KOBAYASHI Masashi 小林正

… Alternative Names

KOBAYASHI Msashi 小林正

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Researcher Number	80115758
Other IDs
Affiliation (based on the past Project Information) *help	2006: 富山大学, 事務局, 理事(副学長) 2006: University of Toyama, Department of Medicine, Exctive Vice President and Director of University Hospital, 事務局・理事(副学長)病院長 2005: 富山大学, 事務局・理事(副学長) 病院長 2003 – 2004: 富山医科薬科大学, 医学部, 教授 1995 – 1996: 富山医科薬科大学, 医学部, 教授 … More 1992 – 1993: 富山医科薬科大学, 医学部, 教授 1988 – 1991: 滋賀医科大学, 医学部, 講師 1990: Shiga University of Medical Science, Assistant Professor. 1986: Shiga University of Medical Science, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics
Keywords	Principal Investigator インスリン抵抗性 / JNK / IRS-1 / mTOR / インスリン受容体異常症 / Insulin resistance / Insulin receptor / serine kinase / proteasome / IKK … More / IL-1 / 点突然変異 / インスリンレセプター異常症 / point mutation / PCR / Insulin receptor disease / プロレセプター / インスリン持抗性糖尿病 / インスリン誘導体 / 糖尿病 / point mutotion / インスリンレセプタ- / point metotion / PCR法 / Kinase activity of beta-subunit / インスリン作用 / IGF-1 / 高インスリン血症 / インスリン低抗性 / インスリンレセプター / serine phosphorylation / insulin resistance / セリンキナーゼ / セリンリン酸化 / anisomycin / rapamycin / プロテアソーム / セリン燐酸化 / negative feedback / セリン・キナーゼ / Insulin Resistance / Insulin receptor Disease / Malecular chaperones / 分子シャペロン / Tyrosine Kinase / Point Mutation / Syndrome of Extreme Insulin Resistance / Insulin Receptor / プロモ-タ- / インスリン受容体遺子 / 点宅燃変異 / インスリンレセプター insulin receptor / チロシン・キナーゼ / インスリン・レセプター異常症 / チロシンキナーゼ / insulin receptor Less

MECHANISMS FOR INSULIN RESISTANCE BY SERINE KINASE ACTIVATIONPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama
Analysis of negative-feed back mechanism through mTOR pathway in insulin action.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
The mechanism of degradation of mutant insulin receptors.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Syndrome of extreme insulin resistance due to decreased promoter activity of 5'-flanking region of insulin receptor gene.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Msashi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  TOYAMA MEDICAL AND PHARMACERTICAL UNIVERSITY
  Shiga University of Medical Science
Insulin Resistance Due to Unprocessed Insulin ProreceptorPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science
Mechanism of Insulin Resistance in Insulin Receptor Disease.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science

All 2007 2006 2005 2004 2003 Other

All Journal Article Book

[Book] 専門医に聞きたいコメディカルのための糖尿病・糖尿病性腎症Q&A101 Q-14糖尿病の治療 7)インスリン治療適応と方法 Q-21アルコールと食事療法(西沢良記, 石村栄治編)2005
- Author(s)
  小林正
- Total Pages
  210
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Book] 糖尿病カレントライブラリー(4)糖床病と遺伝子 IV.遺伝子からみた病態2.インスリン抵抗性に関連するもの PTPaseとSHIP2(堀川幸男, 安田和基編集)2005
- Author(s)
  小林正
- Total Pages
  280
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007
- Author(s)
  Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazaki Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze Haruta T, Kobayashi M
- Journal Title
  
  Endocrinology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007
- Author(s)
  Kanatani Y., Usui I., Ishizuka K., Bukhari A., Fujisaka S., Urakaze M., Haruta T., Kishimoto T., Naka T., Kobayashi M.
- Journal Title
  
  Diabetes 56(3)
  
  Pages: 795-803
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007
- Author(s)
  Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazald Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze M, Haruta T, Kobayashi M.
- Journal Title
  
