Takeshita Yukio 竹下幸男

… Alternative Names

Yukio Takeshita 竹下幸男

TAKESHITA Yukio 竹下幸男

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Researcher Number	70749829
Affiliation (Current)	2025: 山口大学, 医学部, 教授(連携講座)
Affiliation (based on the past Project Information) *help	2023 – 2025: 山口大学, 医学部, 教授(連携講座) 2019 – 2023: 山口大学, 大学院医学系研究科, 助教 2016 – 2017: 山口大学, 医学部附属病院, 診療助教(4日/週)
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 20010:Mechanics and mechatronics-related / Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator Blood-Brain Barrier / 血液脳関門 / 炎症細胞浸潤 / ヒト由来BBB構成細胞株 / 自己免疫性中枢神経疾患 / 炎症細胞浸潤機構 / 多発性硬化症 / 血液神経関門 / migration / Blood-nerve barrier … More / Blood-brain barrier / ラミニン / 視神経脊髄炎 / in vitro model / transmigration / Neuromyelitis optica / laminin / Blood-Nerve Barrier … More Except Principal Investigator 触診感覚の数値化 / 最大筋力 / 可動域 / 示指骨格筋の可動域 / 示指の発生力 / 測定装置 / 末梢神経障害 / 徒手筋力検査(MMT) / iPS細胞 / アルファシヌクレイン / 血管脳関門 / αシヌクレイン / パーキンソン病 / 自己抗体 / ペリサイト / アストロサイト / 血管内皮細胞 / 血液脳関門 Less

Brain drug screening research using a mass-produced human blood-brain barrier modelPrincipal Investigator
- Principal Investigator
  
  竹下幸男
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Development of a device for measurement of specific skeletal muscle mobility and evaluation method for peripheral nerve recovery
- Principal Investigator
  
  江鐘偉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 20010:Mechanics and mechatronics-related
- Research Institution
  Yamaguchi University
Identification of the molecules that promote IgG-translocation across the BBB in autoimmune CNS diseasesPrincipal Investigator
- Principal Investigator
  
  竹下幸男
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Exploration of the mechanism of a-synuclein propagation from peripheral tissues to the central nervous system via exosomes
- Principal Investigator
  
  Tsunemi Taiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Novel strategy to treat intractable CNS disorders, utilizing the properties of BBB-composing cells
- Principal Investigator
  
  神田隆
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Yamaguchi University
Identification of targeted membrane antigens of human brain microvascular endothelial cells in relapsing-remitting multiple sclerosisPrincipal Investigator
- Principal Investigator
  
  Yukio Takeshita
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Construction of new in vitro blood-brain barrier (BBB) and blood-nerve barrier (BNB) model that incorporates multi-culturing system of BBB or BNB components.Principal Investigator
- Principal Investigator
  
  TAKESHITA Yukio
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Yamaguchi University

