Hanaki Yusuke 花木祐輔

Researcher Number	70897818
Other IDs
Affiliation (Current)	2026: 香川大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 香川大学, 農学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Basic Section 38040:Bioorganic chemistry-related
Keywords	Principal Investigator ハマゴウ / ラブダン型ジテルペノイド / 構造活性相関 / がん / 婦人科疾患 / 子宮線筋症 / 子宮内膜 / E-cadherin / Halimane / Labdane / 天然物 / 抗がん剤 / Oscillatoxin … More Except Principal Investigator … More 発がんプロモーション / ビブサニン / プロテインキナーゼC / 抗炎症誘導性 / 炎症 / 骨格多様性 / 分子動力学シミュレーション / 構造活性相関 Less

Elucidation of the molecular structural basis of vibsamin A, an anti-proinflammatory protein kinase C activator
- Principal Investigator
  
  柳田亮
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kagawa University
細胞間接着を保護するラブダン型ジテルペンの合成および子宮腺筋症治療効果の検証Principal Investigator
- Principal Investigator
  
  花木祐輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kagawa University
Structural optimization of vibsanins with scaffold diversity as protein kinase C activator
- Principal Investigator
  
  Yanagita Ryo
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kagawa University
Development of a new anti-cancer seed based on the cell-line selective anti-proliferative activity of oscillatoxin FPrincipal Investigator
- Principal Investigator
  
  Hanaki Yusuke
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kagawa University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Six-step synthesis and epithelial-mesenchymal transition?inhibitory activity of a tetralone-based vitetrifolin analog2025
- Author(s)
  Hanaki Yusuke、Sugiyama Yasunori、Yanagita Ryo C
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: - Issue: 6 Pages: 805-810
- DOI
  10.1093/bbb/zbaf030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06147, KAKENHI-PROJECT-24K17837
[Journal Article] Evaluation of the <i>in vitro</i> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions2021
- Author(s)
  Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 8 Issue: 3 Pages: 69-73
- DOI
  10.2131/fts.8.69
- NAID
  130008052793
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-19H02896, KAKENHI-PROJECT-21K14793, KAKENHI-PROJECT-16H06276
[Journal Article] Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines.2021
- Author(s)
  Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
- Journal Title
  
  Heterocycles
  
  Volume: 102 Issue: 12 Pages: 2353-2362
- DOI
  10.3987/com-21-14538
- NAID
  40022762966
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-19H02896, KAKENHI-PROJECT-21K14793, KAKENHI-PROJECT-16H06276
[Presentation] アヤメ属植物由来のPKC活性化剤iridal類の合成研究2025
- Author(s)
  石井大智、関戸智紀、花木祐輔、柳田亮
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-22K05464
[Presentation] 機械学習を用いた新規PKCリガンドのin silico探索と合成研究2025
- Author(s)
  白井遼太郎、柳田亮、花木祐輔、入江一浩
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-22K05464
[Presentation] 婦人科疾患治療薬シーズの開発を指向した天然物研究2024
- Author(s)
  花木祐輔
- Organizer
  日本農芸化学会中四国支部第39回若手研究者シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-24K17837
[Presentation] 線維環境下での細胞応答に着目した創薬シーズの探索および合成2024
- Author(s)
  花木祐輔
- Organizer
  日本農芸化学会2024年度中四国支部大会（第69回講演会）2024年度日本農芸化学会中四国支部奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-24K17837
[Presentation] 新規Vibsanin A誘導体の合成と生物活性の評価2024
- Author(s)
  髙渕大斗、畠中聡之、柳田亮、花木祐輔
- Organizer
  日本農芸化学会2024年度中四国支部大会（第69回講演会）
- Data Source
  KAKENHI-PROJECT-22K05464
[Presentation] Vibsanin AとプロテインキナーゼC C1ドメインとの結合様式の解析2023
- Author(s)
  畠中聡之, 柳田亮, 大谷真緒, 花木祐輔, 佐藤正資, 川浪康弘, 入江一浩
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-22K05464
[Presentation] Azulene型vibsanin誘導体の合成と生物活性評価2023
- Author(s)
  和田智貴, 柳田亮, 花木祐輔, 川浪康弘
- Organizer
  日本農芸化学会中四国支部第64回講演会
- Data Source
  KAKENHI-PROJECT-22K05464
[Presentation] 海洋天然物・oscillatoxin類の合成および構造展開2022
- Author(s)
  花木祐輔
- Organizer
  香川大学農学部応用生命化学研究センター第13回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14793
[Presentation] アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発2022
- Author(s)
  波田航平, 新木悠介, 野倉吉彦, 花木祐輔, 中崎敦夫, 西川俊夫
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K14793
[Presentation] Synthesis and Biological Evaluation of Oscillatoxins and Aplysiatoxins2021
- Author(s)
  Yusuke Hanaki
- Organizer
  1st Trilateral Symposium on SDGs (Chiang Mai University, National Chiayi University, Kagawa University)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14793

1. Yanagita Ryo (10598121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 杉山康憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 西川俊夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hanaki Yusuke 花木 祐輔

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular structural basis of vibsamin A, an anti-proinflammatory protein kinase C activator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞間接着を保護するラブダン型ジテルペンの合成および子宮腺筋症治療効果の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural optimization of vibsanins with scaffold diversity as protein kinase C activator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new anti-cancer seed based on the cell-line selective anti-proliferative activity of oscillatoxin FPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Six-step synthesis and epithelial-mesenchymal transition?inhibitory activity of a tetralone-based vitetrifolin analog2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the <i>in vitro</i> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] アヤメ属植物由来のPKC活性化剤iridal類の合成研究2025

Author(s)

Organizer

Data Source

[Presentation] 機械学習を用いた新規PKCリガンドのin silico探索と合成研究2025

Author(s)

Organizer

Data Source

[Presentation] 婦人科疾患治療薬シーズの開発を指向した天然物研究2024

Author(s)

Organizer

Data Source

[Presentation] 線維環境下での細胞応答に着目した創薬シーズの探索および合成2024

Author(s)

Organizer

Data Source

[Presentation] 新規Vibsanin A誘導体の合成と生物活性の評価2024

Author(s)

Organizer

Data Source

[Presentation] Vibsanin AとプロテインキナーゼC C1ドメインとの結合様式の解析2023

Author(s)

Organizer

Data Source

[Presentation] Azulene型vibsanin誘導体の合成と生物活性評価2023

Author(s)

Organizer

Data Source

[Presentation] 海洋天然物・oscillatoxin類の合成および構造展開2022

Author(s)

Organizer

Data Source

[Presentation] アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発2022

Hanaki Yusuke 花木祐輔