Yoshihara Masahito 吉原正仁

Researcher Number	70807065
Other IDs	https://orcid.org/0000-0002-8915-9282
Affiliation (Current)	2026: 大阪大学, 大学院医学系研究科, 准教授 2026: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 千葉大学, 大学院医学研究院, 准教授
Review Section/Research Field	Principal Investigator Basic Section 43060:System genome science-related / Basic Section 56060:Ophthalmology-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator トランスクリプトーム / iBM細胞 / 8細胞期胚様細胞 / ヒト初期胚 / 胚性ゲノム活性化 / 硝子体蛋白 / 機械学習 / バイオマーカー / プロテオーム / メタボローム … More / 硝子体液 / 裂孔原性網膜剥離 / 増殖性硝子体網膜症 / 遺伝子発現 / Hi-C / 神経分化 / 疾患関連SNP / 転写制御 / プロモーター / エンハンサー … More Except Principal Investigator オルガノイド / ヒトiPS細胞 / 水晶体 / 眼科再生医療 Less

Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment
- Principal Investigator
  
  馬場耕一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  The University of Osaka
Elucidation of gene regulatory mechanisms during early human development using 8-cell-like cellsPrincipal Investigator
- Principal Investigator
  
  吉原正仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Chiba University
High-depth proteomic profiling of proliferative vitreoretinopathyPrincipal Investigator
- Principal Investigator
  
  Yoshihara Masahito
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Chiba University
A comprehensive enhancer atlas of a human neuronal differentiation model to elucidate the pathophysiology of neuronal disordersPrincipal Investigator
- Principal Investigator
  
  Yoshihara Masahito
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Chiba University

All 2025 2024 2023

All Journal Article Presentation Book

[Book] ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用2023
- Author(s)
  吉原正仁、他59名
- Total Pages
  605
- Publisher
  技術情報協会
- ISBN
  9784861049781
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] Endothelial activating transcription factor 3 promotes angiogenesis and vascular repair in the mouse retina2025
- Author(s)
  Ueda Chihiro、Sakimoto Susumu、Yoshihara Masahito、Takigawa Toru、Shiraki Akihiko、Yamaguchi Kaito、Shiki Kosuke、Shiraki Nobuhiko、Kitajima Shigetaka、Kubota Yoshiaki、Fukushima Yoko、Nishida Kohji
- Journal Title
  
  iScience
  
  Volume: 28 Issue: 1 Pages: 111516-111516
- DOI
  10.1016/j.isci.2024.111516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09717, KAKENHI-PROJECT-23K15903
[Journal Article] Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders2025
- Author(s)
  Yoshihara Masahito、Coschiera Andrea、Bachmann Jorg A、Pucci Mariangela、Li Haonan、Bhagat Shruti、Murakawa Yasuhiro、Weltner Jere、Jouhilahti Eeva-Mari、Swoboda Peter、Sahlen Pelin、Kere Juha
- Journal Title
  
  EMBO Reports
  
  Volume: 26 Issue: 5 Pages: 1212-1237
- DOI
  10.1038/s44319-025-00372-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15903
[Journal Article] The DoGA consortium expression atlas of promoters and genes in 100 canine tissues2024
- Author(s)
  Hortenhuber M, Hytonen MK, Mukarram AK, Arumilli M, Araujo CL, Quintero I, Syrja P, Airas N, Kaukonen M, Kyostila K, Niskanen J, Jokinen TS, Mottaghitalab F, Takan I, Salokorpi N, Raman A, Stevens I, Iivanainen A, Yoshihara M, Gusev O, Bannasch D, Sukura A, Schoenebeck JJ; DoGA Consortium;他5名
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 9082-9082
- DOI
  10.1038/s41467-024-52798-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15903
[Journal Article] Primary cilia promote the differentiation of human neurons through the WNT signaling pathway2024
- Author(s)
  Coschiera Andrea、Yoshihara Masahito、Lauter Gilbert、Ezer Sini、Pucci Mariangela、Li Haonan、Kavsek Alan、Riedel Christian G.、Kere Juha、Swoboda Peter
- Journal Title
  
  BMC Biology
  
  Volume: 22 Issue: 1 Pages: 48-48
- DOI
  10.1186/s12915-024-01845-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] Host-derived protein profiles of human neonatal meconium across gestational ages2024
- Author(s)
  Shitara Yoshihiko、Konno Ryo、Yoshihara Masahito、Kashima Kohei、Ito Atsushi、Mukai Takeo、Kimoto Goh、Kakiuchi Satsuki、Ishikawa Masaki、Kakihara Tomo、Nagamatsu Takeshi、Takahashi Naoto、Fujishiro Jun、Kawakami Eiryo、Ohara Osamu、Kawashima Yusuke、Watanabe Eiichiro
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 5543-5543
- DOI
  10.1038/s41467-024-49805-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15903, KAKENHI-PROJECT-23K15465, KAKENHI-PROJECT-24K18876
[Journal Article] Comparison of Scheimpflug and Anterior Segment Optical Coherence Tomography Imaging Parameters for Japanese Patients With Fuchs Endothelial Corneal Dystrophy With and Without TCF4 Repeat Expansions2024
- Author(s)
  Maeno Sayo、Oie Yoshinori、Koto Ryota、Nishida Nozomi、Yamashita Arisa、Yoshioka Michika、Kai Chifune、Soma Takeshi、Koh Shizuka、Yoshihara Masahito、Kawasaki Ryo、Jhanji Vishal、Nakamori Masayuki、Tsujikawa Motokazu、Nishida Kohji
- Journal Title
  