All 2023 2022 2021 2020 2017 2016

All Journal Article Presentation Patent

[Journal Article] Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells2023
- Author(s)
  Honda Masaya、Shimizu Fumitaka、Sato Ryota、Mizukami Yoichi、Watanabe Kenji、Takeshita Yukio、Maeda Toshihiko、Koga Michiaki、Kanda Takashi
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 10 Issue: 4 Pages: 1-11
- DOI
  10.1212/nxi.0000000000200116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-20H00632, KAKENHI-PROJECT-21H03358
[Journal Article] Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy2023
- Author(s)
  Sato Ryota、Shimizu Fumitaka、Kuwahara Motoi、Mizukami Yoichi、Watanabe Kenji、Maeda Toshihiko、Sano Yasuteru、Takeshita Yukio、Koga Michiaki、Kusunoki Susumu、Kanda Takashi
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 10 Issue: 3
- DOI
  10.1212/nxi.0000000000200086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529
[Journal Article] Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model2022
- Author(s)
  Fujisawa Miwako、Takeshita Yukio、Fujikawa Susumu、Matsuo Kinya、Okamoto Masashi、Tamada Masaya、Shimizu Fumitaka、Sano Yasuteru、Koga Michiaki、Kanda Takashi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 362 Pages: 577783-577783
- DOI
  10.1016/j.jneuroim.2021.577783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529
[Journal Article] New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD.2021
- Author(s)
  Takeshita Y, Fujikawa S, Serizawa K, Fujisawa M, Matsuo K, Nemoto J, Shimizu F, Sano Y, Tomizawa-Shinohara H, Miyake S, Ransohoff RM, Kanda T.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 8 Issue: 6
- DOI
  10.1212/nxi.0000000000001076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00529
[Journal Article] GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder2021
- Author(s)
  Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 9 Issue: 1
- DOI
  10.1212/nxi.0000000000001038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07953, KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-20K07892, KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21H03358, KAKENHI-PROJECT-20H00529
[Journal Article] Glial cell line-derived neurotrophic factor and basic fibroblast growth factor derived from skeletal muscle pericytes increase the barrier function of endothelial cells in the endomysium.2021
- Author(s)
  Eri Ishiguchi, Yasuteru Sano, Toshihiko Maeda, Fumitaka Shimizu, Miwako Fujisawa, Masaya Honda, Yukio Takeshita, Michiaki Koga, Takashi Kanda.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 12 Issue: 4 Pages: 258-267
- DOI
  10.1111/cen3.12674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07437
[Journal Article] HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data2021
- Author(s)
  Watanabe M. Nakamura Y. Sato S. Niino M. Fukaura H. Tanaka M. Ochi H. et al
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 607-607
- DOI
  10.1038/s41598-020-79833-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07997, KAKENHI-PROJECT-20K07899, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07467, KAKENHI-PROJECT-21K11165
[Journal Article] Immunohistochemical analysis of laminin components in blood-nerve barrier and blood-brain barrier.2017
- Author(s)
  Y Takeshita, M Omoto, S Fujikawa, and T Kanda.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 8 Pages: 49-53
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Journal Article] Establishment of a new conditionally immortalized human skeletal muscle microvascular endothelial cell line.2017
- Author(s)
  H Sano, Y Sano, E Ishiguchi, F shimizu, M Omoto, T Maeda, H Nishihara, Y Takeshita, et al.
- Journal Title
  
  J Cell Physiol
  
  Volume: 232 Pages: 12-12
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Journal Article] Effects of Neuromyelitis optica (NMO)-IgG at the blood-brain barrier in vitro.2017
- Author(s)
  Y Takeshita ,B Obermeier, AC Cotleur, SF Spampinato, F Shimizu, E Yamamoto, Y Sano, YJ Kryzer, VA Lennon, T Kanda, and R.M. Ransohoff.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflammation
  
  Volume: 4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Journal Article] Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis.2017
- Author(s)
  H Nishihara, F Shimizu, T Kitagawa, N Yamanaka, J Akada, Y Kuramitsu, Y Sano, Y Takeshita, et al.
- Journal Title
  
  Mult Scler.
  
  Volume: 23 Pages: 382-394
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Journal Article] Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica.2017
- Author(s)
  F shimizu, KL Schaller , GP Owens, AC Cotleur, D Kellner, Y Takeshita, et al.
- Journal Title
  
  Sci Transl Med
  
  Volume: 9 Pages: 394-394
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Journal Article] Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro.2016
- Author(s)
  Takeshita Y, Obermeier B, Cotleur AC, Spampinato SF, Shimizu F, Yamamoto E, Sano Y, Kryzer TJ, Lennon VA, Kanda T, Ransohoff RM.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm.
  
