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Uesaka Naofumi  上阪 直史

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UESAKA Naofumi  上阪 直史

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Researcher Number 70597624
Other IDs
Affiliation (Current) 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2018 – 2019: 東京大学, 大学院医学系研究科(医学部), 講師
2016 – 2017: 東京大学, 大学院医学系研究科(医学部), 助教
2011 – 2015: 東京大学, 医学(系)研究科(研究院), 助教
2012: 東京大学, 大学院・医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Neurophysiology / General neuroscience / Transformative Research Areas, Section (IV) / Neuroscience in general / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Basic Section 46030:Function of nervous system-related / Complex systems
Except Principal Investigator
Medium-sized Section 50:Oncology and related fields
Keywords
Principal Investigator
小脳 / シナプス刈り込み / 発達 / プルキンエ細胞 / 登上線維 / スクリーニング / 神経活動 / シナプス / カルシウム / イメージング … More / 逆行性シグナル / 分子メカニズム / 脳 / 自発活動 / 神経回路形成 / 蛍光タンパク質 / レンチウィルス / リアルタイムイメージング / マルチカラー / 蛍光タンパク / セマフォリン / Arc / 機能的神経回路形成 / シナプス入力 / バーグマングリア / 分子機構 / 神経活動依存性 / 遺伝子操作 / 精巣 / in vivo / 活動操作 / 精子形成 / 神経回路再編成 / 逆行性分子 / 刈り込み / 腫瘍 / 神経細胞 / グリア細胞 / 相互作用 / 脳腫瘍 / 神経伝達物質 / 腫瘍進展 / 同期性 / 同期 … More
Except Principal Investigator
脳腫瘍 / 脳内微小環境 / マウスモデル / コネクトミクス Less
  • Research Projects

    (10 results)
  • Research Products

    (75 results)
  • Co-Researchers

    (37 People)
  •  Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor development

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Design and Build of Brain by Emergence and Transition of Multidimensional Spontaneous ActivityArea Organizer

    • Area Organizer
      上阪 直史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
  •  脳多元自発活動の創発と遷移による脳のデザインビルドPrincipal Investigator

    • Principal Investigator
      上阪 直史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (IV)
    • Research Institution
      Tokyo Medical and Dental University
  •  発達期の脳多元自発活動による小脳ネットワークのデザインビルドPrincipal Investigator

    • Principal Investigator
      上阪 直史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (IV)
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of singularity mechanisms for brain tumor growthPrincipal Investigator

    • Principal Investigator
      上阪 直史
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of a network between brain and testisPrincipal Investigator

    • Principal Investigator
      Uesaka Naofumi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
    • Research Institution
      The University of Tokyo
  •  Activity-dependent mechanisms regulating synapse eliminationPrincipal Investigator

    • Principal Investigator
      Uesaka Naofumi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46030:Function of nervous system-related
    • Research Institution
      Tokyo Medical and Dental University
      The University of Tokyo
  •  Molecular mechanisms of activity dependent neural circuit refinementPrincipal Investigator

    • Principal Investigator
      Uesaka Naofumi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      The University of Tokyo
  •  Elucidation of activity-dependency and molecular mechanisms of synapse eliminationPrincipal Investigator

    • Principal Investigator
      UESAKA Naofumi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      The University of Tokyo
  •  Real-time and multi-color imaging of synapse elimination in the CNS.Principal Investigator

    • Principal Investigator
      UESAKA Naofumi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      The University of Tokyo

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] ATP activation of peritubular cells drives testicular sperm transport2021

    • Author(s)
      Fleck David、Kenzler Lina、Mundt Nadine、Strauch Martin、Uesaka Naofumi、Moosmann Robert、Bruentgens Felicitas、Missel Annika、Mayerhofer Artur、Merhof Dorit、Spehr Jennifer、Spehr Marc
    • Journal Title

      eLife

      Volume: 10 Pages: 10-10

    • DOI

      10.7554/elife.62885

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Journal Article] Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum2021

