Seki Motoaki 関元昭

Researcher Number	70714278
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 特任助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 千葉大学, 医学部附属病院, 特任助教 2018: 東京大学, 先端科学技術研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator DNAバーコード / ウイルス発癌 / EBV胃癌 / 細胞不均一性 / エピゲノム / DNAメチル化 / 細胞老化 / 胃がん / EBウイルス胃癌 / 胃癌 … More / EBウイルス / 癌幹細胞 / 細胞系譜 / 癌オルガノイド … More Except Principal Investigator HDAC / 抗癌小分子化合物 / 抗がん作用 / Motif解析 / H3K27ac / c-Myc / トランスクリプトーム / 白血病細胞株 / 天然化合物 / エピゲノム / transcriptome / Cinobufagin / 生薬 / 抗癌 / 白血病 / 和漢薬 Less

細胞集団の不均一性に着目したEBV胃癌発生メカニズムの解析Principal Investigator
- Principal Investigator
  
  関元昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Mechanism on epigenetic carcinogenesis of EB virus-gastric cancer focused on senescencePrincipal Investigator
- Principal Investigator
  
  SEKI Motoaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Searching for novel anticancer epigenetic drugs from Kampo medicines followed by elucidation of the mechanism through transcriptomic analyses.
- Principal Investigator
  
  Hirasaki Yoshiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Chiba University
Analysis of cellular hierarchy by transcribed DNA barcodesPrincipal Investigator
- Principal Investigator
  
  Seki Motoaki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Chiba University
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma2024
- Author(s)
  Mizokami Harue、Okabe Atsushi、Choudhary Ruchi、Mima Masato、Saeda Kenta、Fukuyo Masaki、Rahmutulla Bahityar、Seki Motoaki、Goh Boon-Cher、Kondo Satoru、Dochi Hirotomo、Moriyama-Kita Makiko、Misawa Kiyoshi、Hanazawa Toyoyuki、Tan Patrick、Yoshizaki Tomokazu、Fullwood Melissa Jane、Kaneda Atsushi
- Journal Title
  
  eBioMedicine
  
  Volume: 102 Pages: 105057-105057
- DOI
  10.1016/j.ebiom.2024.105057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-23K23859
[Journal Article] Genome-Wide Analysis of DNA Methylation in Pseudomyxoma Peritonei Originated from Appendiceal Neoplasms2024
- Author(s)
  Takane Kiyoko、Cai Tingwei、Noguchi Rei、Gohda Yoshimasa、Ikenoue Tsuneo、Yamaguchi Kiyoshi、Ota Yasunori、Kiyomatsu Tomomichi、Yano Hideaki、Fukuyo Masaki、Seki Motoaki、Bahityar Rahmutulla、Kaneda Atsushi、Furukawa Yoichi
- Journal Title
  
  Oncology
  
  Volume: - Issue: 8 Pages: 1-12
- DOI
  10.1159/000536219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-23K08108, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-21K08743
[Journal Article] A multi-kingdom genetic barcoding system for precise target clone isolation2023
- Author(s)
  Ishiguro S、Ishida K、Sakata RC、Mori H、Takana M、King S、Bashth O、Ichiraku M、Masuyama N、Takimoto R、Kijima Y、Adel A、Toyoshima H、Seki M、Oh JH、Archambault AS、Nishida K、Kondo A、Kuhara S、Aburatani H、Klein GRI、Takashima Y、Shakiba N、Yachie N
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.01.18.524633
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07934
[Journal Article] Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma2023
- Author(s)
  Ito Yuki、Usui Genki、Seki Motoaki、Fukuyo Masaki、Matsusaka Keisuke、Hoshii Takayuki、Sata Yuki、Morimoto Junichi、Hata Atsushi、Nakajima Takahiro、Rahmutulla Bahityar、Kaiho Taisuke、Inage Terunaga、Tanaka Kazuhisa、Sakairi Yuichi、Suzuki Hidemi、Yoshino Ichiro、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: Online Issue: 7 Pages: 3003-3013
- DOI
  10.1111/cas.15817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08880, KAKENHI-PROJECT-22K06936, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K19553
[Journal Article] Integrated environmental, lifestyle, and epigenetic risk prediction of primary gastric neoplasia using the longitudinally monitored cohorts2023
- Author(s)
  Usui Genki, Matsusaka Keisuke, Huang Kie Kyon, Zhu Feng, Shinozaki Tomohiro, et al.
- Journal Title
  
