Kawahara Naoki 河原直紀

Researcher Number	70623495
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 卵巣明細胞癌 / アクチノニン / GSK-3beta / HNF-1beta / ARID1A変異 / Cyclin E1 / CDC6 / Cyclin-E1(CCNE1) / ARID1A / CCNE1 … More / Cyclin-E1 / ARID1A遺伝子変異 / 合成致死 / 明細胞癌 / 卵巣癌 … More Except Principal Investigator 合成致死 / 卵巣明細胞癌 / ハイドロキシクロロキン / 全身性エリテマトーデス / 妊娠高血圧症候群 / 抗炎症作用 / 不妊症 / 月経困難症 / ヒドロキシクロロキン / 子宮内膜症 / ダイドロゲステロン / プロゲステロン / 胎児発育不全 / HNF1β / NF-κB / 代謝 / ミトコンドリア / GSK-3beta / HNF-1beta / 細胞周期関連遺伝子 / PIK3CA / PIK3CA遺伝子変異 / synthetic lethality / ARID1A mutation / Cyclin-E1(CCNE1) / CCNE1 / Cyclin-E1 / ARID1A遺伝子変異 Less

ヒドロキシクロロキンを用いた子宮内膜症の新規治療開発
- Principal Investigator
  
  山本皇之祐
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
A investigation into unique energy metabolism of ovarian clear cell carcinomaPrincipal Investigator
- Principal Investigator
  
  河原直紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
Study of the effects of oral dydrogesterone administration on fetal growth restriction
- Principal Investigator
  
  木村麻衣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
A study of the effect of hydroxychloroquine on repeated fetal loss and development of preeclampsia
- Principal Investigator
  
  脇啓太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
The investigation in synthetic lethal effect of CCNE1 for ARID1A mutation in ovarian clear cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Kawahara Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
Search for synthetic lethal candidates for HNF1beta-USP28-CLASPIN-Chk1 inhibition
- Principal Investigator
  
  KIMURA Mai
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University
Search for synthetic lethal candidates for PIK3CA mutations
- Principal Investigator
  
  Mika Nagayasu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nara Medical University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study2024
- Author(s)
  Kawahara Naoki、Yamanaka Shoichiro、Nishikawa Kyohei、Matsuoka Motoki、Maehana Tomoka、Kawaguchi Ryuji、Ozu Naoki、Fujii Tomomi、Sugimoto Aya、Yoshizawa Akihiko、Kimura Fuminori
- Journal Title
  
  Microorganisms
  
  Volume: 12 Issue: 3 Pages: 538-538
- DOI
  10.3390/microorganisms12030538
- Data Source
  KAKENHI-PROJECT-21K16819
[Journal Article] The Prognosis Predictive Score around Neo Adjuvant Chemotherapy (PPSN) Improves Diagnostic Efficacy in Predicting the Prognosis of Epithelial Ovarian Cancer Patients2023
- Author(s)
  Kawahara Naoki、Yamanaka Shoichiro、Sugimoto Sumire、Kamibayashi Junya、Nishikawa Kyohei、Kawaguchi Ryuji、Kimura Fuminori
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 20 Pages: 5062-5062
- DOI
  10.3390/cancers15205062
- Data Source
  KAKENHI-PROJECT-21K16819
[Journal Article] The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy2022
- Author(s)
  Yamanaka Shoichiro、Kawahara Naoki、Kawaguchi Ryuji、Waki Keita、Maehana Tomoka、Fukui Yosuke、Miyake Ryuta、Yamada Yuki、Kobayashi Hiroshi、Kimura Fuminori
- Journal Title
  
  Diagnostics
  
  Volume: 12 Issue: 5 Pages: 1212-1212
- DOI
  10.3390/diagnostics12051212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16819, KAKENHI-PROJECT-20K09648
[Journal Article] The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma.2022
- Author(s)
  Kawahara N, Kawaguchi R, Maehana T, Yamanaka S, Yamada Y, Kobayashi H, Kimura F.
- Journal Title
  
  Biomedicines.
  
