Morimoto Jumpei 森本淳平

Researcher Number	70754935
Other IDs	https://orcid.org/0000-0002-8393-9616
Affiliation (Current)	2025: 東京大学, 大学院工学系研究科(工学部), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 大学院工学系研究科(工学部), 講師 2017 – 2020: 東京大学, 大学院工学系研究科(工学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Chemical biology Except Principal Investigator Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator ペプトイド / ペプチド / 立体構造解析 / フォルダマー / 固相合成法 / 酸化代謝 / ミクロソーム / 膜透過性 / 創薬 / 代謝 … More / 中分子 / タンパク質間相互作用 / 生体分子認識 / 固相合成 / ３次元構造解析 / タンパク質リガンド / N置換ペプチド / 分子認識 / タンパク質 / 人工オリゴマー / 生理活性 / スクリーニング / 細胞膜透過 / ペプチドミメティクス / 細胞膜透過性 / N置換型βペプチド / 量子化学計算 / 生体膜透過性 / 構造解析 / 配座制御 / N置換βペプチド … More Except Principal Investigator 凝集性 / 熱安定性 / タンパク質工学 / シミュレーション / 蛋白質工学 / Supercharging / 単ドメイン抗体 / 分子デザイン / 機能計測 / 物性計測 / ペプチド / 抗体 / 抗体工学 / 分子設計 / 安定性 / 親和性成熟 / 機械学習 / 分子シミュレーション / ペプチド設計 / 抗体設計 Less

A study on metabolism of peptoids toward development of synthetic oligomers that are useful for drug discovery researchPrincipal Investigator
- Principal Investigator
  
  森本淳平
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  The University of Tokyo
Molecular design of real proteins in virtual space
- Principal Investigator
  
  Kuroda Daisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Institute of Infectious Diseases
  The University of Tokyo
Research on synthetic oligomer, peptoid, that realizes selective biomolecular recognitionPrincipal Investigator
- Principal Investigator
  
  Morimoto Jumpei
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  The University of Tokyo
Synthesis and conformational studies of N-substituted beta-peptides toward development of inhibitors against intracellular proteinsPrincipal Investigator
- Principal Investigator
  
  Morimoto Jumpei
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] A High-Resolution Structural Characterization and Physicochemical Study of How a Peptoid Binds to an Oncoprotein MDM22024
- Author(s)
  Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, Satoru Nagatoishi, Kouhei Tsumoto and Shinsuke Sando
- Journal Title
  
  Chemical Science
  
  Volume: - Issue: 19 Pages: 7051-7060
- DOI
  10.1039/d4sc01540a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K26771
[Journal Article] Oligo(N‐methylalanine) as a Peptide‐Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites2022
- Author(s)
  Yokomine Marin、Morimoto Jumpei、Fukuda Yasuhiro、Shiratori Yota、Kuroda Daisuke、Ueda Takumi、Takeuchi Koh、Tsumoto Kouhei、Sando Shinsuke
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 14 Pages: 6994-7000
- DOI
  10.1002/anie.202200119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PROJECT-19H03522, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-19H04202
[Journal Article] Peptoid-based reprogrammable template for cell-permeable inhibitors of protein?protein interactions2021
- Author(s)
  Fukuda Y, Yokomine M, Kuroda D, Tsumoto K, Morimoto J, Sando S.
- Journal Title
  
