Shigemizu Daichi 重水大智

… Alternative Names

SHIGEMIZU Daichi 重水大智

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Researcher Number	70617464
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所メディカルゲノムセンター, 部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所メディカルゲノムセンター, 部長 2021: 国立研究開発法人国立長寿医療研究センター, メディカルゲノムセンター, 部長 2017 – 2020: 国立研究開発法人国立長寿医療研究センター, メディカルゲノムセンター, ユニット長 2017: 東京医科歯科大学, 難治疾患研究所, 非常勤講師 2017: 国立研究開発法人国立長寿医療研究センター, 臨床ゲノム解析推進部, 遺伝統計解析ユニット長 2016: 東京医科歯科大学, 難治疾患研究所, 講師
Review Section/Research Field	Principal Investigator Basic Section 43060:System genome science-related / Human genetics Except Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Biological Sciences
Keywords	Principal Investigator 遺伝子変異 / ゲノムシークエンス / RNA-sequencing / 予測システム / ゲノム解析 / HLA / 疾患予測モデル / アルツハイマー病 / 遺伝子 / 循環器 … More / ゲノム / 遺伝学 / long indel / エクソーム家系解析 / QT延長症候群 / エクソーム解析 / 次世代シークエンサー / 中間サイズインデル … More Except Principal Investigator 感覚器能力 / 心理的能力 / バイタリティ / 移動能力 / 認知能力 / 転倒リスクスコア / 基本チェックリスト / ICOPEハンドブック / 簡易評価 / Intrinsic capacity / 高齢者診療 / 簡易評価票 / Intrinsic Capacity / 原発性免疫不全症 / 乳児白血病 / 小児急性リンパ性白血病 / 疾患感受性 / レアバリアント / 急性リンパ性白血病 / B細胞分化 / 遺伝的背景 / 小児 / 白血病 / XX / オミクス解析 / 代謝アダプテーション / トランスオミクス Less

高齢者における内在能力の簡易評価票の開発のためのコホート研究
- Principal Investigator
  
  佐竹昭介
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Center for Geriatrics and Gerontology
Development of a prognosis prediction model for Alzheimer's disease using integrative multi-omics dataPrincipal Investigator
- Principal Investigator
  
  重水大智
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Genetic background of acute lymphoblastic leukemia in children
- Principal Investigator
  
  Takagi Masatoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Development and application of analysis methodology for next generation human omics
- Principal Investigator
  
  Tsunoda Tatsuhiko
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Tokyo Medical and Dental University
Investigation of disease-causing variants of Long QT syndrome using whole exome sequencingPrincipal Investigator
- Principal Investigator
  
  SHIGEMIZU Daichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  National Center for Geriatrics and Gerontology
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 細胞2017
- Author(s)
  重水　大智
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-16K19068
[Book] BIO Clinica2017
- Author(s)
  重水　大智
- Total Pages
  4
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-16K19068
[Book] アンチ・エイジング医学2017
- Author(s)
  重水　大智
- Total Pages
  5
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-16K19068
[Journal Article] CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer’s disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion2024
- Author(s)
  Asanomi Yuya、Kimura Tetsuaki、Shimoda Nobuyoshi、Shigemizu Daichi、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 69 Issue: 5 Pages: 171-176
- DOI
  10.1038/s10038-024-01224-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Identification of Potential Blood-Based Biomarkers for Frailty by Using an Integrative Approach2024
- Author(s)
  Suganuma Mutsumi、Furutani Motoki、Hosoyama Tohru、Mitsumori Risa、Otsuka Rei、Takemura Marie、Matsui Yasumoto、Nakano Yukiko、Niida Shumpei、Ozaki Kouichi、Satake Shosuke、Shigemizu Daichi
- Journal Title
  
  Gerontology
  
  Volume: Mar 14 Issue: 6 Pages: 1-9
- DOI
  10.1159/000538313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE4 negative Japanese adults2024
- Author(s)
  Shigemizu Daichi、Fukunaga Koya、Yamakawa Akiko、Suganuma Mutsumi、Fujita Kosuke、Kimura Tetsuaki、Watanabe Ken、Mushiroda Taisei、Sakurai Takashi、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  npj Aging
  
