NISHINO Tomoko 西野朋子

Researcher Number	80075613
External Links
Affiliation (based on the past Project Information) *help	2006 – 2009: 日本医科大学, 医学部, 講師 1999 – 2003: NIPPON MEDICAL SCHOOL, BIOCHEMISTRY AND MOLECULAR BIOLOGY, Assistant, 医学部, 助手 1998 – 1999: 横浜市立大学, 医学部, 助手 1992 – 1994: 横浜市立大学, 医学部, 助手 1988: Yokohama city university, School of medicine, research associate, 医学生化学, 助手 1987 – 1988: 横浜市立大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Functional biochemistry / 物質生物化学 / Pathological medical chemistry Except Principal Investigator Pathological medical chemistry / Functional biochemistry / Structural biochemistry
Keywords	Principal Investigator フラビン酵素 / キサンチン酸化酵素 / キサンチン脱水素酵素 / 結晶構造 / 活性酸素 / モリブデン酵素 / dehydrogenase-oxidase conversion / crystal structure / insect cell expression system / reactive oxveen sued … More / molybdenum enzyme / flavoenzvme / xanthine dehvdroeenase / xantine oxidase / 酸化型-脱水素酵素型変換 / 昆虫細胞発現系 / REACTION MECHANISM / FLAVOENZYME / NITRIC OXIDE SYNTHASE / 反応機構 / NO合成酵素 / モリブデン酸素 / 酸化酵素型-脱水素酵素型変換 / ノックインマウス / キサンチチン脱水素酵素 / キサンチチン酸化酵素 / トランスジェニックマウス / キサンチン酸化還元酵素 / スーパーオキシド / 分子病態学 / キサシチン脱水素酵素 … More Except Principal Investigator キサンチン脱水素酵素 / 活性酸素 / 非ヘム鉄 / キサンチン酸化酵素 / X線結晶解析 / Structure and function of the enzyme / cDNA cloning / Xanthine dehydrogenase / Purine nuceotide / プリンヌクレオチド分解 / CDNAクローニング / 反応速度論的解析 / 酵素の構造と機能 / cDNAクローニング / プリンヌクレオチド / Iron-binding protein / Peroxiredoxin / Non-heme iron / X-ray crystallography / Metallo protein / Xanthine Oxidase / Xanthine Dehydrogenase / Active Oxygen / 鉄結合タンパク質 / ペルオキシレドキシン / 金属タンパク質 / superoxide anion / active oxygen / molybdenum enzyme / non-heme iron / flavoprotein / xnathine oxidase / xanthine dehydrogenase / X-ray crystal structure / NO合成酵素 / EPR / 部位特異的変異法 / 金属フラビン酵素 / フリーラジカル / X-線結晶解析 / スーパーオキシド / モリブデン酵素 / フラビン酵素 Less

Phasogenesis study of XOR mutant knock-in mouse.Principal Investigator
- Principal Investigator
  
  OKAMOTO Ken, 西野朋子
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
The mechanism of redox control system revealed by highly superoxide-productive xanthine oxidase mutantPrincipal Investigator
- Principal Investigator
  
  NISHINO Tomoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nippon Medical School
複反応中心をもつ金属フラビン蛋白群の構造と機能Principal Investigator
- Principal Investigator
  
  西野朋子
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
Structure and function complex flavo-proteins which produce free radicals
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  NIPPON MEDICAL SCHOOL
複反応中心をもつ金属フラビソ蛋白群の構造と機能Principal Investigator
- Principal Investigator
  
  西野朋子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
  Yokohama City University
The structure and function of a complex metalloflavoprotein
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nippon Medical School
REACTION MECHANISM OF NITRIC OXIDE SYNTHASEPrincipal Investigator
- Principal Investigator
  
  NISHINO Tomoko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Yokohama City University
Stracture and expression of genes of the enzymes involved in purine nucleotide catabolism
- Principal Investigator
  
  TSUSHIMA Keizo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yokohama city university, School of medicine

