Fujiwara Takaaki 藤原孝彰

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Fujiwara Takaai 藤原孝彰

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Researcher Number	70712751
Other IDs
Affiliation (Current)	2025: 東北大学, 多元物質科学研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 東北大学, 多元物質科学研究所, 助教 2017: 京都大学, 大学院医学研究科, 研究員 2016: 京都大学, 医学研究科, 特定研究員 2015: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Basic Section 43030:Functional biochemistry-related / Structural biochemistry Except Principal Investigator Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields / Transformative Research Areas, Section (II) / Structural biochemistry
Keywords	Principal Investigator 動的構造解析 / X線自由電子レーザー / 室温構造解析 / 温度ジャンプ / 中間体構造 / 糖質関連酵素 / クライオトラップ / セルロース / クライオトラップ法 / シリアルフェムト秒結晶構造解析 … More / 反応中間体 / 糖加水分解酵素 / 部位特異的変異導入 / キメラタンパク質 / タンパク質構造安定化 / シグナル伝達 / アミン受容体 / Gタンパク質共役受容体 / X線結晶構造解析 / 膜タンパク質 / 構造生物 … More Except Principal Investigator 合成生物学 / タンパク質科学 / ターミナルコンプレックス / 複合体タンパク質精製 / 酢酸菌 / 高分子 / 機能欠損体作出 / 状態制御 / タンパクータンパク相互作用 / バイオマス形成 / タンパク質複合体 / 膜タンパク質 / 構造生物学 / タンパク質機能 / 生物素材構造-機能相関 / タンパク質構造-機能相関 / 高分子構造制御 / セルロース合成酵素 / セルロース / 受容体 / アゴニスト / COI1-JAZ / コロナチン / ジャスモン酸 / 癌 / 蛋白質 / G蛋白質共役型受容体 / タンパク質 / シグナル伝達 / Gタンパク質共役型受容体 / 結晶構造解析 Less

時分割構造解析によるテルペン環化酵素の精密反応過程の追跡Principal Investigator
- Principal Investigator
  
  藤原孝彰
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tohoku University
Construction of a natural product nuclear receptor ligand library for latent chemical space
- Principal Investigator
  
  上田実
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tohoku University
Elucidating the inversion reaction mechanism of glycoside hydrolase by structure dynamicsPrincipal Investigator
- Principal Investigator
  
  Fujiwara Takaaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku University
Control of polymer structure by enzyme: structure-function relationship of cellulose synthase
- Principal Investigator
  
  Imai Tomoya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields
- Research Institution
  Kyoto University
Structure and functional study of the agonist-bound dopamine D1 receptor for the development of antiparkinsonPrincipal Investigator
- Principal Investigator
  
  Fujiwara Takaai
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Trial for determining the structure of CXCR7
- Principal Investigator
  
  Shimamura Tatsuro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2018 2016

All Journal Article Presentation

[Journal Article] Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum2024
- Author(s)
  Takaaki Fujiwara, Eriko Mano, Eriko Nango
- Journal Title
  
  FEBS Letters
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06077
[Journal Article] Structural snapshot of a glycoside hydrolase family 8 endo-β-1,4-glucanase capturing the state after cleavage of the scissile bond2022
- Author(s)
  Fujiwara Takaaki、Fujishima Ayumi、Nakamura Yui、Tajima Kenji、Yao Min
- Journal Title
  
  Acta Crystallographica Section D Structural Biology
  
  Volume: 78 Issue: 2 Pages: 228-237
- DOI
  10.1107/s2059798321012882
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00950, KAKENHI-PROJECT-21K06077, KAKENHI-PROJECT-21H01754
[Journal Article] Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA2018
- Author(s)
  Suno Ryoji、Kimura Kanako Terakado、Nakane Takanori、Fujiwara Takaaki、Yamanaka Yasuaki、Im Dohyun、Rosenbaum Daniel M.、Iwata So、Shimamura Tatsuro、Kobayashi Takuya
- Journal Title
  
  Structure
  
  Volume: 26 Issue: 1 Pages: 7-19
- DOI
  10.1016/j.str.2017.11.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-15K08268, KAKENHI-PROJECT-15K18376
[Journal Article] A three dimensional movie of structural changes in bacteriorhodopsin.2016
- Author(s)
  Nango, E., Royant, A.†, Kubo, M.† et al. (†equal contribution)(45名中2番目)
- Journal Title
  