  Volume: 10 Issue: 1 Pages: 3-3
- DOI
  10.1038/s41514-023-00131-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Association between Circulating Levels of CXCL9 and CXCL10 and Physical Frailty in Older Adults2023
- Author(s)
  Li Jiaqi、Hosoyama Tohru、Shigemizu Daichi、Yasuoka Mikako、Kinoshita Kaori、Maeda Keisuke、Takemura Marie、Matsui Yasumoto、Arai Hidenori、Satake Shosuke
- Journal Title
  
  Gerontology
  
  Volume: 70 Issue: 3 Pages: 279-289
- DOI
  10.1159/000535109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21306, KAKENHI-PROJECT-21H02834
[Journal Article] Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data2023
- Author(s)
  Shigemizu Daichi、Akiyama Shintaro、Suganuma Mutsumi、Furutani Motoki、Yamakawa Akiko、Nakano Yukiko、Ozaki Kouichi、Niida Shumpei
- Journal Title
  
  Translational Psychiatry
  
  Volume: 13 Issue: 1 Pages: 1-8
- DOI
  10.1038/s41398-023-02531-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] RNA-Sequencing Analysis Identification of Potential Biomarkers for Diagnosis of Sarcopenia2023
- Author(s)
  Furutani Motoki、Suganuma Mutsumi、Akiyama Shintaro、Mitsumori Risa、Takemura Marie、Matsui Yasumoto、Satake Shosuke、Nakano Yukiko、Niida Shumpei、Ozaki Kouichi、Hosoyama Tohru、Shigemizu Daichi
- Journal Title
  
  The Journals of Gerontology: Series A
  
  Volume: 78 Issue: 11 Pages: 1991-1998
- DOI
  10.1093/gerona/glad150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306, KAKENHI-PROJECT-21H02834
[Journal Article] Network‐based meta‐analysis and the candidate gene association studies reveal novel ethnicity‐specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies2022
- Author(s)
  Shigemizu Daichi、Asanomi Yuya、Akiyama Shintaro、Higaki Sayuri、Sakurai Takashi、Ito Kengo、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  
  Volume: 189 Issue: 5 Pages: 139-150
- DOI
  10.1002/ajmg.b.32908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through immune landscape analysis2022
- Author(s)
  Shigemizu Daichi、Akiyama Shintaro、Mitsumori Risa、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  npj Aging
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41514-022-00096-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer’s disease2022
- Author(s)
  Shigemizu Daichi、Asanomi Yuya、Akiyama Shintaro、Mitsumori Risa、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  Molecular Psychiatry
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] A functional variant of SHARPIN confers increased risk of late-onset Alzheimer’s disease2021
- Author(s)
  Asanomi Yuya、Shigemizu Daichi、Akiyama Shintaro、Miyashita Akinori、Mitsumori Risa、Hara Norikazu、Ikeuchi Takeshi、Niida Shumpei、Ozaki Kouichi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Pages: 203-208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data2021
- Author(s)
  Asanomi Yuya、Shigemizu Daichi、Akiyama Shintaro、Sakurai Takashi、Ozaki Kouichi、Ochiya Takahiro、Niida Shumpei
- Journal Title
  
  Scientific Reports
  
  Volume: 11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] JAMIR-eQTL: Japanese genome-wide identification of microRNA expression quantitative trait loci across dementia types2021
- Author(s)
  Akiyama Shintaro、Higaki Sayuri、Ochiya Takahiro、Ozaki Kouichi、Niida Shumpei、Shigemizu Daichi
- Journal Title
  
  Database
  
  Volume: 2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] Whole-genome sequencing with long reads reveals complex structure and origin of structural variation in human genetic variations and somatic mutations in cancer2021
- Author(s)
  Fujimoto Akihiro、Wong Jing Hao、Yoshii Yukiko、Akiyama Shintaro、Tanaka Azusa、Yagi Hitomi、Shigemizu Daichi、Nakagawa Hidewaki、Mizokami Masashi、Shimada Mihoko
- Journal Title
  