  eBioMedicine
  
  Volume: 98 Pages: 104844-104844
- DOI
  10.1016/j.ebiom.2023.104844
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06936, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K19553
[Journal Article] Barcode fusion genetics-protein-fragment complementation assay (BFG-PCA): tools and resources that expand the potential for binary protein interaction discovery2022
- Author(s)
  Evans-Yamamoto Daniel、Rouleau Francois D、Nanda Piyush、Makanae Koji、Liu Yin、Despres Philippe C、Matsuo Hitoshi、Seki Motoaki、Dube Alexandre K、Ascencio Diana、Yachie Nozomu、Landry Christian R
- Journal Title
  
  Nucleic Acids Research
  
  Volume: gkac045 Issue: 9 Pages: 1-16
- DOI
  10.1093/nar/gkac045
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20J21144, KAKENHI-PROJECT-21K07934
[Journal Article] Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes2022
- Author(s)
  Hirasaki Yoshiro、Okabe Atsushi、Fukuyo Masaki、Rahmutulla Bahityar、Mano Yasunobu、Seki Motoaki、Hoshii Takayuki、Namiki Takao、Kaneda Atsushi
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 360 Pages: 109936-109936
- DOI
  10.1016/j.cbi.2022.109936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-20K07096, KAKENHI-PROJECT-23K23859
[Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike2022
- Author(s)
  Yamasoba Daichi、Kimura Izumi、Nasser Hesham他
- Journal Title
  
  Cell
  
  Volume: 未定 Issue: 12 Pages: 2103-2115
- DOI
  10.1016/j.cell.2022.04.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22968, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-18KK0447, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H02736, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-22KJ0023, KAKENHI-PROJECT-22KJ0809, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K24337
[Journal Article] Association of tumors having <scp>Epstein?Barr</scp> virus in surrounding lymphocytes with poor prognosis2022
- Author(s)
  Yogi Norikazu、Usui Genki、Matsusaka Keisuke、Fukuyo Masaki、Fujiki Ryoji、Seki Motoaki、Takano Shigetsugu、Abe Hiroyuki、Morikawa Teppei、Ushiku Tetsuo、Ohtsuka Masayuki、Kaneda Atsushi
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 2 Pages: 1122-1136
- DOI
  10.1002/cam4.4967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K06936, KAKENHI-PROJECT-22K07164
[Journal Article] Machine learning approach for discrimination of genotypes based on bright-field cellular images2021
- Author(s)
  Suzuki Godai、Saito Yutaka、Seki Motoaki、Evans-Yamamoto Daniel、Negishi Mikiko、Kakoi Kentaro、Kawai Hiroki、Landry Christian R.、Yachie Nozomu、Mitsuyama Toutai
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 7 Issue: 1 Pages: 1-8
- DOI
  10.1038/s41540-021-00190-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20409, KAKENHI-PLANNED-17H06410, KAKENHI-PROJECT-19K06502, KAKENHI-PROJECT-21K07934
[Journal Article] TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.2021
- Author(s)
  Shirai K, Nagae G, Seki M, Kudo Y, Kamio A, Hayashi A, Okabe A, Ota S, Tsutsumi S, Fujita T, Yamamoto S, Nakaki R, Kanki Y, Osawa T, Midorikawa Y, Tateishi K, Ichinose M, Aburatani H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 7 Pages: 2855-2869
- DOI
  10.1111/cas.14897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05744, KAKENHI-PUBLICLY-20H04834, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H03432, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-21K19399, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K21431
[Journal Article] CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations2021
- Author(s)
  Fukushima, T., Tanaka, Y., Adachi, K., Masuyama, N., Tsuchiya, A., Asada, S., Ishiguro, S., Mori, H., Seki, M., Yachie, N., Goyama, S., Kitamura, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-02986-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-21K07934
[Journal Article] Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice2020
- Author(s)
  Nishizono Hirofumi、Darwish Mohamed、Uosaki Hideki、Masuyama Nanami、Seki Motoaki、Abe Hiroyuki、Yachie Nozomu、Yasuda Ryohei
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: － Issue: 158 Pages: 1-1
- DOI
  10.3791/60808
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-18H02428, KAKENHI-PROJECT-17K11222, KAKENHI-PROJECT-18K19471, KAKENHI-PROJECT-18K19777, KAKENHI-PUBLICLY-19H05239, KAKENHI-PROJECT-19H04481
[Journal Article] A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine2019
- Author(s)
  Masoudi Mohammad、Seki Motoaki、Yazdanparast Razieh、Yachie Nozomu、Aburatani Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 19188-19188
- DOI
  10.1038/s41598-019-55893-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02428, KAKENHI-PROJECT-18K19471, KAKENHI-PROJECT-18K19777
[Journal Article] Engineered CRISPR-Cas9 nuclease with expanded targeting space2018
- Author(s)
  Nishimasu Hiroshi、Shi Xi、Ishiguro Soh、Gao Linyi、Hirano Seiichi、Okazaki Sae、Noda Taichi、Abudayyeh Omar O.、Gootenberg Jonathan S.、Mori Hideto、Oura Seiya、Holmes Benjamin、Tanaka Mamoru、Seki Motoaki、Hirano Hisato、Aburatani Hiroyuki、Ishitani Ryuichiro、Ikawa Masahito、Yachie Nozomu、Zhang Feng、Nureki Osamu
- Journal Title
  