  Volume: 4 Issue: 1
- DOI
  10.1212/nxi.0000000000000311
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461271, KAKENHI-PROJECT-16K19513
[Patent] 血液脳関門インヴィトロモデルおよび血液脳関門インヴィトロモデルの作製方法2017
- Inventor(s)
  竹下幸男、神田隆
- Industrial Property Rights Holder
  山口大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19513
[Presentation] The effect of IgG from CIDP and MMN on the blood-nerve barrier2023
- Author(s)
  Fumitaka Shimizu, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Sonoko Misawa, Naoko Matsui, Yukio Takeshita, Toshihiko Maeda, Michiaki Koga, Yuishin Izumi, Satoshi Kuwabara and Takashi Kanda
- Organizer
  第64回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Development of a manual muscle testing device for objective evaluation of peripheral neuropathy2023
- Author(s)
  Ryutaro Kawamura, Zhongwei Jiang, Kenta Dezaki, Yamato Kawakami, Minoru Morita, Yukio Takeshita
- Organizer
  International Conference of Innovative Application Research and Education
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K03745
[Presentation] 末梢神経障害患者を標的とした加速度センサーを用いた新しい筋力評価方法と小型デバイスの開発2023
- Author(s)
  竹下幸男
- Organizer
  日本末梢神経学会
- Data Source
  KAKENHI-PROJECT-23K03745
[Presentation] MAGニューロパチー患者では，血管内皮細胞の自己分泌TNF-αがMAG抗体の微小血管透過性を亢進させている2022
- Author(s)
  佐藤亮太，清水文崇，桑原基，渡邉健司，水上洋一，前田敏彦，竹下幸男，古賀道明，楠進，神田　隆
- Organizer
  第33回日本末梢神経学会学術研究会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effects of sera in NMO, MOG, and MS on IgG translocation to central nervous system.2022
- Author(s)
  Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Mastuo, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effect of IgG from Guillain-Barre syndrome on the blood-nerve barrier2022
- Author(s)
  Fumitaka Shimizu, Michiaki Koga, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Natsumi Fujii, Ken Matsukage, Yukio Takeshita, Yasuteru Sano, Toshihiko Maeda and Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Autocrine TNF-α increases penetration of MAG antibodies across the blood-nerve barrier in anti-MAG neuropathy.2022
- Author(s)
  Ryota Sato, Fumitaka Shimizu, Motoi Kuwahara, Yoichi Mizukami, Kenji Watanabe, Toshihiko Maeda, Yasuteru Sano, Yukio Takeshita, Michiaki Koga, Susumu Kusunoki, Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Blood-brain barrier-breakdown in anti-myelin oligodendrocyte glycoprotein antibody associated disorders2021
- Author(s)
  Shimizu F, Ogawa R, Takahashi T, Takeshita Y, Misu T, Sano Y, Maeda T, Nakashima I, Fujihara K, Kanda T
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 視神経脊髄炎でのIL-6を介した血液脳関門破綻の病態機序と「BBBを治療する」というIL-6受容体阻害薬の新たな作用機序2021
- Author(s)
  竹下幸男, 藤川晋, 芹澤賢一，藤澤美和子,西原秀明,松尾欣哉, 清水文崇, 古賀道明,Richard Ransohoff , 神田隆
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] New in vitro and in ex-vivo triple co-culture BBB models and in vivo EAE model revealed that NMO-IgG increased the intracerebral transferability of NMO-IgG and satralizumab and that IL-6 blockade suppressed the NMO-IgG-induced leukocyte transmigration and barrier dysfunction, leading to prevention of onset of NMOSD.2021
- Author(s)
  Takeshita Y, Fujikawa S, Serizawa K, Fujisawa M, Matsuo K, Nemoto J, Shimizu F, Sano Y, Tomizawa-Shinohara H, Miyake S, Ransohoff RM, Kanda T
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 多発性硬化症でのCD20抗体によるB細胞療法における血液脳関門を中心とした新しい病態機序2021
- Author(s)
  竹下幸男,藤澤美和子,松尾欣哉,福迫陽人, 藤川晋, 玉田雅也, 岡本雅史, 西原秀明, 清水文崇, 古賀道明, 神田隆
- Organizer
  第33回日本神経免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ギラン・バレー症候群での血液神経関門破綻メカニズムの解析2021
- Author(s)
  清水文崇，古賀道明，佐藤亮太，竹下幸男，佐野泰照，松影　顕，藤井菜月美，前田敏彦，神田　隆
- Organizer
  第32回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Intracerebral transferability of satralizumab in neuromyelitis optica using a new multi-cultured in vitro BBB model2021
- Author(s)
  Matsuo K, Takeshita Y, Fujikawa S, Fujisawa M, Serizawa K, Shimizu F, Sano Y, Koga M, Kanda T.
- Organizer
  第62回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ヒトin vitro BBBモデルを用いたアストロサイトからのBDNF分泌を促進させる脂質化合物の同定2021
- Author(s)
  藤澤美和子, 竹下幸男, 藤川　晋, 松尾欣哉, 清水文崇, 古賀道明, 神田　隆
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effects of sera in NMO and MOG on IgG translocation to central nervous system2020
- Author(s)
  Fujisawa M, Takeshita Y, Fujikawa S, Shimizu F, Maeda T, Sano Y, Koga M, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Blood-brain barrier-activation in myelin oligodendrocyte glycoprotein antibody associated disorders2020
- Author(s)
  Shimizu F, Ogawa R, Takahashi T, Takeshita Y, Misu T, Sano Y, Maeda T, Nakashima I, Fujihara K, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Exploring lipophilic compounds which induce BDNF secretion from astrocytes beyond the BBB2020
- Author(s)
  Takeshita Y, Fujikawa S, Okino T, Fujisawa M, Shimizu F, Maeda T, Sano Y, Koga M, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Construction of a new in vitro blood-brain barrier (BBB) model that incorporates triple-culturing system of BBB components2017
- Author(s)
  Yukio Takeshita, Yuki Tomoe, Susumu Fujikawa, Yasuteru Sano, Hideaki Nishihara, Toshihiko Maeda, Fumitaka Shimizu, Takashi Kanda
- Organizer
  69th American Academy of Neurology
- Data Source
  KAKENHI-PROJECT-16K19513
[Presentation] 血液神経関門(BNB)におけるBNB特異的基底膜ラミニンの効果について2017
- Author(s)
  竹下幸男,　藤川晋, 清水文崇, 前田敏彦, 佐野泰照, 神田隆
- Organizer
  第29回日本神経免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K19513
[Presentation] he effect of blood-brain barrier (BBB)-specific laminins for barrier function with a new in vitro BBB model incorporating multi-culturing system of BBB components2017
- Author(s)
  Yukio Takeshita, Susumu Fujikawa, Fumitaka Shimizu, Yasuteru Sano, Toshihiko Maeda, Takashi Kanda
- Organizer
  XXIII World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-16K19513
[Presentation] Construction of a new In vitro blood-brain barrier (BBB) model that incorporates triple culturing system of BBB components2016
- Author(s)
  TAKESHITA Y, TOMOE Y, NISHIHARA H, MAEDA T, SANO Y, KANDA T
- Organizer
  Neuroscience2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513
[Presentation] Construction of a new in vitro blood-brain barrier (BBB) model that incorporates triple-culturing system of BBB components2016
- Author(s)
  TAKESHITA Y, TOMOE Y, NISHIHARA H, MAEDA T, SANO Y, KANDA T
- Organizer
  第57回日本神経学会
- Place of Presentation
  神戸コンベンションセンター(兵庫県神戸市)
- Year and Date
  2016-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19513

