AIMOTO Saburo 相本三郎

Researcher Number	80029967
Other IDs
Affiliation (based on the past Project Information) *help	2004 – 2009: 大阪大学, 蛋白質研究所, 教授 2008: Osaka University, たんぱく質研究所, 教授 2000 – 2003: Institute for Protein Research, Professor, たんぱく質研究所, 教授 1993 – 2001: 大阪大学, 蛋白質研究所, 教授 1993 – 1994: Osaka University, Institute for Protein Research, Professer, たんぱく質研究所, 教授 … More 1993: 大阪大学, 蛋白工学研究所, 助教授 1989 – 1992: 大阪大学, たんぱく質研究所, 助教授 1987 – 1992: 大阪大学, 蛋白質研究所, 助教授 Less
Review Section/Research Field	Principal Investigator 天然物有機化学 / Bioorganic chemistry / Structural biochemistry / Living organism molecular science / Biological Sciences / Cell biology Except Principal Investigator Biological Sciences / Neurophysiology and muscle physiology / Functional biochemistry / Structural biochemistry
Keywords	Principal Investigator 化学合成 / ペプチド合成 / native chemical ligation / GPCR / NMR / thioester method / チオエステル法 / DNA結合タンパク質 / タンパク質の化学合成 / 選択的縮合法 … More / ペプチドチオエステル / 補助基 / ライゲーション法 / 膜蛋白質 / auxiliary / coupling conditions / chemical synthesis / peptide thioester / nociceptin receptor / Argタグ / 7回膜貫通型受容体 / チオスルホネート基 / 縮合条件 / ノシセプチン受容体 / phage library / interferon γ / synthetic peptide / antagonist / interleukin-18 / 膜貫通ドメイン / 抗体 / 合成ペプチド / IL-18受容体 / IL-18 / インターフェロン18(IL-18) / IL-18区分ペプチド / インターフェロンγ産生 / ファージライブラリー / アンタゴニスト / インターロイキン18(IL-18) / X-ray Crystallography / Chemical Synthesis / Solid-state NMR / Protein Nucleic Acid Interaction / Analytical Method / 3-dimensional Structure / Protein / X線結晶構造解析 / 固体NMR / 蛋白質・核酸相互作用 / 解析法 / 高次構造 / 蛋白質 / TAT protein / Solid-phase method / Segnent codensation / Protein synthsis / Peptide syntheis / 固相合成法 / チオエステル / タンパク質合成 / 蛋白質合成法 / ペプチド合成法 / TAT蛋白質 / 固相法 / セグメント縮合 / 蛋白質合成 / DNAータンパク質相互作用。 / 安定同位体標識 / ペプチド結合の形成 / ライゲ-ション法 / ライブラリー / ヒストンH3 / メチル化リシン / 遺伝子発現 / 翻訳後修飾 / メチル化 / ヒストン / Argタグ補助基 / 4回膜貫通型受容体 / 光反応性補助基 / Fmoc法 / v-ATPase / EGF 受容体 / 電位依存性プロトンチャネル / EGF受容体 / 膜近傍部位 / 合成法 / 溶解性 / オキザロイル基 / 選択的化学修飾反応 / 末端アミノ基 / グリオキシロイル基 / 過ヨウ素酸ナトリウム / メチル化DNA結合ドメイン / N-末端特異的標識 … More Except Principal Investigator DNA結合蛋白質 / NMR / 高次構造 / 分子生物学 / 重点領域研究 / 生物物理学 / DNAの構造変化 / 立体構造 / 蛋白質 / 情報伝達 / 蛋白質間相互作用 / シグナル伝達 / 転写因子 / 構造生物学 / DNA / 構造解析 / タンパク質のドメイン / タンパク質の機能構造 / 転写制御蛋白質 / DNAー蛋白質相互作用 / 制御蛋白質 / novel NMR techniques / nuclear signal transduction / intracellular signal transduction / protein-protein interaction / signal transduction / 嫌気センサー / リン酸基転移反応 / 二成分系 / フィロポディア / 班研究会 / 備品整備 / ワークショップ / シンポジウム / 班会議 / 新規NMR技術 / 核内シグナル伝達 / 細胞質内シグナル伝達 / Thioester method / Ab initio X-ray crystallography / Solid state NMR / Magic angle sample spinning / Solution structure determination / Protein segmental labeling / Protein interaction / X線小角散乱 / 同位体標識 / 電子顕微鏡 / X線結晶構造解析 / タンパク質相互作用 / 多波長異常分散法 / 第3世代放射光 / 電子顕微鏡単粒子解析 / X線溶液散乱法 / 安定同位体標識 / 固体高分解能多次元NMR / 立体・位置特異的重水素化 / 部分セグメント標識法 / チオエステル法 / Ab initio X線結晶構造解析法 / 固体NMR / マジック角試料回転 / 溶液構造決定法 / タンパク質区分標識法 / Molecular Biology / RNA-binding Proteins / DNA-binding Proteins / Transcription / Signal Transduction / X-ray Crystallography / Structural Biology / 分子認識 / X線結晶 / Separation science / Uppsala / Sweden / クロマトグラフィー / 電気泳動 / 分離科学 / 科学史 / ウプサラ / スウェーデン / GTP-binding protein / Potassium Channel / Long-term Potentiation / Hippocampus / MCD Peptide / NMDAチャネル / ペプチド合成 / 長期増強効果 / GTP結合蛋白 / カリウムチャンネル / 長期増強 / 海馬 / MCDペプチド / Dnmt3a / ヒストンメチル化酵素 / ヒストン / ヌクレオソーム / DNAメチルトランスフェラーゼ / DNAメチル化 / CBP / コアクチベータ / 低分子量G蛋白 / モエシン / N-WASP / 核内シグナル / 細胞質内シグナル / 多元的情報伝達 / 相互作用 / X線 / NMR装置 / 核磁気共鳴 / X線回折 / RNAポリメラーゼ / 蛋白質-核酸相互作用 / 蛋白質-蛋白質相互作用 / DNA-蛋白質相互作用 / 核磁気共鳴装置 / 分子構造 / 多次元NMR / 蛋白質ー蛋白質相互作用 / 結晶解析 / 放射光 / 蛋白質のドメイン / 機能構造 / 転写制御 / X線構造解析 / 識別機構 Less