    • Author(s)
      Rai Yurie、Watanabe Takaki、Matsuyama Kyoko、Sakimura Kenji、Uesaka Naofumi、Kano Masanobu
    • Journal Title

      Neuroscience

      Volume: 462 Pages: 30268-2

    • DOI

      10.1016/j.neuroscience.2020.04.035

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-18H02540, KAKENHI-ORGANIZER-20H05914, KAKENHI-PLANNED-20H05915, KAKENHI-PROJECT-21H04785
  • [Journal Article] Setdla Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities2020

    • Author(s)
      Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Yusuke Kishi, Keita Kawaji, Michinori Koebis, Kazuki Nakao, Yukiko Gotoh, Atsu Aiba, Naofumi Uesaka, Masanobu Kano
    • Journal Title

      Cell Reports

      Volume: 32 Pages: 108126-108126

    • DOI

      10.1016/j.celrep.2020.108126

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-19H05204, KAKENHI-PUBLICLY-19H05253, KAKENHI-PUBLICLY-20H05383, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-16H06279
  • [Journal Article] Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations2020

    • Author(s)
      Nagumo Y, Ueta Y, Nakayama H, Osaki H, Takeuchi Y, Uesaka N, Kano M, Miyata M
    • Journal Title

      Cell Reports

      Volume: 31 Pages: 107797-107797

    • DOI

      10.1016/j.celrep.2020.107797

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18KK0236, KAKENHI-PUBLICLY-19H05224, KAKENHI-PROJECT-19H03550, KAKENHI-PROJECT-20K06862, KAKENHI-PUBLICLY-19H05415, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PUBLICLY-20H05481
  • [Journal Article] Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus.2020

    • Author(s)
      Saito Ryo、Koebis Michinori、Nagai Taku、Shimizu Kimiko、Liao Jingzhu、Wulaer Bolati、Sugaya Yuki、Nagahama Kenichiro、Uesaka Naofumi、Kushima Itaru、Mori Daisuke、Maruyama Kazuaki、Nakao Kazuki、Kurihara Hiroki、Yamada Kiyofumi、Kano Masanobu、Fukada Yoshitaka、Ozaki Norio、Aiba Atsu
    • Journal Title

      Transl Psychiatry

      Volume: 10 Pages: 35-35

    • DOI

      10.1038/s41398-020-0723-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05204, KAKENHI-PUBLICLY-19H05415, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-17H02220, KAKENHI-PROJECT-17H04031, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-17H05090, KAKENHI-PROJECT-18K19322, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K20602, KAKENHI-PROJECT-17H06096, KAKENHI-PROJECT-18K19511, KAKENHI-PROJECT-19H01048
  • [Journal Article] Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex2020

    • Author(s)
      Sacai Hiroaki、Sakoori Kazuto、Konno Kohtarou、Nagahama Kenichiro、Suzuki Honoka、Watanabe Takaki、Watanabe Masahiko、Uesaka Naofumi、Kano Masanobu
    • Journal Title

      Nature Communications

      Volume: 11 Pages: 5140-5140

    • DOI

      10.1038/s41467-020-18861-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-19H05204, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539
  • [Journal Article] AUTS2 governs cerebellar development, Purkinje cell maturation, motor function and social communication2020

    • Author(s)
      Yamashiro Kunihiko、Hori Kei、Lai Esther S.K.、Aoki Ryo、Shimaoka Kazumi、Arimura Nariko、Egusa Saki F.、Sakamoto Asami、Abe Manabu、Sakimura Kenji、Watanabe Takaki、Uesaka Naofumi、Kano Masanobu、Hoshino Mikio
    • Journal Title

      iScience.