  Chemical Science
  
  Volume: 12 Issue: 40 Pages: 13292-13300
- DOI
  10.1039/d1sc01560e
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-19H04202
[Journal Article] Per-Residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions2020
- Author(s)
  Jumpei Morimoto, Jungyeon Kim, Daisuke Kuroda, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 5 Pages: 2277-2284
- DOI
  10.1021/jacs.9b10496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15692, KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-19H04202
[Journal Article] Peptoids with Substituents on the Backbone Carbons as Conformationally Constrained Synthetic Oligoamides2020
- Author(s)
  Jumpei Morimoto, Shinsuke Sando
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 78 Issue: 11 Pages: 1076-1084
- DOI
  10.5059/yukigoseikyokaishi.78.1076
- NAID
  130007937265
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2020-11-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15692
[Journal Article] A Parallel Permeability Assay of Peptides across Artificial Membrane and Cell Monolayers Using a Fluorogenic Reaction2019
- Author(s)
  Jumpei Morimoto, Rei Amano, Takahiro Ono, and Shinsuke Sando
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 11 Pages: 2887-2891
- DOI
  10.1039/c9ob00133f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13265
[Journal Article] A Peptoid with Ectended Shape in Water2019
- Author(s)
  Morimoto J, Fukuda Y, Kuroda D, Watanabe T, Yoshida F, Asada M, Nakamura T, Senoo A, Nagatoishi S, Tsumoto K, *Sando S
- Journal Title
  
  J Am Chem Soc.
  
  Volume: 141 Issue: 37 Pages: 14612-14623
- DOI
  10.1021/jacs.9b04371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-19H04202
[Journal Article] Isolation of a peptide containing d-amino acid residues that inhibits the α-helix-mediated p53-MDM2 interaction from a one-bead one-compound library2018
- Author(s)
  Morimoto Jumpei、Hosono Yuki、Sando Shinsuke
- Journal Title
  
  Bioorganic and medicinal chemistry letters
  
  Volume: 28 Issue: 3 Pages: 231-234
- DOI
  10.1016/j.bmcl.2018.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13265
[Journal Article] Solid-Phase Synthesis of β-Peptoids with Chiral Backbone Substituents Using Reductive Amination2017
- Author(s)
  Morimoto Jumpei、Fukuda Yasuhiro、Sando Shinsuke
- Journal Title
  