Development of a synthetic method of modified histone aiming at elucidation of the molecular mechanism of the gene expression regulationPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka University
ヒストンの特異的な残基のメチル化修節がDNAメチル化活性に果たす役割の解析
- Principal Investigator
  
  田嶋正二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Development of a method for membrane protein synthesis based on ligation chemistryPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  2003 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of a method for chemical synthesis of G-protein coupled receptorPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Osaka University
蛋白質のN-末端特異的蛍光標識法の開発と生細胞内メチル化DNAの直接検出法の開発Principal Investigator
- Principal Investigator
  
  相本三郎
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Development of New Methodologies for Protein-Interaction Analysis
- Principal Investigator
  
  AKUTSU Hideo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Yokohama National University
Protein-protein interaction in intracellular signal transduction
- Principal Investigator
  
  INAGAKI Fuyuhiko
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  HOKKAIDO UNIVERSITY
  Tokyo Metropolitan Organization for Medical Research
Suppression of the inflammatory cytokine IL-18 activity by controlling the receptor functionPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
構造生物学にもとづくシグナル伝達機構の解明
- Principal Investigator
  
  稲垣冬彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Development of Novel Methods for Structural Analyses of ProteinsPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  1994 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Analyses of Signal Transduction Mechanisms based on Protein Structures
- Principal Investigator
  
  NISHIMURA Yoshifumi
- Project Period (FY)
  1994 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
DNAの高次構造を識別する蛋白質(まとめ)
- Principal Investigator
  
  京極好正
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
蛋白質の高次構造に基づくシグナル認識機構の解明
- Principal Investigator
  
  西村善文
- Project Period (FY)
  1993
- Research Institution
  Yokohama City University
Japanese-Swedish Cooperative Research on Bioseparation Science
- Principal Investigator
  
  TAKAGI Toshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Inprovement of Thioester Method and Synthesis of Cysteine-Containing ProteinsPrincipal Investigator
- Principal Investigator
  
  AIMOTO Saburo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Osaka University
制御蛋白質の機能構造
- Principal Investigator
  
  饗場弘二
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
DNAの高次講造を識別する蛋白質
- Principal Investigator
  
  京極好正
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
制御蛋白質の機能構造
- Principal Investigator
  
  饗場弘二
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
DNAの高次構造を識別する蛋白質
- Principal Investigator
  
  京極好正
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
制御蛋白質の機能構造
- Principal Investigator
  
  饗場弘二
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
DNAの高次構造を識別する蛋白質
- Principal Investigator
  