  Volume: 10(11) Issue: 11 Pages: 2683-2683
- DOI
  10.3390/biomedicines10112683
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16819, KAKENHI-PROJECT-20K09648
[Journal Article] Macrophages Protect Endometriotic Cells Against Oxidative Damage Through a Cross-Talk Mechanism2022
- Author(s)
  Ogawa Kenji、Liu Tingting、Kawahara Naoki、Kobayashi Hiroshi
- Journal Title
  
  Reproductive Sciences
  
  Volume: - Issue: 8 Pages: 2165-2178
- DOI
  10.1007/s43032-022-00890-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16819, KAKENHI-PROJECT-20K09648
[Journal Article] The prognosis predictive score around primary debulking surgery (PPSP) improves diagnostic efficacy in predicting the prognosis of ovarian cancer.2022
- Author(s)
  Kawahara N, Kawaguchi R, Waki K, Maehana T, Yamanaka S, Yamada Y, Kimura F.
- Journal Title
  
  Sci Rep.
  
  Volume: 12(1) Issue: 1 Pages: 22636-22636
- DOI
  10.1038/s41598-022-27333-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16819
[Journal Article] CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma2021
- Author(s)
  Kawahara Naoki、Yamada Yuki、Kobayashi Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 5869-5869
- DOI
  10.3390/ijms22115869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09809, KAKENHI-PROJECT-21K16819
[Journal Article] A Novel Predictive Tool for Discriminating Endometriosis Associated Ovarian Cancer from Ovarian Endometrioma: The R2 Predictive Index2021
- Author(s)
  Kawahara Naoki、Miyake Ryuta、Yamanaka Shoichiro、Kobayashi Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 15 Pages: 3829-3829
- DOI
  10.3390/cancers13153829
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09758, KAKENHI-PROJECT-21K16819
[Journal Article] GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma2020
- Author(s)
  Kawahara Naoki、Mizutani Ayano、Matsubara Sho、Takeda Yoshinori、Kobayashi Hiroshi
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 20 Issue: 5 Pages: 122-122
- DOI
  10.3892/etm.2020.9250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09604, KAKENHI-PROJECT-20K09647
[Presentation] CCNE1 Is a Novel Synthetic Lethal Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma2023
- Author(s)
  河原直紀、山田有紀、川口龍二
- Organizer
  第75回日本産婦人科学会
- Data Source
  KAKENHI-PROJECT-21K16819
[Presentation] HNF-1beta 強発現を呈する卵巣明細胞癌に対する合成致死候補の検索2019
- Author(s)
  河原直紀，竹田善紀, 松原翔, 山田有紀，小林浩
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09809

1. 木村文則 (90322148)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KIMURA Mai (30812333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 小林浩 (40178330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 山中彰一郎 (30866009)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 三宅龍太 (20866008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 市川麻祐子 (30833678)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Mika Nagayasu (80623496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松原翔 (20825236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小川憲二 (60623494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉元千陽 (00526725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川口龍二 (50382289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山尾佳穂 (00973174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山本皇之祐 (50973179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山田有紀 (20588537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 脇啓太 (00930710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 赤坂珠理晃 (90526724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kawahara Naoki 河原 直紀

Research Projects

Research Products

Co-Researchers

ヒドロキシクロロキンを用いた子宮内膜症の新規治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A investigation into unique energy metabolism of ovarian clear cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the effects of oral dydrogesterone administration on fetal growth restriction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of the effect of hydroxychloroquine on repeated fetal loss and development of preeclampsia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation in synthetic lethal effect of CCNE1 for ARID1A mutation in ovarian clear cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for synthetic lethal candidates for HNF1beta-USP28-CLASPIN-Chk1 inhibition

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for synthetic lethal candidates for PIK3CA mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Prognosis Predictive Score around Neo Adjuvant Chemotherapy (PPSN) Improves Diagnostic Efficacy in Predicting the Prognosis of Epithelial Ovarian Cancer Patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophages Protect Endometriotic Cells Against Oxidative Damage Through a Cross-Talk Mechanism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The prognosis predictive score around primary debulking surgery (PPSP) improves diagnostic efficacy in predicting the prognosis of ovarian cancer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma2021

Author(s)

Journal Title

DOI

Kawahara Naoki 河原直紀