      Volume: 23 Pages: 101820-101820

    • DOI

      10.1016/j.isci.2020.101820

    • NAID

      120006979860

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07071, KAKENHI-ORGANIZER-16H06524, KAKENHI-PUBLICLY-19H05415, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-19H03536, KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538
  • [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.2018

    • Author(s)
      Kano M, Watanabe T, Uesaka N, Watanabe M.
    • Journal Title

      Cerebellum

      Volume: 17 Issue: 6 Pages: 722-734

    • DOI

      10.1007/s12311-018-0964-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19322, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-25000015
  • [Journal Article] Presynaptic mechanisms mediating retrograde semaphorin signals for climbing fiber synapse elimination during postnatal cerebellar development.2018

    • Author(s)
      Uesaka N, Kano M
    • Journal Title

      The Cerebellum

      Volume: 17 Pages: 17-22

    • DOI

      10.1007/s12311-017-0888-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-15H05568
  • [Journal Article] Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum2018

    • Author(s)
      Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K and Kano M
    • Journal Title

      Neuron

      Volume: 94(4)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Journal Article] Retrograde BDXF to TrkB signaling promotes synapse elimination in the developing cerebellum.2017

    • Author(s)
      Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M.
    • Journal Title

      Nature Communications

      Volume: 8(1) Issue: 1 Pages: 195-195

    • DOI

      10.1038/s41467-017-00260-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08485, KAKENHI-PROJECT-17K19444, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06297, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-15H05568
  • [Journal Article] The metabotropic glutamate receptor subtype 1 mediates experience-dependent maintenance of mature synaptic connectivity in the visual thalamus.2017

    • Author(s)
      Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M
    • Journal Title

      Neuron

      Volume: 91 Pages: 1097-109

    • DOI

      10.1016/j.neuron.2016.07.035

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01667, KAKENHI-PUBLICLY-16H01344, KAKENHI-PUBLICLY-16H01615, KAKENHI-PLANNED-25115010, KAKENHI-PLANNED-25117006, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-26290010, KAKENHI-PROJECT-15K06732, KAKENHI-PROJECT-15K09602, KAKENHI-PROJECT-16K19672, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-15H05568, KAKENHI-PUBLICLY-17H05752, KAKENHI-PROJECT-15K19195
  • [Journal Article] Consensus Paper : Cerebellar Development.2016

    • Author(s)
      Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerkova G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R
    • Journal Title

      Cerebellum

      Volume: online Pages: 789-828

    • DOI

      10.1007/s12311-015-0724-2

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22111006, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-25281024, KAKENHI-PROJECT-15H05568
  • [Journal Article] Retrograde signaling for climbing fiber synapse elimination2015

    • Author(s)
      Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M
    • Journal Title

      Cerebellum

      Volume: 14 Pages: 42-101

    • DOI

      10.1007/s12311-014-0615-y

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-25830004, KAKENHI-PROJECT-25830031
  • [Journal Article] Cellular and molecular mechanisms of synapse elimination in the Mammalian brai2014

    • Author(s)
      Uesaka N, Kawata S, Kano M
    • Journal Title

      Brain Nerve

      Volume: 66 Pages: 1069-77

    • Data Source
      KAKENHI-PROJECT-25830004
  • [Journal Article] Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.2014

    • Author(s)
      Uesaka N, Uchigashima,M, Mikuni T, Nakazawa T, Nakao H, Hirai K, Aiba A, Watanabe M, Kano M
    • Journal Title

      Science

      Volume: 344 Pages: 1020-1023

    • DOI

      10.1126/science.1252514

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-25000015, KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-25640033, KAKENHI-PROJECT-25830004, KAKENHI-PROJECT-25830031
  • [Journal Article] Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.2013

    • Author(s)
      Mikuni et al.
    • Journal Title

      Neuron

      Volume: 78 Pages: 1024-1035

    • DOI

      10.1016/j.neuron.2013.04.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24300117, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-25830004
  • [Journal Article] Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression2012

    • Author(s)
      Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Manabu Abe, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura and Masanobu Kano
    • Journal Title

      Proc Natl Acad Sci U S A

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain2012

    • Author(s)
      Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M
    • Journal Title

      J. Neurosci

      Volume: 32(34) Pages: 11657-11670

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.2012

    • Author(s)
      Uesaka N
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Pages: 11657-11670

