Horiguchi Hiroto 堀口拓人

… Alternative Names

堀口拓人ホリグチヒロト

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Researcher Number	70634674
Other IDs	https://orcid.org/0000-0001-6811-3042
Affiliation (Current)	2026: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 札幌医科大学, 医学部, 講師 2023 – 2024: 札幌医科大学, 医学部, 助教 2019 – 2022: 札幌医科大学, 医学部, 研究員 2015 – 2017: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 神経ペプチド / 急性骨髄性白血病 / TIP39 / acute myeloid leukemia / neuropeptide / P120 / リンパ系腫瘍 / 急性リンパ性白血病 / リンパ性白血病 / KAISO … More Except Principal Investigator … More 白血病幹細胞 / 骨髄異形成症候群 / MDS / 骨髄微細環境 / PTH２R / 急性骨髄性白血病 / オートファジー / 神経ペプチド / AML / caspase3 / autophagy / TIP39 / Neuropeptide / PTH2R / 細胞外小胞 / 骨髄間質 / 間葉系幹細胞 / エキソソーム / PCBP1 / 骨髄間質細胞 / 白血病 / マイクロRNA / エクソソーム Less

骨髄微細環境における神経－白血病系の解析Principal Investigator
- Principal Investigator
  
  堀口拓人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Development of new therapy for AML by targeting of neuropeptide-PTH2R system
- Principal Investigator
  
  Kobune Masayoshi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Function of neuropeptide, TIP39, in bone marrow microenvironment with hematopoietic neoplasmPrincipal Investigator
- Principal Investigator
  
  HORIGUCHI HIROTO
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Role of KAISO and P120 complex in lymphoid leukemiaPrincipal Investigator
- Principal Investigator
  
  Horiguchi Hiroto
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Sapporo Medical University
The effect of exosomal miRNA on AML/MDS stromal cells
- Principal Investigator
  
  Kobune Masayoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University

All 2025 2024 2023 2022 2020 2017 2015

All Journal Article Presentation

[Journal Article] Prognostic impact of TET2 mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study2025
- Author(s)
  Iyama Satoshi、Chi SungGi、Idogawa Masashi、Ikezoe Takayuki、Fukushima Kentaro、Utsu Yoshikazu、Kanda Junya、Yoshimoto Goichi、Kobayashi Takahiro、Kojima Kensuke、et al
- Journal Title
  
  Annals of Hematology
  
  Volume: 104 Pages: 275-284
- DOI
  10.1007/s00277-025-06227-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08396, KAKENHI-PROJECT-22K08509, KAKENHI-PROJECT-24K10378
[Journal Article] Neuropeptide TIP39 induces autophagy in PTH2 receptor-positive myeloid neoplasms2025
- Author(s)
  Kento Ono, Hiroto Horiguchi, Satoshi Iyama, Ken Sato, Saori Ibuki-Shimoyama, Shotaro Shirato, Yusuke Sugama, Akari Goto, Masayoshi Kobune
- Journal Title
  
  Int J Hematol.
  
  Volume: - Issue: 3 Pages: 400-412
- DOI
  10.1007/s12185-025-03985-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08509
[Journal Article] Successful Pregnancy and Fetal Outcomes Following Brentuximab Vedotin for Early Relapsed Classic Hodgkin Lymphoma After Autologous Stem Cell Transplant2024
- Author(s)
  Goto Akari、Fujita Chisa、Horiguchi Hiroto、Iyama Satoshi、Kobune Masayoshi
- Journal Title
  
  Cureus
  
  Volume: 16
- DOI
  10.7759/cureus.57291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08509
[Journal Article] Novel method for assessing sinusoidal obstruction syndrome using four‐dimensional computed tomography2024
- Author(s)
  Shimoyama‐Ibuki Saori、Iyama Satoshi、Ohashi Yoshiya、Ono Kento、Sugama Yusuke、Fujita Chisa、Goto Akari、Horiguchi Hiroto、Fujimi Akihito、Tanaka Takeo、Takada Kohichi、Sakata Koh‐Ichi、Kobune Masayoshi
- Journal Title
  
