Takahashi Nobuaki 高橋重成

… Alternative Names

Takakahashi Nobuaki 高橋重成

TAKAHASHI Nobuaki 高橋重成

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Researcher Number	70604635
Other IDs	https://orcid.org/0000-0002-0606-3921
Affiliation (Current)	2025: 京都大学, 工学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 京都大学, 工学研究科, 准教授 2020 – 2021: 京都大学, 白眉センター, 特定准教授 2011 – 2012: 京都大学, 先端医工学研究ユニット, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 43030:Functional biochemistry-related / Neurochemistry/Neuropharmacology Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator 転写因子 / TRPチャネル / pH適応 / がん / pHストレス適応 / pH / 低酸素 / 進化 / 赤血球 / pH生物学 … More / ストレス感知 / 海洋酸性化 / 発生 / シグナル伝達 / イオンチャネル / 迷走神経 / TRPA1 / 呼吸 / レドックス / 高酸素 / 酸素 … More Except Principal Investigator 光遺伝学 / 海洋酸性化 / シグナル / ストレス / pH Less

pH応答生物学の確立
- Principal Investigator
  
  荻沼政之
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
pHストレス誘導型転写因子の同定Principal Investigator
- Principal Investigator
  
  高橋重成
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
低酸素センサーTRPA1チャネルが司る生物学的意義の解明Principal Investigator
- Principal Investigator
  
  高橋重成
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyoto University
哺乳類の赤血球はなぜ脱核したのか？Principal Investigator
- Principal Investigator
  
  高橋重成
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kyoto University
Establishment of pH BiologyArea Organizer
- Area Organizer
  
  高橋重成
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
Establishment of pH BiologyPrincipal Investigator
- Principal Investigator
  
  Takakahashi Nobuaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Identification of pH-induced transcription factors governing pH stress adaptationPrincipal Investigator
- Principal Investigator
  
  Takakahashi Nobuaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Physiologicalsignificance or redox-sensitive ion channelsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Nobuaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021 2020 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] 実験医学2012
- Author(s)
  植田誉志史, 高橋重成, 森泰生
- Total Pages
  30
- Publisher
  TRPA1チャネルを介した酸素・活性酸素種センシング
- Data Source
  KAKENHI-PROJECT-23800035
[Book] TRPチャネルを介する新しい酸素センシング機構2012
- Author(s)
  高橋重成
- Total Pages
  7
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-23800035
[Book] TRPA1チャネルによる酸素感受性2012
- Author(s)
  高橋重成
- Total Pages
  3
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23800035
[Book] 医学のあゆみ2012
- Author(s)
  高橋重成
- Total Pages
  241
- Publisher
  TRPA1チャネルによる酸素感受性
- Data Source
  KAKENHI-PROJECT-23800035
[Book] 血管医学2012
- Author(s)
  植田誉志史, 高橋重成, 森泰生
- Total Pages
  13
- Publisher
  新たな酸素センサー/チャネルによる低酸素応答制御
- Data Source
  KAKENHI-PROJECT-23800035
[Book] 実験医学2012
- Author(s)
  高橋重成, 植田誉志史, 森泰生
- Total Pages
  30
- Publisher
  TRP チャネルを介する新しい酸素センシング機構
- Data Source
  KAKENHI-PROJECT-23800035
[Journal Article] TRPA1 contributes to respiratory depression from tobacco aerosol2025
- Author(s)
  Chen Sichong、Takahashi Nobuaki、Okahara Momoka、Kashiwadani Hideki、Mori Yasuo、Hao Liying、Kuwaki Tomoyuki
- Journal Title
  