    • DOI

      10.1523/jneurosci.1097-12.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21220006, KAKENHI-PROJECT-22300125, KAKENHI-PROJECT-23650160, KAKENHI-PROJECT-23650204
  • [Presentation] アストロサイトは2型イノシトール3リン酸受容体を介して発達期小脳のシナプス刈り込みを制御する2021

    • Author(s)
      上阪直史、赤松翼, 鈴木穂香, 狩野方伸
    • Organizer
      第98回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] MEF2D は発達期の小脳において後期のシナプス刈り込みに関与する2021

    • Author(s)
      鈴木 穂香, Choo Myeongjeong, 渡邉 貴樹, 崎村 建司, 上阪 直史, 狩野 方伸
    • Organizer
      第98回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Protocadherin 10は一部のアルドラーゼC陽性の小脳プルキンエ細胞において発達期の登上線維シナプスの刈り込みを遅延させる2020

    • Author(s)
      渡邉 貴樹, 佐郡 和人, 鈴木 穂香, 赤松 翼, 松山 恭子, 井上 秀太郎, 阿部 学, 﨑村 建司, 上阪 直史, 狩野 方伸
    • Organizer
      43回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum2020

    • Author(s)
      Takaki Watanabe1, 2,Honoka Suzuki1,Kazuto Sakoori1,Shutaro Inoue1,Tsubasa Akamatsu1, Manabu Abe3,Kenji Sakimura3,Naofumi Uesaka1, 2,Masanobu Kano1,
    • Organizer
      第97回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum2020

    • Author(s)
      Takaki Watanabe,Honoka Suzuki,Kazuto Sakoori,Shutaro Inoue,Tsubasa Akamatsu, Manabu Abe,Kenji Sakimura,Naofumi Uesaka,Masanobu Kano,
    • Organizer
      第97回日本生理学会大会・大分
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Astrocytes regulate synapse elimination in the developing cerebellum2020

    • Author(s)
      上阪直史
    • Organizer
      NIG Symposium 2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Activity-dependent synapse elimination in the developing cerebellum2019

    • Author(s)
      Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
    • Organizer
      FAOPS2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] 精神疾患関連エピジェネティクス因子の欠損が、マウス内側前頭前野錐体細胞への興奮性シナプス入力の減弱と異常行動を引き起こす2019

    • Author(s)
      濱 健一郎 / 佐郡 和人 / 渡邉 貴樹 / 古戎 道典 / 上阪 直史 / 饗場 篤 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] 精神疾患関連エピジェネティクス因子の欠損が、マウス内側前頭前野錐体細胞への興奮性シナプス入力の減弱と異常行動を引き起こす2019

    • Author(s)
      濱 健一郎 / 佐郡 和人 / 渡邉 貴樹 / 古戎 道典 / 上阪 直史 / 饗場 篤 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor2019

    • Author(s)
      Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 102019

    • Author(s)
      Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Activity-dependent synapse elimination in the developing cerebellum2019

    • Author(s)
      Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
    • Organizer
      FAOPS2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 102019

    • Author(s)
      Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum2019

    • Author(s)
      Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] 発達期小脳において、アルドラーゼC陽性プルキンエ細胞の登上線維シナプス刈り込みはアルドラーゼC陰性プルキンエ細胞よりも遅れ、ホスホリパーゼC β3を必要とする2019

    • Author(s)
      渡邉 貴樹 / 賴 友梨恵 / 鈴木 穂香 / 赤松 翼 / 上阪 直史 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor2019

    • Author(s)
      Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum2019

    • Author(s)
      Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] 発達期小脳において、アルドラーゼC陽性プルキンエ細胞の登上線維シナプス刈り込みはアルドラーゼC陰性プルキンエ細胞よりも遅れ、ホスホリパーゼC β3を必要とする2019

    • Author(s)
      渡邉 貴樹 / 賴 友梨恵 / 鈴木 穂香 / 赤松 翼 / 上阪 直史 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2018

    • Author(s)
      Tzu-Huei Kao, Kyoko Matsuyama, Naofumi Uesaka, Masanobu Kano
    • Organizer
      第41回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum2018