  Organic letters
  
  Volume: 19 Issue: 21 Pages: 5912-5915
- DOI
  10.1021/acs.orglett.7b02909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13265
[Patent] タンパク質相互作用を阻害するペプトイドの合理的創出法2019
- Inventor(s)
  山東信介、森本淳平、福田泰啓
- Industrial Property Rights Holder
  山東信介、森本淳平、福田泰啓
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-130113
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] MDM2結合性ペプトイドとMDM2の結合様式の評価2023
- Author(s)
  横峰真琳・森本淳平・福田泰啓・上田卓見・竹内恒・鈴木机倫・前田理・梅澤公二・長門石曉・津本浩平・山東信介
- Organizer
  第１７回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K26771
[Presentation] IMPROVEMENT OF THE METABOLIC STABILITY OF A BACKBONE-ALANYL PEPTOID IN LIVER MICROSOME2023
- Author(s)
  Hiroka Kobayashi, Eri Watanabe, Jumpei Morimoto, Shinsuke Sando
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-23K26771
[Presentation] Alanyl-backbone peptoid as a rigid synthetic oligomer useful for intracellular ppi inhibitors2023
- Author(s)
  Jumpei Morimoto
- Organizer
  International Mini-Symposium on Peptide Design and Functional Extension A Satellite Symposium of the 60th Japanese Peptide Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-23K26771
[Presentation] N置換ペプチドを足場とするMDM2リガンドの設計2021
- Author(s)
  横峰真琳、福田泰啓、黒田大祐、津本浩平、森本淳平、山東信介
- Organizer
  日本化学会　第101春季年会（2021）
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] 予測可能な立体構造を形成する人工オリゴアミドの開発と生体分子操作への展開2021
- Author(s)
  森本淳平
- Organizer
  日本化学会　第101春季年会（2021）
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] Oligo(N-substituted alanine) as a peptoid with a defined shape in water2021
- Author(s)
  Jumpei Morimoto
- Organizer
  Online Peptoid Symposia
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] 主鎖アラニン型ペプトイドを用いた細胞内タンパク質阻害剤の合理設計とアポトーシス誘導剤への展開2020
- Author(s)
  福田泰啓、森本淳平、山東信介
- Organizer
  第56回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] 主鎖アラニン型ペプトイドの配座安定性評価と生体分子認識への応用2019
- Author(s)
  森本淳平・福田泰啓・黒田大祐・渡邊拓夢・吉田文彦・浅田瑞枝・中村敏和・妹尾暁暢・長門石曉・津本浩平・山東信介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] A Design Strategy for β-Peptoids with Constraint on Multiple Backbone Dihedral Angles2019
- Author(s)
  Jungyeon Kim, Jumpei Morimoto, Shinsuke Sando
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] Development of Inhibitors for Intracellular Protein-protein Interactions Using Peptoids with Alanyl Backbones2019
- Author(s)
  Yasuhiro Fukuda, Jumpei Morimoto, Daisuke Kuroda, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19K15692
[Presentation] Oligo(N-substituted alanines) as a Peptoid with Defined Shape in Water: Synthesis and Conformational Studies2018
- Author(s)
  Jumpei Morimoto, Yasuhiro Fukuda, Takumu Watanabe, Shinsuke Sando
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13265
[Presentation] Conformational Studies of Oligo(N-substituted alanines) by X-ray Crystallographic Analysis2018
- Author(s)
  Yasuhiro Fukuda, Jumpei Morimoto, Shinsuke Sando
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13265
[Presentation] Evaluation of the Effect of Amide-to-ester Substitution on Membrane Permeability and Tertiary Structure of Peptides2018
- Author(s)
  Yuki Hosono, Yui Sakurai, Jumpei Morimoto, Shinsuke Sando
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13265
[Presentation] Design and Synthesis of Conformationally Constrained β-Peptoids with Chiral Backbone Substituents and Macrocyclization2018
- Author(s)
  Jumpei Morimoto, Jungyeon Kim, Yasuhiro Fukuda, Shinsuke Sando
- Organizer
  日本化学会第98春期年会
- Data Source
  KAKENHI-PROJECT-17K13265
[Presentation] Solid-phase synthesis of oligo-N-substituted peptides with chiral backbone substituents using reductive amination2017
- Author(s)
  Yasuhiro Fukuda, Jumpei Morimoto, Shinsuke Sando
- Organizer
  The Second International Symposium on Biofunctional Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13265
[Presentation] 配座制御されたオリゴN置換アラニンの合成2017
- Author(s)
  福田泰啓、森本淳平、山東信介
- Organizer
  第7回CSJ化学フェスタ 2017
- Data Source
  KAKENHI-PROJECT-17K13265

1. Kuroda Daisuke (60756732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 田部亜季 (60786367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAGATOISHI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morimoto Jumpei 森本 淳平

Research Projects

Research Products

Co-Researchers

A study on metabolism of peptoids toward development of synthetic oligomers that are useful for drug discovery researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular design of real proteins in virtual space

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on synthetic oligomer, peptoid, that realizes selective biomolecular recognitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis and conformational studies of N-substituted beta-peptides toward development of inhibitors against intracellular proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A High-Resolution Structural Characterization and Physicochemical Study of How a Peptoid Binds to an Oncoprotein MDM22024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oligo(N‐methylalanine) as a Peptide‐Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptoid-based reprogrammable template for cell-permeable inhibitors of protein?protein interactions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Per-Residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptoids with Substituents on the Backbone Carbons as Conformationally Constrained Synthetic Oligoamides2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] A Parallel Permeability Assay of Peptides across Artificial Membrane and Cell Monolayers Using a Fluorogenic Reaction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Peptoid with Ectended Shape in Water2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of a peptide containing d-amino acid residues that inhibits the α-helix-mediated p53-MDM2 interaction from a one-bead one-compound library2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solid-Phase Synthesis of β-Peptoids with Chiral Backbone Substituents Using Reductive Amination2017

Author(s)

Journal Title

DOI

Data Source

[Patent] タンパク質相互作用を阻害するペプトイドの合理的創出法2019

Inventor(s)

Industrial Property Rights Holder

Morimoto Jumpei 森本淳平