 2 Pages: 445-450
- DOI
  10.3892/or.2012.2161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390382, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-24792193, KAKENHI-PROJECT-24792194, KAKENHI-PROJECT-24792195, KAKENHI-PROJECT-25861923
[Presentation] 重症型血友病Bの幼児の上顎骨に生じた血友病性偽腫瘍の1 例2019
- Author(s)
  北原寛子，加藤広禄，宮澤広樹，小林久乃，野口夏代，大井一浩，川尻秀一
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] 重症型血友病Bの幼児の上顎骨に生じた血友病性偽腫瘍の1 例2019
- Author(s)
  北原寛子，加藤広禄，小林一彦，川尻秀一
- Organizer
  第31回日本小児口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] エリブリンの高浸潤性頭頸部癌に対する選択的高感受性の検討2019
- Author(s)
  小林泰，中村博幸，北原寛子，川尻秀一
- Organizer
  第43回頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] 当科で治療を行った舌扁平上皮癌StageⅠ，Ⅱ症例における潜在的頸部リンパ節転移と病理組織学的因子との関係2019
- Author(s)
  加藤広禄，宮澤広樹，小林久乃，北原寛子，野口夏代，大井一浩，川尻秀一
- Organizer
  第43回頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] Perioperative Evaluation and Management of Obstructive Sleep Apnea after Mandibular Setback by Saggital Splitting Ramus Osteotomy2018
- Author(s)
  R.Jyokaji, K.Ooi, K.Ide, M.Ishimiya, Y.Kobayashi, H.Kitahara, N.Noguchi, K. katoh, H.Nakamura, S.Takamichi, M.Nakata, K.Kasahara, S.Kawashiri
- Organizer
  23rd International Conference on Oral and Maxillofacial Surgeon
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] The role of PD-L1 in a high-grade invasive human oral squamous cell carcinoma microenvironment2017
- Author(s)
  Hirai M, Kitahara H, Kobayashi Y, Nakamura H, Kawashiri S
- Organizer
  European Society for Medical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] Oral Squamous cell carcinoma cells were sensitized to cetuximab by Eribulin via inducation of the mesenchymal-to-epithelial transition2017
- Author(s)
  Kitahara H, Hirai M, Kobayashi Y, Nakamura H, Kawashiri S
- Organizer
  European Society for Medical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] Oral squamous cell carcinoma cells were sensitized to cetuximab by Eribulin via inducation of the mesenchymal-to-epithelial transition.2017
- Author(s)
  Kitahara H., Hirai M., Kobayashi Y., Kawashiri S and Nakamura H.
- Organizer
  European Society for Medical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11869
[Presentation] The role of PD-L1 in a high-grade invasive human oral squamous cell carcinoma microenvironment.2017
- Author(s)
  Hirai M., Kitahara H., Kobayashi Y., Kawashiri S and Nakamura H.
- Organizer
  European Society for Medical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11869
[Presentation] 口腔扁平上皮癌細胞のIndadopodia形成と癌関連線維芽細胞(CAF)との関連2017
- Author(s)
  加藤広禄、北原寛子、野口夏代、中村博幸、川尻秀一
- Organizer
  第41回頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] 舌に発生した平滑筋腫の1例2017
- Author(s)
  吉本泰祐、加藤広禄、本保敦志、北原寛子、大井一浩、中村博幸、川尻秀一
- Organizer
  第60回日本口腔科学会中部地方会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] 下顎下縁の歯牙様硬組織に起因した外歯瘻の1例2017
- Author(s)
  北原寛子、加藤広禄、小林一彦、川尻秀一
- Organizer
  第62回日本口腔外科学会総会学術大会
- Data Source
  KAKENHI-PROJECT-17K11870
[Presentation] 口腔扁平上皮癌細胞のInvadopodia形成と癌関連線維芽細胞(CAF)との関連2016
- Author(s)
  加藤広禄、宮澤広樹、加藤阿希、平井真理子、吉本泰祐、木村依世、北原寛子、野口夏代、中村博幸、川尻秀一
- Organizer
  第61日本口腔外科学会総会学術大会
- Place of Presentation
  幕張メッセ（千葉）
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] The regulation of PD-L1 expression at microenvironment of high grade invasive human oral squamous cell carcinoma2016
- Author(s)
  M Hirai, H Kitahara, I Kimura, K kato, G Bou-gharios, H nakamura, S kawashiri
- Organizer
  24th Biennial congress of the european association for cancer research
- Place of Presentation
  Manchester(UK)
- Year and Date
  2016-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] 薬剤関連顎骨壊死（MRONJ）の早期発見における bone scan index の有用性2016
- Author(s)
  野口夏代、平井真理子、加藤阿希、吉本泰祐、木村依世、北原寛子、大井一浩、加藤広禄、中村博幸、川尻秀一
- Organizer
  第61日本口腔外科学会総会学術大会
- Place of Presentation
  幕張メッセ（千葉）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] Eribulin differentiaes cetuximab resistant oral squamous cell carcinoma cells to sensitive by inducing mesenchymal-epithelial transition(MET)2016
- Author(s)
  H Kitahara, M Hirai, H Nakamura, S kawashiri
- Organizer
  24th Biennial congress of the european association for cancer research
- Place of Presentation
  Manchester(UK)
- Year and Date
  2016-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] セツキシマブ非感受性口腔癌細胞でのエリブリンの作用検討2016
- Author(s)
  北原寛子、平井真理子、中村博幸、川尻秀一
- Organizer
  第70回日本口腔科学会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-04-17
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] エリブリンのセツキシマブ非感受性口腔癌細胞での作用機序2016
- Author(s)
  北原寛子、中村博幸、加藤広禄、野口夏代、大井一浩、川尻秀一
- Organizer
  第40回日本頭頸部癌学会
- Place of Presentation
  ソニックシティ（埼玉）
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] 口腔扁平上皮癌におけるPD-L1発現の検討2016
- Author(s)
  平井真理子、北原寛子、中村博幸、川尻秀一
- Organizer
  第70回日本口腔科学会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-04-16
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] セツキシマブ非感受性口腔癌の解析と新しい治療法の検討2015
- Author(s)
  中村博幸、北原寛子、木村依世、川尻秀一
- Organizer
  第60回日本口腔外科学会総会学術大会
- Place of Presentation
  名古屋国際会議場（愛知）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] Loss of EGFR expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2015
- Author(s)
  H Nakamura, I Kimura, H KItahara, A Kawashiri
- Organizer
  European Cancer Congress 2015
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] セツキシマブ非感受性口腔癌細胞でのエリブリンの作用検討2015
- Author(s)
  北原寛子、木村依世、中村博幸、川尻秀一
- Organizer
  第60回日本口腔外科学会総会学術大会
- Place of Presentation
  名古屋国際会議場（愛知）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] Loss of EGFR expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2015
- Author(s)
  I Kimura, H Kitahara, H Nakamura, S Kawashiri
- Organizer
  The Joint Meeting of 4th Congress go Asian Society of Head and Neck Oncology(ASHNO) and 39th Annual Meeting of Japan Society for Head and Neck Cancer(JSHNC)
- Place of Presentation
  神戸国際会議場（兵庫）
- Year and Date
  2015-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20510
[Presentation] 口腔扁平上皮癌におけるFocal adhesion kinase (FAK) 発現の臨床病理学的意義2014
- Author(s)
  加藤阿希、吉澤邦夫、吉本泰祐、北原寛子、加藤広禄、野口夏代、中村博幸、川尻秀一
- Organizer
  第51回口腔組織培養学会学術大会
- Place of Presentation
  九州歯科大学講堂（福岡）
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] 口腔扁平上皮癌におけるVEGF-AおよびVEGF-C発現の免疫組織学的検討2013
- Author(s)
  柳瀬瑞希、加藤広禄、野口夏代、吉澤邦夫、北原寛子、川尻秀一
- Organizer
  第67回に本口腔科学会学術集会
- Place of Presentation
  栃木県総合文化センター（栃木）
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] 口腔扁平上皮がん浸潤様式4D型におけるがん悪性化に関わる各遺伝子発現についての検討2013
- Author(s)
  吉澤邦夫、北原寛子、野口夏代、加藤広禄、中村博幸、川尻秀一
- Organizer
  第37回日本頭頸部癌学会
- Place of Presentation
  京王プラザ（東京）
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] 口腔扁平上皮癌におけるCaveolin-1発現に関する免疫組織化学的検討2013
- Author(s)
  加藤広禄、平井真理子、加藤亜希、木村依世、柳瀬瑞希、杉浦史郎、岡宗絢子、北原寛子、野口夏代、吉澤邦夫、中村博幸、川尻秀一
- Organizer
  第58回（公社）日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] Expression of various canceration related proteins on highly invasive oral squamous cell carcinoma showing type4D (YK-criteria: Mode of invasion)
- Author(s)
  K Yoshizawa, H Kitahara, N Noguchi, H Nakamura, S Kawashiri
- Organizer
  6th European Congress on Head and Neck Oncology
- Place of Presentation
  LIverpool
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] 口腔扁平上皮がん浸潤様式4D型におけるがん悪性化に関わる各タンパク発現についての検討
- Author(s)
  吉澤邦夫、能崎晋一、柳瀬瑞希、木村依世、北原寛子、野口夏代、加藤広禄、中村博幸、川尻秀一
- Organizer
  第38回日本頭頸部癌学会総会
- Place of Presentation
  東京ファッションタウンビル（東京）
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25861923
[Presentation] 口腔扁平上皮癌におけるBevacizumab の抗腫瘍効果の実験的検討
- Author(s)
  平井真理子、野口夏代、加藤広禄、北原寛子、木村依世、中村博幸、川尻秀一
- Organizer
  第59回日本口腔外科学会学術大会
- Place of Presentation
  幕張メッセ（千葉）
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25861923