    • Author(s)
      Myeong Jeong Choo, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
    • Organizer
      第41回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2018

    • Author(s)
      Tzu-Huei Kao:Kyoko Matsuyama:Naofumi Uesaka:Masanobu Kano
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Impaired Synapse Development in Mouse Medial Prefrontal Cortex by Deletion of a Histone-Modifying Enzyme Implicated in Psychiatric Disorder2018

    • Author(s)
      Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      第41回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-18H02539
  • [Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum2018

    • Author(s)
      Myeong Jeong Choo:Naofumi Uesaka:Masahiko Watanabe:Kenji Sakimura:Masanobu Kano:
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] Impaired Synapse Development in Mouse Medial Prefrontal Cortex by Deletion of a Histone-Modifying Enzyme Implicated in Psychiatric Disorder2018

    • Author(s)
      Kenichiro Nagahama: Kazuto Sakoori:Takaki Watanabe:Naofumi Uesaka:Masanobu Kano
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-18K19322
  • [Presentation] BDNF to TrkB signaling promotes climbing fiber synapse elimination in the developing cerebellum2017

    • Author(s)
      Myeong Jeong Choo,Taisuke Miyazaki, Maya Yamasaki, Meiko Kawamura, Takanobu Nakazawa, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
    • Organizer
      第40回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Regulation of climbing fiber synapse elimination in the developing cerebellum by retrograde signaling2017

    • Author(s)
      Naofumi Uesaka and Masanobu Kano
    • Organizer
      第40回日本神経科学学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Involvement of Fndc3b, a fibronectin type III domain-containing protein, in climbing fiber synapse elimination during postnatal cerebellar development2017

    • Author(s)
      Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      第40回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Calcium channels in cerebellar synapses bind to extracellular ligand and organize presynaptic active zones2017

    • Author(s)
      Hiroshi Nishimune,Takafumi Mizushige, Naofumi Uesaka, Tomohiro Numata, Jie Chen, Badawi Yomna, Yomna Badawi, Yasuo Mori, Masanobu Kano
    • Organizer
      第40回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Screening of autism spectrum disorder-associated molecules that are involved in climbing fiber-Purkinje cell synapse elimination in the developing mouse cerebellum2017

    • Author(s)
      Takaki Watanabe, Shutaro Inoue, Naofumi Uesaka, Masanobu Kano
    • Organizer
      第40回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Roles of retrograde signaling in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2017

    • Author(s)
      Naofumi Uesaka and Masanobu Kano
    • Organizer
      the 8th International Symposium of the Society for Research on the Cerebellum and Ataxia
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Type 1 metabotropic glutamate receptor maintains matu re retinogenicu late synaptic connectivity in the visual thalamus2016

    • Author(s)
      鳴島 円、内ヶ島 基政、矢ヶ崎 有希、原田 武志、南雲 康之、上阪 直史、渡邉 貴樹、 橋本 浩一、饗場 篤、渡辺 雅彦、宮田 麻理子、狩野 方伸
    • Organizer
      第93回 日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] The frontotemporal dementia related gene, granulin regulates developmental synapse elimination in the cerebellum2016

    • Author(s)
      上阪 直史、狩野 方伸
    • Organizer
      第93回 日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] 逆行性シグナルによる発達期シナプス刈り込みの制御2015

    • Author(s)
      上阪直史
    • Organizer
      生理研研究会「シナプスの構造構築と機能発現の分子基盤」
    • Place of Presentation
      生理学研究所(愛知・岡崎)
    • Year and Date
      2015-06-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Roles of neuroligin-2 in inhibitory synaptic transmission and climbing fiber synapse elimination in Purkinje cells during postnatal cerebellar development2015

    • Author(s)
      Suk King Lai、Naofumi Uesaka、Masanobu Kano
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Progranulin regulates climbing fiber synapse elimination during postnatal cerebellar development2015

    • Author(s)
      上阪直史、阿部 学、山崎 真弥、今野 幸太郎、三國 貴康、渡辺 雅彦、崎村 建司、狩野 方伸
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] 脳の機能発達を担うシナプス刈り込みの機構2015