  eJHaem
  
  Volume: 5 Issue: 5 Pages: 1038-1042
- DOI
  10.1002/jha2.990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08509
[Journal Article] Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study2023
- Author(s)
  Kunimoto Yusuke、Matamura Ryosuke、Ikeda Hiroshi、Horiguchi Hiroto、Fujii Satoshi、Kobune Masayoshi、Fukudo Masahide、Toda Takaki
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 9 Issue: 1 Pages: 45-45
- DOI
  10.1186/s40780-023-00315-9
- Data Source
  KAKENHI-PROJECT-22K08509
[Journal Article] Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial.2015
- Author(s)
  Hirayama Y, Ishitani K, Sato Y, Iyama S, Takada K, Murase K, Kuroda H, Nagamachi Y, Konuma Y, Fujimi A, Sagawa T, Ono K, Horiguchi H, Terui T, Koike K, Kusakabe T, Sato T, Takimoto R, Kobune M, Kato J
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 20 Issue: 5 Pages: 866-871
- DOI
  10.1007/s10147-015-0810-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09482, KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-25461430
[Presentation] A Neuropeptide TIP39 Could Induce Autophagy and Enhance Cell Survival in Leukemic Cell Lines.2024
- Author(s)
  Hiroto Horiguchi, Kento Ono, Shotaro Shirato , Ken Sato, Saori Ibuki-Shimoyama, Akari Goto, Satoshi Iyama, Masayoshi Kobune
- Organizer
  The 14th JSH International Symposium 2024 in Hakodate
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11546
[Presentation] NEUROPEPTIDE TIP39 INDUCES AUTOPHAGY IN PTH2 RECEPTOR-POSITIVE MYELOID NEOPLASMS2024
- Author(s)
  Hiroto Horiguchi, Kento Ono, Shotaro Shirato , Ken Sato, Saori Ibuki-Shimoyama, Akari Goto, Satoshi Iyama, Masayoshi Kobune
- Organizer
  European hematology association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11546
[Presentation] シンポジウム2「鉄剤の適正使用による貧血治療指針」:鉄欠乏・鉄欠乏性貧血の疫学・症状2023
- Author(s)
  小船雅義、堀口拓人、後藤亜香利、宮西浩嗣
- Organizer
  第47回日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08509
[Presentation] A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System: HM-Screen-JAPAN02.2022
- Author(s)
  Arai H, Chi S, Utsu Y, Masuda S, Aotsuka N, Ueda T, Fukushima K, Ikeda D, Hosono N, Yamauchi T, Yoshimoto G, Horiguchi H, Iyama S, Kanda J, Katagiri S, Gotoh A, Koyama D, Ikezoe T, Kondo T, Nakamura Y, Ogasawara F, Fukuhara S, Izutsu K, Yamauchi N, Yuda J, Minami Y.
- Organizer
  American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16273
[Presentation] CD34+ Positive Myelodysplastic Cells with Ring Sideroblasts or SF3B1 Mutation Produce High Erythroferrone and GDF152020
- Author(s)
  Hiroto Horiguchi, Masayoshi Kobune, Kento Ono, Saori Shimoyama, Chisa Fujita, Akari Goto, Hiroshi Ikeda, Satoshi Iyama
- Organizer
  62nd ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23921
[Presentation] PCBP1発現低下による骨髄間質細胞の機能不全発症機序の解析2017
- Author(s)
  小船雅義、堀口拓人、宮西浩嗣、加藤淳二
- Organizer
  日本鉄バイオサイエンス学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09482
[Presentation] Exosomal microRNAs in bone marrow cavity induce stromal dysfunction in AML/MDS2015
- Author(s)
  Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Yasushi Sato1), Koji Miyanishi1), Rishu Takimoto, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県金沢市ホテル日航金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09482

1. Kobune Masayoshi (90336389)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. 後藤亜香利 (60722387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 佐藤勉 (40404602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 高田弘一 (90398321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 村瀬和幸 (90444918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 井山諭 (50398319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 池田博 (60570132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 小島研介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horiguchi Hiroto 堀口 拓人

堀口 拓人 ホリグチ ヒロト

Research Projects

Research Products

Co-Researchers

骨髄微細環境における神経－白血病系の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapy for AML by targeting of neuropeptide-PTH2R system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of neuropeptide, TIP39, in bone marrow microenvironment with hematopoietic neoplasmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of KAISO and P120 complex in lymphoid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of exosomal miRNA on AML/MDS stromal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prognostic impact of TET2 mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuropeptide TIP39 induces autophagy in PTH2 receptor-positive myeloid neoplasms2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful Pregnancy and Fetal Outcomes Following Brentuximab Vedotin for Early Relapsed Classic Hodgkin Lymphoma After Autologous Stem Cell Transplant2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel method for assessing sinusoidal obstruction syndrome using four‐dimensional computed tomography2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] A Neuropeptide TIP39 Could Induce Autophagy and Enhance Cell Survival in Leukemic Cell Lines.2024

Author(s)

Organizer

Data Source

[Presentation] NEUROPEPTIDE TIP39 INDUCES AUTOPHAGY IN PTH2 RECEPTOR-POSITIVE MYELOID NEOPLASMS2024

Author(s)

Organizer

Data Source

[Presentation] シンポジウム2「鉄剤の適正使用による貧血治療指針」:鉄欠乏・鉄欠乏性貧血の疫学・症状2023

Author(s)

Organizer

Data Source

[Presentation] A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System: HM-Screen-JAPAN02.2022

Author(s)

Organizer

Horiguchi Hiroto 堀口拓人

堀口拓人ホリグチヒロト