  Endocrinology. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007
- Author(s)
  Kanatani Y., Usui I., Ishizuka K., Bukhari A., Fujisaka S., Urakaze M., Haruta T., Kishimoto T., Naka T., Kobayashi M
- Journal Title
  
  Diabetes 56(3)
  
  Pages: 795-803
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin-1 {alpha} Inhibit Insulin Signaling with Phosphoylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20(1)
  
  Pages: 114-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin-1 {alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20・1
  
  Pages: 114-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin- 1 {alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20・1
  
  Pages: 114-124
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A Kawahara J, Usui I, Kobayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 335・33
  
  Pages: 836-842
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A Kawahara J, Usui I, Kobayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 335・3
  
  Pages: 836-842
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylatian, translocatian, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, Kobayashi M
- Journal Title
  
  Biochem Biophys Res Cammun 335・3
  
  Pages: 836-842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Impact of src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.2004
- Author(s)
  Zurakami S., Sasaoka T., Wada T.et al., Kobayashi M.
- Journal Title
  
  Endocrinology 145
  
  Pages: 3215-3233
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Originating mechanisms of growth hormone-induced cellular insulin resistance.2004
- Author(s)
  Usui I., Takano A., Haruta T., Kobayashi M.
- Journal Title
  
  Clin Pediatr Endcrinol 13
  
  Pages: 31-36
- NAID
  110002984509
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.2004
- Author(s)
  Sasaoka T., Wada T., Fukui K.et al., Kobayashi M.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 14835-14843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.2004
- Author(s)
  Sasaoka T., Wada T., Fukui K., Murakami S., Ishihara H., Suzuki R., Tobe K., Kadowaki T., Kobayashi M.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 14835-14843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.2004
- Author(s)
  Yoshizaki T., Maegawa H., Egawa K., Ugi S., Nishio Y., Imamura T., Kobayashi M., Tamura S., Olefsky J.M., Kashiwagi A.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 22715-22726
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Impact of src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.2004
- Author(s)
  Murakami S., Sasaoka T., Wada T., Fukui K., Nagira K., Ishihara H., Usui I., Kobayashi M.
- Journal Title
  
  Endocrinology 145
  
  Pages: 3215-3223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Originating mechanisms of growth hormone-induced cellular insulin resistance.2004
- Author(s)
  Usui I., Takano A., Haruta T., Kobayashi M.
- Journal Title
  
  Clin Pediatr Endocrinol 13
  
  Pages: 31-36
- NAID
  110002984509
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Protein phosphatase 2C alpha as a positive regulator of insulin sensitivity through direct activation of phospharidylinositol 3-kinase in 3T3-L1 adipocytes.2004
- Author(s)
  Yoshizaki T., Maegawa H., Egawa K., Ugi S., Nishino Y., Imamura T., Kobayashi M., Tamura S., Olefsky J.M., Kashiwagi A.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 22715-22726
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Dual role of src homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor 1 signaling in rat vascular smooth muscle cells.2003
- Author(s)
  Sasaoka T., Kikuchi K., Wada T., Sato A., Hori H., Murakami S., Fukui K., Ishihara H., Aota R., Kimura I., Kobayashi M.
- Journal Title
  
  Endocrinology 144
  
  Pages: 4204-4214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.2003
- Author(s)
  Ishihara H., Sasaoka T., Kagawa S., et al., Kobayashi M.
- Journal Title
  
  FEBS Lett. 554
  
  Pages: 450-454
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Clinical features of diabetes mellitus with the mitochondrial DNA 3243(A-G) mutation in Japanese : Maternal inheritance and mitochondria-related complications.2003
- Author(s)
  Suzuki S., Oka Y., Kadowaki T., Kanatsuka A., Kuzuya T., Kobayashi M., Sanke T., Seine Y., Nanjyo K.
- Journal Title
  
  Diabet Res Clin Pract 59
  
  Pages: 207-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.2003
- Author(s)
  Ishihara H., Sasaoka T., Kagawa S., Murkami S., Fukui K., Kawagishi Y., Yamazaki K., Sato A., Iwata M., Urakaze M., Ishiki M., Wada T., Yaguchi S., Tsuneki H., Kimura I., Kobayashi M.
- Journal Title
  
