Shimizu Kouhei 清水康平

Researcher Number	70727073
Other IDs	https://orcid.org/0000-0001-9523-4296
Affiliation (Current)	2024: 大阪公立大学, 大学院医学研究科, 講師
Affiliation (based on the past Project Information) *help	2024: 大阪公立大学, 大学院医学研究科, 助教 2022: 大阪公立大学, 大学院医学研究科, 助教 2019 – 2021: 大阪市立大学, 大学院医学研究科, 助教 2017 – 2018: 東北大学, 歯学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 48040:Medical biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Dental engineering/Regenerative dentistry Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 51:Brain sciences and related fields / Basic Section 57040:Regenerative dentistry and dental engineering-related
Keywords	Principal Investigator ユビキチン / Skp2 / タンパク質分解 / 幹細胞 / 再生医療 / がん / プロテオスタシス / プロテアソーム / 生体防御応答 / 免疫 … More / NF-κB / 細胞死 / 炎症 / LUBAC / 歯髄幹細胞 / 分化誘導 / プロテインノックダウン / 細胞分化 / 腫瘍化 … More Except Principal Investigator 炎症 / ユビキチン / タンパク質分解 / 自然免疫 / NF-κB / 細胞死 / 化合物探索 / 細胞質封入体 / 疾患修飾薬 / 筋萎縮性側索硬化症 / 神経変性疾患 / 酵素 / タンパク質 / 歯周組織再生 / Lipin / Lipin2 / マクロファージ / 神経成長因子 / 歯髄幹細胞 / 蛋白質分解 / p75NTR Less

複雑化ユビキチン修飾による細胞生死制御の細胞・個体レベルでの解析と病態との関連
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka Metropolitan University
新規RING型E3によるSkp2プロテオスタシス制御の破綻と発がん機構の解明Principal Investigator
- Principal Investigator
  
  清水康平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka Metropolitan University
複合型ユビキチン鎖を標的とした筋萎縮性側索硬化症の病態解明と創薬シーズの開拓
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka Metropolitan University
Studies on a novel E3 ligase regulating LUBAC and host defense responsePrincipal Investigator
- Principal Investigator
  
  Shimizu Kouhei
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
歯周組織再生を目指した効率的な抗炎症療法の開発
- Principal Investigator
  
  犬塚博之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Tohoku University
パーキンソン病-骨代謝連関制御と歯髄幹細胞を用いた再生へ向けた分子基盤の解明
- Principal Investigator
  
  福島秀文
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
Establishment of a method for improving the efficiency of stem cell differentiation using a protein knockdown strategyPrincipal Investigator
- Principal Investigator
  
  Shimizu Kouhei
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka City University
  Tohoku University
Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory function
- Principal Investigator
  
  Inuzuka Hiroyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
腫瘍性タンパク質Skp2の量的制御を司る幹細胞腫瘍化抑制機構の包括的解析Principal Investigator
- Principal Investigator
  
  清水康平
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD12023
- Author(s)
  Oikawa Daisuke、Shimizu Kouhei、Tokunaga Fuminori
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 2 Pages: 350-350
- DOI
  10.3390/antiox12020350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00291
[Journal Article] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis2023
- Author(s)
  Sato Yusuke、Terawaki Seigo、Oikawa Daisuke、Shimizu Kouhei、Okina Yoshinori、Ito Hidefumi、Tokunaga Fuminori
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1089213-1089213
- DOI
  10.3389/fmolb.2023.1089213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-21H02418, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00283, KAKENHI-PUBLICLY-21H00291
[Journal Article] OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways2022
- Author(s)
  Oikawa Daisuke、Gi Min、Kosako Hidetaka、Shimizu Kouhei、Takahashi Hirotaka、Shiota Masayuki、Hosomi Shuhei、Komakura Keidai、Wanibuchi Hideki、Tsuruta Daisuke、Sawasaki Tatsuya、Tokunaga Fuminori
- Journal Title
  