  KYOUGOKU Yoshimasa
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Osaka University
Molecular Biological Studies on Mechanisms Underlying Long Term Potentiation in Hippocampus Induced by a Bee Venom.
- Principal Investigator
  
  IKENAKA Kazuhiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Osaka University
DNAとの動的相互作用解析を目的とした^<13>C標識DNA結合蛋白質の全合成Principal Investigator
- Principal Investigator
  
  相本三郎
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Osaka University
タンパク質の迅速かつ精密な化学合成のための方法論的研究Principal Investigator
- Principal Investigator
  
  相本三郎
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Osaka University

All 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Patent

[Journal Article] Formation of Peptide Thioesters by an N to S Acyl Shift Reaction at the Cysteinyl Prolyl Cysteine Position2010
- Author(s)
  Sakiko Shimizu, Saburo Aimoto, Toru Kawakami
- Journal Title
  
  Peptide Science 2009
  
  Pages: 153-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Synthesis of Peptide Thioesters Based on an N to S Acyl Shift Reaction2010
- Author(s)
  Toru Kawakami, Sakiko Shimizu, Saburo Aimoto
- Journal Title
  
  Peptide Science 2009
  
  Pages: 79-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Methylthio Groups for Thiol Protection that realize the Sequential Ligation by Native Chemical Ligation followed by Thioester method2009
- Author(s)
  Yuichi Akai, Lisa Takemura, Yuko Aoki, Masazumi Waseda, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Peptide Science 2008
  
  Pages: 201-201
- NAID
  10027166211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] The Use of a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit in Peptide Ligation Reactions2009
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3871-3877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Structure of the transmembrane dimer of the amyloid precursor protein: Implications for proteolysis by g-secretase2009
- Author(s)
  T. Sato, T.-C.Tang, G. Reubins, J.Z. Fei, T. Fujimoto, P. Kienlen-Campard, S. N. Constantinescu, J.-N. Octave, S. Aimoto, S. O. Smith
- Journal Title
  
  Proc. Natl Acad. Sci. USA 106
  
  Pages: 1421-1426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Synthesis of peptide thioesters via an N-S acyl shift reaction under mild acidic conditions using an N-4, 5-dimethoxy-2-mercaptobenzyl auxiliary group2009
- Author(s)
  Ken'ichiro Nakamura, Tomoki Kanao, Tomoya Uesugi, Toshiaki Hara, Takeshi Sato, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  J. Peptide Sci 15
  
  Pages: 731-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] 2-Nitrobenzylcarbamate-type Photocleavable Linker Having Fmoc-aminoalkyloxy Group: Preparation and Application to Peptide Purification2009
- Author(s)
  Toshiaki Hara, Akira Tainosho, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Peptide Science 2008
  
  Pages: 199-201
- NAID
  10027166207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide purification by affinity chromatography based on α-ketoacyl group chemistry2009
- Author(s)
  T. Hara, A. Tainosho, K. Nakamura, T. Sato, T. Kawakami, S. Aimoto
- Journal Title
  
  J. Peptide Sci. 15
  
  Pages: 369-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Peptide purification by affinity chromatography based on a-ketoacyl group chemistry2009
- Author(s)
  Toshiaki Hara, Akira Tainosho, Ken'ichiroh Nakamura, Takeshi Sato, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  J. Peptide Sci 15
  
  Pages: 369-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Synthesis of Peptide Thioester, by the Cysteinyl Prolyl Ester (CPE) Method2009
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Peptide Science 2008
  
  Pages: 171-172
- NAID
  10027166150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide Purification Using The Selective Reaction Between Aminooxy Group and Isothiocyanate Group2009
- Author(s)
  Akira Tainosho, Toshiaki Hara, Ken'ichiro Nakamura, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Peptide Science 2008
  
  Pages: 205-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] The use of a cysteinyl prolyl ester (CPE) autoactivating unit in peptide ligation reactions2009
- Author(s)
  T. Kawakami, S. Aimoto
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3871-3877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Peptide purification by affinity chromatography based on α-ketoacyl group chemistry2009
- Author(s)
  Toshiaki Hara, Akira Tainosho, Ken'ichiroh Nakamura, Takeshi Sato, Toru Kawakami, Saburo Aimoto
- Journal Title
  