  Science
  
  Volume: 354 Issue: 6319 Pages: 1552-1557
- DOI
  10.1126/science.aah3497
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01055, KAKENHI-PROJECT-15H03841, KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-15H05476, KAKENHI-PROJECT-15K18486, KAKENHI-PROJECT-15K18523, KAKENHI-PROJECT-16H06315
[Presentation] アルギン酸分解・変換酵素AlgEの酵素特性解析2023
- Author(s)
  藤原孝彰，間野絵梨子，南後恵理子
- Organizer
  日本応用糖質科学会
- Data Source
  KAKENHI-PROJECT-21K06077
[Presentation] アルギン酸分解・変換酵素AlgEの立体構造解析2022
- Author(s)
  藤原孝彰，南後恵理子
- Organizer
  日本応用糖質科学会 2022年度大会
- Data Source
  KAKENHI-PROJECT-21K06077
[Presentation] バクテリアセルロース分解酵素BcsZの反応機構解明2021
- Author(s)
  藤原孝彰，藤島あゆみ，中村結衣，姚閔
- Organizer
  日本応用糖質科学会 2021年度大会
- Data Source
  KAKENHI-PROJECT-21K06077
[Presentation] GH8 に属するエンドグルカナーゼBcsZ の構造機能解析2021
- Author(s)
  藤原孝彰、藤島あゆみ、中村結衣、田島健二、姚閔
- Organizer
  日本結晶学会令和３年度年会
- Data Source
  KAKENHI-PROJECT-19H00950
[Presentation] GH8に属するエンドグルカナーゼBcsZの構造機能解析2021
- Author(s)
  藤原孝彰, 藤島あゆみ, 中村結衣, 田島健二, 姚閔
- Organizer
  令和3年（2021年）度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-21K06077
[Presentation] ヒスタミンH1受容体による抗ヒスタミン薬の認識機構2016
- Author(s)
  藤原孝彰，森本志保，山中保明，中根崇智，平田邦生，山下恵太郎，岩田想，島村達郎
- Organizer
  日本結晶学会2016年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15H04338
[Presentation] ヒスタミンH1受容体による抗ヒスタミン薬の認識機構2016
- Author(s)
  藤原孝彰，森本志保，山中保明，中根崇智，平田邦生，山下恵太郎，岩田想，島村達郎
- Organizer
  日本結晶学会2016年度年会
- Place of Presentation
  茨城県立県民文化センター（茨城県・水戸市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K18486

1. Shimamura Tatsuro (90391979)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. SUGA Hiroaki (00361668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMANAKA Yasuaki (10724049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. NOMURA Norimichi (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Imai Tomoya (90509142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 上田実 (60265931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田島健次 (00271643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 姚閔 (40311518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 近藤辰哉 (40965969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Morimoto SHIHO

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. IM Dohyun

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 久保稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Takaaki 藤原 孝彰

Fujiwara Takaai 藤原 孝彰

Research Projects

Research Products

Co-Researchers

時分割構造解析によるテルペン環化酵素の精密反応過程の追跡Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of a natural product nuclear receptor ligand library for latent chemical space

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the inversion reaction mechanism of glycoside hydrolase by structure dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of polymer structure by enzyme: structure-function relationship of cellulose synthase

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure and functional study of the agonist-bound dopamine D1 receptor for the development of antiparkinsonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trial for determining the structure of CXCR7

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum2024

Author(s)

Journal Title

Data Source

[Journal Article] Structural snapshot of a glycoside hydrolase family 8 endo-β-1,4-glucanase capturing the state after cleavage of the scissile bond2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A three dimensional movie of structural changes in bacteriorhodopsin.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] アルギン酸分解・変換酵素AlgEの酵素特性解析2023

Author(s)

Organizer

Data Source

[Presentation] アルギン酸分解・変換酵素AlgEの立体構造解析2022

Author(s)

Organizer

Data Source

[Presentation] バクテリアセルロース分解酵素BcsZの反応機構解明2021

Author(s)

Organizer

Data Source

[Presentation] GH8 に属するエンドグルカナーゼBcsZ の構造機能解析2021

Author(s)

Organizer

Data Source

[Presentation] GH8に属するエンドグルカナーゼBcsZの構造機能解析2021

Author(s)

Organizer

Data Source

Fujiwara Takaaki 藤原孝彰

Fujiwara Takaai 藤原孝彰