  Cell Death & Disease
  
  Volume: 13 Issue: 8 Pages: 694-694
- DOI
  10.1038/s41419-022-05145-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H02951, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K10431, KAKENHI-PROJECT-21K19230, KAKENHI-PUBLICLY-21H00287, KAKENHI-PUBLICLY-21H00291
[Journal Article] Interplay between protein acetylation and ubiquitination controls MCL1 protein stability2021
- Author(s)
  Shimizu Kouhei、Gi Min、Suzuki Shugo、North Brian J.、Watahiki Asami、Fukumoto Satoshi、Asara John M.、Tokunaga Fuminori、Wei Wenyi、Inuzuka Hiroyuki
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 6 Pages: 109988-109988
- DOI
  10.1016/j.celrep.2021.109988
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16146, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-20K20612, KAKENHI-PROJECT-16H06276
[Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021
- Author(s)
  Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
- Journal Title
  
  Inflammation Research
  
  Volume: In press Issue: 5 Pages: 539-541
- DOI
  10.1007/s00011-021-01458-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K17912, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-20H05337, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
[Journal Article] Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling2021
- Author(s)
  Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
- Journal Title
  
  Plos One
  
  Volume: - Issue: 3 Pages: e0248158-e0248158
- DOI
  10.1371/journal.pone.0248158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17912, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
[Journal Article] Phosphorylation‐dependent osterix degradation negatively regulates osteoblast differentiation2020
- Author(s)
  Hoshikawa Seira、Shimizu Kouhei、Watahiki Asami、Chiba Mitsuki、Saito Kan、Wei Wenyi、Fukumoto Satoshi、Inuzuka Hiroyuki
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 11 Pages: 14930-14945
- DOI
  10.1096/fj.202001340r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16146, KAKENHI-PROJECT-18H03009, KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-19J11773
[Journal Article] Lipin-2 degradation elicits a proinflammatory gene signature in macrophages2020
- Author(s)
  Watahiki Asami、Shimizu Kouhei、Hoshikawa Seira、Chiba Mitsuki、Kitamura Hiroshi、Egusa Hiroshi、Fukumoto Satoshi、Inuzuka Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 477-483
- DOI
  10.1016/j.bbrc.2020.01.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-19J11773, KAKENHI-PROJECT-18K19282, KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-18K06035
[Journal Article] Physiological functions of FBW7 in cancer and metabolism2018
- Author(s)
  Shimizu Kouhei、Nihira Naoe Taira、Inuzuka Hiroyuki、Wei Wenyi
- Journal Title
  
  Cellular Signalling
  
  Volume: 46 Pages: 15-22
- DOI
  10.1016/j.cellsig.2018.02.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19282, KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-17H06531
[Journal Article] NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.2017
- Author(s)
  Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M
- Journal Title
  