    • Author(s)
      上阪直史
    • Organizer
      若手研究者による小脳研究の最前線
    • Place of Presentation
      東京・品川
    • Year and Date
      2015-01-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] Retrograde signaling involved in climbing fiber synapse elimination in the developing cerebellum2015

    • Author(s)
      狩野方伸、上阪直史
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸)
    • Year and Date
      2015-07-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Knockdown of CNTNAP2 in neurons of the prefrontal cortex impairs synaptic function and causes impaired social behavior2015

    • Author(s)
      酒井 浩旭 、佐郡 和人 、上阪 直史 、狩野 方伸
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-15H05568
  • [Presentation] Retrograde signaling regulates synapse elimination in developing brain2014

    • Author(s)
      Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Hirai Hirokazu, Watanabe Masahiko, Kano Masanobu
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島、日本
    • Invited
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] Identification of retrograde signaling molecules required for developmental synapse elimination in the cerebellum by an RNAi-based approach2013

    • Author(s)
      Naofumi Uesaka, Takayasu Mikuni, Hirokazu Hirai, Masanobu Kano
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] Functional screening of molecules required for developmental synapse elimination in the cerebellum by RNAi-based approach2013

    • Author(s)
      Naofumi Uesaka, Takayasu Mikuni, Hirokazu Hirai, Masanobu Kano
    • Organizer
      Gordon Research Conference on the Cerebellum
    • Place of Presentation
      Colby-Sawyer College New London, NH, USA
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズムの解明2013

    • Author(s)
      上阪 直史
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京・タワーホール船堀
    • Invited
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズムの解明2013

    • Author(s)
      上阪直史
    • Organizer
      第90回(平成24年度)日本生理学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Presentation] 2-アラキドノイルグリセロールリパーゼは小脳皮質においてシナプス非特異的に 分解される2011

    • Author(s)
      谷村 あさみ, 山崎 真弥, 内が島 基政, 上阪 直史, 三国 貴康, 橋本 浩一, 渡辺 雅彦, 崎村 建二, 狩野 方伸
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Presentation] Postsynaptic Purkinje cell activity accelerates climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata2011

    • Author(s)
      三國 貴康, 上阪 直史, 狩野 方伸
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      ワシントン、米国
    • Data Source
      KAKENHI-PROJECT-23650160
  • [Presentation] 自閉症感受性遺伝子を前頭前野でノックダウンしたマウスのシナプス機能異常と 社会的行動の異常

    • Author(s)
      酒井 浩旭, 佐郡 和人, 上阪 直史, 狩野 方伸
    • Organizer
      第92回生理学会大会
    • Place of Presentation
      兵庫・神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 前頭側頭型認知症原因遺伝子granulinが発達期シナプス刈り込みを制御する

    • Author(s)
      上阪直史,阿部学,山崎真弥,今野幸太郎,三國 貴康,渡辺 雅彦,崎村 建司,狩野方伸
    • Organizer
      第38回日本神経科学学会
    • Place of Presentation
      兵庫・神戸
    • Year and Date
      2015-07-28 – 2015-07-31
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 発達期におこるシナプス刈り込みを制御する逆行性シグナル

    • Author(s)
      上阪直史
    • Organizer
      生理研研究会 「シナプス・神経ネットワークの機能ダイナミクス」
    • Place of Presentation
      愛知・岡崎
    • Year and Date
      2014-12-02 – 2014-12-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] SCREENING OF RETROGRADE SIGNALING MOLECULES FOR SYNAPSE ELIMINATION IN THE DEVELOPING CEREBELLUM

    • Author(s)
      N. Uesaka, M. Uchigashima, T. Mikuni, T. Nakazawa, H. Hirai, M. Watanabe, M. Kano
    • Organizer
      ヨーロッパ神経科学学会(FENS)
    • Place of Presentation
      イタリア・ミラノ
    • Year and Date
      2014-07-05 – 2014-07-09
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 前頭前野ニューロンにおけるCNTNAP2のノックダウンはシナプス機能の障害と自閉症様行動を引き起こす