  Respiratory Physiology & Neurobiology
  
  Volume: 332 Pages: 104385-104385
- DOI
  10.1016/j.resp.2024.104385
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01976, KAKENHI-PROJECT-23K06015, KAKENHI-PROJECT-24K22034
[Journal Article] Intratumour oxidative hotspots provide a niche for cancer cell dissemination2025
- Author(s)
  Ueda Yoshifumi、Kiyonaka Shigeki、Selfors Laura M.、Inoue Keisuke、Harada Hiroshi、Doura Tomohiro、Onuma Kunishige、Uchiyama Makoto、Kurogi Ryuhei、Yamada Yuji、Sun Jiacheng H.、Sakaguchi Reiko、Tado Yuki、Omatsu Haruki、Suzuki Harufumi、Aoun Mike、Nakayama Takahiro、Kajimoto Taketoshi、...(5名) ...、Takahashi Nobuaki
- Journal Title
  
  Nature Cell Biology
  
  Volume: 27 Issue: 3 Pages: 530-543
- DOI
  10.1038/s41556-025-01617-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K24078, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-24K01976, KAKENHI-PROJECT-23K06360, KAKENHI-PROJECT-24K08607, KAKENHI-PROJECT-24K22034
[Journal Article] Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals2024
- Author(s)
  Sakaguchi R, Takahashi N, Yoshida T, Ogawa N, Ueda Y, Hamano S, Yamaguchi K, Sawamura S, Yamamoto S, Hara Y, Kawamoto T, Suzuki R, Nakao A, Mori MX, Furukawa T, Shimizu S, Inoue R, Mori Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 300 Issue: 9 Pages: 107705-107705
- DOI
  10.1016/j.jbc.2024.107705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24078, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-24K01976, KAKENHI-PROJECT-23K06215, KAKENHI-PROJECT-24K08607, KAKENHI-PROJECT-24K22034
[Journal Article] TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour2023
- Author(s)
  Kuwaki Tomoyuki、Takahashi Nobuaki
- Journal Title
  
  The Journal of Physiology
  
  Volume: online only Issue: 19 Pages: 4755-4762
- DOI
  10.1113/jp284076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07330, KAKENHI-PROJECT-24K01976, KAKENHI-PROJECT-24K22034
[Journal Article] <i>N</i>-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV12022
- Author(s)
  Kida Tatsuya、Takahashi Nobuaki、Mori Masayuki X.、Sun Jiacheng H.、Oota Hideto、Nishino Kosuke、Okauchi Takashi、Ochi Yuta、Kano Daisuke、Tateishi Ukihide、Watanabe Yasuyoshi、Cui Yilong、Mori Yasuo、Doi Hisashi
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 13 Issue: 10 Pages: 1197-1204
- DOI
  10.1039/d2md00158f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07668, KAKENHI-PROJECT-19K05859, KAKENHI-PROJECT-20K21777, KAKENHI-ORGANIZER-20H05787, KAKENHI-PLANNED-20H05788
[Journal Article] Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders2021
- Author(s)
  Nakao A, Matsunaga Y, Hayashida K, Takahashi N.
- Journal Title
  
  Front Cell Dev Biol.
  
  Volume: 9 Pages: 615569-615569
- DOI
  10.3389/fcell.2021.615569
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-20H05787, KAKENHI-PLANNED-20H05788
[Journal Article] 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis2020
- Author(s)
  Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, and Brugge JS
- Journal Title
  
  Molecular Cell
  
  Volume: 80 Issue: 5 Pages: 828-844
- DOI
  10.1016/j.molcel.2020.10.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-20H05787, KAKENHI-PLANNED-20H05788
[Journal Article] TRP channels : sensors and transducers of gasotransmitter signals.2012
- Author(s)
  Takahashi N, Kozai D, Mori Y
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 3 Pages: 324-324
- DOI
  10.3389/fphys.2012.00324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06008, KAKENHI-PROJECT-23800035
[Journal Article] 活性酸素で活性化されるTRPチャネル2012
- Author(s)
  清中茂樹、高橋重成、森泰生
- Journal Title
  