  J. Peptide Sci. 15
  
  Pages: 369-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Synthesis of a Partial Sequence of Site-2008
- Author(s)
  Hisao Fujimoto, Chieko Kita, Akira Tainosho, Yuichi Akai, Lisa Takemura, Hitomi Kanda, Toru, Kawakami, Saburo Aimoto
- Journal Title
  
  Specifically Methylated Histone H3 Peptide Science 2007
  
  Pages: 209-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Polypeptide Synthesis via the N-to S-Acyl Shift Reaction2007
- Author(s)
  Toru Kawakami, Ken'ichiro Nakamura, Saburo Aimoto
- Journal Title
  
  Peptides 2006
  
  Pages: 198-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus2007
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Chem. Lett. 36
  
  Pages: 76-77
- NAID
  10018663050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Sequential Peptide Ligation by Using a Controlled Cysteinyl Prolyl Ester (CPE) Autoactivating Unit2007
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 1903-1905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus2007
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Chem. Lett 36
  
  Pages: 76-77
- NAID
  10018663050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Sequential Peptide Ligation by Using a Controlled Cysteinyl Prolyl Ester (CPE) Autoactivating Unit2007
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 1903-1905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide Ligation Using the Cysteinyl Prolyl Ester (CPE) Activating Unit at the Carboxy Terminus2007
- Author(s)
  T. Kawakami, S. Aimoto
- Journal Title
  
  Chem. Lett. 36
  
  Pages: 76-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Peptide Thioester Synthesis via an Auxiliary-Mediated N-S Acyl Shift Reaction in SolutionInt2007
- Author(s)
  Ken'ichiro Nakamura, Hiroaki Mori, Toru Kawakami, Hironobi Hojo, Yoshiaki Nakahara, Saburo Aimoto
- Journal Title
  
  J. Peptide Res. Therapeutics 13
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Peptide ligation thinvolves an intramolecular N to S acyl shift reaction2006
- Author(s)
  Toru Kawakami, Ken'ichiro Nakamura, Saburo Aimoto
- Journal Title
  
  Peptide Science 2006 29
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Generation of an S-Peptide via an N-S Acyl Shift Reaction in TFA Solution2006
- Author(s)
  K. Nakamura, M. Sumida, T. Kawakami, T. Vorherr, S. Aimoto
- Journal Title
  
  Bull Chem Soc. Jpn. 79
  
  Pages: 1773-1780
- NAID
  10019373528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] N-S acyl shift reaction on peptide backbone and its application to preparation of peptide thioesters2006
- Author(s)
  Ken'ichiro Nakamura, Toru Kawakami, Hironobu Hojo, Yoshiaki Nakahara, Saburo Aimoto
- Journal Title
  
  Peptide Science 2006 42
- NAID
  10020528860
- Data Source
  KAKENHI-PROJECT-18310145
[Journal Article] Inhibitors of amyloid toxicity based on beta-sheet packing of Aβ40 and Aβ42.2006
- Author(s)
  T. Sato, P. Kienlen-Campard, M. Ahmed, W. Liu, H. Li, J. I. Elliott, S. Aimoto, S. N. Constantinescu, J. N. Octave, S. O. Smith
- Journal Title
  
  Biochemistry 45
  
  Pages: 5503-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Synthesis of the C-terminal Region of Opioid Receptor Like 1 in an SDS Micelle by the Native Chemical Ligation: Effect of Thiol Additive and SDS Concentration on Ligation Efficiency,2005
- Author(s)
  T. Sato, Y. Saito, S. Aimoto
- Journal Title
  