  Cornea
  
  Volume: - Issue: 7 Pages: 805-811
- DOI
  10.1097/ico.0000000000003488
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15903, KAKENHI-PROJECT-21K09718, KAKENHI-PROJECT-23K21480, KAKENHI-PROJECT-21K19570, KAKENHI-PROJECT-23K21411
[Journal Article] Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors2023
- Author(s)
  Hosaka Kayoko、Wang Chenchen、Zhang Shiyue、Lv Xue、Seki Takahiro、Zhang Yin、Jing Xu、Wu Jieyu、Du Qiqiao、He Xingkang、Fan Yulong、Li Xuan、Kondo Makoto、Yoshihara Masahito、Qian Hong、Shi Lihong、Zhu Ping、Xu Yuanfu、Yang Yunlong、Cheng Tao、Cao Yihai
- Journal Title
  
  Cancer Communications
  
  Volume: 43 Issue: 6 Pages: 637-660
- DOI
  10.1002/cac2.12423
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] Comprehensive characterization of the embryonic factor LEUTX2023
- Author(s)
  Gawriyski L, Jouhilahti EM, Yoshihara M, Fei L, Weltner J, Airenne TT, Trokovic R, Bhagat S, Tervaniemi MH, Murakawa Y, Salokas K, Liu X, Miettinen S, Burglin TR, Sahu B, Otonkoski T, Johnson MS, Katayama S, Varjosalo M, Kere J.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 3 Pages: 106172-106172
- DOI
  10.1016/j.isci.2023.106172
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] Primary cilia promote the differentiation of human neurons through the WNT signaling pathway2023
- Author(s)
  Andrea Coschiera, Masahito Yoshihara, Gilbert Lauter, Sini Ezer, Juha Kere, Peter Swoboda
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.04.06.535895
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] Transcriptomic differences between human 8-cell-like cells reprogrammed with different methods2023
- Author(s)
  Yoshihara Masahito、Kere Juha
- Journal Title
  
  Stem Cell Reports
  
  Volume: 18 Issue: 8 Pages: 1621-1628
- DOI
  10.1016/j.stemcr.2023.06.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Journal Article] B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors2023
- Author(s)
  Kaemena Daniel F.、Yoshihara Masahito、Beniazza Meryam、Ashmore James、Zhao Suling、Bertenstam Marten、Olariu Victor、Katayama Shintaro、Okita Keisuke、Tomlinson Simon R.、Yusa Kosuke、Kaji Keisuke
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 488-488
- DOI
  10.1038/s41467-023-36097-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20622
[Presentation] メタボローム解析による増殖性硝子体網膜症の病態解明と治療標的探索2025
- Author(s)
  川俣勇人、吉原正仁、岩瀬雄仁、三浦玄、辰巳智章、川上英良、馬場隆之
- Organizer
  第129回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-23K15903
[Presentation] ヒト多能性幹細胞を用いた8細胞期胚様細胞 (8CLCs)の作製2024
- Author(s)
  吉原正仁
- Organizer
  第47回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K15903
[Presentation] ヒト8細胞期胚様細胞 (8CLCs)の網羅的遺伝子発現比較解析2023
- Author(s)
  吉原正仁, Juha Kere
- Organizer
  NGS EXPO 2023
- Data Source
  KAKENHI-PROJECT-22K20622
[Presentation] 新規初期化因子によるヒト初期胚様幹細胞の作製2023
- Author(s)
  吉原正仁
- Organizer
  アステラス病態代謝研究会第53回研究報告会
- Data Source
  KAKENHI-PROJECT-22K20622
[Presentation] ヒト8細胞期胚様細胞(8CLCs)の作製およびトランスクリプトーム比較解析2023
- Author(s)
  吉原正仁
- Organizer
  幹細胞を用いた化学物質リスク情報共有化コンソーシアム第5回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20622
[Presentation] 角膜疾患の治療を目指した網羅的遺伝子発現解析2023
- Author(s)
  吉原正仁
- Organizer
  第127回日本眼科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K15903

1. 馬場耕一 (00436172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 原進 (00536956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 西田幸二 (40244610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKUSHIMA Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshihara Masahito 吉原 正仁

Research Projects

Research Products

Co-Researchers

Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of gene regulatory mechanisms during early human development using 8-cell-like cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

High-depth proteomic profiling of proliferative vitreoretinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A comprehensive enhancer atlas of a human neuronal differentiation model to elucidate the pathophysiology of neuronal disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Endothelial activating transcription factor 3 promotes angiogenesis and vascular repair in the mouse retina2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The DoGA consortium expression atlas of promoters and genes in 100 canine tissues2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary cilia promote the differentiation of human neurons through the WNT signaling pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host-derived protein profiles of human neonatal meconium across gestational ages2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of Scheimpflug and Anterior Segment Optical Coherence Tomography Imaging Parameters for Japanese Patients With Fuchs Endothelial Corneal Dystrophy With and Without TCF4 Repeat Expansions2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive characterization of the embryonic factor LEUTX2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary cilia promote the differentiation of human neurons through the WNT signaling pathway2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptomic differences between human 8-cell-like cells reprogrammed with different methods2023

Yoshihara Masahito 吉原正仁