    • Author(s)
      酒井浩旭,上阪直史, 狩野方伸
    • Organizer
      第38回日本神経科学学会
    • Place of Presentation
      兵庫・神戸
    • Year and Date
      2015-07-28 – 2015-07-31
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] Sema3AとSema7Aによる逆行性シグナルがシナプス刈り込みを制御している

    • Author(s)
      上阪 直史,内ヶ島 基政,三國 貴康,中澤 敬信,中尾 晴美,平井 宏和,饗場 篤,渡辺 雅彦, 狩野 方伸
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      神奈川・横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 発達期シナプス刈り込みを制御する逆行性シグナル分子の同定

    • Author(s)
      上阪直史、狩野方伸
    • Organizer
      第92回生理学会大会
    • Place of Presentation
      兵庫・神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] 発達期小脳シナプス刈り込みにプルキンエ細胞由来BDNFが寄与している

    • Author(s)
      秋 明貞, 宮崎 太輔, 山崎 真弥, 谷村 あさみ, 上阪 直史, 渡辺 雅彦, 崎村 健司,狩野 方伸
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      神奈川・横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] IMPAIRMENT OF DEVELOPMENTAL SYNAPSE ELIMINATION IN THE CEREBELLUM OF PURKINJE CELL-SPECIFIC BDNF KNOCKOUT MICE

    • Author(s)
      M. Choo, T. Miyazaki, M. Yamasaki, A. Tanimura, N. Uesaka, M. Watanabe, K. Sakimura, M. Kano
    • Organizer
      ヨーロッパ神経科学学会(FENS)
    • Place of Presentation
      イタリア・ミラノ
    • Year and Date
      2014-07-05 – 2014-07-09
    • Data Source
      KAKENHI-PROJECT-25830004
  • [Presentation] Granulin-Sort1シグナルが発達期シナプス刈り込みにおけるシナプス強化・維持シグナルとして働く

    • Author(s)
      上阪 直史
    • Organizer
      グリアクラブ
    • Place of Presentation
      北海道・函館
    • Year and Date
      2015-01-26 – 2015-01-28
    • Data Source
      KAKENHI-PROJECT-25830004
  • 1.  川内 大輔 (10400996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  丸山 玲緒 (60607985)
    # of Collaborated Projects: 1 results
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  • 3.  岩崎 真樹 (00420018)
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  • 4.  水野 秀信 (00567159)
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  • 5.  早川 隆 (30756789)
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  • 6.  千葉 逸人 (70571793)
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  • 7.  TAKEUCHI Yuichi
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    # of Collaborated Products: 1 results
  • 8.  NAKAYAMA Hisako
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    # of Collaborated Products: 1 results
  • 9.  MIYAZAKI Taisuke
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    # of Collaborated Products: 1 results
  • 10.  NAKAZAWA Takanobu
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    # of Collaborated Products: 1 results
  • 11.  UCHIGASHIMA Motokazu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 12.  YAGASAKI Yuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  NARIKO Arimura
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  狩野 方伸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results
  • 15.  岸 雄介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  宮田 麻理子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 17.  宮田 卓樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  鯉淵 典之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  阿部 学
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    # of Collaborated Products: 1 results
  • 20.  崎村 建司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  宮崎 龍彦
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    # of Collaborated Products: 1 results
  • 22.  永井 拓
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  • 23.  山田 清文
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  • 24.  久島 周
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  • 25.  尾崎 紀夫
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  • 26.  清水 貴美子
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  • 27.  深田 吉孝
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  • 28.  饗場 篤
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    # of Collaborated Products: 3 results
  • 29.  栗原 裕基
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    # of Collaborated Products: 1 results
  • 30.  平井 宏和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  阿部 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  渡辺 雅彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 33.  橋本 浩一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  鳴島 円
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  南雲 康行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  星野 幹雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  阿部 十也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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