All 2011 2010 2009 2008 2007 2006 2002 2000 1999 Other

All Journal Article Presentation Book

[Book] METALIONS IN BIOLOGOCAL SISTEMS : Molybdenum and Tungsten : Their Roles in Biological Processes (The Molybdenum-Containing Xanthine Oxidoreductases and Picolinate Dehydrogenases.)2002
- Author(s)
  E.F.Pai, T.Nishino
- Total Pages
  24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Book] Flavins and Flavoproteins : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center. (S.Ghisla et al., eds.)1999
- Author(s)
  C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
- Total Pages
  4
- Publisher
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Book] Flavins and Flavoproteins : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis. (S.Ghisla et al., eds.)1999
- Author(s)
  T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
- Total Pages
  4
- Publisher
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011
- Author(s)
  Matsumoto K, Okamoto K, Ashizawa N, Nishino T
- Journal Title
  
  J Pharmacol Exp Ther. Jan ; 336(1)
  
  Pages: 95-103
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011
- Author(s)
  Matsumoto K, Okamoto K, Ashizawa N, Nishino T.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 336 Pages: 95-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.2010
- Author(s)
  Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T.
- Journal Title
  
  J Am Chem Soc.
  
  Volume: 132 Pages: 17080-17083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Structure and mechanism of molybdenum hydroxylase2008
- Author(s)
  Okamoto K, Nishino T.
- Journal Title
  
  [Article in Japanese]Seikagaku. Jun ; 80(6)
  
  Pages: 531-9
- NAID
  10021192278
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors : allopurinol, febuxostat, and FYX-0512008
- Author(s)
  Okamoto K, Nishino T
- Journal Title
  
  J Nippon Med Sch. Feb ; 75(1)
  
  Pages: 2-3
- NAID
  130004057313
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mammalian Xanthine Oxidoreductase:Mechanism of transition from xanthine dehydrogenase to xanthine oxidase2008
- Author(s)
  Nishino, T.
- Journal Title
  
  FEBS Journal (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570137
[Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase.2008
- Author(s)
  Nishino T
- Journal Title
  
  FEBS J. 275
  
  Pages: 3278-3289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mechanism of inhibition of xanthine oxidoreductase by allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.2008
- Author(s)
  Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids. Jun ; 27(6)
  
  Pages: 888-93
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine ehydrogenase to xanthine oxidase.2008
- Author(s)
  Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T
- Journal Title
  
  FEBS J. Jul ; 275(13)
  
  Pages: 3278-89
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mammalian xanthine oxidoreductase : Mechanism of transition from xanthine dehydrogenase to xanthine oxidase2008
- Author(s)
  Nishino, T
- Journal Title
  
  Eur. J. Biochem (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570137
[Journal Article] Two Mutations Convert Mammalian Xanthine Oxidoreductase to Highly Superoxide-Productive Xanthine Oxidase.2007
- Author(s)
  Asai R., Nishino T., Matsumura T., Okamoto K., Igarashi K., Pal EF, Nishino T.
- Journal Title
  
  Journal of Biochemistry doi:10.1093/jb/mvm054
- NAID
  10020100130
- Data Source
  KAKENHI-PROJECT-18570137
[Journal Article] METAL IONS IN BIOLOGOCAL SISTEMS : Molybdenum and Tungsten : Their Roles in Biological Processes2002
- Author(s)
  E.F.Pai, T.Nishino
- Journal Title
  
  The Molybdenum-Containing Xanthine Oxidoreductases and Picolinate Dehydrogenases
  
  Pages: 24-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Purification, crystallization and preliminary X-ray siffraction studies of xanthine dehydrogebse and xanthine oxidase isolated from bovine milk.2000
- Author(s)
  B.T.Eger, K.Okamoto, C.Enroth, M.Sato, T.Nishino, E.F.Pai, T.Nishino
- Journal Title
  
  Acta Cryst. D56
  
  Pages: 1656-1658
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase.2000
- Author(s)
  T.Nishino, K.Okamoto
- Journal Title
  