  ファルマシア
  
  Volume: 48 Pages: 31-36
- NAID
  110009885020
- Data Source
  KAKENHI-PROJECT-23800035
[Journal Article] TRP channels: sensors and transducers of gasotransmitter signals2012
- Author(s)
  Takahashi N, Kozai D, Mori Y
- Journal Title
  
  Front Physiol
  
  Volume: 3 Pages: 324-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800035
[Journal Article] TRP Channels as Sensors and Signal Integrators of Redox Status Changes2011
- Author(s)
  Takahashi N, Mori Y
- Journal Title
  
  Front Pharmacol
  
  Volume: 2 Pages: 58-58
- DOI
  10.3389/fphar.2011.00058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800035
[Journal Article] TRPA1 underlies a sensing mechanism for O_22011
- Author(s)
  Takahashi N, Kuwaki K, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J & Mori Y
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 7 Issue: 10 Pages: 701-711
- DOI
  10.1038/nchembio.640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249015, KAKENHI-ORGANIZER-21106001, KAKENHI-PLANNED-21106002, KAKENHI-PROJECT-21390022, KAKENHI-PUBLICLY-22121512, KAKENHI-PROJECT-22681033, KAKENHI-PROJECT-22790208, KAKENHI-PROJECT-22790288, KAKENHI-PUBLICLY-23117709, KAKENHI-PUBLICLY-23136505, KAKENHI-PROJECT-23750127, KAKENHI-PROJECT-23800035
[Journal Article] TRP channels as sensors of oxygen availability
- Author(s)
  Numata T, Ogawa N, Takahashi N, Mori Y
- Journal Title
  