  Science
  
  Volume: 361 Issue: 6408 Pages: 1259-1262
- DOI
  10.1126/science.aas9129
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19471, KAKENHI-PROJECT-18K19777, KAKENHI-PLANNED-16H06574, KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-18H02428, KAKENHI-PROJECT-16J06287, KAKENHI-PROJECT-18H02384
[Presentation] In-human assembly: efficient DNA assembly in cultured mammalian cells2019
- Author(s)
  Motoaki Seki, Soh Ishiguro, Kentaro Kakoi & Nozomu Yachie
- Organizer
  LSBM Symposium 2019
- Data Source
  KAKENHI-PROJECT-18K19471
[Presentation] 診療施設併設型バイオバンクとアカデミア解析・教育センターにおけるバイオバンク連携．2019
- Author(s)
  3.関　元昭、加野将之、飯田慶子、小林嵩平、鬼澤歩、小松亜樹、村上健太郎、糸賀　栄、衣鳩　恵、西村　基、吉富秀幸、野島広之、大岡美彦、大和田千佳子、坂本信一、丸山陽佳、中島崇裕、島井健一郎、荒屋敷亮子、田村　裕、鈴木隆弘、花岡英紀、松下一之、太田　聡、大塚将之、市川智彦、松原久裕、金田篤志、滝口裕一．
- Organizer
  第5回クリニカルバイオバンク学会
- Data Source
  KAKENHI-PROJECT-18K19471

1. Hirasaki Yoshiro (40436374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 金田篤志 (10313024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 福世真樹 (40639085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 岡部篤史 (80778118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 齋藤裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中島崇裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 谷内江望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 北村俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 関満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 魚崎英毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seki Motoaki 関 元昭

Research Projects

Research Products

Co-Researchers

細胞集団の不均一性に着目したEBV胃癌発生メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism on epigenetic carcinogenesis of EB virus-gastric cancer focused on senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching for novel anticancer epigenetic drugs from Kampo medicines followed by elucidation of the mechanism through transcriptomic analyses.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cellular hierarchy by transcribed DNA barcodesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-Wide Analysis of DNA Methylation in Pseudomyxoma Peritonei Originated from Appendiceal Neoplasms2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A multi-kingdom genetic barcoding system for precise target clone isolation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrated environmental, lifestyle, and epigenetic risk prediction of primary gastric neoplasia using the longitudinally monitored cohorts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Barcode fusion genetics-protein-fragment complementation assay (BFG-PCA): tools and resources that expand the potential for binary protein interaction discovery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of tumors having <scp>Epstein?Barr</scp> virus in surrounding lymphocytes with poor prognosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine learning approach for discrimination of genotypes based on bright-field cellular images2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.2021

Author(s)

Seki Motoaki 関元昭