1. Nakamura Hiroyuki (30542253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. NOGUCHI Natsuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. YOSHIZAWA Kunio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 川尻秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 加藤広禄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KITAHARA HIROKO 北原 寛子

Research Projects

Research Products

Co-Researchers

Analysis of Tumor Immunosuppressive Mechanisms in the Oral Cancer Invasive Microenvironment.

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Association analysis of microtubules and the mechanism of highly invasive acquisition in oral cancerPrincipal Investigator

Principal Investigator

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Elucidation of permeation, metastaticity acquisition mechanism due to the platelet in the tissue in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

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Role of the adhesion molecules between the cell in invasion, the metastasis of oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

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[Journal Article] Selectively high efficacy of eribulin against high?grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicopathological Significace of the ET Axis in Human Oral Squamous Cell Carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage.2018

Author(s)

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DOI

NAID

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[Journal Article] 56POral squamous cell carcinoma cells were sensitized to cetuximab by Eribulin via induction of the mesenchymal-to-epithelial transition2017

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DOI

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[Journal Article] Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment.2017

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NAID

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[Journal Article] 1721PThe role of PD-L1 in a high-grade invasive human oral squamous cell carcinoma microenvironment2017

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DOI

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[Journal Article] Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition.2016

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NAID

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[Journal Article] Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2016

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NAID

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[Journal Article] Prognostic value of vascular endothelial growth factor A and C in oral squamous cell carcinoma2014

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[Journal Article] Loss of claudin-7 is a negative prognostic factor for invasion andmetastasis in oral squamous cell carcinoma2013

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KITAHARA HIROKO 北原寛子