  Genome Medicine
  
  Volume: 13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21306
[Journal Article] A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data2019
- Author(s)
  Shigemizu Daichi、Akiyama Shintaro、Asanomi Yuya、Boroevich Keith A.、Sharma Alok、Tsunoda Tatsuhiko、Sakurai Takashi、Ozaki Kouichi、Ochiya Takahiro、Niida Shumpei
- Journal Title
  
  BMC Medical Genomics
  
  Volume: 12 Issue: 1 Pages: 150-150
- DOI
  10.1186/s12920-019-0607-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06307, KAKENHI-PROJECT-16H06299
[Journal Article] Bigram-PGK: phosphoglycerylation prediction using the technique of bigram probabilities of position specific scoring matrix2019
- Author(s)
  Chandra Abel、Sharma Alok、Dehzangi Abdollah、Shigemizu Daichi、Tsunoda Tatsuhiko
- Journal Title
  
  BMC Molecular and Cell Biology
  
  Volume: 20 Issue: S2 Pages: 57-57
- DOI
  10.1186/s12860-019-0240-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06307, KAKENHI-PROJECT-16H06299
[Journal Article] DeepInsight: A methodology to transform a non-image data to an image for convolution neural network architecture2019
- Author(s)
  Sharma Alok、Vans Edwin、Shigemizu Daichi、Boroevich Keith A.、Tsunoda Tatsuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 11399-11399
- DOI
  10.1038/s41598-019-47765-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06307, KAKENHI-PROJECT-16H06299
[Journal Article] Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.2018
- Author(s)
  Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T.
- Journal Title
  
  Hum Genet.
  