1. Tsunemi Taiji (50401344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 神田隆 (40204797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
3. 清水文崇 (90535254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
4. 赤松和土 (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 江鐘偉 (60225357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SANO Yasuteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 三須建郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 渡邉健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 渡邉充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村優理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshita Yukio 竹下 幸男

Yukio Takeshita 竹下 幸男

TAKESHITA Yukio 竹下 幸男

Research Projects

Research Products

Co-Researchers

Brain drug screening research using a mass-produced human blood-brain barrier modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a device for measurement of specific skeletal muscle mobility and evaluation method for peripheral nerve recovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the molecules that promote IgG-translocation across the BBB in autoimmune CNS diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the mechanism of a-synuclein propagation from peripheral tissues to the central nervous system via exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel strategy to treat intractable CNS disorders, utilizing the properties of BBB-composing cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of targeted membrane antigens of human brain microvascular endothelial cells in relapsing-remitting multiple sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of new in vitro blood-brain barrier (BBB) and blood-nerve barrier (BNB) model that incorporates multi-culturing system of BBB or BNB components.Principal Investigator

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[Journal Article] Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells2023

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[Journal Article] Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy2023

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[Journal Article] Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model2022

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[Journal Article] New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD.2021

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[Journal Article] GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder2021

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[Journal Article] Glial cell line-derived neurotrophic factor and basic fibroblast growth factor derived from skeletal muscle pericytes increase the barrier function of endothelial cells in the endomysium.2021

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[Journal Article] HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data2021

Author(s)

Takeshita Yukio 竹下幸男

Yukio Takeshita 竹下幸男

TAKESHITA Yukio 竹下幸男