  Pflugers Arch
- NAID
  120005474466
- URL
  http://link.springer.com/article/10.1007%2Fs00424-013-1237-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800035
[Patent] 過酸化水素の製造方法2021
- Inventor(s)
  高橋重成、藤原拓郎、森泰生、坂口怜子
- Industrial Property Rights Holder
  高橋重成、藤原拓郎、森泰生、坂口怜子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-083340
- Filing Date
  2021
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] Molecular evolutionary study reveals TRPA1 channel as the hypoxic stress sensor that regulates blood supply to the fetus in maternal anemia2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  78th IRCMS seminar at Kumamoto University
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  Redox week in Sendai 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] 腫瘍内H2O2イメージングにより明らかになった新規がん酸化ストレス防御機構2022
- Author(s)
  高橋重成
- Organizer
  第16回日本分子イメージング学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  ION CHANNELS & CANCER MEETING 2022 in France
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] 腫瘍内H2O2イメージングにより明らかになった新規がん酸化ストレス防御機構2022
- Author(s)
  高橋重成
- Organizer
  第31回日本がん転移学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Molecular evolutionary study reveals TRPA1 channel as the hypoxic stress sensor that regulates blood supply to the fetus in maternal anemia2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  8th IRCMS seminar at Kumamoto University
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  ION CHANNELS & CANCER MEETING 2022 in France
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  Redox week in Sendai 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] Oxidative Stress Defense Programs in Cancer2022
- Author(s)
  Nobuaki Takahashi
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] 腫瘍内H2O2イメージングにより明らかになった新規がん酸化ストレス防御機構2022
- Author(s)
  高橋重成
- Organizer
  第16回日本分子イメージング学会総会・学術集会
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] 腫瘍内H2O2イメージングにより明らかになった新規がん酸化ストレス防御機構2022
- Author(s)
  高橋重成
- Organizer
  第31回日本がん転移学会学術集会・総会
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] がん細胞による酸化ストレス適応戦略2022
- Author(s)
  高橋重成
- Organizer
  臨床Ｘ工学（化学）異分野交流会　京都大学
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] がん細胞による酸化ストレス適応戦略2022
- Author(s)
  高橋重成
- Organizer
  京都大学臨床×工学（化学）異分野交流会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] pHストレス・酸化ストレスの連関2021
- Author(s)
  高橋重成
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] Oxidative Stress Defense in Cancer2021
- Author(s)
  Nobuaki Takahashi
- Organizer
  Smart Aging Research Center at Tohoku University
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense in Cancer2021
- Author(s)
  Nobuaki Takahashi
- Organizer
  Smart Aging Research Center at Tohoku University
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] pHストレス・酸化ストレスの連関2021
- Author(s)
  高橋重成
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense Programs in Cancer2020
- Author(s)
  Nobuaki Takahashi
- Organizer
  Cancer Program Meeting in Broad Institute of MIT
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05788
[Presentation] Oxidative Stress Defense Programs in Cancer2020
- Author(s)
  Nobuaki Takahashi
- Organizer
  Cancer Program Meeting in Broad Institute of MIT
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-20H05787
[Presentation] TRPC5チャネル複合体によるCa2+動員およびNO産生の時空間制御2013
- Author(s)
  高橋重成
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPA1 senses oxygen availability in vagus2013
- Author(s)
  Nobuaki Takahashi
- Organizer
  57th Annual meeting of Biophysics Society
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] Nitric-oxide directly activates TRP channels via oxidative cysteine modification2013
- Author(s)
  Nobuaki Takahashi, Yasuo Mori
- Organizer
  Biophysical Society 57th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2013-02-04
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPC5チャネル複合体によるCa^2+ 動員およびNO産生の制御2012
- Author(s)
  高橋重成, 吉田卓史, 山本伸一郎, 眞本達生, 飯沼ゆり子, 原雄二, 森泰生
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] Sensing of O_2 availability by TRPA1 regulates O_2 intake2012
- Author(s)
  Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Yasuo Mori
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPC5チャネル複合体によるCa2+動員およびNO産生の制御2012
- Author(s)
  高橋重成
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPチャネルによる新たな生体内酸素感受機構2012
- Author(s)
  高橋重成
- Organizer
  岐阜薬科大学大学院薬学研究科特別講義
- Place of Presentation
  岐阜市
- Year and Date
  2012-05-28
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPチャネルによる新たな生体内酸素感受機構2012
- Author(s)
  高橋重成
- Organizer
  岐阜薬科大学大学院薬学研究科特別講義
- Place of Presentation
  岐阜市
- Invited
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPA1 は体内への酸素供給を制御する酸素センサーである2011
- Author(s)
  高橋重成, 森泰生
- Organizer
  第18回MPO研究会
- Place of Presentation
  熊本市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23800035
[Presentation] TRPA1は体内への酸素供給を制御する酸素センサーである2011
- Author(s)
  高橋重成、森泰生
- Organizer
  第17回MPO研究会
- Place of Presentation
  熊本市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23800035

1. 栗原晴子 (40397568)

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2. 船戸洋佑 (60505775)

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14. TATEISHI Ukihide

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15. 桑木共之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 森泰生

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Nobuaki 高橋 重成

Takakahashi Nobuaki 高橋 重成

TAKAHASHI Nobuaki 高橋 重成

Research Projects

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Co-Researchers

pH応答生物学の確立

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pHストレス誘導型転写因子の同定Principal Investigator

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低酸素センサーTRPA1チャネルが司る生物学的意義の解明Principal Investigator

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哺乳類の赤血球はなぜ脱核したのか？Principal Investigator

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Establishment of pH BiologyArea Organizer

Area Organizer

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Establishment of pH BiologyPrincipal Investigator

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Identification of pH-induced transcription factors governing pH stress adaptationPrincipal Investigator

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Physiologicalsignificance or redox-sensitive ion channelsPrincipal Investigator

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[Book] 実験医学2012

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[Book] TRPチャネルを介する新しい酸素センシング機構2012

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[Book] TRPA1チャネルによる酸素感受性2012

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[Book] 医学のあゆみ2012

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[Book] 血管医学2012

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[Book] 実験医学2012

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Takahashi Nobuaki 高橋重成

Takakahashi Nobuaki 高橋重成

TAKAHASHI Nobuaki 高橋重成