Okabe Atsushi 岡部篤史

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OKABE Atsushi 岡部篤史

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Researcher Number	80778118
Other IDs	https://orcid.org/0000-0001-7748-6078
Affiliation (Current)	2023: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2022: 千葉大学, 大学院医学研究院, 助教 2019: 千葉大学, 医学(系)研究科(研究院), 助教 2015: 千葉大学, 医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related Except Principal Investigator Digestive surgery / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator クロマチン構造 / 胃癌 / Epstein-Barrウイルス / Chromatin structure / EBV / Epigenome / Histone modification / Gastric cancer / エピゲノム / 発癌 … More Except Principal Investigator … More エピゲノム / 天然化合物 / トランスクリプトーム / 白血病細胞株 / Cinobufagin / c-Myc / H3K27ac / Motif解析 / 和漢薬 / 抗がん作用 / 抗癌小分子化合物 / HDAC Less

癌ウイルスによるクロマチン構造破綻が誘導する新規発癌機構の解明Principal Investigator
- Principal Investigator
  
  岡部篤史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
胃癌におけるクロマチン構造異常による癌化機構の解明Principal Investigator
- Principal Investigator
  
  岡部篤史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
和漢薬からのエピゲノムを標的とする新規抗癌薬の探索及び作用機序の解明
- Principal Investigator
  
  平崎能郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Chiba University
Analysis of epigenetic aberrations induced by oncovirus infectionPrincipal Investigator
- Principal Investigator
  
  Okabe Atsushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
Analysis on alterated chromatin status of viral genome in the host cells.
- Principal Investigator
  
  Kaneda Atsushi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype2022
- Author(s)
  Yamada Harumi、Takeshima Hideyuki、Fujiki Ryoji、Yamashita Satoshi、Sekine Shigeki、Ando Takayuki、Hattori Naoko、Okabe Atsushi、Yoshikawa Takaki、Obama Kazutaka、Katai Hitoshi、Kaneda Atsushi、Ushijima Toshikazu
- Journal Title
  
  Cancer Letters
  
  Volume: 532 Pages: 215587-215587
- DOI
  10.1016/j.canlet.2022.215587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08456, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-21K15525, KAKENHI-PROJECT-19KK0415
[Journal Article] An integrative transcriptional logic model of hepatic insulin resistance2021
- Author(s)
  Kitamoto Takumi、Kuo Taiyi、Okabe Atsushi、Kaneda Atsushi、Accili Domenico
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118
- DOI
  10.1073/pnas.2102222118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Journal Article] TET1 upregulation drives cancer cell growth by aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma2021
- Author(s)
  Shirai K, Nagae G, Seki M, Kudo Y, Kamio A, Hayashi A, Okabe A, Ota S, Tsutsumi S, Fujita T, Yamamoto S, Nakaki R, Kanki Y, Osawa T, Midorikawa Y, Tateishi K, Ichinose M, Aburatani H.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Pages: 2855-2869
- DOI
  10.1111/cas.14897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05744, KAKENHI-PUBLICLY-20H04834, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H03432, KAKENHI-PROJECT-21H02894, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-21K19399, KAKENHI-PROJECT-19KK0415
[Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus?positive gastric cancer2021
- Author(s)
  Li Wenzhe、Okabe Atsushi、Usui Genki、Fukuyo Masaki、Matsusaka Keisuke、Rahmutulla Bahityar、Mano Yasunobu、Hoshii Takayuki、Funata Sayaka、Hiura Nobuhiro、Fukayama Masashi、Tan Patrick、Ushiku Tetsuo、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Pages: 3349-3362
- DOI
  10.1111/cas.14978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415
[Journal Article] Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer2021
- Author(s)
  Okabe Atsushi、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Pages: 2081-2088
- DOI
  10.1111/cas.14884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415
[Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein?Barr virus?positive gastric adenocarcinoma2020
- Author(s)
  Okabe Atsushi, Huang Kie Kyon, Matsusaka Keisuke, Fukuyo Masaki, Xing Manjie, Ong Xuewen, Hoshii Takayuki, Usui Genki, Seki Motoaki, Mano Yasunobu, Rahmutulla Bahityar, Kanda Teru, Suzuki Takayoshi, Rha Sun Young, Ushiku Tetsuo, Fukayama Masashi, Tan Patrick, Kaneda Atsushi
- Journal Title
  
  Nat Genet
  
  Volume: 52 Pages: 919-930
- DOI
  10.1038/s41588-020-0665-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K09184, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-18J00861, KAKENHI-PROJECT-18K06983, KAKENHI-PROJECT-19K22399, KAKENHI-PROJECT-19K16101
[Journal Article] Epstein-Barr virus positive gastric cancer involves enhancer activation through ATF3.2020
- Author(s)
  Asakawa Yuta、Okabe Atsushi、Fukuyo Masaki、Li Wenzhe、Ikeda Eriko、Mano Yasunobu、Funata Sayaka、Namba Hiroe、Fujii Takahiro、Kita Kazuko、Matsusaka Keisuke、Kaneda Atsushi
- Journal Title
  
  Cancer Sci.
  