  FEBS Lett 554
  
  Pages: 450-454
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Dual role of src homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor 1 signaling in rat vascular smooth muscle cells.2003
- Author(s)
  Sasaoka T., Kikuchi K., Wada T., Sato A.et al.Kobayashi M.
- Journal Title
  
  Endocrinology 145
  
  Pages: 4204-4214
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.2003
- Author(s)
  Ishihara H., Sasaoka T., Kagawa S., Murakami S., Fukui K., Kawagishi Y., Yamazaki K., Sato A., Iwata M., Urakaze M., Ishiki M., Wada T., Yaguchi S., Tsuneki H., Kimura I., Kobayashi M.
- Journal Title
  
  FEBS Lett. 554
  
  Pages: 450-454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Clinical features of diabetes mellitus with the mitochontrial DNA 3243(A-G) mutation in Japanese : Maternal inheritance and mitochondria-related complications.2003
- Author(s)
  Suzuki S., Oka Y., Kadowaki T., Kanatsua A., Kuzuya T., Kobayashi M., Sanke T.Seino Y., Nanjyo K.
- Journal Title
  
  Diabet Res Clin Pract 59
  
  Pages: 207-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Roles of mTOR and JNK in insulin or anisomycin-induced IRS-1 serine phosphorylation and its correlation with translocation and degradation of IRS-1.
- Author(s)
  Hiratani K., Tetsuro H., Tani A., Kawahara J., Usui I., Kobayashi M.
- Journal Title
  
  (投稿中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Roles of mTOR and JNK in insulin or anisomycin-induced IRS-1 Serine phosphorylation and its correlation with translocation and degradation of IRS-1.
- Author(s)
  Hiratani K., Haruta T., Tani A., Kawahara J., Usui I., Kobayashi M.
- Journal Title
  
  (submitted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Interleukin-1α inhibits insulin signaling with phosphorylating insulin receptor substrate-1 serine residues in 3T3-L1 adipocytes.
- Author(s)
  He J., Usui I., Ishizuka K., Kanatani Y., Hiratani K., Iwata M., Bukhari A., Haruta T., Sasaoka T., Kobayashi M.
- Journal Title
  
  (submitted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590932
[Journal Article] Interleukin-1αinhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
- Author(s)
  He J., Usui I., Ishizuka K., Kanatani Y., Hiratani K., Iwata M., Bukhari A., Haruta T., Sasaoka T., Kobayashi M.
- Journal Title
  
  (投稿中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590932

1. TAKATA Yasumitsu (50242491)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. USUI Isao (50377272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. 前川聡 (00209363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. INOUE Ken

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TERAOKA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBAYASHI Masashi 小林 正

KOBAYASHI Msashi 小林 正

Research Projects

Research Products

Co-Researchers

MECHANISMS FOR INSULIN RESISTANCE BY SERINE KINASE ACTIVATIONPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of negative-feed back mechanism through mTOR pathway in insulin action.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of degradation of mutant insulin receptors.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Syndrome of extreme insulin resistance due to decreased promoter activity of 5'-flanking region of insulin receptor gene.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Insulin Resistance Due to Unprocessed Insulin ProreceptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of Insulin Resistance in Insulin Receptor Disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 専門医に聞きたいコメディカルのための糖尿病・糖尿病性腎症Q&A101 Q-14糖尿病の治療 7)インスリン治療適応と方法 Q-21アルコールと食事療法(西沢良記, 石村栄治編)2005

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 糖尿病カレントライブラリー(4)糖床病と遺伝子 IV.遺伝子からみた病態2.インスリン抵抗性に関連するもの PTPaseとSHIP2(堀川幸男, 安田和基編集)2005

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-1 {alpha} Inhibit Insulin Signaling with Phosphoylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Interleukin-1 {alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006

Author(s)

Journal Title

KOBAYASHI Masashi 小林正

KOBAYASHI Msashi 小林正