  J. Peptide Sci. 11
  
  Pages: 410-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Sequential Peptide Chemical Ligation by the Thioester Method and Extended Chemical Ligation.2005
- Author(s)
  T. Kawakami, M. Tsuchiya, K. Nakamura, S. Aimoto
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 5533-5536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Journal Article] Peptide Thioester Preparation Based on an N-S Acyl Shift Reaction Mediated by a Thiol Ligation Auxiliary.2005
- Author(s)
  T. Kawakami,M. Sumida, K. Nakamura, T. Vorherr, S. Aimoto
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 8805-8807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083204
[Patent] ペプチドエステル試薬,およびそのライゲーションまたチオエステル化合物の製造のための使用2006
- Inventor(s)
  相本三郎、川上徹
- Industrial Property Rights Holder
  相本三郎、川上徹、大阪大学、大阪産業振興機構
- Filing Date
  2006
- Overseas
- Data Source
  KAKENHI-PROJECT-15083204
[Patent] ペプチドエステルを用いたライゲーション法、およびチオエステル化合物の製造方法2005
- Inventor(s)
  相本三郎, 川上徹
- Industrial Property Rights Holder
  発明者大阪大学大阪産業振興機構
- Filing Date
  2005-10-14
- Data Source
  KAKENHI-PROJECT-15083204
[Patent] ペプチドエステルを用いたライゲーション法、およびチオエステル化合物の製造方法2005
- Inventor(s)
  川上徹、相本三郎
- Industrial Property Rights Holder
  川上徹、相本三郎、大阪大学、大阪産業振興機構
- Filing Date
  2005
- Data Source
  KAKENHI-PROJECT-15083204
[Presentation] 2-ニトロベンジルカルバメイト型光分解リンカーを用いる化学合成ペプチドの精製2010
- Author(s)
  原利明、田結荘明、川上徹、相本三郎
- Organizer
  日本化学会第90回春季年会
- Place of Presentation
  近畿大学、東大阪市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Cys-Pro-Cys部位におけるN-Sアシル基転位反応を利用したペプチドチオエステルの合成2010
- Author(s)
  清水咲子、相本三郎、川上徹
- Organizer
  日本化学会第90回春季年会
- Place of Presentation
  近畿大学、東大阪市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Histone H3K9 trimethylation stimulates the histone H3K27 methylation activity of PRC2 bypassing Eed2010
- Author(s)
  Isao Suetake, Saburo Aimoto, Yuko Aoki, Kyoichi Isono, Toru Kawakami, Hiroshi Kimura, Akihiko Koseki, Yuichi Mishima; Osamu Nishimura, Shoji Tajima, Makoto Watanabe
- Organizer
  Keystone symposium
- Place of Presentation
  Sagebrush Inn and Conference Center, Taos, New Mexico
- Year and Date
  2010-01-20
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Synthesis of Peptide Thioesters Based on an N to S Acyl Shift Reaction2009
- Author(s)
  Toru Kawakami, Sakiko Shimizu, Saburo Aimoto
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州国際会議場、北九州市
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Formation of Peptide Thioesters by an N to S Acyl Shift Reaction at the Cysteinyl Prolyl Cysteine Position2009
- Author(s)
  Sakiko Shimizu, Saburo Aimoto, Toru Kawakami
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州国際会議場、北九州市
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] メチルチオ基をチオール保護基として用いるネイティブケミカルライゲーション法とチオエステル法による連続ライゲーション法2009
- Author(s)
  赤井優一、早稲田真澄、青木優子、竹村梨沙、川上徹、相本三郎
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  千葉
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] ポリコーム群蛋白質複合体PRC2によるH3K27メチル化の新たな活性調節機構2009
- Author(s)
  三島優一、磯野協一、青木優子、川上徹、渡辺真、木村宏、西村紀、相本三郎、古関明彦、田嶋正二、末武勲
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Fmoc-アミノプロピルオキシ基を導入した2-ニトロベンジルカルバメイト型リンカーの合成とペプチド精製への応用2008
- Author(s)
  原利明、田結荘明、川上徹、相本三郎
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] アミノオキシ基とイソチオシアネート基の選択的化学反応とそれに続くエドマン分解を利用したペプチドの精製2008
- Author(s)
  田結荘明、原利明、中村健一郎、川上徹、相本三郎
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] ネイティブケミカルライゲーション法とチオエステル法の併用を可能にするチオール保護基としてのメチルチオ基の利用2008
- Author(s)
  赤井優一、竹村梨沙、青木優子、早稲田真澄、川上徹、相本三郎
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Synthesis of Peptide Thioester by the Cysteinyl Prolyl Ester (CPE) Method2008
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] ペプチドCys-Proエステルを合成ブロックとして用いるトリメチルリシン含有ヒストンH3合成法の研究2008
- Author(s)
  赤井優一、藤本久雄、竹村梨沙、田結荘明、喜多知恵子、神田仁美、川上徹、相本三郎
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] α-ケトアシル基の形成と切断を鍵反応とするペプチド精製法の開発2008
- Author(s)
  原利明、田結荘明、藤本大樹、川上徹、相本三郎
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] N to S Acyl Shift Reaction in Peptide Ligation2007
- Author(s)
  Toru Kawakami, Ken'ichiroh Nakamura, Hisao Fujimoto, Saburo Aimoto
- Organizer
  4th international Peptide Symposium
- Place of Presentation
  ーストラリア・ケアンズ
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Peptide Ligation via the N to S Acyl Shift Reaction2007
- Author(s)
  oru Kawakami, Saburo Aimoto
- Organizer
  Chemical Protein Synthesis Meeting
- Place of Presentation
  オーストラリア・ヘロン島
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] 部位特異的に修飾されたヒストンH3部分配列の合成2007
- Author(s)
  藤本久雄、喜多千恵子、田結荘明、赤井優一、竹村梨沙、神田仁美、川上徹、相本三郎
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山市
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] PEPTIDE THIOESTER SYNTHESIS BY AN ON-RESINAUXILIARY-MEDIATED N-S ACYL SHIFT REACTION2007
- Author(s)
  S., Aimoto
- Organizer
  Modern Solid Phase Peptied Synthesis & Its Applications
- Place of Presentation
  オーストラリア・ポートダグラス
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-15083204
[Presentation] PEPTIDE THIOESTER SYNTHESIS BY AN ON-RESIN AUXILIARY-MEDIATED N-S ACYL SHIFT REACTION2007
- Author(s)
  Saburo Aimoto
- Organizer
  Modern Solid Phase Peptide Synthesis, Its Applications
- Place of Presentation
  オーストラリア・ポートダグラス
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] Peptide Ligation via the In-Situ Transformation of an Amide into a Thioester at a Cysteine Residue2007
- Author(s)
  Toru Kawakami, Saburo Aimoto
- Organizer
  20th American Peptide Society Symposium
- Place of Presentation
  カナダ・モントリオール
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-18310145
[Presentation] PEPTIDE THIOESTER SYNTHESIS BY AN ON-RESINAUXILIARY-MEDIATED N-S ACYL SHIFT REACTION2007
- Author(s)
  S. Aimoto
- Organizer
  Modern Solid Phase Peptide Synthesis & Its Applications
- Place of Presentation
  オーストラリア・ポートダグラス
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18310145