  Mol Cell
  
  Volume: Nov 16;68(4) Issue: 4 Pages: 645-658
- DOI
  10.1016/j.molcel.2017.10.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17310, KAKENHI-PROJECT-25221303, KAKENHI-PROJECT-17H01606, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16H05548, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-17H04396, KAKENHI-PROJECT-16K15811, KAKENHI-PLANNED-17H06301, KAKENHI-PROJECT-17H06531
[Presentation] OTUD1-KEAP1による炎症、酸化ストレス、細胞死制御と炎症性疾患抑制2022
- Author(s)
  及川大輔、魏民、清水康平、小迫英尊、塩田正之、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K18385
[Presentation] 脱ユビキチン化酵素 OTUD1による炎症・細胞死制御と病態2022
- Author(s)
  及川大輔、魏民、清水康平、小迫英尊、塩田正之、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  第27回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K18385
[Presentation] 新規LUBAC結合タンパク質による細胞死制御機構の解析2022
- Author(s)
  清水康平、魏民、Tran Thi Thuy Linh、及川大輔、小迫英尊、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K18385
[Presentation] p300-mediated acetylation promotes MCL1 stabilization and tumorigenesis2021
- Author(s)
  清水康平, 魏民, 鈴木周五, 徳永文稔, 犬塚博之, Wenyi Wei
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] Cellular functions regulated by complex-type ubiquitination including linear polyubiquitin chain2021
- Author(s)
  徳永文稔, 寺脇正剛, 及川大輔, 清水康平
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] Identification of OTUD1 deubiquitinase as a regulator for innate immune responses, cell death, and inflammatory bowel disease2021
- Author(s)
  及川大輔, 魏民, 小迫英尊, 清水康平, 塩田正之, 高橋宏隆, 澤崎達也, 徳永文稔
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] A novel LUBAC-associated protein regulates NF-κB activation, apoptosis and necroptosis pathways2021
- Author(s)
  清水康平, Tran Thi Thuy Linh, 及川大輔, 小迫英尊, 高橋宏隆, 澤崎達也, 徳永文稔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] A novel LUBAC-associated protein plays important roles in inflammatory response through regulation of programmed cell death2021
- Author(s)
  Tran Thi Thuy Linh, 清水康平, 及川大輔, 高橋宏隆, 澤崎達也, 徳永文稔
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] Acetylation-dependent mechanism of MCL1 stabilization in cancers2020
- Author(s)
  Kouhei Shimizu, Hiroyuki Inuzuka
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16146
[Presentation] Regulation of cell survival through post-translational modifications of MCL-1 in tumorigenesis2019
- Author(s)
  Hiroyuki Inuzuka, Kouhei Shimizu, Mitsuki Chiba, Satoshi Fukumoto, Wenyi Wei
- Organizer
  The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
- Invited
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] マクロファージの細菌性炎症応答制御におけるLipin2の役割2019
- Author(s)
  綿引麻美，清水康平，星川聖良，千葉満生，福本敏，江草宏，犬塚博之
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03834
[Presentation] Lipin2タンパク質分解を介したマクロファージ活性化調節機構の解析2018
- Author(s)
  綿引　麻美、清水　康平、瓜生　英尚、星川　聖良、福本　敏、江草　宏、犬塚　博之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018
- Author(s)
  星川　聖良、千葉　満生、綿引　麻美、清水　康平、犬塚　博之、福本　敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018
- Author(s)
  星川聖良、千葉満生、綿引麻美、清水康平、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] アセチル化による抗アポトーシスタンパク質MCL1の安定化機構とその制御方法の検討2018
- Author(s)
  清水　康平、千葉　満生、犬塚　博之、福本　敏
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018
- Author(s)
  清水康平、千葉満生、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018
- Author(s)
  清水　康平、千葉　満生、犬塚　博之、福本　敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] Hajdu-Cheney症候群におけるNotch2変異を介した骨粗鬆症病態の分子機構解明2018
- Author(s)
  清水　康平、福島　秀文
- Organizer
  第3回口腔医科学フロンティア研究会
- Data Source
  KAKENHI-PROJECT-17H06531
[Presentation] Lipin 2タンパク質分解を介したマクロファージ活性化調節機構の解析2018
- Author(s)
  綿引麻美、清水康平、瓜生英尚、星川聖良、福本敏、江草宏、犬塚博之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] The role of acetylation in the regulation of MCL1 stability2017
- Author(s)
  清水　康平
- Organizer
  第15回松山国際学術シポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06531
[Presentation] 抗アポトーシスタンパク質MCL1の安定性制御におけるアセチル化の役割2017
- Author(s)
  清水　康平、犬塚　博之、福島　秀文、福本　敏
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17H06531

1. Inuzuka Hiroyuki (20335863)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 福本敏 (30264253)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. 徳永文稔 (00212069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 及川大輔 (20455330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 福島秀文 (70412624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 齋藤正寛 (40215562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 塩田正之 (30381990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 魏民 (70336783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 澤崎達也 (50314969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. ARAKAKI Makiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岩崎成仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Kouhei 清水 康平

Research Projects

Research Products

Co-Researchers

複雑化ユビキチン修飾による細胞生死制御の細胞・個体レベルでの解析と病態との関連

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規RING型E3によるSkp2プロテオスタシス制御の破綻と発がん機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複合型ユビキチン鎖を標的とした筋萎縮性側索硬化症の病態解明と創薬シーズの開拓

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on a novel E3 ligase regulating LUBAC and host defense responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯周組織再生を目指した効率的な抗炎症療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

パーキンソン病-骨代謝連関制御と歯髄幹細胞を用いた再生へ向けた分子基盤の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a method for improving the efficiency of stem cell differentiation using a protein knockdown strategyPrincipal Investigator

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Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory function

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腫瘍性タンパク質Skp2の量的制御を司る幹細胞腫瘍化抑制機構の包括的解析Principal Investigator

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[Journal Article] Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD12023

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[Journal Article] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis2023

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[Journal Article] OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways2022

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[Journal Article] Interplay between protein acetylation and ubiquitination controls MCL1 protein stability2021

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[Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021

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Shimizu Kouhei 清水康平