  Volume: 37(6-7) Issue: 6-7 Pages: 521-533
- DOI
  10.1007/s00439-018-1906-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-17K10301, KAKENHI-PROJECT-18K07565, KAKENHI-PLANNED-17H06307, KAKENHI-PROJECT-16H05379, KAKENHI-PROJECT-18H03121
[Journal Article] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis2018
- Author(s)
  Shigemizu Daichi、Miya Fuyuki、Akiyama Shintaro、Okuda Shujiro、Boroevich Keith A、Fujimoto Akihiro、Nakagawa Hidewaki、Ozaki Kouichi、Niida Shumpei、Kanemura Yonehiro、Okamoto Nobuhiko、Saitoh Shinji、Kato Mitsuhiro、Yamasaki Mami、Matsunaga Tatsuo、Mutai Hideki、Kosaki Kenjiro、Tsunoda Tatsuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 5608-5608
- DOI
  10.1038/s41598-018-23978-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15530, KAKENHI-PROJECT-16K19068, KAKENHI-PROJECT-18K09336, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-16H06299
[Presentation] Genome wide association study identifies new genetic risk loci for dementia with Lewy body in Japanese2023
- Author(s)
  Mitsumori R., Asanomi Y., Shigemizu D., Akiyama S., Morizono T., Niida S., and Ozaki K.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Ferroptotic aspects of cartilage degeneration in mouse osteoarthritis2023
- Author(s)
  Ishii K., Ma L., Shigemizu D., Asanomi Y., Nakamura H., Ozaki K., and Watanabe K.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] RNA-seq データ解析に基づく軽度認知機能障害からアルツハイマー型認知症への移行に関与する血液バイオマーカーの探索2023
- Author(s)
  山川明子、光森理紗、菅沼睦美、秋山真太郎、新飯田俊平、尾崎浩一、重水大智
- Organizer
  第12回日本認知症予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Circulating CXCL9 levels, but not CXCL10 levels, were associated with frailty in older adults2023
- Author(s)
  Li J., Hosoyama T., Shigemizu D., Yasuoka M., Kinoshita K., Maeda K., Takemura M., Matsui Y., Arai H., Satake S.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of blood-based biomarkers for early diagnosis of frailty through a combined analysis of the clinical data, gene-expression data, and aging-related factors2023
- Author(s)
  Suganuma M., Furutani M., Hosoyama T., Akiyama S., Mitsumori R., Otsuka R., Takemura M., Matsui Y., Nakano Y., Niida S., Ozaki K., Satake S., and Shigemizu D.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人集団で見つかったレビー小体型認知症に関連する MFSD3 多型の機能解析2023
- Author(s)
  木村哲晃、菅沼睦美、澤村嘉代子、浅海裕也、細山徹、下田修義、小木曽昇、新飯田俊平、尾崎浩一、重水大智
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] An integrative approach to detect potential blood-based biomarkers for frailty2023
- Author(s)
  Suganuma M, Furutani M, Hosoyama T, Akiyama S, Mitsumori R, Otsuka R, Takemura M, Matsui Y, Nakano Y, Niida S, Ozaki K, Satake S, and Shigemizu D.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Exploration of blood-based biomarkers to predict the progression of Alzheimer's disease by RNA-sequencing data analysis2023
- Author(s)
  Yamakawa A., Mitsumori R., Suganuma M., Akiyama S., Niida S., Ozaki K., and Shigemizu D.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Association between spatio-temporal gait parameters and the risk of falls in older adults2023
- Author(s)
  Li J., Yasuoka M., Kinoshita K., Hirano Y., Maeda K., Takemura M., Matsui Y., Hosoyama T., Shigemizu D., Arai H., and Satake S.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Functional analysis of MFSD3 associated with dementia with Lewy bodies2023
- Author(s)
  Kimura T, Suganuma M, Hosoyama T, Sawamura K, Shimoda N, Ogiso N, Niida S, Ozaki K, and Shigemizu D.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人および民族間横断的ゲノムワイド関連解析によるレビー小体認知症感受性座位の探索2023
- Author(s)
  光森理紗, 浅海裕也, 重水大智, 秋山真太郎, 森園隆, 新飯田俊平, 尾崎浩一
- Organizer
  第31回日本医学会総会2023東京
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人集団で見つかったレビー小体型認知症に関連するMFSD3多型の機能解析2023
- Author(s)
  木村哲晃、菅沼睦美、澤村嘉代子、細山徹、下田修義、小木曽昇、新飯田俊平、尾崎浩一、重水大智
- Organizer
  第12回日本認知症予防学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Genome-wide association study for non-specific chronic pain in Japanese elderly2023
- Author(s)
  Shigemizu D., Sakai Y., Honjo K., Wakao N., Matsui H., Shimada H., Mitsumori R., Ozaki K., and Watanabe K.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] MFSD3 loss of function with dementia with Lewy bodies causes an increase of butyrylcholinesterase activity in the brain2023
- Author(s)
  Kimura T., Suganuma M., Sawamura K., Hosoyama T., Ogiso N., Niida S., Ozaki K., and Shigemizu D.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] RNA-seq data analysis identifies blood-based biomarkers for diagnosis and disease progression of Alzheimer's disease2023
- Author(s)
  Yamakawa A., Mitsumori R., Suganuma M., Akiyama S., Niida S., Ozaki K., and Shigemizu D.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 遺伝子発現データに基づくアルツハイマー病移行予測診断システムの開発2023
- Author(s)
  山川明子、光森理紗、菅沼睦美、秋山真太郎、新飯田俊平、尾崎浩一、重水大智
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Functional analysis of MFSD3 associated with dementia with Lewy bodies2023
- Author(s)