1. NISHIMURA Yoshifumi (70107390)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. SHIRAKAWA Masahiro (00202119)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. 嶋本伸雄 (20127658)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. 饗場弘二 (20025662)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. KYOUGOKU Yoshimasa (90012632)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. KAWAKAMI Toru (70273711)

# of Collaborated Projects: 5 results

# of Collaborated Products: 42 results
7. INAGAKI Fuyuhiko (70011757)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. 箱嶋敏雄 (00164773)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. AKUTSU Hideo (60029965)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. MORIKAWA Kosuke (80012665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. SUETAKE Isao (80304054)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
12. TAJIMA Shoji (50132931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
13. KATAHIRA Masato (70211844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. SATO Mamoru (60170784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TSUKIHARA Tomitake (00032277)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 今川正良 (20136823)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 石浜明 (80019869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. SATO Takeshi (90403013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. IKENAKA Kazuhiro (00144527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HOJO Hironobu (00209214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TAKAGI Toshio (00029943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAMEYAMA Keiichi (60177607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ONO Akira (10183253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. FUJIWARA Toshimichi (20242381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KATO Koichi (20211849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KATAOKA Mikio (30150254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KAINOSHO Masatsune (20137029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAMAZAKI Toshio (60273710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KASHIWAMURA Shinichiro (00185761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. OKAMURA Haruki (60111043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 中村義一 (40114590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 牧野耕三 (20181620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 貝淵弘三 (00169377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 田中勲 (70093052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 嶋田一夫 (70196476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. HANESKOG Lars

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. HJERTEN Stellan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. LUNDAHI Per

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. JANSON JanーC

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. PER Lundahl

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AIMOTO Saburo 相本 三郎

Research Projects

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Co-Researchers

Development of a synthetic method of modified histone aiming at elucidation of the molecular mechanism of the gene expression regulationPrincipal Investigator

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Development of a method for membrane protein synthesis based on ligation chemistryPrincipal Investigator

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Development of a method for chemical synthesis of G-protein coupled receptorPrincipal Investigator

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蛋白質のN-末端特異的蛍光標識法の開発と生細胞内メチル化DNAの直接検出法の開発Principal Investigator

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Suppression of the inflammatory cytokine IL-18 activity by controlling the receptor functionPrincipal Investigator

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Development of Novel Methods for Structural Analyses of ProteinsPrincipal Investigator

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Inprovement of Thioester Method and Synthesis of Cysteine-Containing ProteinsPrincipal Investigator

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AIMOTO Saburo 相本三郎