  Volume: 00 Pages: 1-11
- DOI
  10.1111/cas.14370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-18J00861, KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin disruption and chromatin structural rewiring induced by Epstein-Barr virus infection in gastric adenocarcinoma2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Genki Usui, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021
- Author(s)
  岡部篤史、Kie Kyon Huang、松坂恵介、福世真樹、星居孝之、臼井源紀、関元昭、眞野恭伸、Bahityar Rahmutulla、神田輝、鈴木孝禎、牛久哲男、深山正久、Patrick Tan、金田篤志
- Organizer
  第14回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Heterochromatin rewiring by oncovirus infection through the novel mechanism ”enhancer infestation” in gastric adenocarcinoma2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Genki Usui, Motoaki Seki, Yasunobu Mano, Bahityar Rahmutulla, Teru Kanda, Takayoshi Suzuki, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin structural alteration induced by oncovirus infection aberrantly activate transcriptional regulation2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Genki Usui, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] CHROMATIN REWIRING BY ONCOVIRUS INFECTION THROUGH THE NOVEL MECHANISM ”ENHANCER INFESTATION” IN GASTRIC ADENOCARCINOMA2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Manjie Xing, Xuewen Ong, Patrick Tan, Atsushi Kaneda
- Organizer
  15th Asian Epigenomics Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Tissue-wide analysis of chromatin structural aberrations induced by oncovirus infection2021
- Author(s)
  Atsushi Okabe, Takahiro Fjii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] CHROMATIN REWIRING BY ONCOVIRUS INFECTION THROUGH THE NOVEL MECHANISM ”ENHANCER INFESTATION” IN GASTRIC ADENOCARCINOMA2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Manjie Xing, Xuewen Ong, Patrick Tan, Atsushi Kaneda
- Organizer
  15th Asian Epigenomics Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021
- Author(s)
  岡部篤史、Kie Kyon Huang、松坂恵介、福世真樹、星居孝之、臼井源紀、関元昭、眞野恭伸、Bahityar Rahmutulla、神田輝、鈴木孝禎、牛久哲男、深山正久、Patrick Tan、金田篤志
- Organizer
  第14回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin disruption and chromatin structural rewiring in gastric adenocarcinoma infected by Epstein-Barr virus2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  Cold Spring Harbor Meeting Epigenetics and Chromatin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] (イ)Heterochromatin reprogramming and chromatin structural rewiring induced by oncovirus infection in gastric adenocarcinoma2020
- Author(s)
  (エ)Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Takayuki Hoshii, Patrick Tan, Atsushi Kaneda
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin disruption and chromatin structural rewiring in gastric adenocarcinoma infected by Epstein-Barr virus2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  Cold Spring Harbor Meeting Epigenetics and Chromatin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] (イ)Heterochromatin reprogramming and chromatin structural rewiring induced by oncovirus infection in gastric adenocarcinoma2020
- Author(s)
  (エ)Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Takayuki Hoshii, Patrick Tan, Atsushi Kaneda
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin Structural Aberrations due to oncovirus infection activate neighboring oncogenes through enhancer activation2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin Structural Aberrations due to oncovirus infection activate neighboring oncogenes through enhancer activation2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin reprogramming induced by Epstein-Barr virus infection induces oncogenic activation through aberrant enhancer activation2019
- Author(s)
  Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Hiroe Namba, Sayaka Funata, Atsushi Kaneda
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] 癌ウイルス感染がもたらすヘテロクロマチンリプログラミングによる癌遺伝子の活性化2019
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] EBV infection induces domain structural changes which lead to oncogenic activation2019
- Author(s)
  Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16101

1. Kaneda Atsushi (10313024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. FUNATA Sayaka (80756081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平崎能郎 (40436374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福世真樹 (40639085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 関元昭 (70714278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 川島祐介 (30588124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 神田輝 (50333472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. HOSHII Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. USHIKU Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. KANKI Yasuharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MIDORIKAWA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木孝禎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 山田晴美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 藤木亮次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okabe Atsushi 岡部 篤史

OKABE Atsushi 岡部 篤史

Research Projects

Research Products

Co-Researchers

癌ウイルスによるクロマチン構造破綻が誘導する新規発癌機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胃癌におけるクロマチン構造異常による癌化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

和漢薬からのエピゲノムを標的とする新規抗癌薬の探索及び作用機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of epigenetic aberrations induced by oncovirus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on alterated chromatin status of viral genome in the host cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An integrative transcriptional logic model of hepatic insulin resistance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET1 upregulation drives cancer cell growth by aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus?positive gastric cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein?Barr virus?positive gastric adenocarcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epstein-Barr virus positive gastric cancer involves enhancer activation through ATF3.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Heterochromatin disruption and chromatin structural rewiring induced by Epstein-Barr virus infection in gastric adenocarcinoma2021

Author(s)

Organizer

Data Source

[Presentation] ウイルスがもたらすヘテロクロマチン破綻と 新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021

Author(s)

Organizer

Data Source

[Presentation] Heterochromatin rewiring by oncovirus infection through the novel mechanism ”enhancer infestation” in gastric adenocarcinoma2021

Author(s)

Okabe Atsushi 岡部篤史

OKABE Atsushi 岡部篤史

[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021

[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021