  Kimura T, Suganuma M, Hosoyama T, Sawamura K, Shimoda N, Ogiso N, Niida S, Ozaki K, and Shigemizu D.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Genomic research on dementia in the Japanese population2023
- Author(s)
  Shigemizu D.
- Organizer
  NCGG ICAH TMIG Joint Symposium 2023 IAGG-AOR Sattelite
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of an East Asian-specific variant associated with Lewy bodies dementia by genome-wide association study in Japanese subjects2023
- Author(s)
  Mitsumori R, Asanomi Y, Shigemizu D, Akiyama S, Morizono T, Niida S, and Ozaki K.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Genomic research on dementia in the Japanese population2023
- Author(s)
  Shigemizu D., and Ozaki K.
- Organizer
  Human Genetics Asia 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Knock-in of late-onset Alzheimer’s disease-risk variant SHARPIN G186R lessens NF-κB pathway and accelerates Aβ secretion2023
- Author(s)
  Asanomi Y, Kimura T, Shimoda N, Shigemizu D, Niida S, and Ozaki K.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of blood-based biomarkers associated with conversion from mild cognitive impairment to Alzheimer’s disease by RNA-sequencing data analysis2023
- Author(s)
  山川明子、光森理紗、菅沼睦美、秋山真太郎、新飯田俊平、尾崎浩一、重水大智
- Organizer
  IIBMP2023
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] East Asian-specific late-onset Alzheimer's disease risk variant alters the endogenous SHARPIN function2023
- Author(s)
  Asanomi Y., Shigemizu D., Akiyama S., Mitsumori R., Niida S., Ozaki K.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of blood-based biomarkers associated with conversion from mild cognitive impairment to Alzheimer’s disease by RNA-sequencing data analysis.2023
- Author(s)
  Yamakawa A., Mitsumori R., Akiyama S., Niida S., Ozaki K., and Shigemizu D.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] A genome wide association study identifies an East Asian-specific risk variant for Lewy bodies dementia in Japanese2023
- Author(s)
  Mitsumori R, Asanomi Y, Shigemizu D, Akiyama S, Morizono T, Niida S, and Ozaki K.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of potential blood-based biomarkers for frailty by using an integrative approach2023
- Author(s)
  Suganuma M, Furutani M, Hosoyama T, Akiyama S, Mitsumori R, Otsuka R, Takemura M, Matsui Y, Nakano Y, Niida S, Ozaki K, Satake S, and Shigemizu D.
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] CRISPR/Cas9-mediated knock-in of late-onset Alzheimer’s disease-risk variant, SHARPIN G186R, lessens the NF-κB pathway and accelerates Aβ secretion2023
- Author(s)
  Asanomi Y, Kimura T, Shimoda N, Shigemizu D, Niida S, and Ozaki K.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人および民族間横断的ゲノムワイド関連解析によるレビー小体認知症感受性座位の探索2022
- Author(s)
  光森理紗, 浅海裕也, 重水大智, 秋山真太郎, 森園隆, 新飯田俊平, 尾崎浩一
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人集団におけるQTL解析2022
- Author(s)
  古谷元樹, 森園隆, 光森理紗, 呉谷文, 中野由紀子, 新飯田俊平, 重水大智, 尾崎浩一
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人大規模データを用いたアルツハイマー病トランスクリプトームワイド関連解析2022
- Author(s)
  呉谷文, 森園隆, 秋山真太郎, 新飯田俊平, 尾崎浩一, 重水大智
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 大規模ヒトゲノム・オミクス解析における認知症原因・感受性遺伝子の同定と発症予測モデルの開発2022
- Author(s)
  重水　大智
- Organizer
  熊本大学大学院生命科学研究部附属健康長寿代謝制御研究センター・国立長寿医療研究センター第一回共同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人における遅発性アルツハイマー病関連遺伝子SHARPINの同定と解析2022
- Author(s)
  浅海裕也, 重水大智, 秋山真太郎, 光森理紗, 新飯田俊平, 尾崎浩一
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of a novel functional missense variant associated with late-onset Alzheimer's disease in Japanese.2022
- Author(s)
  Asanomi Y., Shigemizu D., Akiyama S., Mitsumori R., Niida S., and Ozaki K
- Organizer
  第11回生命医薬情報学連合大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 大規模ゲノム・オミクス解析を使った認知症研究の最前線2022
- Author(s)
  重水　大智
- Organizer
  第765回新潟医学会例会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 認知症における日本人大規模ゲノム研究の最前線2022
- Author(s)
  重水　大智
- Organizer
  九州大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 全ゲノム解析による認知症関連レアバリアント解析2022
- Author(s)
  重水　大智
- Organizer
  第11回生命医薬情報学連合大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 全ゲノムシーケンスによるアルツハイマー病に関連したMLKL遺伝子の日本人に特異的な新規希少バリアントの発見2022
- Author(s)
  木村哲晃, 浅海裕也, 秋山真太郎, 光森理紗, 森園隆, 新飯田俊平, 尾崎浩一, 重水大智
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of potential blood biomarkers for Sarcopenia through RNA sequencing analysis.2022
- Author(s)
  Furunani M., Suganuma M, Akiyama S., Mitsumori R., Hosoyama T., Takemura M., Matsui Y., Satake S., Nakano Y., Niida S., Ozaki K., and Shigemizu D.
- Organizer
  The 8th Asian Conference for Frailty and Sarcopenia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 認知症における日本人大規模ゲノム研究の最前線2022
- Author(s)
  重水　大智
- Organizer
  東レバイオ要素技術連絡会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人および民族横断的ゲノムワイド関連解析による認知症の感受性座位の探索2021
- Author(s)
  光森理紗, 浅海裕也, 重水大智, 秋山真太郎, 森園隆, 寺尾知可史, 新飯田俊平, 尾崎浩一