  Journal of Inorganic Biochemistry 82
  
  Pages: 43-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase2000
- Author(s)
  T.Nishino, K.Okamoto
- Journal Title
  
  Journal of Inorganic Biochemistry 82
  
  Pages: 43-49
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase : Structure-based mechanism of conversion.2000
- Author(s)
  C.Enroth, B.T.Eger, K.Okamoto, T.Nishino, T.Nishino, E.F.Pai
- Journal Title
  
  Proc.Natle.Acad, Scie., USA 97
  
  Pages: 10723-10728
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis2000
- Author(s)
  T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
- Journal Title
  
  J.Biochem. 127
  
  Pages: 771-778
- NAID
  10005443636
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis.2000
- Author(s)
  T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
- Journal Title
  
  J.Biochem. 127
  
  Pages: 771-778
- NAID
  10005443636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Cellobiose Dehydrogenase from the Fungi Phanerochaete chrysosporium and Humicola insolens1999
- Author(s)
  K.Igarashi, M.Verhagen, M.Samejima, M.Schulein, K.L.Eriksson, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 3338-3344
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis.1999
- Author(s)
  T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
- Journal Title
  
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
  
  Pages: 4-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Modulation of the Remote Heme Site Geometry of Recombinant Mouse Neuronal Nitric-oxide Synthase by the N-terminal Hook Region1999
- Author(s)
  T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7705-7713
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Characterization of Mouse nNOS2, a Natural Variant of Neuronal Nitric-oxide Synthase Produced in the Central Nervous System by Selective Alternative Splicing1999
- Author(s)
  T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino, K.Tamura, S.Oue, T.Iizuka, T.Ogura, H.Esumi
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 17559-17566
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Cellobiose Dehydrogenase from the Fungi Phanerochaete chrysosporium and Humicola insolens.1999
- Author(s)
  K.Igarashi, M.Verhagen, M.Samejima, M.Schulein, K.L.Eriksson, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 3338-3344
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Modulation of the Remote Heme Site Geometry of Recombinant Mouse Neuronal Nitric-oxide Synthase by the N-terminal Hook Region.1999
- Author(s)
  T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7705-7713
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide1999
- Author(s)
  K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7763-7768
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Characterization of Mouse nNOS2, a Natural Variant of Neuronal Nitric-oxide Synthase Produced in the Central Nervous System by Selective Alternative Splicing.1999
- Author(s)
  T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino, K.Tamura, S.Oue, T.Iizuka, T.Ogura, H.Esumi
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 17559-7566
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center.1999
- Author(s)
  C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
- Journal Title
  
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
  
  Pages: 4-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide.1999
- Author(s)
  K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7763-7768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.
- Author(s)
  Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T
- Journal Title
  
  J Am Chem Soc.
  