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Genetic research in dementia2021
- Author(s)
  Shigemizu D.
- Organizer
  An international online congress, Aging Management
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 日本人集団における頻脈誘発性心筋症のゲノムワイド関連解析2021
- Author(s)
  古谷元樹, 岡村祥央, 森園隆, 重水大智, 新飯田俊平, 中野由紀子, 尾崎浩一
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 変形性関節症自然発症マウスモデルSTR/ortの軟骨変性に関わる遺伝子変異の同定とferroptosisの関与2021
- Author(s)
  馬凌云, 重水大智, 中村博幸, 尾崎浩一, 渡邉研
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 認知症における日本人大規模ゲノム解析による新規感受性遺伝子の同定2021
- Author(s)
  重水大智
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 大規模ゲノム・オミクス解析による認知症研究2021
- Author(s)
  重水大智
- Organizer
  日本プロテオーム学会2021年大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] 遅発性アルツハイマー病関連遺伝子SHARPINの疾患リスクとなる新規機能的ミスセンスバリアントの同定2021
- Author(s)
  浅海裕也, 重水大智, 秋山真太郎, 宮下哲典, 光森理紗, 原範和, 池内健, 新飯田俊平, 尾崎浩一
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-23K21306
[Presentation] Identification of novel long QT syndrome-associated mutations by targeted sequencing analyses.2017
- Author(s)
  Watanabe, R., Ohno, S., Aiba, T., Ishikawa, Nakano, Y., Aizawa, Y., Hayashi, K., Murakoshi, N., Nakajima, T., Yagihara, N., Shigemizu, D., et al
- Organizer
  European Human Genetics Conference
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Exome sequencing analyses for late-onset Alzheimer's disease in Japanese2017
- Author(s)
  Asanomi, Y., Shigemizu, D., Nagata, Y., Mitsumori, R., Mori, T., Niida, S., and Ozaki, K.
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] 既存のexome解析では疾患原因変異同定が困難な検体の原因変異探索手法の開発.2017
- Author(s)
  宮冬樹, 重水大智, 齋藤伸治, 須藤章, 中川英刀, 奥田修二郎, 岡本伸彦, 加藤光広, 山崎麻美, Keith A. Boroevich, 金村米博, 小崎健次郎, 角田達彦
- Organizer
  NGS現場の会第５回研究会
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment into spit reads.2017
- Author(s)
  Shigemizu, D., Miya, F., Akiyama, S., Okuda, S., Boroevich, KA., Fujimoto, A., Nakagawa, H., and Tsunoda, T.
- Organizer
  The American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Development of an accurate intermediate-size indel detection tool for discovery of mutations associated with human disease.2017
- Author(s)
  Shigemizu, D., Miya, F., Akiyama, S., Okuda, S., Boroevich, KA., Fujimoto, A., Nakagawa, H., Ozaki, K., Niida, S., Kanemura, Y., Okamoto, N., Saitoh, S., Kato, M., Yamasaki, M., Matsunaga, T., Mutai, H., Kosaki, K., and Tsunoda, T.
- Organizer
  第6回生命医薬情報学連合大会 (IIBMP2017)
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Genome wide association study for late-onset Alzheimer's Disease in a Japanese population.2017
- Author(s)
  Mitsumori, R., Asanomi, Y., Shigemizu, D., Nagata, Y., Mori, T., Akiyama, S., Niida, S., and Ozaki, K.
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] 次世代シークエンサーを用いた臨床研究の実際2017
- Author(s)
  重水　大智
- Organizer
  科研費基盤研究S ＆第8回生物統計ネットワークシンポジウム統計科学が切り拓く個別化医療：方法論・実践のフロンティア
- Place of Presentation
  アクロス福岡（福岡県福岡市）
- Year and Date
  2017-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] An accurate intermediate-size indel detection tool for discovery of mutations associated with human disease.2017
- Author(s)
  Shigemizu, D., Miya, F., Akiyama, S., Okuda, S., Boroevich, KA., Fujimoto, A., Nakagawa, H., Ozaki, K., Niida, S., Kanemura, Y., Okamoto, N., Saitoh, S., Kato, M., Yamasaki, M., Matsunaga, T., Mutai, H., Kosaki, K., and Tsunoda, T.
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Development and assessment of a pathogenic mutations search method for subjects where exome has previously failed.2017
- Author(s)
  Miya, F., Shigemizu, D., Kanemura, Y., Saitoh, S., Okamoto, N., Kato, M., Yamasaki, M., Matsunaga, T., Mutai, H., and Kosaki, K.
- Organizer
  The Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] 疾患原因遺伝子同定のためのエクソーム解析の現在2016
- Author(s)
  重水　大智
- Organizer
  第２回バイオインフォマティクスアゴラ
- Place of Presentation
  東京工業大学（東京都目黒区大岡山）
- Invited
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Performance comparison of four commercial human whole-exome capture platforms2016
- Author(s)
  Shigemizu, D., Momozawa, Y., Abe, T., Morizono, T., Boroevich, KA., Takata, S., Ashikawa, K., Kubo, M., and Tsunoda, T.
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  Kyoto International Conference Center (Kyoto, Kyoto)
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] 疾患原因となる遺伝子変異同定のためのエクソーム解析の現在2016
- Author(s)
  重水　大智
- Organizer
  科研費基盤研究Aシンポジウム (I)複雑な生命現象を読み解くための大規模データ解析とモデリング
- Place of Presentation
  久留米シティプラザ（福岡県久留米市）
- Year and Date
  2016-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K19068
[Presentation] Development of a long indel detection method using the realignment of the misaligned reads2016
- Author(s)
  Shigemizu, D., Miya, F., Fujimoto, A., Boroevich, KA., Okuda, S., and Tsunoda, T
- Organizer
  The American Society of Human Genetics
- Place of Presentation
  Vancouver Convention Centre (Canada, Vancouver)
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19068