  Pages: 2010-2010
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura1、Koji Matsumoto、Takeshi Nishino
- Organizer
  14th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  東京
- Year and Date
  2011-02-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura 1、Koji Matsumoto、Takeshi Nishino
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ウシキサンチン酸化還元酵素と天然基質キサンチンとの反応中間体結晶構造Structure of xanthine oxidoreductase in action ; Reaction intermediate structure of milk xanthine oxidoreductase and natural substrate xanthine.2010
- Author(s)
  Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
- Organizer
  2010年日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 哺乳類ヘムペルオキシダーゼによる一重項酸素の生成2009
- Author(s)
  辻田和宏, 草野輝男, 牧内正男, 西野朋子, 柿沼カツ子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 新規キサンチン酸化還元酵素剤FYX-051の酵素学的,構造生物学的解析2009
- Author(s)
  松本浩二, 岡本研, 松村智裕, 草野輝男, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] knock-outマウスを用いたラクトペルオキシダーゼの組織局在の網羅的解析2009
- Author(s)
  草野輝男, 松田陽子, 西野朋子, 石渡俊行, 内藤善哉, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  岡本研, 松村智裕, 草野輝男, 松本浩二, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態に於ける二量体サブユニット構造の非対称性2009
- Author(s)
  西野朋子, 岡本研, 川口裕子, 辻井厚子, 他
- Organizer
  第9回蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素におけるCH...O結合がFADの酸化還元電位に与える影響について2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  西野朋子, 岡本研、川口裕子
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 近赤外極微弱光検出装置を用いたヘムペルオキシダーゼ由来の一重項酸素の定量的測定法2009
- Author(s)
  牧内正男, 辻田和宏, 草野輝男, 西野朋子, 柿沼カツ子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ブチロフィリンが有す多機能B30.2/SPRYドメインとミルクキサンチン脱水素酵素との結合様式について2009
- Author(s)
  西野朋子, 李穎, 岡本研, 草野輝男, 川口裕子, 松村智裕, 他
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素における機能的CH...O水素結合の存在2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第9回蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態における構造変2009
- Author(s)
  西野朋子, 岡本研、川口裕子
- Organizer
  蛋白質科学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素/酸化酵素の変換における二量体構造の非対称性2008
- Author(s)
  西野朋子
- Organizer
  第81回日本生化学大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素酸化酵素の変換機構/C末ペプチドの役割2007
- Author(s)
  西野朋子
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570137
[Presentation] キサンチン脱水素酵素酸化酵素の変換機構/C末ペプチドの役割2007
- Author(s)
  西野朋子
- Organizer
  第80回日本生化学大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18570137
[Presentation] The mechanism of xanthine dehydrogenase/oxidase conversion : The role of C-terminal peptide2007
- Author(s)
  Nishino, T
- Organizer
  The 80th Annual Meeting of the Japanese Biochemical Society
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570137
[Presentation] The mechanisms of dehydrogenase/oxidase conversion.-Biochemical and X-raq structural studies using various xanthine oxidoreductase mutants2006
- Author(s)
  Nishino, T.
- Organizer
  The 20th IUBMB International Congress of Bioche mistry and Molecular Biology
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570137
[Presentation] The mechanisms of dehydrogenase/oxidase conversion. -Biochemical and X-ray structural studies using various xanthine oxidoreductase mutants2006
- Author(s)
  Nishino, T
- Organizer
  The 20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  in Kyoto
- Year and Date
  2006-06-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570137

1. OKAMOTO Ken (60267143)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
2. NISHINO Takeshi (40094312)

# of Collaborated Projects: 5 results

# of Collaborated Products: 44 results
3. MATSUMURA Tomohiro (20297930)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. IWASAKI Toshio (40277497)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. KUSANO Teruo (30434129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. TSUSHIMA Keizo (20045917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAZAKI Kenichi (40182480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 阿部靖子 (60089612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. PAI Emil F.

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

NISHINO Tomoko 西野 朋子

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Phasogenesis study of XOR mutant knock-in mouse.Principal Investigator

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The mechanism of redox control system revealed by highly superoxide-productive xanthine oxidase mutantPrincipal Investigator

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複反応中心をもつ金属フラビン蛋白群の構造と機能Principal Investigator

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Structure and function complex flavo-proteins which produce free radicals

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複反応中心をもつ金属フラビソ蛋白群の構造と機能Principal Investigator

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The structure and function of a complex metalloflavoprotein

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REACTION MECHANISM OF NITRIC OXIDE SYNTHASEPrincipal Investigator

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Stracture and expression of genes of the enzymes involved in purine nucleotide catabolism

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[Book] METALIONS IN BIOLOGOCAL SISTEMS : Molybdenum and Tungsten : Their Roles in Biological Processes (The Molybdenum-Containing Xanthine Oxidoreductases and Picolinate Dehydrogenases.)2002

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[Book] Flavins and Flavoproteins : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center. (S.Ghisla et al., eds.)1999

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[Book] Flavins and Flavoproteins : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis. (S.Ghisla et al., eds.)1999

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[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011

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[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011

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[Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.2010

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NISHINO Tomoko 西野朋子