1. Tsunoda Tatsuhiko (10273468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Takagi Masatoshi (10406267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 盛武浩 (40336300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 浦山ケビン (60726850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 尾崎浩一 (50373288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 46 results
6. 佐竹昭介 (50508116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 細山徹 (20638803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 木下かほり (60896306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 前田圭介 (50775179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松井康素 (50501623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 荒木厚 (60539196)

# of Collaborated Projects: 1 results

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12. 田村嘉章 (50842142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AKATSU Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. OHARA Hirotaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 斉藤伸治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shigemizu Daichi 重水 大智

SHIGEMIZU Daichi 重水 大智

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高齢者における内在能力の簡易評価票の開発のためのコホート研究

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Development of a prognosis prediction model for Alzheimer's disease using integrative multi-omics dataPrincipal Investigator

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Genetic background of acute lymphoblastic leukemia in children

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Development and application of analysis methodology for next generation human omics

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Investigation of disease-causing variants of Long QT syndrome using whole exome sequencingPrincipal Investigator

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[Book] 細胞2017

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[Book] BIO Clinica2017

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[Book] アンチ・エイジング医学2017

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[Journal Article] CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer’s disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion2024

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[Journal Article] Identification of Potential Blood-Based Biomarkers for Frailty by Using an Integrative Approach2024

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[Journal Article] The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE4 negative Japanese adults2024

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[Journal Article] Association between Circulating Levels of CXCL9 and CXCL10 and Physical Frailty in Older Adults2023

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[Journal Article] Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data2023

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[Journal Article] RNA-Sequencing Analysis Identification of Potential Biomarkers for Diagnosis of Sarcopenia2023

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Shigemizu Daichi 重水大智

SHIGEMIZU Daichi 重水大智

[Journal Article] The HLA-DRB109:01-DQB103:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE4 negative Japanese adults2024